Nicholas Schnicker
@nschnick.bsky.social
Director | Protein Structure, Analysis, & Design Core
Adj Assistant Professor | Molecular Physiology & Biophysics
University of Iowa
Structural Biology | Biophysical Characterization | Protein Design
Views are my own.
Adj Assistant Professor | Molecular Physiology & Biophysics
University of Iowa
Structural Biology | Biophysical Characterization | Protein Design
Views are my own.
Reposted by Nicholas Schnicker
🎉 Joint paper from the Freudenthal and @tmweaver.bsky.social Labs!
Abbey Vito’s first publication discusses a tug-of-war between BER enzymes and chromatin for access to damaged DNA, a battle central to genome stability.
Built on Tyler's foundational work! tinyurl.com/ywkt2bt5
Abbey Vito’s first publication discusses a tug-of-war between BER enzymes and chromatin for access to damaged DNA, a battle central to genome stability.
Built on Tyler's foundational work! tinyurl.com/ywkt2bt5
Base excision repair in chromatin: A tug-of-war for DNA damage
Base excision repair (BER) is a genome surveillance pathway responsible for repairing DNA base lesions distributed throughout the chromatinized eukary…
tinyurl.com
November 3, 2025 at 3:47 PM
🎉 Joint paper from the Freudenthal and @tmweaver.bsky.social Labs!
Abbey Vito’s first publication discusses a tug-of-war between BER enzymes and chromatin for access to damaged DNA, a battle central to genome stability.
Built on Tyler's foundational work! tinyurl.com/ywkt2bt5
Abbey Vito’s first publication discusses a tug-of-war between BER enzymes and chromatin for access to damaged DNA, a battle central to genome stability.
Built on Tyler's foundational work! tinyurl.com/ywkt2bt5
Reposted by Nicholas Schnicker
Happening this week! Register for the Thursday October 30 Virtual Office Hour on Structure Summary Pages
Learn how a exploring a single PDB structure at RCSB PDB can lead to visualizations, analyses, and searches across the archive
Learn how a exploring a single PDB structure at RCSB PDB can lead to visualizations, analyses, and searches across the archive
Register for the Oct 30 Virtual Office Hour on Structure Summary Pages
Learn how a exploring a single PDB structure at RCSB.org can lead to visualizations, analyses, and searches across the archive
www.rcsb.org
October 27, 2025 at 4:44 PM
Happening this week! Register for the Thursday October 30 Virtual Office Hour on Structure Summary Pages
Learn how a exploring a single PDB structure at RCSB PDB can lead to visualizations, analyses, and searches across the archive
Learn how a exploring a single PDB structure at RCSB PDB can lead to visualizations, analyses, and searches across the archive
Reposted by Nicholas Schnicker
Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
October 22, 2025 at 4:41 PM
Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
Great info here!
New blogpost on the latest in AI antibody design.
Including some code to easily run Germinal and IgGM on modal!
blog.booleanbiotech.com/ai-antibody-...
Including some code to easily run Germinal and IgGM on modal!
blog.booleanbiotech.com/ai-antibody-...
Boolean Biotech
blog.booleanbiotech.com
September 28, 2025 at 2:43 PM
Great info here!
Reposted by Nicholas Schnicker
In another preprint from the @brianhie.bsky.social Lab and @synbiogaolab.bsky.social, they introduce Germinal, a generative AI system for de novo antibody design.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
September 24, 2025 at 3:07 PM
In another preprint from the @brianhie.bsky.social Lab and @synbiogaolab.bsky.social, they introduce Germinal, a generative AI system for de novo antibody design.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
Love this pipeline! Congrats to all involved!
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 27, 2025 at 8:40 PM
Love this pipeline! Congrats to all involved!
Reposted by Nicholas Schnicker
🧪 Skip the trial and error for structure determination of soluble proteins. Join the #webinar 10/8 for a gene-to-structure case study of CYP3A4, a 57 kDa cytochrome P450 monooxygenase, solved to 3.1 Å by #cryoEM.
nimgs.zoom.us/webinar/regi...
nimgs.zoom.us/webinar/regi...
