Marten Chaillet
@martenchaillet.bsky.social
CryoET open-source software developer 🤓 Postdoc to tackle tilt-series alignment with deep-learning. Working at the Hubrecht Instute, with funding from Genentech.
interests outside of work: DnD, cooking, cyling!
interests outside of work: DnD, cooking, cyling!
Pinned
pytom-match-pick: A tophat-transform constraint for automated classification in template matching pubmed.ncbi.nlm.nih.gov/40475324/ #cryoem
Final PhD paper now reviewed and published in JSB:X. I was happy with some great reviews that improved the paper! Thanks to Sander Roet for his help with the code base, and Remco Veltkamp and @fridof.bsky.social
Reposted by Marten Chaillet
Door de sterke opwarming van de Zuidelijke Oceaan smelten gletsjers aan de rand van het Antarctische continent aan de onderkant snel weg. Hierdoor worden de landinwaarts gelegen ijsmassa’s instabiel, en storten uiteindelijk in.
De onvermijdelijkheid van zeespiegelstijging
Door de sterke opwarming van de Zuidelijke Oceaan smelten gletsjers aan de rand van het Antarctische continent aan de onderkant snel weg. Hierdoor worden de landinwaarts gelegen ijsmassa’s instabiel,
www.knmi.nl
November 5, 2025 at 10:50 AM
Door de sterke opwarming van de Zuidelijke Oceaan smelten gletsjers aan de rand van het Antarctische continent aan de onderkant snel weg. Hierdoor worden de landinwaarts gelegen ijsmassa’s instabiel, en storten uiteindelijk in.
Reposted by Marten Chaillet
Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 3, 2025 at 4:47 PM
Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
Congrats to the applicants! Great news for EM in the Netherlands
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 4, 2025 at 12:19 PM
Congrats to the applicants! Great news for EM in the Netherlands
Reposted by Marten Chaillet
CryoJAX - A Cryo-Electron Microscopy Image Simulation Library in JAX www.biorxiv.org/content/10.1101/2025.10.23.682564v1 #cryoem
October 25, 2025 at 11:29 AM
CryoJAX - A Cryo-Electron Microscopy Image Simulation Library in JAX www.biorxiv.org/content/10.1101/2025.10.23.682564v1 #cryoem
Reposted by Marten Chaillet
Reposted by Marten Chaillet
Op sociale media delen PVV-fanaccounts levensechte AI-beelden, veelal van knappe, blonde vrouwen die worden bedreigd door migranten. Deze pagina’s blijken te worden beheerd door minstens twee PVV-Kamerleden.
👉 buff.ly/MFNFcU3
👉 buff.ly/MFNFcU3
October 11, 2025 at 5:10 AM
Op sociale media delen PVV-fanaccounts levensechte AI-beelden, veelal van knappe, blonde vrouwen die worden bedreigd door migranten. Deze pagina’s blijken te worden beheerd door minstens twee PVV-Kamerleden.
👉 buff.ly/MFNFcU3
👉 buff.ly/MFNFcU3
Reposted by Marten Chaillet
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
October 13, 2025 at 9:04 AM
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
Reposted by Marten Chaillet
Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam.
Try the demo here: store.steampowered.com/app/4045010/...
Give Muyuan feedback: steamcommunity.com/app/4045010
#ScienceGaming #StructuralBiology #CryoEM #STEMOutreach
Try the demo here: store.steampowered.com/app/4045010/...
Give Muyuan feedback: steamcommunity.com/app/4045010
#ScienceGaming #StructuralBiology #CryoEM #STEMOutreach
October 4, 2025 at 1:34 PM
Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam.
Try the demo here: store.steampowered.com/app/4045010/...
Give Muyuan feedback: steamcommunity.com/app/4045010
#ScienceGaming #StructuralBiology #CryoEM #STEMOutreach
Try the demo here: store.steampowered.com/app/4045010/...
