Mihaela Zavolan
@mihaelazavolan.bsky.social
Regulation of and by RNAs
Former @ZavolanLab on X
Former @ZavolanLab on X
Is this f*g real? The comedic tragedy we're living in.
"Don't take Tylenol!" -- Trump has said this about a dozen times during this press conference
September 25, 2025 at 2:42 AM
Is this f*g real? The comedic tragedy we're living in.
Reposted by Mihaela Zavolan
Are you excited to pursue your own research interests and contribute to our group’s experimental research in the quantitative biology of microbes? We have an opening for a potentially permanent position as research associate.
Please repost and notify potential candidates!
Please repost and notify potential candidates!
Research Associate (100%)
Starting from 1 November 2025 or as per agreement
Group @erikvannimwegen.bsky.social
@biozentrum.unibas.ch
@unibas.ch
www.biozentrum.unibas.ch/open-positio...
#job #research #biology #microbiology #science #basel #recruiting #career
Starting from 1 November 2025 or as per agreement
Group @erikvannimwegen.bsky.social
@biozentrum.unibas.ch
@unibas.ch
www.biozentrum.unibas.ch/open-positio...
#job #research #biology #microbiology #science #basel #recruiting #career
September 18, 2025 at 9:26 AM
Are you excited to pursue your own research interests and contribute to our group’s experimental research in the quantitative biology of microbes? We have an opening for a potentially permanent position as research associate.
Please repost and notify potential candidates!
Please repost and notify potential candidates!
Reposted by Mihaela Zavolan
What novel biological dynamics might be hiding under the measurement noise of your time-lapse fluorescence microscopy data?
Try our new RealTrace tool to find out!
Fantastic work by Bjoern Kscheschinski and others.
Tweetorial follows. 1/n
www.biorxiv.org/content/10.1...
Try our new RealTrace tool to find out!
Fantastic work by Bjoern Kscheschinski and others.
Tweetorial follows. 1/n
www.biorxiv.org/content/10.1...
RealTrace: Uncovering biological dynamics hidden under measurement noise in time-lapse microscopy data
One of the most powerful approaches for identifying the mechanisms underlying complex biological phenomena is not just to measure bulk populations, or even take single-cell snapshots, but to directly ...
www.biorxiv.org
September 17, 2025 at 2:19 PM
What novel biological dynamics might be hiding under the measurement noise of your time-lapse fluorescence microscopy data?
Try our new RealTrace tool to find out!
Fantastic work by Bjoern Kscheschinski and others.
Tweetorial follows. 1/n
www.biorxiv.org/content/10.1...
Try our new RealTrace tool to find out!
Fantastic work by Bjoern Kscheschinski and others.
Tweetorial follows. 1/n
www.biorxiv.org/content/10.1...
Reposted by Mihaela Zavolan
Publication by the Becskei & Zavolan labs w/ co-1st authors Asier González, Muskan Pandey & Niels Schlusser "Multi-omic assessment of mRNA translation dynamics in liver cancer cell lines" in Scientific Data
buff.ly/WYwzw5V
@mihaelazavolan.bsky.social
@biozentrum.unibas.ch
buff.ly/WYwzw5V
@mihaelazavolan.bsky.social
@biozentrum.unibas.ch
September 3, 2025 at 7:01 AM
Publication by the Becskei & Zavolan labs w/ co-1st authors Asier González, Muskan Pandey & Niels Schlusser "Multi-omic assessment of mRNA translation dynamics in liver cancer cell lines" in Scientific Data
buff.ly/WYwzw5V
@mihaelazavolan.bsky.social
@biozentrum.unibas.ch
buff.ly/WYwzw5V
@mihaelazavolan.bsky.social
@biozentrum.unibas.ch
Hey there, #mRNAtranslation buffs! Our latest multi-faceted dataset from liver cancer cell lines is out in #ScientificData: RNA-seq, ribosome run-off/ribo-seq, polysome-seq, pSILAC. rdcu.be/eC86H. Great team effort spearheaded by Asier Gonzalez Sevine and Niels Schlusser. Happy data crunching!