Welcome! You are invited to join a webinar: Soluble Proteins in Focus: Preparing for Cryo-EM Success. After registering, you will receive a confirmation email about joining the webinar.
Are you using cryo-EM to look at small soluble proteins?
Join Dr. Claudio Catalano, a Senior Scientist at NanoImaging Services, to get expert advice on how to set your project up for success. He wil...
nimgs.zoom.us
August 27, 2025 at 6:12 PM
🧪 Skip the trial and error for structure determination of soluble proteins. Join the #webinar 10/8 for a gene-to-structure case study of CYP3A4, a 57 kDa cytochrome P450 monooxygenase, solved to 3.1 Å by #cryoEM.
nimgs.zoom.us/webinar/regi...
nimgs.zoom.us/webinar/regi...
Reposted by Nicholas Schnicker
Major update from #SCIMaP...
FY26 House district level scorecards.
Our FY26 budget analysis tab includes clickable district info, breaking down the expected economic and job loss given the White House's budget proposal that would slash NIH research funding by >40%.
scienceimpacts.org/fy26
FY26 House district level scorecards.
Our FY26 budget analysis tab includes clickable district info, breaking down the expected economic and job loss given the White House's budget proposal that would slash NIH research funding by >40%.
scienceimpacts.org/fy26
SCIMaP - Impacts of Federal Cuts to Science and Medical Research
View Projected Impact of the FY2026 Budget Cuts to the NIH
scienceimpacts.org
August 15, 2025 at 2:48 AM
Major update from #SCIMaP...
FY26 House district level scorecards.
Our FY26 budget analysis tab includes clickable district info, breaking down the expected economic and job loss given the White House's budget proposal that would slash NIH research funding by >40%.
scienceimpacts.org/fy26
FY26 House district level scorecards.
Our FY26 budget analysis tab includes clickable district info, breaking down the expected economic and job loss given the White House's budget proposal that would slash NIH research funding by >40%.
scienceimpacts.org/fy26
Just made my first webapp mostly for analyzing structures from #BindCraft
👉🏼 pdb-viewer.lovable.app
It’s bare 🦴 at this point but curious if others find something like this useful and features they’d like?
🧬🧶
👉🏼 pdb-viewer.lovable.app
It’s bare 🦴 at this point but curious if others find something like this useful and features they’d like?
🧬🧶
Protein Structure Viewer
Upload and interactively visualize multiple Protein Data Bank (.pdb) structures.
pdb-viewer.lovable.app
August 13, 2025 at 4:37 AM
Just made my first webapp mostly for analyzing structures from #BindCraft
👉🏼 pdb-viewer.lovable.app
It’s bare 🦴 at this point but curious if others find something like this useful and features they’d like?
🧬🧶
👉🏼 pdb-viewer.lovable.app
It’s bare 🦴 at this point but curious if others find something like this useful and features they’d like?
🧬🧶
Reposted by Nicholas Schnicker
We’ve refreshed the AlphaFold Database Entry Pages!
Explore the cleaner design, improved 3D viewer, and easier access from any device 👇
www.alphafold.ebi.ac.uk/entry/P04637
Or read more👇
www.ebi.ac.uk/about/news/u...
#AlphaFold #Bioinformatics #UXForScience
@pdbeurope.bsky.social
Explore the cleaner design, improved 3D viewer, and easier access from any device 👇
www.alphafold.ebi.ac.uk/entry/P04637
Or read more👇
www.ebi.ac.uk/about/news/u...
#AlphaFold #Bioinformatics #UXForScience
@pdbeurope.bsky.social
August 7, 2025 at 12:19 PM
We’ve refreshed the AlphaFold Database Entry Pages!
Explore the cleaner design, improved 3D viewer, and easier access from any device 👇
www.alphafold.ebi.ac.uk/entry/P04637
Or read more👇
www.ebi.ac.uk/about/news/u...