Give Muyuan feedback: steamcommunity.com/app/4045010
#ScienceGaming #StructuralBiology #CryoEM #STEMOutreach
Reposted by Marten Chaillet
But there’s a curious loose end to this story. Scientists have been looking at PSII organization in thylakoids for over 50 years (including some really stunning freeze fracture 🔬😍). Sometimes PSII looks randomly oriented, and other times it forms extended 2D crystalline arrays in the membrane 💠
9/🧵
9/🧵
September 25, 2025 at 6:34 PM
But there’s a curious loose end to this story. Scientists have been looking at PSII organization in thylakoids for over 50 years (including some really stunning freeze fracture 🔬😍). Sometimes PSII looks randomly oriented, and other times it forms extended 2D crystalline arrays in the membrane 💠
9/🧵
9/🧵
👀 this is really interesting!
Dose-efficient cryo-electron microscopy for thick samples using tilt- corrected scanning transmission electron microscopy pubmed.ncbi.nlm.nih.gov/40987871/ #cryoem
September 24, 2025 at 1:38 PM
👀 this is really interesting!
Reposted by Marten Chaillet
PSA: 9 billion USD in research funds stolen by publishers over a 5 year period for open access fees - this takes away from your ability to pay your people what they are worth. Preprints forever.
September 21, 2025 at 8:02 PM
PSA: 9 billion USD in research funds stolen by publishers over a 5 year period for open access fees - this takes away from your ability to pay your people what they are worth. Preprints forever.
This is the research we need 😋 I have been struggling for years to make reliable cacio e pepe, can't wait to try it out
ista.ac.at/en/news/2025...
ista.ac.at/en/news/2025...
2025 Ig Nobel Prize for Perfect Pasta Sauce
The Ig Nobel Prize honors research that first makes people laugh, then makes them think. Its 35th award ceremony possibly also makes people hungry: ISTA physicist Fabrizio Olmeda and colleagues resear...
ista.ac.at
September 20, 2025 at 11:10 AM
This is the research we need 😋 I have been struggling for years to make reliable cacio e pepe, can't wait to try it out
ista.ac.at/en/news/2025...
ista.ac.at/en/news/2025...
Reposted by Marten Chaillet
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching https://www.biorxiv.org/content/10.1101/2025.09.11.675606v1
September 17, 2025 at 3:49 AM
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching https://www.biorxiv.org/content/10.1101/2025.09.11.675606v1
Reposted by Marten Chaillet
Together with colleagues at the Dept. of Microsystems Engineering, we are looking for a PhD student to develop methods for femtoliter-scale sample dispensing in cryoEM sample preparation.
edu.nl/h436k
If you like interdisciplinary research & fascinating physics at ultrasmall scales, please apply!
edu.nl/h436k
If you like interdisciplinary research & fascinating physics at ultrasmall scales, please apply!
September 8, 2025 at 1:48 PM
Together with colleagues at the Dept. of Microsystems Engineering, we are looking for a PhD student to develop methods for femtoliter-scale sample dispensing in cryoEM sample preparation.
edu.nl/h436k
If you like interdisciplinary research & fascinating physics at ultrasmall scales, please apply!
edu.nl/h436k
If you like interdisciplinary research & fascinating physics at ultrasmall scales, please apply!
Reposted by Marten Chaillet
First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...
Leopard-EM: An extensible 2DTM package to accelerate in situ structural biology
The ability to generate high-resolution views of cells with cryogenic electron microscopy (cryo-EM) can reveal the molecular mechanisms of biological processes in their native cellular context. The re...
www.biorxiv.org
August 30, 2025 at 12:49 AM
First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...
Reposted by Marten Chaillet
Mitochondria finally made the headlines, yay!
Oh wait, ... oh no ....
Oh wait, ... oh no ....
via @acyn.bsky.social
RFK JR: I’m looking at kids as I walk through the airports today...and I see these kids that are just overburdened with mitochondrial challenges, inflammation—you can tell from their faces, movements, and lack of social connection
RFK JR: I’m looking at kids as I walk through the airports today...and I see these kids that are just overburdened with mitochondrial challenges, inflammation—you can tell from their faces, movements, and lack of social connection
August 28, 2025 at 3:43 PM
Mitochondria finally made the headlines, yay!
Oh wait, ... oh no ....
Oh wait, ... oh no ....