Multi-omic assessment of mRNA translation dynamics in liver cancer cell lines
Scientific Data - Multi-omic assessment of mRNA translation dynamics in liver cancer cell lines
rdcu.be
August 30, 2025 at 11:40 AM
Hey there, #mRNAtranslation buffs! Our latest multi-faceted dataset from liver cancer cell lines is out in #ScientificData: RNA-seq, ribosome run-off/ribo-seq, polysome-seq, pSILAC. rdcu.be/eC86H. Great team effort spearheaded by Asier Gonzalez Sevine and Niels Schlusser. Happy data crunching!
Reposted by Mihaela Zavolan
Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!
Open faculty position!
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
August 27, 2025 at 3:27 AM
Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!
Reposted by Mihaela Zavolan
🤔 Can migrating cells 'remember' their past trajectories?
In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question:
Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history!
www.nature.com/articles/s41...
In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question:
Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history!
www.nature.com/articles/s41...
The actin cortex acts as a mechanical memory of morphology in confined migrating cells - Nature Physics
Cells often navigate through confined spaces. Now it is shown that cells retain a mechanical memory of previous confinement events, which makes them more efficient at migrating through narrow microenv...
www.nature.com
August 25, 2025 at 9:49 AM
🤔 Can migrating cells 'remember' their past trajectories?
In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question:
Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history!
www.nature.com/articles/s41...
In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question:
Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history!
www.nature.com/articles/s41...
The key point here is rather "who would your rather trust"? Because what is offered is not for anyone to decide for themselves, but rather one is coerced to go along with decisions made by few. People are expected to follow the orders of someone who understands nothing.
1. "'Trusting the experts is not a feature of either a science or democracy," Kennedy said."
It's literally a vital feature of both science and of representative democracy.
I've written a fair bit about trust in expertise as a vital mechanism in the collective epistemology of science.
It's literally a vital feature of both science and of representative democracy.
I've written a fair bit about trust in expertise as a vital mechanism in the collective epistemology of science.
RFK Jr. in interview with Scripps News: ‘Trusting the experts is not science’
HHS Secretary RFK Jr. sat down with Scripps News for a wide-ranging interview, discussing mRNA vaccine funding policy changes and a recent shooting at the Centers for Disease Control and Prevention.
www.scrippsnews.com
August 13, 2025 at 8:49 AM
The key point here is rather "who would your rather trust"? Because what is offered is not for anyone to decide for themselves, but rather one is coerced to go along with decisions made by few. People are expected to follow the orders of someone who understands nothing.
Reposted by Mihaela Zavolan
OTD in 1949 Soviets forcibly deported 30,000 people from Moldova, after we had "liberated them from fascism".
Imagine mass deportations happening today...
Imagine mass deportations happening today...
July 6, 2025 at 9:32 AM
OTD in 1949 Soviets forcibly deported 30,000 people from Moldova, after we had "liberated them from fascism".
Imagine mass deportations happening today...
Imagine mass deportations happening today...
Right! Maybe these folks who like to push others into various spheres of influence should try living there.
⚡️NATO expansion 'fair' concern for Putin, Kellogg says.
NATO expansion 'fair' concern for Putin, Kellogg says
"And that's one of the issues Russia will bring up... They're also talking about Georgia, they're talking about Moldova, they're talking — obviously — about Ukraine. And we're saying, 'Okay, let's add...
kyivindependent.com
June 28, 2025 at 11:13 AM
Right! Maybe these folks who like to push others into various spheres of influence should try living there.
Really nice to see some fresh initiatives on the Romanian science scene 1health.ro/biotech-boot... kudos to the biomentorhub.ro and all those who made this possible.
Biotech Bootcamp 2025 – One Health Incubator
1health.ro
June 22, 2025 at 12:05 PM
Really nice to see some fresh initiatives on the Romanian science scene 1health.ro/biotech-boot... kudos to the biomentorhub.ro and all those who made this possible.
Back to reality www.brainonllm.com. Now imagine the cognitive debt on stuff that involves some abstraction...
