A new model of #TumorNecrosis👹

Tumor CXCL1➡️myeloid skewing➡️
Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️
Intratumoral vascular occlusion➡️
Pleomorphic Necrosis-to-Metastasis

a role of TGFβ
@adrover.bsky.social @megeblad.bsky.social Nature 2025
www.nature.com/articles/s41...

Blocking interleukin-6 to prevent the inflammation underpinning cardiovascular disease, genetically informed, without increased risk of infection
www.nature.com/articles/s44...
www.nature.com/articles/s44...

The basic sciences are HIRING at UCSF: open recruitment in the Department of Biochemistry & Biophysics. Please share and please apply! aprecruit.ucsf.edu/JPF05702

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...

Inflammatory mischief managed: How retinoic acid calms heart attacks at the (marrow) source | Science Immunology www.science.org/doi/10.1126/...

This is crazy!

Here we study the origin of the cardiac cell lineages in the mouse embryo. Separate but coordinated lineages independently specified at gastrulation generate the myocardium and endocardium. Credits: Miquel Sendra & coll: Jorge Dominguez, K. McDole and L. Guinard
authors.elsevier.com/sd/article/S...

Congratulations to Pilar Alcaide for a great presentation and the Presidents Award from #ISHR! 🙌

Great opening ceremony of the #ISHR2025 XXV World Congress in Nara. Excited to discuss science with colleagues of the Cardiovascular field during this ISHR meeting.

Great experience this week participating in the recently launched @ucsanfrancisco.bsky.social Clinically Inspired Discovery Program. Many interesting talks and stimulating discussions with students.

I had a wonderful time! Great conference and speakers! Thanks @casanova-acebes.bsky.social @sancholab.bsky.social and Carlos Silvestre for the great work organizing such an amazing meeting!

@adrover.bsky.social rocking on a fantastic new and vascular-damaging Ly6Clo neutrophils, he will now investigate deeper in his #brandnewlab #EPW2025

Hey @ucsanfrancisco.bsky.social students! On April 10, I will be participating in #UREKA, a new program aiming to identify current challenges in the clinic and come up with novel approaches to tackle them. #5k$ prices for proposals presented by attendants to the event. Sign up! ucsfureka.com

#immunosky #epw2025 Fantastic meeting starting! Thx to the wonderful co-organizers @mcasanova.bsky.social & @silvestreroiglab.bsky.social
Thx to support by #SEI (Spanish society for immunology), Inmunotek @miltenyibiotec.bsky.social @embo.org @efis-immunology.bsky.social @eurjimmunol.bsky.social

Meet @plosbiology.org’s great microbiology and immunology editor ⬇️⬇️
She’s wise, a joy and has been such an asset to the team.

You can book office hours with her at the link Mel posted, and with all the other lovely editors. Find the links here:

journals.plos.org/plosbiology/...

Last contribution to the understanding of #neutrophil biology. Superb work from Tommaso, @alazozcan.bsky.social, and Jackson that I had the pleasure to contribute to and see growing during my time at @drusqui.bsky.social lab.

Finally making the transition from Twitter/X to Bluesky! Excited to keep up with the amazing work of friends and fellow scientists here. Also, follow this account for future updates on our lab work. #blueskyforscience.