Dimitry Tegunov
@dtegunov.bsky.social
Mostly #cryoEM-related tweets. Group leader at a biotech company in the Bay Area. Views are my own.
https://github.com/warpem/warp
https://github.com/warpem/warp
California is famous for its sunsets, but sunny early mornings are the real magic here
February 6, 2026 at 4:25 PM
California is famous for its sunsets, but sunny early mornings are the real magic here
Do we have “I am a robot” CAPTCHAs for Moltbook yet?
February 1, 2026 at 3:49 AM
Do we have “I am a robot” CAPTCHAs for Moltbook yet?
If someone's age is a prime number, are they in their prime?
January 23, 2026 at 6:06 PM
If someone's age is a prime number, are they in their prime?
This exciting new method has a bright future!
January 22, 2026 at 5:36 PM
This exciting new method has a bright future!
Great CV advice in this thread! I'll also add that for computational scientists, a GitHub/GitLab link is a must. Sure, there are people whose work I know well enough to not care about their repos, but don't bet on that.
I've reviewed about 150 CVs in the past few days. A few observations: (1) I am sooo impressed by the talent pool out there; (2) do not try to make your CV fit onto one page if it makes things difficult to read - just go multipage, keeping the key messages upfront;
January 14, 2026 at 9:35 PM
Great CV advice in this thread! I'll also add that for computational scientists, a GitHub/GitLab link is a must. Sure, there are people whose work I know well enough to not care about their repos, but don't bet on that.
2026 will bring great tilt series alignments for the ribosome-deficient among us 🎆
January 1, 2026 at 12:01 AM
2026 will bring great tilt series alignments for the ribosome-deficient among us 🎆
Here is why friends don't let friends calculate FSC on denoised half-maps. I took EMD-17961, denoised the maps using Warp's Noise2Map, and calculated the FSC between various things. With noise gone from the half-maps, their consistency is no longer related to SSNR. Denoised map vs. model still works
December 15, 2025 at 1:53 AM
Here is why friends don't let friends calculate FSC on denoised half-maps. I took EMD-17961, denoised the maps using Warp's Noise2Map, and calculated the FSC between various things. With noise gone from the half-maps, their consistency is no longer related to SSNR. Denoised map vs. model still works
Don't get me wrong: the original IsoNet was the coolest thing to happen in cryoET in at least a decade. But after the initial “wow” moment it's time to make this topic more sciency
It would be a great start if the individual methods papers could quantify the quality of their own results instead of relying on visual vibes
December 13, 2025 at 8:08 PM
Don't get me wrong: the original IsoNet was the coolest thing to happen in cryoET in at least a decade. But after the initial “wow” moment it's time to make this topic more sciency
I'm not superstitious but I never set my TV's volume to 13
November 18, 2025 at 10:31 PM
I'm not superstitious but I never set my TV's volume to 13
I'm used to seeing driverless Waymos at this point, but seeing a Waymo with no driver *and* no passengers roll down a hill still gave me a moment of “OMG THE PARKING BRAKE FAILED” panic
October 29, 2025 at 6:29 PM
I'm used to seeing driverless Waymos at this point, but seeing a Waymo with no driver *and* no passengers roll down a hill still gave me a moment of “OMG THE PARKING BRAKE FAILED” panic
Cool, definitely a visual improvement! But do I understand correctly the FSC was calculated between 2 *denoised* half-maps? You can't quantify resolution like that, only consistency.
Icecream: High-Fidelity Equivariant Cryo-Electron Tomography [new]
Equivariant imaging for cryo-ET denoising/recovery via self-supervision & dose-split data.
Equivariant imaging for cryo-ET denoising/recovery via self-supervision & dose-split data.
October 18, 2025 at 12:03 AM
Cool, definitely a visual improvement! But do I understand correctly the FSC was calculated between 2 *denoised* half-maps? You can't quantify resolution like that, only consistency.
😂
Zoom-ins to show the remaining parts of these erased curves in the upper left of the plot and the gridlines:
October 14, 2025 at 11:46 PM
😂
OMG they will go so well with my Bliss ugly Christmas sweater
You can now buy Microsoft’s Windows XP Crocs for $79.95
You can now buy Microsoft’s Windows XP Crocs for $79.95
The limited edition Crocs include Internet Explorer and Clippy shoe charms.
buff.ly
October 10, 2025 at 4:54 PM
OMG they will go so well with my Bliss ugly Christmas sweater
It took me several weeks to notice how perfect this arrangement was
October 4, 2025 at 7:37 PM
It took me several weeks to notice how perfect this arrangement was
The things Apple will do to procrastinate improving Siri
September 25, 2025 at 3:34 AM
The things Apple will do to procrastinate improving Siri
Ugh, I'm starting to get spam texts with em dashes
September 24, 2025 at 6:27 PM
Ugh, I'm starting to get spam texts with em dashes
Reposted by Dimitry Tegunov
Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026
www.nexperion.net/semcm2026
September 23, 2025 at 10:42 AM
Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026
www.nexperion.net/semcm2026
The North Bay is so packed with Porsches that the non-Porsches (Norsches?) are the real exotics there
September 23, 2025 at 7:32 PM
The North Bay is so packed with Porsches that the non-Porsches (Norsches?) are the real exotics there
Important to remember the theoretical size limit is based on assumptions and a model that may or may not be complete. It isn't some indisputable universal truth.
‘We expect that this approach may be useful for cryo-EM analysis of other small particles near or below the theoretical size limit.’ 🤯
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
September 13, 2025 at 9:07 PM
Important to remember the theoretical size limit is based on assumptions and a model that may or may not be complete. It isn't some indisputable universal truth.
A fun introduction to problems arising from having to do Cartesian things on a sphere: www.bowerbyte.com/posts/blocky...
Blocky Planet — Making Minecraft Spherical
Discover the unique design challenges of creating a spherical planet out of Minecraft-like blocks.
www.bowerbyte.com
September 1, 2025 at 4:37 PM
A fun introduction to problems arising from having to do Cartesian things on a sphere: www.bowerbyte.com/posts/blocky...
You're absolutely right!
August 21, 2025 at 6:40 PM
You're absolutely right!
K-Pop Demon Hunters OST playing on the radio? Cool!
August 15, 2025 at 7:52 PM
K-Pop Demon Hunters OST playing on the radio? Cool!
I just found out the latest version of MacOS finally implements the motion cue dots iOS has had for a few years now, and it's doing wonders for me when I need to use my laptop on bus rides
August 7, 2025 at 3:19 PM
I just found out the latest version of MacOS finally implements the motion cue dots iOS has had for a few years now, and it's doing wonders for me when I need to use my laptop on bus rides
I don't know what cursed token sequence puts Claude into stupid mode, but it's impossible to recover from it and you have to start a new conversation
August 1, 2025 at 2:53 AM
I don't know what cursed token sequence puts Claude into stupid mode, but it's impossible to recover from it and you have to start a new conversation