Nitika Taneja @TanejaLab
@nitikataneja.bsky.social
Associate Professor @ErasmusMC, @OncodeInstitute #proudMom #WomanInSTEM RI: #ChromatinOrganization #ReplicationStress #Epigenetics. Funding: #ERC #VIDI #Oncode
Reposted by Nitika Taneja @TanejaLab
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 30, 2025 at 8:41 PM
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Halloween borrel at the department 🎃 : our PhDs & Postdocs showed next-level creativity by revealing the hidden monstrous sides of their PIs! 👻😂
Absolutely hilarious & scary indeed😜… though I’m starting to wonder if that’s really how they see me 👀😅
Absolutely hilarious & scary indeed😜… though I’m starting to wonder if that’s really how they see me 👀😅
November 1, 2025 at 12:10 AM
Halloween borrel at the department 🎃 : our PhDs & Postdocs showed next-level creativity by revealing the hidden monstrous sides of their PIs! 👻😂
Absolutely hilarious & scary indeed😜… though I’m starting to wonder if that’s really how they see me 👀😅
Absolutely hilarious & scary indeed😜… though I’m starting to wonder if that’s really how they see me 👀😅
Reposted by Nitika Taneja @TanejaLab
I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress
Using biochemical assays and a mutant disrupting RNF168-dependent ubiquitination of
the histone variant macroH2A1.2, Galloy et al. identified an unexpected role for histone
mH2A1.2 ubiquitination in p...
www.cell.com
August 13, 2025 at 3:20 PM
I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Nitika Taneja @TanejaLab
First preLights post from Jenny Singh (@jennysingh.bsky.social)
She covers work showing that Lamin A/C maintains replication fork integrity during mild replication stress by modulating chromatin structure & restraining RECQ1 activity. #preprint
#preLight ⬇️
prelights.biologists.com/highlights/n...
She covers work showing that Lamin A/C maintains replication fork integrity during mild replication stress by modulating chromatin structure & restraining RECQ1 activity. #preprint
#preLight ⬇️
prelights.biologists.com/highlights/n...
Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels - preLights
Lamin A/C maintains replication fork integrity during mild replication stress by modulating chromatin structure and restraining RECQ1 activity.
prelights.biologists.com
June 5, 2025 at 11:03 AM
First preLights post from Jenny Singh (@jennysingh.bsky.social)
She covers work showing that Lamin A/C maintains replication fork integrity during mild replication stress by modulating chromatin structure & restraining RECQ1 activity. #preprint
#preLight ⬇️
prelights.biologists.com/highlights/n...
She covers work showing that Lamin A/C maintains replication fork integrity during mild replication stress by modulating chromatin structure & restraining RECQ1 activity. #preprint
#preLight ⬇️
prelights.biologists.com/highlights/n...
Reposted by Nitika Taneja @TanejaLab
⏰🚨FINAL DEADLINE APPROACHING
#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!
Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF
#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!
Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF
May 28, 2025 at 9:47 AM
⏰🚨FINAL DEADLINE APPROACHING
#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!
Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF
#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!
Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF
Reposted by Nitika Taneja @TanejaLab
A must for all DNA repair aficionados!
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
April 9, 2025 at 8:05 AM
A must for all DNA repair aficionados!
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
Reposted by Nitika Taneja @TanejaLab
Abortion bans kill women
My dear friend’s niece, who in October developed sepsis when a Georgia hospital refused her a D&C after a miscarriage, will be taken off life support tomorrow.
I don’t know the names of the countless others who have suffered and will suffered because of anti-abortion laws.
But her name was Haley.
I don’t know the names of the countless others who have suffered and will suffered because of anti-abortion laws.
But her name was Haley.
March 19, 2025 at 1:24 PM
Abortion bans kill women
Reposted by Nitika Taneja @TanejaLab
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
March 17, 2025 at 9:58 PM
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
Reposted by Nitika Taneja @TanejaLab
Join us in Lisbon this July to learn how cells "Balance Genome Fidelity & Plasticity". deadline for talks extended and a # of fellowships are available to offset trainee registration. www.fusion-conferences.com/conference/1...
