Nicole Mather
@nicolemather.bsky.social
Science. Data Science
IBM. NED at Sanger and Cell & Gene Therapy Catapult. Ex OLS. Love Outdoors
IBM. NED at Sanger and Cell & Gene Therapy Catapult. Ex OLS. Love Outdoors
Reposted by Nicole Mather
In the first investment from the CGT Catapult as part of the Cross-Catapult Investment Pilot, Spliceor has received funding to accelerate the pre-clinical development of its trans-splicing #GeneTherapy platform for liver cancer.
Learn more: lnkd.in/e4h9xNkQ
@catapultnetwork.bsky.social
Learn more: lnkd.in/e4h9xNkQ
@catapultnetwork.bsky.social
July 22, 2025 at 10:52 AM
In the first investment from the CGT Catapult as part of the Cross-Catapult Investment Pilot, Spliceor has received funding to accelerate the pre-clinical development of its trans-splicing #GeneTherapy platform for liver cancer.
Learn more: lnkd.in/e4h9xNkQ
@catapultnetwork.bsky.social
Learn more: lnkd.in/e4h9xNkQ
@catapultnetwork.bsky.social
Reposted by Nicole Mather
@nicolemather.bsky.social delivered a powerful talk on how AI & digital technologies can transform ATMP production at our CGT Catapult & Alliance for Regenerative Medicine Industrialisation workshop today!
Key areas included: data standardisation, platform scale out & flexible automation.
Key areas included: data standardisation, platform scale out & flexible automation.
June 12, 2025 at 3:25 PM
@nicolemather.bsky.social delivered a powerful talk on how AI & digital technologies can transform ATMP production at our CGT Catapult & Alliance for Regenerative Medicine Industrialisation workshop today!
Key areas included: data standardisation, platform scale out & flexible automation.
Key areas included: data standardisation, platform scale out & flexible automation.
Reposted by Nicole Mather
Following the ATI North event last month, we reflect on key takeaways from the “Digitally Driven” panel chaired by @nicolemather.bsky.social.
Discussion explored how digital tools are helping to reduce the cost of #ATMPs and unlock patient-centric therapies.
Read the blog: ow.ly/u0Fy50VZQQC
Discussion explored how digital tools are helping to reduce the cost of #ATMPs and unlock patient-centric therapies.
Read the blog: ow.ly/u0Fy50VZQQC
May 28, 2025 at 8:20 AM
Following the ATI North event last month, we reflect on key takeaways from the “Digitally Driven” panel chaired by @nicolemather.bsky.social.
Discussion explored how digital tools are helping to reduce the cost of #ATMPs and unlock patient-centric therapies.
Read the blog: ow.ly/u0Fy50VZQQC
Discussion explored how digital tools are helping to reduce the cost of #ATMPs and unlock patient-centric therapies.
Read the blog: ow.ly/u0Fy50VZQQC
Looking forward to speaking at #ReWired2025 about how #AI is already transforming #NHS #Productivity away from the front line, reducing waiting lists & time taken for clinical coding & HR support. Talking about how to #spread & #scale this approach nationally so patients and staff can benefit more
March 10, 2025 at 5:11 PM
Looking forward to speaking at #ReWired2025 about how #AI is already transforming #NHS #Productivity away from the front line, reducing waiting lists & time taken for clinical coding & HR support. Talking about how to #spread & #scale this approach nationally so patients and staff can benefit more
Reposted by Nicole Mather
By mapping how thousands of inherited genetic changes play a role in developing chronic conditions, researchers have uncovered new connections between our genes and health 🧬
www.sanger.ac.uk/news_item/tr...
www.sanger.ac.uk/news_item/tr...
Translating genetic changes into future health impact
New resource helps bridge the gap between identifying genetic changes linked to health conditions and understanding how these changes impact biological processes.
www.sanger.ac.uk
March 4, 2025 at 3:29 PM
By mapping how thousands of inherited genetic changes play a role in developing chronic conditions, researchers have uncovered new connections between our genes and health 🧬
www.sanger.ac.uk/news_item/tr...
www.sanger.ac.uk/news_item/tr...
