Rad paper alert!
📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠
tinyurl.com/3wvmm8v3
tinyurl.com/3wvmm8v3
Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
Microglia replacement holds great promise for the study and treatment of neurological diseases. We previously achieved high-efficiency replacement by …
tinyurl.com
November 15, 2025 at 12:21 AM
Rad paper alert!
Beautiful paper by @nicolecoufal.bsky.social . Check it out and the link to our N&V ( rdcu.be/eL8lM) expertly written by @chopresearch.bsky.social @pennmedresearch.bsky.social MSTP star Ryan Rahman.
October 31, 2025 at 2:11 PM
Beautiful paper by @nicolecoufal.bsky.social . Check it out and the link to our N&V ( rdcu.be/eL8lM) expertly written by @chopresearch.bsky.social @pennmedresearch.bsky.social MSTP star Ryan Rahman.
One of our best friends (non scientists) told us their kiddo is planning a school report on... microglia!!! We're sending a swag pack tomorrow and want to print out beautiful micrographs for their report -- want to get in on the action? Share your pretty pics!!!
October 31, 2025 at 2:05 PM
One of our best friends (non scientists) told us their kiddo is planning a school report on... microglia!!! We're sending a swag pack tomorrow and want to print out beautiful micrographs for their report -- want to get in on the action? Share your pretty pics!!!
Reposted by Mariko Bennett
A university that signs the “compact” is one that acknowledges its own inability to compete and succeed based talent and merit. It would signal insecurity and mediocrity to current and future students and faculty. Say no. Recruit the best people, protect their freedom and support their hard work.
October 18, 2025 at 12:05 AM
A university that signs the “compact” is one that acknowledges its own inability to compete and succeed based talent and merit. It would signal insecurity and mediocrity to current and future students and faculty. Say no. Recruit the best people, protect their freedom and support their hard work.
Reposted by Mariko Bennett
Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling
Stroke is a major cause of disability. Astrocytes respond to stroke in a gradated manner, but details of that response and its consequences for tissue…
www.sciencedirect.com
October 10, 2025 at 11:13 PM
Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Mariko Bennett
Reposted by Mariko Bennett
Three in two weeks. Could not be more proud of the newly minded Dr. Sameera Zia after successfully defending her PhD yesterday. This bright young star will do amazing things! Also, a huge thanks to @nachoriko.bsky.social for making the trip to Edmonton to serve as an external examiner
June 26, 2025 at 4:32 PM
Three in two weeks. Could not be more proud of the newly minded Dr. Sameera Zia after successfully defending her PhD yesterday. This bright young star will do amazing things! Also, a huge thanks to @nachoriko.bsky.social for making the trip to Edmonton to serve as an external examiner
Reposted by Mariko Bennett
Joined the Advisory Board of @standupforscience.bsky.social alongside Viktor Ambros, @jeremymberg.bsky.social, Carol Greider, @michaelemann.bsky.social, & @katestarbird.bsky.social. Impressed with @cdelawalla.bsky.social and the entire Stand Up for Science team!
www.standupforscience.net/cadres.
www.standupforscience.net/cadres.
Cadres — STAND UP FOR SCIENCE
www.standupforscience.net
June 26, 2025 at 10:16 PM
Joined the Advisory Board of @standupforscience.bsky.social alongside Viktor Ambros, @jeremymberg.bsky.social, Carol Greider, @michaelemann.bsky.social, & @katestarbird.bsky.social. Impressed with @cdelawalla.bsky.social and the entire Stand Up for Science team!
www.standupforscience.net/cadres.
www.standupforscience.net/cadres.
Reposted by Mariko Bennett
Calling all postdocs! Looking to enter the job market and gain hands-on experience with job talks & chalk talks? Apply to our NeuroYes Program @urneuroscience.bsky.social Neuroscience Commission NeuroYes 2025-2026 applications are open!!! Click on the link below to find out more! neuroyes.urmc.edu
June 19, 2025 at 10:06 PM
Calling all postdocs! Looking to enter the job market and gain hands-on experience with job talks & chalk talks? Apply to our NeuroYes Program @urneuroscience.bsky.social Neuroscience Commission NeuroYes 2025-2026 applications are open!!! Click on the link below to find out more! neuroyes.urmc.edu
She shouted along, asked what nearly every sign meant, greeted the police, told someone dressed like a founding father about the "golden rule", and agreed that "wooder" ICE is the most palatable Philly ice and butterflies are the only suitable orange monarch.