February 28, 2025 at 1:35 AM
Join us in Lisbon this July to learn how cells "Balance Genome Fidelity & Plasticity". deadline for talks extended and a # of fellowships are available to offset trainee registration. www.fusion-conferences.com/conference/1...
Happy to have contributed(along with PhD students @joannapaulson.bsky.social & Collin Bakker) to such great work from @lopeslab.bsky.social and team!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 19, 2025 at 8:31 PM
Happy to have contributed(along with PhD students @joannapaulson.bsky.social & Collin Bakker) to such great work from @lopeslab.bsky.social and team!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Nitika Taneja @TanejaLab
Online today @science.org 👀Molecular basis of FIGNL1 in dissociating RAD51 from #DNA and #chromatin by @alexcarver.bsky.social @layates.bsky.social et al. in @imperialcollegeldn.bsky.social @mskcancercenter.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NEW in @science.org, so happy to contribute to our understanding of the molecular machine, Fidgetin-like 1 (FIGNL1), and elucidating the mechanism of why cells cannot survive when it is lost! #ScienceResearch science.org/doi/10.1126/... (1/7)
Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin
Maintaining genome integrity is an essential and challenging process. RAD51 recombinase, the central player of several crucial processes in repairing DNA and protecting genome integrity, forms filamen...
science.org
December 5, 2024 at 9:11 PM
Online today @science.org 👀Molecular basis of FIGNL1 in dissociating RAD51 from #DNA and #chromatin by @alexcarver.bsky.social @layates.bsky.social et al. in @imperialcollegeldn.bsky.social @mskcancercenter.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Nitika Taneja @TanejaLab
What are your plans for October 2025? It would be a fantastic time to visit Norway for the Endogenous DNA Damage and Repair conference with a stellar set of speaker covering a wide range of topics. www.endodnadamage.com
December 4, 2024 at 11:14 AM
What are your plans for October 2025? It would be a fantastic time to visit Norway for the Endogenous DNA Damage and Repair conference with a stellar set of speaker covering a wide range of topics. www.endodnadamage.com
Reposted by Nitika Taneja @TanejaLab
Dear all, my first post! I have postdoc positions available if you would like to join my lab in beautiful Sussex by the Sea! Please contact me on k.w.caldecott@sussex.ac.uk
December 3, 2024 at 11:47 AM
Dear all, my first post! I have postdoc positions available if you would like to join my lab in beautiful Sussex by the Sea! Please contact me on k.w.caldecott@sussex.ac.uk
Reposted by Nitika Taneja @TanejaLab
behold our paper on Medusavirus nucleosomes. Fantastic work by Chelsea Toner, @nhoitsma.bsky.social, and Sashi Weerawarana This giant virus also encodes a linker histone, more about that in the paper 🧪👩🔬 🧵.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 23, 2024 at 6:19 PM
behold our paper on Medusavirus nucleosomes. Fantastic work by Chelsea Toner, @nhoitsma.bsky.social, and Sashi Weerawarana This giant virus also encodes a linker histone, more about that in the paper 🧪👩🔬 🧵.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nitika Taneja @TanejaLab
Happy to share our new paper with Goran Kokic and the Svejstrup lab in Cell!
We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair.
Great teamwork by Diana, Marta and Paula!
www.cell.com/cell/fulltex...
We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair.
Great teamwork by Diana, Marta and Paula!
www.cell.com/cell/fulltex...
November 16, 2024 at 2:06 PM
Happy to share our new paper with Goran Kokic and the Svejstrup lab in Cell!
We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair.
Great teamwork by Diana, Marta and Paula!
www.cell.com/cell/fulltex...
We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair.
Great teamwork by Diana, Marta and Paula!
www.cell.com/cell/fulltex...