Your Brain on ChatGPT: Accumulation of Cognitive Debt when Using an AI Assistant for Essay Writing Task
Your Brain on ChatGPT: Accumulation of Cognitive Debt when Using an AI Assistant for Essay Writing Task
www.brainonllm.com
June 22, 2025 at 11:07 AM
Back to reality www.brainonllm.com. Now imagine the cognitive debt on stuff that involves some abstraction...
Reposted by Mihaela Zavolan
RNase L cleaves most tRNAs in the anticodon loops into various tRNA-derived RNAs (tDRs) including 5'-tDRAla that shows a translation inhibitory effect. Some tRNAs are also cleaved in variable loops bit.ly/3YTwlNq
June 9, 2025 at 1:52 PM
RNase L cleaves most tRNAs in the anticodon loops into various tRNA-derived RNAs (tDRs) including 5'-tDRAla that shows a translation inhibitory effect. Some tRNAs are also cleaved in variable loops bit.ly/3YTwlNq
Reposted by Mihaela Zavolan
'Data analysed by the BBC show that Ukraine's Western allies have paid Russia more for its hydrocarbons than they have given Ukraine in aid.'
What a bleak set of statistics.
What a bleak set of statistics.
How the West is helping Russia to fund its war on Ukraine
Data shows that Russian fossil fuel revenues are three times higher than aid allocated to Ukraine.
www.bbc.co.uk
May 30, 2025 at 8:33 AM
'Data analysed by the BBC show that Ukraine's Western allies have paid Russia more for its hydrocarbons than they have given Ukraine in aid.'
What a bleak set of statistics.
What a bleak set of statistics.
It's really happening: AI-enabled noise injection in scientific information, from which models are trained, for more automated noisy inferences... journals.plos.org/plosbiology/...
May 19, 2025 at 6:02 AM
It's really happening: AI-enabled noise injection in scientific information, from which models are trained, for more automated noisy inferences... journals.plos.org/plosbiology/...
Reposted by Mihaela Zavolan
Bonsai is out! Finally, we can visually explore high-dimensional data in a distortion-free way. Try it out! It works from scRNA-seq data (bonsai.unibas.ch/bonsai-scout...) up to football statistics (bonsai.unibas.ch/bonsai-scout...).
Ever wondered why low-dimensional embeddings like t-SNE
May 9, 2025 at 11:55 AM
Bonsai is out! Finally, we can visually explore high-dimensional data in a distortion-free way. Try it out! It works from scRNA-seq data (bonsai.unibas.ch/bonsai-scout...) up to football statistics (bonsai.unibas.ch/bonsai-scout...).
Ever wondered why low-dimensional embeddings like t-SNE
Reposted by Mihaela Zavolan
An alternative to tSNE & UMAP for more accurate data visualization:
Tree representations for distortion-free visualization and exploratory analysis of single-cell omics data.
The trees are constructed to accurately represent true distances between the objects in the high-dimensional space.
Tree representations for distortion-free visualization and exploratory analysis of single-cell omics data.
The trees are constructed to accurately represent true distances between the objects in the high-dimensional space.
May 9, 2025 at 11:07 AM
An alternative to tSNE & UMAP for more accurate data visualization:
Tree representations for distortion-free visualization and exploratory analysis of single-cell omics data.
The trees are constructed to accurately represent true distances between the objects in the high-dimensional space.
Tree representations for distortion-free visualization and exploratory analysis of single-cell omics data.
The trees are constructed to accurately represent true distances between the objects in the high-dimensional space.
Amazing tour-de-force through the representation and analysis of scRNA-data analysis from @dhdegroot.bsky.social @erikvannimwegen.bsky.social, with strikingly deep implications. Oranje boven! 😂
Here it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social.
I'm so excited about this!
www.biorxiv.org/content/10.1...
I'm so excited about this!
www.biorxiv.org/content/10.1...