June 15, 2025 at 2:13 PM
She shouted along, asked what nearly every sign meant, greeted the police, told someone dressed like a founding father about the "golden rule", and agreed that "wooder" ICE is the most palatable Philly ice and butterflies are the only suitable orange monarch.
Reposted by Mariko Bennett
It was a lot of fun co-writing this Spotlight with a talented graduate student @jingyiyang0321.bsky.social in my lab. Congrats to @fchrisbennett.bsky.social @nachoriko.bsky.social @waisenberg.bsky.social @Movahedi lab on these two important papers on microglia replacement! @cp-immunity.bsky.social
Hello world! My first post here, and it's a special one!
I'm excited to share that my first piece of work in grad school titled "Microglia Replacement: From Monocytic Origin to Therapy" is now online in Trends in Immunology!
Read it here: www.sciencedirect.com/science/arti...
I'm excited to share that my first piece of work in grad school titled "Microglia Replacement: From Monocytic Origin to Therapy" is now online in Trends in Immunology!
Read it here: www.sciencedirect.com/science/arti...
Microglia replacement: from monocytic origin to therapy
Microglia replacement is reshaping neurodegenerative disease therapy, yet its key prerequisites remain unclear. In the current issue of Immunity, Aise…
www.sciencedirect.com
May 26, 2025 at 4:41 PM
It was a lot of fun co-writing this Spotlight with a talented graduate student @jingyiyang0321.bsky.social in my lab. Congrats to @fchrisbennett.bsky.social @nachoriko.bsky.social @waisenberg.bsky.social @Movahedi lab on these two important papers on microglia replacement! @cp-immunity.bsky.social
Reposted by Mariko Bennett
Let’s get the word out about the importance of federal funding of curiosity -driven science
We all have similar stories to share
We all have similar stories to share
Protecting the Brain Requires Persistence
@bethstevenslab.bsky.social, NIH-supported investigator of Alzheimer’s and other disorders, explains how one discovery can lead to another.
news.harvard.edu/gazette/stor...
@bethstevenslab.bsky.social, NIH-supported investigator of Alzheimer’s and other disorders, explains how one discovery can lead to another.
news.harvard.edu/gazette/stor...
Taking the long view on Alzheimer’s — Harvard Gazette %
Beth Stevens' work has built a foundation for new kinds of medicines to treat neurodegenerative diseases. "I was just following the science."
news.harvard.edu
May 9, 2025 at 11:10 PM
Let’s get the word out about the importance of federal funding of curiosity -driven science
We all have similar stories to share
We all have similar stories to share
Reposted by Mariko Bennett
Check out this paper from the Movahedi lab! It’s a great companion to ours - showing the populations of brain macrophages that monocytes can replace.
Congrats to first author Jonathan Bastos!
Congrats to first author Jonathan Bastos!
Online now: Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia
Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia
Replacing brain macrophages holds substantial therapeutic promise but remains challenging. Bastos et al. uncover the requirements for monocytes to replace microglia and border-associated macrophages. They show that monocyte ontogeny shapes brain macrophage identity, with fetal monocytes acquiring a true microglial state. Using xenotransplantation and Alzheimer’s patient data, they identify human monocyte-derived microglia. These findings are important for microglia replacement therapies.
dlvr.it
May 1, 2025 at 2:10 AM
Check out this paper from the Movahedi lab! It’s a great companion to ours - showing the populations of brain macrophages that monocytes can replace.
Congrats to first author Jonathan Bastos!
Congrats to first author Jonathan Bastos!
Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.
Online now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated macrophages (globoid cells) and demonstrate that brain-specific high-efficiency macrophage replacement in the twitcher model of Krabbe disease improves neuropathology, macrophage dysfunction, and survival.
dlvr.it
April 30, 2025 at 9:20 PM
Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.
