Li-Kun Phng
@phnglab.bsky.social
Cell, Developmental and Vascular Biologist. Laboratory for Vascular Morphogenesis. RIKEN Center for Biosystems Dynamics Research.
Reposted by Li-Kun Phng
🪰Yu-Chiun Wang’s team & Univ. of Hohenheim group discovered how fly embryos solve the “tissue tectonic collision” that occurs in morphogenetic movements between tissues and why the #cephalicfurrow evolved, a longstanding mystery to developmental biologists.
In @nature.com
doi.org/10.1038/s415...
In @nature.com
doi.org/10.1038/s415...
Divergent evolutionary strategies pre-empt tissue collision in gastrulation - Nature
Flies have evolved two distinct strategies for managing mechanical stresses during embryogenesis: out-of-plane cell division in midges and transient out-of-plane tissue folding in fruit flies.
doi.org
September 18, 2025 at 9:49 AM
🪰Yu-Chiun Wang’s team & Univ. of Hohenheim group discovered how fly embryos solve the “tissue tectonic collision” that occurs in morphogenetic movements between tissues and why the #cephalicfurrow evolved, a longstanding mystery to developmental biologists.
In @nature.com
doi.org/10.1038/s415...
In @nature.com
doi.org/10.1038/s415...
Reposted by Li-Kun Phng
Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.
September 15, 2025 at 2:12 AM
Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.
Another successful #leducq #ReVAMP meeting held at Orford, Canada! Great science, food and friendship... Thanks @ondinecleaver.bsky.social for hosting us and showing us the way up the mountain! A la prochaine!
September 9, 2025 at 4:23 PM
Another successful #leducq #ReVAMP meeting held at Orford, Canada! Great science, food and friendship... Thanks @ondinecleaver.bsky.social for hosting us and showing us the way up the mountain! A la prochaine!
Reposted by Li-Kun Phng
Tiny molecular spirals in cells can scale up to control the twist and turn of entire tissues, an important step towards understanding left-right symmetry in tissues and organs.
buff.ly/2pSf3xS
buff.ly/2pSf3xS
September 9, 2025 at 3:11 PM
Tiny molecular spirals in cells can scale up to control the twist and turn of entire tissues, an important step towards understanding left-right symmetry in tissues and organs.
buff.ly/2pSf3xS
buff.ly/2pSf3xS
Reposted by Li-Kun Phng
Now published in @natcomms.nature.com! 🥳
👉 rdcu.be/eATn3
We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
👉 rdcu.be/eATn3
We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
August 15, 2025 at 12:13 PM
Now published in @natcomms.nature.com! 🥳
👉 rdcu.be/eATn3
We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
👉 rdcu.be/eATn3
We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
Reposted by Li-Kun Phng
A fantastic week at the Mechanobiology Conference in Vietnam, filled with fascinating talks, fruitful discussions, and amazing people.
Huge thanks to the organizers and ICISE for making it all possible!
Huge thanks to the organizers and ICISE for making it all possible!
July 11, 2025 at 4:49 PM
A fantastic week at the Mechanobiology Conference in Vietnam, filled with fascinating talks, fruitful discussions, and amazing people.
Huge thanks to the organizers and ICISE for making it all possible!
Huge thanks to the organizers and ICISE for making it all possible!
Thanks to the generosity of #FujiharaFoundation and the excellent organization of Fumio Motegi and his team, the ' #Mechanics of Life Across Scales' symposium was held successfully at beautiful Awaji. We had 3 days of fantastic #mechanobiology talks with speakers from Japan, India, Europe and US.
June 2, 2025 at 12:49 AM
Thanks to the generosity of #FujiharaFoundation and the excellent organization of Fumio Motegi and his team, the ' #Mechanics of Life Across Scales' symposium was held successfully at beautiful Awaji. We had 3 days of fantastic #mechanobiology talks with speakers from Japan, India, Europe and US.
Had the absolute pleasure of hosting the Leducq ReVAMP biannual meeting @riken-bdr.bsky.social in Kobe this spring! #endothelial #mechanobiology #vascularmalformations See you all again in Fall @ondinecleaver.bsky.social @mvikkula.bsky.social
April 22, 2025 at 5:23 AM
Had the absolute pleasure of hosting the Leducq ReVAMP biannual meeting @riken-bdr.bsky.social in Kobe this spring! #endothelial #mechanobiology #vascularmalformations See you all again in Fall @ondinecleaver.bsky.social @mvikkula.bsky.social
Check us out @the-node.bsky.social !