Reposted by Marten Chaillet
As teams grow, new Ph.D. graduates are less likely to land tenure-track jobs and more likely to leave science—especially women and international researchers, according to research from last year. https://scim.ag/3JHinJs #ScienceMagArchives
Larger teams worsen academic career prospects
As teams grow, new Ph.D. graduates are less likely to land tenure-track jobs and more likely to leave science—especially women and international researchers
scim.ag
August 23, 2025 at 8:52 PM
As teams grow, new Ph.D. graduates are less likely to land tenure-track jobs and more likely to leave science—especially women and international researchers, according to research from last year. https://scim.ag/3JHinJs #ScienceMagArchives
Reposted by Marten Chaillet
PVV-programma wil trans mensen erkenning ontnemen, docenten screenen op "politieke neutraliteit", XR en Antifa als "terroristisch" aanmerken en verbieden, "Alle Syriërs terug", uit EVRM en VN-Vluchtelingenverdrag, verbod op "links-liberale seksuele indoctrinatie".
NOS: "er zijn scherpe randjes af".
NOS: "er zijn scherpe randjes af".
August 23, 2025 at 10:51 AM
PVV-programma wil trans mensen erkenning ontnemen, docenten screenen op "politieke neutraliteit", XR en Antifa als "terroristisch" aanmerken en verbieden, "Alle Syriërs terug", uit EVRM en VN-Vluchtelingenverdrag, verbod op "links-liberale seksuele indoctrinatie".
NOS: "er zijn scherpe randjes af".
NOS: "er zijn scherpe randjes af".
Reposted by Marten Chaillet
It's hard to express how much gratitude I have to everyone involved in the journey, both mine and @napari.org's, that has led to this point. #EurekaPrizes A small attempt below: 👇
@napari.org @jni.codes is a finalist in the @ardc.edu.au Eureka Prize for Excellence in Research Software.
Learn more: youtu.be/0g_MkTa_NwQ
#EurekaPrizes
Learn more: youtu.be/0g_MkTa_NwQ
#EurekaPrizes
August 1, 2025 at 7:29 AM
It's hard to express how much gratitude I have to everyone involved in the journey, both mine and @napari.org's, that has led to this point. #EurekaPrizes A small attempt below: 👇
Reposted by Marten Chaillet
ASS is short for acephalic spermatozoa syndrome in which head and tail of sperm are detached⛓️💥, commonly caused by mutations in the gene encoding for SUN5. Using in situ cryo-ET❄️🔬 we find that SUN5 forms a protein lattice in the nuclear envelope (NE) at the head-tail junction of mammalian sperm.1/4
July 31, 2025 at 3:40 PM
ASS is short for acephalic spermatozoa syndrome in which head and tail of sperm are detached⛓️💥, commonly caused by mutations in the gene encoding for SUN5. Using in situ cryo-ET❄️🔬 we find that SUN5 forms a protein lattice in the nuclear envelope (NE) at the head-tail junction of mammalian sperm.1/4
Reposted by Marten Chaillet
In our latest preprint on bioRxiv, we present the in situ structure of
the human gap junction at 14 Å resolution using cryo-ET.
The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.
the human gap junction at 14 Å resolution using cryo-ET.
The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.
July 8, 2025 at 5:33 AM
In our latest preprint on bioRxiv, we present the in situ structure of
the human gap junction at 14 Å resolution using cryo-ET.
The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.
the human gap junction at 14 Å resolution using cryo-ET.
The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.
Reposted by Marten Chaillet
Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...
To tilt or not to tilt? Strategies for in situ cryo-EM data collection
Recent breakthroughs in single-particle cryogenic electron microscopy (cryo-EM) and protein structure prediction have transformed our ability to resol…
www.sciencedirect.com
June 28, 2025 at 2:04 PM
Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...
Reposted by Marten Chaillet
Exited to share my first PostDoc contribution! Like Magellan explored the globe, you can explore your cryoEM data with Magellon. Congrats to all involved. Scott Stagg Lab & Michael Cianfrocco Lab @landerlab.bsky.social www.biorxiv.org/content/10.1... 🌎❄️🔬
June 23, 2025 at 11:28 PM
Exited to share my first PostDoc contribution! Like Magellan explored the globe, you can explore your cryoEM data with Magellon. Congrats to all involved. Scott Stagg Lab & Michael Cianfrocco Lab @landerlab.bsky.social www.biorxiv.org/content/10.1... 🌎❄️🔬
Reposted by Marten Chaillet