Reposted by Nicole Mather
A treasure chest of all of our immune system exposures and responses is hiding in our B and T cell receptors. Now that's being decoded to make diagnoses.
erictopol.substack.com/p/the-first-...
erictopol.substack.com/p/the-first-...
The First Diagnostic Immunome
A Big Step Forward By Sequencing B and T Cell Receptors Plus A.I.
erictopol.substack.com
February 25, 2025 at 8:37 PM
A treasure chest of all of our immune system exposures and responses is hiding in our B and T cell receptors. Now that's being decoded to make diagnoses.
erictopol.substack.com/p/the-first-...
erictopol.substack.com/p/the-first-...
Reposted by Nicole Mather
New: The largest medical A.I. randomized controlled trial yet performed, enrolling >100,000 women undergoing mammography screening
The use of AI led to 29% higher detection of cancer, no increase of false positives, and reduced workload compared with radiologists w/o AI thelancet.com/journals/lan...
The use of AI led to 29% higher detection of cancer, no increase of false positives, and reduced workload compared with radiologists w/o AI thelancet.com/journals/lan...
Screening performance and characteristics of breast cancer detected in the Mammography Screening with Artificial Intelligence trial (MASAI): a randomised, controlled, parallel-group, non-inferiority, ...
The findings suggest that AI contributes to the early detection of clinically relevant
breast cancer and reduces screen-reading workload without increasing false positives.
thelancet.com
February 4, 2025 at 3:00 AM
New: The largest medical A.I. randomized controlled trial yet performed, enrolling >100,000 women undergoing mammography screening
The use of AI led to 29% higher detection of cancer, no increase of false positives, and reduced workload compared with radiologists w/o AI thelancet.com/journals/lan...
The use of AI led to 29% higher detection of cancer, no increase of false positives, and reduced workload compared with radiologists w/o AI thelancet.com/journals/lan...
Reposted by Nicole Mather
Been waiting for someone to test this and see if it works - can multiple AI agents fact-checking each other reduce hallucinations?
The answer appears to be yes - using 3 agents with a structured review process reduced hallucination scores by 96% across 310 test cases. arxiv.org/pdf/2501.13946
The answer appears to be yes - using 3 agents with a structured review process reduced hallucination scores by 96% across 310 test cases. arxiv.org/pdf/2501.13946
February 2, 2025 at 8:42 PM
Been waiting for someone to test this and see if it works - can multiple AI agents fact-checking each other reduce hallucinations?
The answer appears to be yes - using 3 agents with a structured review process reduced hallucination scores by 96% across 310 test cases. arxiv.org/pdf/2501.13946
The answer appears to be yes - using 3 agents with a structured review process reduced hallucination scores by 96% across 310 test cases. arxiv.org/pdf/2501.13946
Great to meet so many folks at #FOG2025 Festival of Genomics today to talk about super interesting stuff our research teams are doing with biomedical foundation models in omics, agentic workflows in labs and pB storage solutions. Booth 81 if you are there tomorrow?
January 29, 2025 at 10:09 PM
Great to meet so many folks at #FOG2025 Festival of Genomics today to talk about super interesting stuff our research teams are doing with biomedical foundation models in omics, agentic workflows in labs and pB storage solutions. Booth 81 if you are there tomorrow?
Reposted by Nicole Mather
We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳
Re-posts appreciated.
www.nature.com/naturecareer...
Re-posts appreciated.
www.nature.com/naturecareer...
Research Group Leader Tenure Track - Structural Studies - LMB 2549 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12835196
Research Group Leader Tenure Track Starting Salary £65,940 to £74,448 per annum MRC Laboratory of Molecular Biology, Cambridge, UK
www.nature.com
January 27, 2025 at 9:38 AM
We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳
Re-posts appreciated.
www.nature.com/naturecareer...
Re-posts appreciated.
www.nature.com/naturecareer...
Reposted by Nicole Mather
Something you don't see every day!
