@oli4wolf.bsky.social
Reposted
1) New sociology paper on severe ME/CFS. The authors analyzed 342 messages on Twitter/X to get insights into the daily reality of people with severe ME/CFS.
They highlight the feeling of being trapped by the illness, profound isolation and longing for the outside world.
They highlight the feeling of being trapped by the illness, profound isolation and longing for the outside world.
November 22, 2025 at 8:39 AM
1) New sociology paper on severe ME/CFS. The authors analyzed 342 messages on Twitter/X to get insights into the daily reality of people with severe ME/CFS.
They highlight the feeling of being trapped by the illness, profound isolation and longing for the outside world.
They highlight the feeling of being trapped by the illness, profound isolation and longing for the outside world.
Reposted
This exemplifies a poorly conceived and executed trial for a potential #LongCovid treatment
58 total participants
51% dropout rate in the intervention group (NR, to raise NAD+ levels)
Negative, woefully underpowered trial
www.thelancet.com/journals/ecl...
58 total participants
51% dropout rate in the intervention group (NR, to raise NAD+ levels)
Negative, woefully underpowered trial
www.thelancet.com/journals/ecl...
Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled trial
In long-COVID, NR increased NAD+ within 5 weeks but did not significantly improve
cognition, fatigue, sleep, or mood vs. PBO. Exploratory analyses suggested within-group
benefits after 10 weeks of NR,...
www.thelancet.com
November 13, 2025 at 3:15 PM
This exemplifies a poorly conceived and executed trial for a potential #LongCovid treatment
58 total participants
51% dropout rate in the intervention group (NR, to raise NAD+ levels)
Negative, woefully underpowered trial
www.thelancet.com/journals/ecl...
58 total participants
51% dropout rate in the intervention group (NR, to raise NAD+ levels)
Negative, woefully underpowered trial
www.thelancet.com/journals/ecl...
Reposted
Vergeudete Lebenszeit.
Das sehe ich *so oft*, weil Dinge wie MCAS, POTS, hEDS nicht erkannt und die Symptome als psychosomatisch interpretiert werden.
Bemerkenswert, dass das alles Erkrankungen sind, die bei jungen Frauen häufig vorkommen.
Das sehe ich *so oft*, weil Dinge wie MCAS, POTS, hEDS nicht erkannt und die Symptome als psychosomatisch interpretiert werden.
Bemerkenswert, dass das alles Erkrankungen sind, die bei jungen Frauen häufig vorkommen.
Vielen Dank fürs Teilen! Bitte Kolleg:innen informieren. Ich musste das selbst herausfinden: trial&error. Jahrzehnte lang psychologisiert, alles Mögliche ausprobiert, viel Zeit im dunklen Zimmer (=nicht arbeitsfähig),... dann: deutl. Verbesserung durch Antihistaminika. Viel vergeudete Lebenszeit.
November 8, 2025 at 8:22 AM
Vergeudete Lebenszeit.
Das sehe ich *so oft*, weil Dinge wie MCAS, POTS, hEDS nicht erkannt und die Symptome als psychosomatisch interpretiert werden.
Bemerkenswert, dass das alles Erkrankungen sind, die bei jungen Frauen häufig vorkommen.
Das sehe ich *so oft*, weil Dinge wie MCAS, POTS, hEDS nicht erkannt und die Symptome als psychosomatisch interpretiert werden.
Bemerkenswert, dass das alles Erkrankungen sind, die bei jungen Frauen häufig vorkommen.
Reposted
The dysregulated immune system in #LongCovid with #MECFS. with sex-specific changes, increased inflammation (as seen by cells, chemokines and cytokines), and disrupted hormone levels www.cell.com/cell-reports...
November 7, 2025 at 4:00 PM
The dysregulated immune system in #LongCovid with #MECFS. with sex-specific changes, increased inflammation (as seen by cells, chemokines and cytokines), and disrupted hormone levels www.cell.com/cell-reports...
Reposted
We've just launched the first large, site-less (home, direct to participant) randomized trial for treatment of #LongCovid, testing tirzepatide (a GLP-1 drug) vs placebo. Please help spread the word
www.scripps.edu/news-and-eve...
www.scripps.edu/news-and-eve...