#AlphaFold #Bioinformatics #UXForScience
@pdbeurope.bsky.social
Explore the cleaner design, improved 3D viewer, and easier access from any device 👇
www.alphafold.ebi.ac.uk/entry/P04637
Or read more👇
www.ebi.ac.uk/about/news/u...
#AlphaFold #Bioinformatics #UXForScience
@pdbeurope.bsky.social
Reposted by Nicholas Schnicker
Affinity-ligand purification of native human low-abundance multi-protein complexes for structure determination www.biorxiv.org/content/10.1101/2025.07.31.667873v1 #cryoem
August 3, 2025 at 12:55 PM
Affinity-ligand purification of native human low-abundance multi-protein complexes for structure determination www.biorxiv.org/content/10.1101/2025.07.31.667873v1 #cryoem
Reposted by Nicholas Schnicker
Check out our new preprint from the @landerlab.bsky.social, Stagg-Lab and Cianfrocco-Lab: CryoSift - An accessible and automated CNN-driven tool for cryo-EM 2D class selection www.biorxiv.org/content/10.1...
Happy testing: cryosift.org #cryoEM #CNN
Happy testing: cryosift.org #cryoEM #CNN
August 1, 2025 at 3:20 PM
Check out our new preprint from the @landerlab.bsky.social, Stagg-Lab and Cianfrocco-Lab: CryoSift - An accessible and automated CNN-driven tool for cryo-EM 2D class selection www.biorxiv.org/content/10.1...
Happy testing: cryosift.org #cryoEM #CNN
Happy testing: cryosift.org #cryoEM #CNN
Reposted by Nicholas Schnicker
NEW from me at STAT:
We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out.
More @statnews.com:
www.statnews.com/2025/07/21/c...
🖥️🩺🧪🧬 #bioML
We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out.
More @statnews.com:
www.statnews.com/2025/07/21/c...
🖥️🩺🧪🧬 #bioML
AlphaFold developer Google DeepMind to fund CASP as NIH funding falls short
Protein structure prediction contest CASP gets temporary funding from Google DeepMind as NIH grant runs out.
www.statnews.com
July 21, 2025 at 4:40 PM
NEW from me at STAT:
We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out.
More @statnews.com:
www.statnews.com/2025/07/21/c...
🖥️🩺🧪🧬 #bioML
We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out.
More @statnews.com:
www.statnews.com/2025/07/21/c...
🖥️🩺🧪🧬 #bioML
Reposted by Nicholas Schnicker
Designed protein pockets recognize intrinsically disordered protein regions @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.statnews.com/2025/07/17/n...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.statnews.com/2025/07/17/n...
Disorder meets its match
Designed protein pockets recognize intrinsically disordered protein regions
www.science.org
July 17, 2025 at 7:42 PM
Designed protein pockets recognize intrinsically disordered protein regions @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.statnews.com/2025/07/17/n...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.statnews.com/2025/07/17/n...
Reposted by Nicholas Schnicker
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology
SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...
www.nature.com
July 3, 2025 at 7:45 PM
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
Reposted by Nicholas Schnicker
CASP is the main reason the protein structure prediction technology and research field advanced over the last 30 years. And the main reason AI based methods have been accepted and widely applied in biology. So shortsighted of NIH to postpone or even halt funding. John Moult is a scientific hero.
Exclusive: An international scientific competition widely credited with spurring the development of artificial intelligence for biology appears to be on its deathbed. scim.ag/44ukS90
Exclusive: Famed protein structure competition nears end as NIH grant money runs out
Agency silent on funding renewal for contest that inspired creation of AIs that predicted how proteins would fold
scim.ag
July 2, 2025 at 10:36 PM
CASP is the main reason the protein structure prediction technology and research field advanced over the last 30 years. And the main reason AI based methods have been accepted and widely applied in biology. So shortsighted of NIH to postpone or even halt funding. John Moult is a scientific hero.
Reposted by Nicholas Schnicker
We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design!
github.com/martinpacesa...
github.com/martinpacesa...
June 30, 2025 at 7:45 PM
We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design!
github.com/martinpacesa...
github.com/martinpacesa...