Bonsai: Tree representations for distortion-free visualization and exploratory analysis of single-cell omics data
Single-cell omics methods promise to revolutionize our understanding of gene regulatory processes during cell differentiation, but analysis of such data continues to pose a major challenge. Apart from...
www.biorxiv.org
May 9, 2025 at 12:00 PM
Amazing tour-de-force through the representation and analysis of scRNA-data analysis from @dhdegroot.bsky.social @erikvannimwegen.bsky.social, with strikingly deep implications. Oranje boven! 😂
Reposted by Mihaela Zavolan
Reposted by Mihaela Zavolan
Bacteria have a simple yet potent mechanism that controls their sensitivity to environmental stimuli. A new study by researchers led by <a href="https://bsky.app/profile/did:plc:mpi2uwwkiofxvcgr5lzmjnra" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@erikvannimwegen.bsky.social @biozentrum.unibas.ch shows: the slower cells grow, the more sensitively they respond to their environment.
Slow-growing bacteria respond more sensitively to their environment
Bacteria have a simple yet potent mechanism that controls their sensitivity to environmental stimuli. A new study by researchers at the Univer...
www.unibas.ch
May 8, 2025 at 8:15 AM
Bacteria have a simple yet potent mechanism that controls their sensitivity to environmental stimuli. A new study by researchers led by <a href="https://bsky.app/profile/did:plc:mpi2uwwkiofxvcgr5lzmjnra" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@erikvannimwegen.bsky.social @biozentrum.unibas.ch shows: the slower cells grow, the more sensitively they respond to their environment.
This is how you do it!
Day 1165 of my 3 day war. A Ukrainian sea drone costing $250k converted 2 Russian fighters, worth $60,000,000, into submarines.
I remain a master strategist.
I remain a master strategist.
May 4, 2025 at 4:38 PM
This is how you do it!
Reposted by Mihaela Zavolan
📢 We are pleased to announce the Molecular Mechanisms of RNA in Disease – The NCCR RNA & Disease Final Symposium Jan 26-29, 2026, in St. Moritz!
🔗 Details & updates: finalsymposium.nccr-rna-and-disease.ch
@snf-fns-ch.bsky.social @unibe.ch @ethzurich.bsky.social
🔗 Details & updates: finalsymposium.nccr-rna-and-disease.ch
@snf-fns-ch.bsky.social @unibe.ch @ethzurich.bsky.social
May 2, 2025 at 6:22 AM
📢 We are pleased to announce the Molecular Mechanisms of RNA in Disease – The NCCR RNA & Disease Final Symposium Jan 26-29, 2026, in St. Moritz!
🔗 Details & updates: finalsymposium.nccr-rna-and-disease.ch
@snf-fns-ch.bsky.social @unibe.ch @ethzurich.bsky.social
🔗 Details & updates: finalsymposium.nccr-rna-and-disease.ch
@snf-fns-ch.bsky.social @unibe.ch @ethzurich.bsky.social
Surreal!
Want to get rid of your shitty husband AND get to the head of the queue for a new Lada at the same time? Just send him to die in Ukraine and thank the Führer for getting him killed.
May 1, 2025 at 2:13 PM
Surreal!
Yeah, missing metadata in SRA was a motivation for academic.oup.com/bioinformati...
May 1, 2025 at 2:12 PM
Yeah, missing metadata in SRA was a motivation for academic.oup.com/bioinformati...
Reposted by Mihaela Zavolan
tRNA modification and m6A functionally interact in tuning decoding and mRNA decay.
Great collaboration with the Steinmetz lab!
Now out in Cell. Submission date still 2023...
www.sciencedirect.com/science/arti...
Great collaboration with the Steinmetz lab!
Now out in Cell. Submission date still 2023...
www.sciencedirect.com/science/arti...
May 1, 2025 at 11:14 AM
tRNA modification and m6A functionally interact in tuning decoding and mRNA decay.
Great collaboration with the Steinmetz lab!
Now out in Cell. Submission date still 2023...
www.sciencedirect.com/science/arti...
Great collaboration with the Steinmetz lab!
Now out in Cell. Submission date still 2023...
www.sciencedirect.com/science/arti...