Scripps Research scientists launch new digital clinical trial to test repurposed drug for long COVID symptom relief
www.scripps.edu
October 31, 2025 at 5:07 PM
We've just launched the first large, site-less (home, direct to participant) randomized trial for treatment of #LongCovid, testing tirzepatide (a GLP-1 drug) vs placebo. Please help spread the word
www.scripps.edu/news-and-eve...
www.scripps.edu/news-and-eve...
Reposted
On our #LongCovid clinical trial launched today!
thesicktimes.org/2025/10/30/w... @julialmv.bsky.social @scripps.edu
thesicktimes.org/2025/10/30/w... @julialmv.bsky.social @scripps.edu
We need more at-home clinical trials for Long COVID. Here’s how we designed the largest one yet. - The Sick Times
We are now recruiting for the Long COVID Treatment Trial-Tirzepatide (LoCITT-T), which participants can complete entirely from bed.
thesicktimes.org
October 30, 2025 at 11:05 PM
On our #LongCovid clinical trial launched today!
thesicktimes.org/2025/10/30/w... @julialmv.bsky.social @scripps.edu
thesicktimes.org/2025/10/30/w... @julialmv.bsky.social @scripps.edu
Reposted
Some generative A.I. tips for patients
www.wsj.com/opinion/a-ch...
www.wsj.com/opinion/a-ch...
August 30, 2025 at 2:09 PM
Some generative A.I. tips for patients
www.wsj.com/opinion/a-ch...
www.wsj.com/opinion/a-ch...
Reposted
After 5 years of seeing people suffer with #LongCovid, this meta-analysis of 51 small randomized trials is very sobering. Essentially there is nothing, no clear validated treatment, and I don't agree with their conclusions and emphasis.
www.thelancet.com/journals/ecl...
www.thelancet.com/journals/ecl...
Effects of therapeutic interventions on long COVID: a meta-analysis of randomized controlled trials
Exercise training should be prioritized for improving cardiopulmonary function and
exercise capacity in Long COVID, supported by high-certainty evidence. Respiratory
muscle training and PEA-LUT offer ...
www.thelancet.com
August 5, 2025 at 9:02 PM
After 5 years of seeing people suffer with #LongCovid, this meta-analysis of 51 small randomized trials is very sobering. Essentially there is nothing, no clear validated treatment, and I don't agree with their conclusions and emphasis.
www.thelancet.com/journals/ecl...
www.thelancet.com/journals/ecl...
Reposted
A rundown on the big advances we’re seeing on the brain-immune axis
erictopol.substack.com/p/our-braini...
erictopol.substack.com/p/our-braini...
Our Brain—Immune Axis Gets A Jolt
Facts, data and analytics about biomedical matters
erictopol.substack.com
August 3, 2025 at 6:33 PM
A rundown on the big advances we’re seeing on the brain-immune axis
erictopol.substack.com/p/our-braini...
erictopol.substack.com/p/our-braini...
Reposted
This is some of the most exciting observational research into post-viral illness. At the end, @virusesimmunity.bsky.social says that positive results would lead them to try to pursue trials with immunotherapies like FcRn inhibitors, B cell targeting therapies, and IVIg.
Solve ME: 'Probing Functional Autoantibodies in Patients with ME/CFS'
'Dr. Akiko Iwasaki (Sterling Professor of Immunobiology and Molecular, Cellular and Developmental Biology at Yale University) is the first recipient of Solve’s ME/CFS Catalyst Award..'
www.youtube.com/watch?v=9ar0...
'Dr. Akiko Iwasaki (Sterling Professor of Immunobiology and Molecular, Cellular and Developmental Biology at Yale University) is the first recipient of Solve’s ME/CFS Catalyst Award..'
www.youtube.com/watch?v=9ar0...
Probing Functional Autoantibodies in Patients with ME/CFS
YouTube video by SolveME
www.youtube.com
August 1, 2025 at 4:51 PM
This is some of the most exciting observational research into post-viral illness. At the end, @virusesimmunity.bsky.social says that positive results would lead them to try to pursue trials with immunotherapies like FcRn inhibitors, B cell targeting therapies, and IVIg.