Lab Meeting with the Phng Lab
Meet the lab of @phnglab.bsky.social, based @riken-bdr.bsky.social, Kobe, Japan. The lab is interested in vascular #morphogenesis, in particular, endothelial cell mechanobiology in #zebrafish 🐟
Find out more about the lab and what it's like working at RIKEN BDR:
Meet the lab of @phnglab.bsky.social, based @riken-bdr.bsky.social, Kobe, Japan. The lab is interested in vascular #morphogenesis, in particular, endothelial cell mechanobiology in #zebrafish 🐟
Find out more about the lab and what it's like working at RIKEN BDR:
Lab Meeting with the Phng Lab - the Node
Meet the Phng Lab, based at the RIKEN Center for Biosystems Dynamics Research, Japan. The lab is interested in vascular morphogenesis and, in particular, endothelial cell mechanobiology.
thenode.biologists.com
April 15, 2025 at 12:57 AM
Check us out @the-node.bsky.social !
Reposted by Li-Kun Phng
📢 Mechanobiology Conference III: From Fundamental Research to Applications
📅 July 06-12
📍 ICISE Quy Nhon, central Vietnam
The registration and abstract submission is now open!
🔗 icisequynhon.com/conferences/...
📅 July 06-12
📍 ICISE Quy Nhon, central Vietnam
The registration and abstract submission is now open!
🔗 icisequynhon.com/conferences/...
January 21, 2025 at 11:23 AM
📢 Mechanobiology Conference III: From Fundamental Research to Applications
📅 July 06-12
📍 ICISE Quy Nhon, central Vietnam
The registration and abstract submission is now open!
🔗 icisequynhon.com/conferences/...
📅 July 06-12
📍 ICISE Quy Nhon, central Vietnam
The registration and abstract submission is now open!
🔗 icisequynhon.com/conferences/...
Thank you @the-node.bsky.social for inviting me to write a 'Behind the Story' piece on our recent study!
Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis thenode.biologists.com/exploring-th...
Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis thenode.biologists.com/exploring-th...
Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis - the Node
Behind the Paper Story of “Combined forces of hydrostatic pressure and actin polymerisation drive endothelial tip cell migration and sprouting angiogenesis”.
thenode.biologists.com
April 2, 2025 at 8:11 PM
Thank you @the-node.bsky.social for inviting me to write a 'Behind the Story' piece on our recent study!
Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis thenode.biologists.com/exploring-th...
Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis thenode.biologists.com/exploring-th...
Reposted by Li-Kun Phng
Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...
March 10, 2025 at 2:43 AM
Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...
At #RIKEN BDR, women represent 10% of PIs, 31% of researchers, 38% of students and 74% of technical staff. On #IDWGIS last month, we celebrated their achievements and contributions to research at BDR. www.bdr.riken.jp/en/news/bdr-... #internationalwomensday
Careers in Science—Perspectives of Women Researchers and Technical Staff
www.bdr.riken.jp
March 10, 2025 at 12:36 AM
At #RIKEN BDR, women represent 10% of PIs, 31% of researchers, 38% of students and 74% of technical staff. On #IDWGIS last month, we celebrated their achievements and contributions to research at BDR. www.bdr.riken.jp/en/news/bdr-... #internationalwomensday
Reposted by Li-Kun Phng
Zebrafish study reveals that, along with actin polymerisation, hydrostatic pressure underlies the push of endothelial tip cells into new territory
📹: Igor Kondrychyn et al RIKEN Center for Biosystems Dynamics Research, Kobe, Japan in @elife.bsky.social
➡️: bpod.org.uk/archive/2025...
📹: Igor Kondrychyn et al RIKEN Center for Biosystems Dynamics Research, Kobe, Japan in @elife.bsky.social
➡️: bpod.org.uk/archive/2025...
March 6, 2025 at 1:41 PM
Zebrafish study reveals that, along with actin polymerisation, hydrostatic pressure underlies the push of endothelial tip cells into new territory
📹: Igor Kondrychyn et al RIKEN Center for Biosystems Dynamics Research, Kobe, Japan in @elife.bsky.social
➡️: bpod.org.uk/archive/2025...