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
January 10, 2025 at 6:56 PM
Something you don't see every day!
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
Reposted by Nicole Mather
How the brain gets rid of its chemical waste through the glymphatics during sleep, via blood vessel oscillations, regulated by norepinephrine. Impeded by Ambien!
www.cell.com/cell/abstrac...
www.science.org/content/arti...
www.cell.com/cell/abstrac...
www.science.org/content/arti...
January 9, 2025 at 4:44 PM
How the brain gets rid of its chemical waste through the glymphatics during sleep, via blood vessel oscillations, regulated by norepinephrine. Impeded by Ambien!
www.cell.com/cell/abstrac...
www.science.org/content/arti...
www.cell.com/cell/abstrac...
www.science.org/content/arti...
Reposted by Nicole Mather
I'm honoured to have been asked to give this year's @healthfoundation.bsky.social annual REAL Challenge lecture - on the theme of AI and health. Thursday 13th Feb in person / online. You can register here and please do share with any networks that may be interested www.health.org.uk/events/hype-...
Hype, hallucination, hope – what might AI mean for our health?
In our fifth REAL Challenge annual lecture, Hetan Shah will warn of the risk of rushing breathlessly to unleash technology. He will explore how policymakers can navigate the hype and critically assess...
www.health.org.uk
January 6, 2025 at 8:43 AM
I'm honoured to have been asked to give this year's @healthfoundation.bsky.social annual REAL Challenge lecture - on the theme of AI and health. Thursday 13th Feb in person / online. You can register here and please do share with any networks that may be interested www.health.org.uk/events/hype-...
Reposted by Nicole Mather
The Department for Energy Security and Net Zero is looking for members for a new Science and Technology Advisory Council and are looking for expertise which includes economics, social science and statistics. £350 a day. 12 vacancies
apply-for-public-appointment.service.gov.uk/roles/8465
apply-for-public-appointment.service.gov.uk/roles/8465
Appointment details – Department for Energy Security and Net Zero - Science and Technology Advisory Council (STAC) - Members – Apply for a public appointment – GOV.UK
GOV.UK
apply-for-public-appointment.service.gov.uk
December 10, 2024 at 10:22 AM
The Department for Energy Security and Net Zero is looking for members for a new Science and Technology Advisory Council and are looking for expertise which includes economics, social science and statistics. £350 a day. 12 vacancies
apply-for-public-appointment.service.gov.uk/roles/8465
apply-for-public-appointment.service.gov.uk/roles/8465
Reposted by Nicole Mather
Ofcom looking for NEDs to join new Advisory Committee on Disinformation & Misinformation. 7-10 days (paid) per year. Closes 13 Jan
Good opportunity for researchers with expertise in "disinformation, misinformation, foreign interference or related areas"
ofcom.wd3.myworkdayjobs.com/en-US/Ofcom_...
Good opportunity for researchers with expertise in "disinformation, misinformation, foreign interference or related areas"
ofcom.wd3.myworkdayjobs.com/en-US/Ofcom_...
December 6, 2024 at 3:15 PM
Ofcom looking for NEDs to join new Advisory Committee on Disinformation & Misinformation. 7-10 days (paid) per year. Closes 13 Jan
Good opportunity for researchers with expertise in "disinformation, misinformation, foreign interference or related areas"
ofcom.wd3.myworkdayjobs.com/en-US/Ofcom_...
Good opportunity for researchers with expertise in "disinformation, misinformation, foreign interference or related areas"
ofcom.wd3.myworkdayjobs.com/en-US/Ofcom_...
Reposted by Nicole Mather
Lilly released it's head-to-head with Wegovy today and it appears to have a meaningful edge on long-term weight loss (handy chart from Liz Cairns)
December 4, 2024 at 1:48 PM
Lilly released it's head-to-head with Wegovy today and it appears to have a meaningful edge on long-term weight loss (handy chart from Liz Cairns)
Reposted by Nicole Mather
Can a single small molecule rescue the stability of nearly all mutations in a protein?