Reposted
We've known that Covid increases the risk in survivors of cancer, but today @nature.com a mechanism of reactivation of cancer cells elucidated in the experimental model
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
July 30, 2025 at 4:36 PM
We've known that Covid increases the risk in survivors of cancer, but today @nature.com a mechanism of reactivation of cancer cells elucidated in the experimental model
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
My codebase is growing fast with AI-generated code and pull-requests from outside. I sometimes don’t feel in control anymore. How do I maintain this long-term?
July 28, 2025 at 7:20 PM
My codebase is growing fast with AI-generated code and pull-requests from outside. I sometimes don’t feel in control anymore. How do I maintain this long-term?
Reposted
I don’t smoke, but this was easily one of my favorite projects at #OpenSauce 🔥🔥🔥 #OpenSauce2025 #maker #RaspberryPi @opencv.bsky.social
July 21, 2025 at 5:20 PM
I don’t smoke, but this was easily one of my favorite projects at #OpenSauce 🔥🔥🔥 #OpenSauce2025 #maker #RaspberryPi @opencv.bsky.social
Reposted
Why happens when you put SARS-CoV-2 in with human neural (retinal) tissue in culture (organoid)?
It induces Alzheimer’s-like pathology.
www.science.org/doi/10.1126/...
It induces Alzheimer’s-like pathology.
www.science.org/doi/10.1126/...
July 7, 2025 at 11:37 PM
Why happens when you put SARS-CoV-2 in with human neural (retinal) tissue in culture (organoid)?
It induces Alzheimer’s-like pathology.
www.science.org/doi/10.1126/...
It induces Alzheimer’s-like pathology.
www.science.org/doi/10.1126/...
Reposted
SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids | Science Advances www.science.org/doi/10.1126/...
SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids
SARS-CoV-2 induces amyloid-β pathology in the central nervous system.
www.science.org
July 7, 2025 at 8:45 AM
SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids | Science Advances www.science.org/doi/10.1126/...
Reposted
The output of computer-vision research is overwhelmingly aimed towards monitoring humans
https://go.nature.com/45HQI4f
https://go.nature.com/45HQI4f
Don’t sleepwalk from computer-vision research into surveillance
The output of computer-vision research is overwhelmingly aimed towards monitoring humans. The potential ethical implications need more scrutiny.
go.nature.com
June 26, 2025 at 9:33 AM
The output of computer-vision research is overwhelmingly aimed towards monitoring humans
https://go.nature.com/45HQI4f
https://go.nature.com/45HQI4f
Reposted
Outstanding review of neuroinflammation and dysfunction in #LongCovid onlinelibrary.wiley.com/doi/full/10....
@virusesimmunity.bsky.social @jannamoen.bsky.social
@virusesimmunity.bsky.social @jannamoen.bsky.social
June 21, 2025 at 4:08 PM
Outstanding review of neuroinflammation and dysfunction in #LongCovid onlinelibrary.wiley.com/doi/full/10....
@virusesimmunity.bsky.social @jannamoen.bsky.social
@virusesimmunity.bsky.social @jannamoen.bsky.social
Reposted
We are pushing so many people into housing insecurity. Imagine being very sick AND homeless. This is the reality of millions with #LongCovid.
Thank you the @thesicktimes.bsky.social for keep talking about it.
Thank you the @thesicktimes.bsky.social for keep talking about it.
June 17, 2025 at 5:59 PM
We are pushing so many people into housing insecurity. Imagine being very sick AND homeless. This is the reality of millions with #LongCovid.
Thank you the @thesicktimes.bsky.social for keep talking about it.
Thank you the @thesicktimes.bsky.social for keep talking about it.