📹: Igor Kondrychyn et al RIKEN Center for Biosystems Dynamics Research, Kobe, Japan in @elife.bsky.social
➡️: bpod.org.uk/archive/2025...
Chuffed to find out that our work was featured as an Insight article in @elife.bsky.social elifesciences.org/articles/106.... Thank you Sean Sun and colleague for highlighting our work!
Morphogenesis: Fluid transport comes to the fore
Proteins that allow water to move in and out of cells help shape the development of new blood vessels.
elifesciences.org
March 5, 2025 at 9:26 AM
Chuffed to find out that our work was featured as an Insight article in @elife.bsky.social elifesciences.org/articles/106.... Thank you Sean Sun and colleague for highlighting our work!
Reposted by Li-Kun Phng
Proteins that allow water to move in and out of cells help shape the development of new blood vessels.
buff.ly/41n6ii0
buff.ly/41n6ii0
March 3, 2025 at 9:21 AM
Proteins that allow water to move in and out of cells help shape the development of new blood vessels.
buff.ly/41n6ii0
buff.ly/41n6ii0
Reposted by Li-Kun Phng
What an honor to host @itaiyanai.bsky.social at RIKEN-BDR, Kobe! From learning Night Science creativity, to see them come alive with Day Science rigor, Itai truly demonstrated the "yes, and" attitude in person! Thank you for your great energy, passion and generosity! Can't wait to have you back!
February 22, 2025 at 2:48 AM
What an honor to host @itaiyanai.bsky.social at RIKEN-BDR, Kobe! From learning Night Science creativity, to see them come alive with Day Science rigor, Itai truly demonstrated the "yes, and" attitude in person! Thank you for your great energy, passion and generosity! Can't wait to have you back!
Read the Research Highlight here! www.riken.jp/en/news_pubs... @RIKEN BDR
Water gives cells a push in blood vessel formation
RIKEN researchers have shown that that hydrostatic pressure is one of two mechanisms that control endothelial cell migration during angiogenic sprouting in zebrafish
www.riken.jp
February 21, 2025 at 7:51 AM
Read the Research Highlight here! www.riken.jp/en/news_pubs... @RIKEN BDR
Happy to announce that the final version of our paper on #endothelial cell #migration #mechanobiology, #angiogenesis, #hydrostaticpressure is out on @elife.bsky.social doi.org/10.7554/eLif... !! In our revised paper, we show that disrupted osmotic gradient and water inflow impair tip cell migration!
Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis
Investigation of Aquaporin water channels unveils water inflow and build-up of hydrostatic pressure in endothelial tip cells as a novel mechanism of endothelial cell migration and blood vessel formati...
doi.org
February 21, 2025 at 7:45 AM
Happy to announce that the final version of our paper on #endothelial cell #migration #mechanobiology, #angiogenesis, #hydrostaticpressure is out on @elife.bsky.social doi.org/10.7554/eLif... !! In our revised paper, we show that disrupted osmotic gradient and water inflow impair tip cell migration!
Reposted by Li-Kun Phng
Excited to host @itaiyanai.bsky.social at RIKEN BDR, Kobe over the next few days! Looking forward to learning about "Tails" and how to use Night Science "Tales" to supercharge creativity in science! Thank you Itai for accepting our invitation!
February 18, 2025 at 10:33 PM
Excited to host @itaiyanai.bsky.social at RIKEN BDR, Kobe over the next few days! Looking forward to learning about "Tails" and how to use Night Science "Tales" to supercharge creativity in science! Thank you Itai for accepting our invitation!
Excited to announce that we will be holding another #mechanobiology across scales symposium this year in beautiful Awaji Island #Japan! We have a star-studded lineup of speakers and it's free participation (free accommodation and food!)! Register here: www.igm.hokudai.ac.jp/85th-fujihar...
January 21, 2025 at 4:28 AM
Excited to announce that we will be holding another #mechanobiology across scales symposium this year in beautiful Awaji Island #Japan! We have a star-studded lineup of speakers and it's free participation (free accommodation and food!)! Register here: www.igm.hokudai.ac.jp/85th-fujihar...