What an exciting day for the lab at the Dutch Chromatin Meeting! Congrats to Ashutosh (a.k.a Vincent 😉)for winning the poster prize on 3D reorganization of stressed forks & Joanna for her fantastic talk on phase separation during replication stress. Proud of you guys! 🤩
November 15, 2024 at 7:07 PM
What an exciting day for the lab at the Dutch Chromatin Meeting! Congrats to Ashutosh (a.k.a Vincent 😉)for winning the poster prize on 3D reorganization of stressed forks & Joanna for her fantastic talk on phase separation during replication stress. Proud of you guys! 🤩
Reposted by Nitika Taneja @TanejaLab
Two back-to-back papers in Nature comms from mylab explore the link between destabilization of the actin cytoskeleton and aberrant base excision repair - passing through nuclear actin and the actin-dependent nucleosome remodeler INO80C.
November 15, 2024 at 7:02 PM
Two back-to-back papers in Nature comms from mylab explore the link between destabilization of the actin cytoskeleton and aberrant base excision repair - passing through nuclear actin and the actin-dependent nucleosome remodeler INO80C.
Reposted by Nitika Taneja @TanejaLab
The latest from our group, led by Megan Ostrowski and @martyyang.bsky.social, is now published in final form (www.cell.com/cell/fulltex...! Many thanks to our excellent peer reviewers for suggesting several experiments (including CAF-1 perturbation) to really improve the study =) #epigenetics
The single-molecule accessibility landscape of newly replicated mammalian chromatin
By developing a long-read sequencing method to simultaneously map replication status
and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated
chromatin is enriched for unw...
www.cell.com
November 15, 2024 at 3:35 PM
The latest from our group, led by Megan Ostrowski and @martyyang.bsky.social, is now published in final form (www.cell.com/cell/fulltex...! Many thanks to our excellent peer reviewers for suggesting several experiments (including CAF-1 perturbation) to really improve the study =) #epigenetics
Reposted by Nitika Taneja @TanejaLab
First post here!
New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...
New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...
Profound synthetic lethality between SMARCAL1 and FANCM
Feng et al. uncover a critical genetic interaction between the DNA translocases SMARCAL1
and FANCM. Their combined loss leads to catastrophic genome instability, particularly
at simple-repeat sequence...
www.cell.com
November 10, 2024 at 11:46 AM
First post here!
New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...
New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...
Fantastic study… Congratulations Francesca n team! 👏
The peer-reviewed version of our paper is out! Thanks to all co-authors, editor and reviewers for the smooth process 🤓🎉
And don’t miss the chromatin haiku!
www.cell.com/molecular-ce...
And don’t miss the chromatin haiku!
www.cell.com/molecular-ce...
November 14, 2024 at 9:57 PM
Fantastic study… Congratulations Francesca n team! 👏
Reposted by Nitika Taneja @TanejaLab
Being haiku-ed is an honor! You were so fast, too 🤩
Depleting CAF-1
Slows replisome, chromatin
G0 arrest
#ChromatinHaiku @fmattiroli.bsky.social
www.cell.com/molecular-ce...
Slows replisome, chromatin
G0 arrest
#ChromatinHaiku @fmattiroli.bsky.social
www.cell.com/molecular-ce...
November 12, 2024 at 7:28 PM
Being haiku-ed is an honor! You were so fast, too 🤩
Reposted by Nitika Taneja @TanejaLab
New function for an 'old' chromatin remodeler: great collaboration with @nitikataneja.bsky.social and others. Fantastic work from our own @nhoitsma.bsky.social. Check out how SMARCAD1 contributes to resolving R-loops during replication, before they become a problem.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 17, 2024 at 11:09 AM
New function for an 'old' chromatin remodeler: great collaboration with @nitikataneja.bsky.social and others. Fantastic work from our own @nhoitsma.bsky.social. Check out how SMARCAD1 contributes to resolving R-loops during replication, before they become a problem.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
How are R-loops & conflicts rapidly resolved ahead of actively progressing forks? Is there a remodeler that associates with active forks, binds directly to R-loops, and senses & suppresses them? Check out our new study here!👇 www.biorxiv.org/content/10.1...
SMARCAD1 Regulates R-Loops at Active Replication Forks Linked to Cancer Mutation Hotspots
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
September 17, 2024 at 7:52 AM
How are R-loops & conflicts rapidly resolved ahead of actively progressing forks? Is there a remodeler that associates with active forks, binds directly to R-loops, and senses & suppresses them? Check out our new study here!👇 www.biorxiv.org/content/10.1...