Reposted by Mariko Bennett
Emily Whitehead and her father on CNN with Jake Tapper speaking to the value of science. She is alive thanks to CAR T therapy developed at Penn and CHOP.
March 7, 2025 at 11:46 PM
Emily Whitehead and her father on CNN with Jake Tapper speaking to the value of science. She is alive thanks to CAR T therapy developed at Penn and CHOP.
A fight of inches. I love this.
They can ignore today's protests but they don't know if the next one will be the tipping point so this forces them to recalibrate.
This is a fight of inches and every inch matters.
4/4
This is a fight of inches and every inch matters.
4/4
March 8, 2025 at 12:55 AM
A fight of inches. I love this.
March 8, 2025 at 12:54 AM
Reposted by Mariko Bennett
More important than my time at Science is my service as Director of the National Institute of General Medical Sciences at NIH from 2003-2011. It is heartbreaking to see this great institution torn apart over a bunch of policy issues that don't have much relevance to the core missions of NIH.
Important, ongoing thread from former EIC of journal Science, piecing together what is happening at NIH.
I am not going to call this a Bluetorial, because I do not want to sully that term (which, at least I, find joyful).
Let’s call it a Orwellial.
Let’s call it a Orwellial.
March 2, 2025 at 4:30 PM
More important than my time at Science is my service as Director of the National Institute of General Medical Sciences at NIH from 2003-2011. It is heartbreaking to see this great institution torn apart over a bunch of policy issues that don't have much relevance to the core missions of NIH.
Reposted by Mariko Bennett
Philadelphia Stand Up For Science! #standupforscience2025
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
February 26, 2025 at 1:35 AM
Philadelphia Stand Up For Science! #standupforscience2025
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
Reposted by Mariko Bennett
I am not going to call this a Bluetorial, because I do not want to sully that term (which, at least I, find joyful).
Let’s call it a Orwellial.
Let’s call it a Orwellial.
a cartoon of homer simpson holding a card
ALT: a cartoon of homer simpson holding a card
media.tenor.com
March 2, 2025 at 1:57 PM
I am not going to call this a Bluetorial, because I do not want to sully that term (which, at least I, find joyful).
Let’s call it a Orwellial.
Let’s call it a Orwellial.
Reposted by Mariko Bennett
WHERE WILL YOU BE ON MARCH 7TH!?
Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one!
#standupforscience2025
Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one!
#standupforscience2025
March 2, 2025 at 2:04 AM
WHERE WILL YOU BE ON MARCH 7TH!?
Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one!
#standupforscience2025
Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one!
#standupforscience2025
In this #rarediseaseday2025 we cannot remain silent. We must fight on the beach and the bench. Share. Tell your stories. Call your elected officials. Call your unelected officials. #fightonthebench
March 1, 2025 at 1:05 AM
In this #rarediseaseday2025 we cannot remain silent. We must fight on the beach and the bench. Share. Tell your stories. Call your elected officials. Call your unelected officials. #fightonthebench
Reposted by Mariko Bennett
Reposted by Mariko Bennett
This was the first year we’ve had the honour of hosting a ceremony for the Ben Barres Spotlight Awards.
Named after our late colleague, the awards provide funds for researchers from underrepresented and underfunded groups. #12DaysOfeLife
Named after our late colleague, the awards provide funds for researchers from underrepresented and underfunded groups. #12DaysOfeLife
Ben Barres Spotlight Awards: The 2024 Awards Ceremony
Watch our online celebration of pioneering researchers from around the world as we revealed the winners of the 2024 Ben Barres Spotlight Awards in our first-...
buff.ly
December 26, 2024 at 1:59 PM
This was the first year we’ve had the honour of hosting a ceremony for the Ben Barres Spotlight Awards.
Named after our late colleague, the awards provide funds for researchers from underrepresented and underfunded groups. #12DaysOfeLife
Named after our late colleague, the awards provide funds for researchers from underrepresented and underfunded groups. #12DaysOfeLife