Reposted
Nature research paper: Physical restoration of a painting with a digitally constructed mask
https://go.nature.com/43T31YW
https://go.nature.com/43T31YW
Physical restoration of a painting with a digitally constructed mask - Nature
A digital restoration technique for damaged paintings was developed, in which a colour-accurate bilayer mask of printed pigments on polymeric films was used, reducing treatment time and cost while adhering to ethical conservation principles.
go.nature.com
June 11, 2025 at 3:28 PM
Nature research paper: Physical restoration of a painting with a digitally constructed mask
https://go.nature.com/43T31YW
https://go.nature.com/43T31YW
Reposted
Damage to the vascular lining leads to interactions with red blood cells that hint at how to treat dangerous complications of heart attack, stroke and COVID-19
https://go.nature.com/4jyBzpe
https://go.nature.com/4jyBzpe
Sticky membranes of dead red blood cells obstruct small vessels
Damage to the vascular lining leads to interactions with red blood cells that hint at how to treat dangerous complications of heart attack, stroke and COVID-19.
go.nature.com
June 4, 2025 at 5:01 PM
Damage to the vascular lining leads to interactions with red blood cells that hint at how to treat dangerous complications of heart attack, stroke and COVID-19
https://go.nature.com/4jyBzpe
https://go.nature.com/4jyBzpe
Reposted
Microvascular obstruction is known to be a #LongCovid feature. Now a potential mechanism found for the obstruction induced by death of endothelial cells->sticky red blood cells. Which wouldn't respond to blood thinners or anti-platelet Rx
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
June 4, 2025 at 7:38 PM
Microvascular obstruction is known to be a #LongCovid feature. Now a potential mechanism found for the obstruction induced by death of endothelial cells->sticky red blood cells. Which wouldn't respond to blood thinners or anti-platelet Rx
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
Reposted
Another hallmark of #Alzheimer is misfolded Tau accumulation. Everything in 🟡 in the image below is dying neurons in the human hippocampus, a major region of memory processing. This 🧠 is from a donor with advanced Alzheimer. Healthy neurons in 🔵, Dapi🟣
It's still #FluorescenceFriday in California 😁🔬
It's still #FluorescenceFriday in California 😁🔬
May 31, 2025 at 5:06 AM
Another hallmark of #Alzheimer is misfolded Tau accumulation. Everything in 🟡 in the image below is dying neurons in the human hippocampus, a major region of memory processing. This 🧠 is from a donor with advanced Alzheimer. Healthy neurons in 🔵, Dapi🟣
It's still #FluorescenceFriday in California 😁🔬
It's still #FluorescenceFriday in California 😁🔬
Reposted
On finding treatments for #LongCovid
“What’s so sad here is people are so desperate, and we don’t have anything [of so many solid candidates] validated."
gift link: www.washingtonpost.com/wellness/202...
“What’s so sad here is people are so desperate, and we don’t have anything [of so many solid candidates] validated."
gift link: www.washingtonpost.com/wellness/202...
Long covid patients are desperate for treatments. These trials may help.
Some trials are focusing on drugs that target the immune system, which is affected by different pathways to long covid.
www.washingtonpost.com
May 16, 2025 at 7:53 PM
On finding treatments for #LongCovid
“What’s so sad here is people are so desperate, and we don’t have anything [of so many solid candidates] validated."
gift link: www.washingtonpost.com/wellness/202...
“What’s so sad here is people are so desperate, and we don’t have anything [of so many solid candidates] validated."
gift link: www.washingtonpost.com/wellness/202...
Reposted
The 2 new papers this is based on, w/ advances toward biomarkers
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
May 1, 2025 at 2:06 PM
The 2 new papers this is based on, w/ advances toward biomarkers
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
Sehr eindrückliche (und traurige) Geschichten. Aber in der Schweiz werden die Long Covid-Sprechstunden präferiert geschlossen, anstatt das Betreuungsangebot ausgebaut. #LongCovid #MECFS
Leben mit Long-Covid: «Mein Körper ist in einer Nacht um 35 Jahre gealtert»
Der Fotograf Andreas Seibert hat rund 80 Long-Covid-Betroffene porträtiert. Was er während dieser Arbeit sah und nun in einem Bildband festhält, hat ihn «erschüttert und beschämt».
www.derbund.ch
April 21, 2025 at 8:58 AM
Sehr eindrückliche (und traurige) Geschichten. Aber in der Schweiz werden die Long Covid-Sprechstunden präferiert geschlossen, anstatt das Betreuungsangebot ausgebaut. #LongCovid #MECFS