Reposted by Nicholas Schnicker
🧪 We're beta testing - and we want your thoughts!
Try the redesigned PDBe entry pages & let us know:
🔸 What’s working?
🔸 What’s confusing?
🔸 What features do you miss?
💬 Feedback form: tinyurl.com/pdbe-beta-form
#PDBeBeta #Bioinformatics #Biochemistry #Science #UserVoice
Try the redesigned PDBe entry pages & let us know:
🔸 What’s working?
🔸 What’s confusing?
🔸 What features do you miss?
💬 Feedback form: tinyurl.com/pdbe-beta-form
#PDBeBeta #Bioinformatics #Biochemistry #Science #UserVoice
June 19, 2025 at 3:16 PM
🧪 We're beta testing - and we want your thoughts!
Try the redesigned PDBe entry pages & let us know:
🔸 What’s working?
🔸 What’s confusing?
🔸 What features do you miss?
💬 Feedback form: tinyurl.com/pdbe-beta-form
#PDBeBeta #Bioinformatics #Biochemistry #Science #UserVoice
Try the redesigned PDBe entry pages & let us know:
🔸 What’s working?
🔸 What’s confusing?
🔸 What features do you miss?
💬 Feedback form: tinyurl.com/pdbe-beta-form
#PDBeBeta #Bioinformatics #Biochemistry #Science #UserVoice
Reposted by Nicholas Schnicker
The videos for the recent CCP4 Study Weekend 2025 are now available on YouTube.
www.youtube.com/playlist?lis...
www.youtube.com/playlist?lis...
CCP4 Study Weekend 2025 - Using software, AI and other methods to advance macromolecular models. - YouTube
Recordings of talks from the CCP4 Study Weekend 2025 held at EMCC, Nottingham between 7-9 January 2025. The theme of the meeting was "Using software, AI and ...
www.youtube.com
June 10, 2025 at 11:51 AM
The videos for the recent CCP4 Study Weekend 2025 are now available on YouTube.
www.youtube.com/playlist?lis...
www.youtube.com/playlist?lis...
Reposted by Nicholas Schnicker
Fantastic day sharing knowledge with the brilliant researchers at NIH who valiantly work to advance the frontiers of science for the cause of improving human health. Thank you again for your service 🙏 🇺🇸
Today, Nobel laureate (and former NIGMS Advisory Council member) gave an NIH-wide lecture. She enthusiastically signed the #BethesdaDeclaration.
She was introduced by NIH Director Bhattacharya...(likely slightly awkward)
1/2
She was introduced by NIH Director Bhattacharya...(likely slightly awkward)
1/2
June 12, 2025 at 1:51 AM
Fantastic day sharing knowledge with the brilliant researchers at NIH who valiantly work to advance the frontiers of science for the cause of improving human health. Thank you again for your service 🙏 🇺🇸
Reposted by Nicholas Schnicker
The cryo-em core at kumc is looking for a lab manager. This is an exciting opportunity to join a growing facility. kumc.wd5.myworkdayjobs.com/en-US/kumc-j...
May 8, 2025 at 4:04 PM
The cryo-em core at kumc is looking for a lab manager. This is an exciting opportunity to join a growing facility. kumc.wd5.myworkdayjobs.com/en-US/kumc-j...
Happy to share we got the NoA for the NIH S10 proposal I submitted for a Glacios #cryoEM 🔬 for #IowaResearch #structuralbiology
May 6, 2025 at 8:59 PM
Happy to share we got the NoA for the NIH S10 proposal I submitted for a Glacios #cryoEM 🔬 for #IowaResearch #structuralbiology
Reposted by Nicholas Schnicker
1/5: Over the last few months, I have been working on an update for the #FollowRelionGracefully dashboard, which offers improved real-time job previews for #cryoEM #Relion jobs.
April 27, 2025 at 8:49 PM
1/5: Over the last few months, I have been working on an update for the #FollowRelionGracefully dashboard, which offers improved real-time job previews for #cryoEM #Relion jobs.