Our new preprint by Taylor Mighell
www.biorxiv.org/content/10.1...
thread on the other place: x.com/taylor_mighe...
Our new preprint by Taylor Mighell
www.biorxiv.org/content/10.1...
thread on the other place: x.com/taylor_mighe...
A pharmacological chaperone stabilizer rescues the expression of the vast majority of pathogenic variants in a G protein-coupled receptor
Reduced protein stability is the most frequent mechanism by which rare missense variants cause disease. A promising therapeutic avenue for treating destabilizing variants is pharmacological chaperones...
www.biorxiv.org
December 3, 2024 at 9:40 AM
Can a single small molecule rescue the stability of nearly all mutations in a protein?
Our new preprint by Taylor Mighell
www.biorxiv.org/content/10.1...
thread on the other place: x.com/taylor_mighe...
Our new preprint by Taylor Mighell
www.biorxiv.org/content/10.1...
thread on the other place: x.com/taylor_mighe...
The way science is being done has been transformed by AI. Thought provoking essay from the @deep-mind.bsky.social team open.substack.com/pub/aipolicy... #GeneSky #DataScience
A new golden age of discovery
Seizing the AI for Science opportunity
open.substack.com
November 26, 2024 at 11:07 PM
The way science is being done has been transformed by AI. Thought provoking essay from the @deep-mind.bsky.social team open.substack.com/pub/aipolicy... #GeneSky #DataScience
Scaling up cell & gene therapies and reducing cost of goods so many more patients can benefit is urgent. I spoke with Matthew Durdy, our CEO at @cgtcatapult.bsky.social about how tech can help. Thank you to #CellTherapiesIntegrates for the invite #automation #predictiveanalytics #digitaltwins #data
November 26, 2024 at 2:53 PM
Scaling up cell & gene therapies and reducing cost of goods so many more patients can benefit is urgent. I spoke with Matthew Durdy, our CEO at @cgtcatapult.bsky.social about how tech can help. Thank you to #CellTherapiesIntegrates for the invite #automation #predictiveanalytics #digitaltwins #data
Weekend reading.. Scale proteomics gives insights into disease progression, aging and related druggable targets. #ProteomicSky #GeneSky
November 24, 2024 at 9:56 AM
Weekend reading.. Scale proteomics gives insights into disease progression, aging and related druggable targets. #ProteomicSky #GeneSky
Delighted to contribute #HumanCellAtlas pics to #FluorescenceFriday. Long time since I took some myself but proud of the #WellcomeSanger contribution here - shows human thymus @mehurles.bsky.social
November 22, 2024 at 6:30 PM
Delighted to contribute #HumanCellAtlas pics to #FluorescenceFriday. Long time since I took some myself but proud of the #WellcomeSanger contribution here - shows human thymus @mehurles.bsky.social
Reposted by Nicole Mather
Wes Streeting comes in as a surprise speaker at the #HSJAwards.
He’s “only been in office for four Liz Trusses” but received warmly amidst an audience of 1700 amazing health and social care champions.
He’s “only been in office for four Liz Trusses” but received warmly amidst an audience of 1700 amazing health and social care champions.
November 21, 2024 at 7:54 PM
Wes Streeting comes in as a surprise speaker at the #HSJAwards.
He’s “only been in office for four Liz Trusses” but received warmly amidst an audience of 1700 amazing health and social care champions.
He’s “only been in office for four Liz Trusses” but received warmly amidst an audience of 1700 amazing health and social care champions.
Reposted by Nicole Mather
A women-led team of 20, working remotely, is showing up a trillion dollar megacorp. Truly inspiring.
November 21, 2024 at 3:27 AM
A women-led team of 20, working remotely, is showing up a trillion dollar megacorp. Truly inspiring.
Reposted by Nicole Mather
A big day of output for the Human Cell Atlas, a global collaborative project with 100 countries to understand our ~37 trillion cells
A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...
A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...
November 20, 2024 at 5:04 PM
A big day of output for the Human Cell Atlas, a global collaborative project with 100 countries to understand our ~37 trillion cells
A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...
A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...