Ioannis Skalidis
@johnskal.bsky.social
MSCA post-doctoral researcher at Förster lab, Utrecht university.
SPA guy trying to navigate Tomo.
Lover of big protein complexes and even bigger scopes.
I'm new here. #structuralbiology #cryoem
SPA guy trying to navigate Tomo.
Lover of big protein complexes and even bigger scopes.
I'm new here. #structuralbiology #cryoem
Reposted by Ioannis Skalidis
Direct evidence of acid-driven protein desolvation www.biorxiv.org/content/10.1101/2025.09.01.673474v1 #cryoem
September 2, 2025 at 8:57 AM
Direct evidence of acid-driven protein desolvation www.biorxiv.org/content/10.1101/2025.09.01.673474v1 #cryoem
A project that would never leave my mind during my PhD is finally out!
We used #cryo-em #spa #md to see how the solvation layer of a protein is affected during acidification!
Really cool insights and a truly fundamental work, congrats to all involved!
www.biorxiv.org/content/10.1...
We used #cryo-em #spa #md to see how the solvation layer of a protein is affected during acidification!
Really cool insights and a truly fundamental work, congrats to all involved!
www.biorxiv.org/content/10.1...
Direct evidence of acid-driven protein desolvation
Water and its ability to modulate the protonation states of biomolecules govern the physical chemistry of life, dictating their metabolic functions. However, how amino acid protonation alters protein ...
www.biorxiv.org
September 2, 2025 at 9:58 AM
A project that would never leave my mind during my PhD is finally out!
We used #cryo-em #spa #md to see how the solvation layer of a protein is affected during acidification!
Really cool insights and a truly fundamental work, congrats to all involved!
www.biorxiv.org/content/10.1...
We used #cryo-em #spa #md to see how the solvation layer of a protein is affected during acidification!
Really cool insights and a truly fundamental work, congrats to all involved!
www.biorxiv.org/content/10.1...
The first project I worked on, right after joining @bijvoet-centre.bsky.social!
Structure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosus www.biorxiv.org/content/10.1101/2025.03.19.643997v1 #cryoem
March 23, 2025 at 3:26 PM
The first project I worked on, right after joining @bijvoet-centre.bsky.social!
Damn, I'm sad I just found out about this one only now!
Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 22, 2025 at 9:27 AM
Damn, I'm sad I just found out about this one only now!
I guess I should have posted a bit earlier, but I'm very excited that my #MSCA application got accepted! I'll be working at @fridof.bsky.social lab @utrechtuniversity.bsky.social to develop my #teamtomo skills on my project: Protein ER-ways! Here's to gaining new insights on ER protein biogenesis!
February 11, 2025 at 11:47 AM
I guess I should have posted a bit earlier, but I'm very excited that my #MSCA application got accepted! I'll be working at @fridof.bsky.social lab @utrechtuniversity.bsky.social to develop my #teamtomo skills on my project: Protein ER-ways! Here's to gaining new insights on ER protein biogenesis!
Having now worked myself on tomo data collection and analysis makes me appreciate the enormity of this work even more! Amazing stuff...
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
January 17, 2025 at 8:07 PM
Having now worked myself on tomo data collection and analysis makes me appreciate the enormity of this work even more! Amazing stuff...