Dimitry Tegunov
@dtegunov.bsky.social
Mostly #cryoEM-related tweets. Group leader at a biotech company in the Bay Area. Views are my own.
https://github.com/warpem/warp
https://github.com/warpem/warp
I'm used to seeing driverless Waymos at this point, but seeing a Waymo with no driver *and* no passengers roll down a hill still gave me a moment of “OMG THE PARKING BRAKE FAILED” panic
October 29, 2025 at 6:29 PM
I'm used to seeing driverless Waymos at this point, but seeing a Waymo with no driver *and* no passengers roll down a hill still gave me a moment of “OMG THE PARKING BRAKE FAILED” panic
Cool, definitely a visual improvement! But do I understand correctly the FSC was calculated between 2 *denoised* half-maps? You can't quantify resolution like that, only consistency.
Icecream: High-Fidelity Equivariant Cryo-Electron Tomography [new]
Equivariant imaging for cryo-ET denoising/recovery via self-supervision & dose-split data.
Equivariant imaging for cryo-ET denoising/recovery via self-supervision & dose-split data.
October 18, 2025 at 12:03 AM
Cool, definitely a visual improvement! But do I understand correctly the FSC was calculated between 2 *denoised* half-maps? You can't quantify resolution like that, only consistency.
😂
Zoom-ins to show the remaining parts of these erased curves in the upper left of the plot and the gridlines:
October 14, 2025 at 11:46 PM
😂
OMG they will go so well with my Bliss ugly Christmas sweater
You can now buy Microsoft’s Windows XP Crocs for $79.95
You can now buy Microsoft’s Windows XP Crocs for $79.95
The limited edition Crocs include Internet Explorer and Clippy shoe charms.
buff.ly
October 10, 2025 at 4:54 PM
OMG they will go so well with my Bliss ugly Christmas sweater
It took me several weeks to notice how perfect this arrangement was
October 4, 2025 at 7:37 PM
It took me several weeks to notice how perfect this arrangement was
The things Apple will do to procrastinate improving Siri
September 25, 2025 at 3:34 AM
The things Apple will do to procrastinate improving Siri
Ugh, I'm starting to get spam texts with em dashes
September 24, 2025 at 6:27 PM
Ugh, I'm starting to get spam texts with em dashes
Reposted by Dimitry Tegunov
Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026
www.nexperion.net/semcm2026
September 23, 2025 at 10:42 AM
Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026
www.nexperion.net/semcm2026
The North Bay is so packed with Porsches that the non-Porsches (Norsches?) are the real exotics there
September 23, 2025 at 7:32 PM
The North Bay is so packed with Porsches that the non-Porsches (Norsches?) are the real exotics there
Important to remember the theoretical size limit is based on assumptions and a model that may or may not be complete. It isn't some indisputable universal truth.
‘We expect that this approach may be useful for cryo-EM analysis of other small particles near or below the theoretical size limit.’ 🤯
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
September 13, 2025 at 9:07 PM
Important to remember the theoretical size limit is based on assumptions and a model that may or may not be complete. It isn't some indisputable universal truth.
A fun introduction to problems arising from having to do Cartesian things on a sphere: www.bowerbyte.com/posts/blocky...
Blocky Planet — Making Minecraft Spherical
Discover the unique design challenges of creating a spherical planet out of Minecraft-like blocks.
www.bowerbyte.com
September 1, 2025 at 4:37 PM
A fun introduction to problems arising from having to do Cartesian things on a sphere: www.bowerbyte.com/posts/blocky...
You're absolutely right!
August 21, 2025 at 6:40 PM
You're absolutely right!
K-Pop Demon Hunters OST playing on the radio? Cool!
August 15, 2025 at 7:52 PM
K-Pop Demon Hunters OST playing on the radio? Cool!
I just found out the latest version of MacOS finally implements the motion cue dots iOS has had for a few years now, and it's doing wonders for me when I need to use my laptop on bus rides
August 7, 2025 at 3:19 PM
I just found out the latest version of MacOS finally implements the motion cue dots iOS has had for a few years now, and it's doing wonders for me when I need to use my laptop on bus rides
I don't know what cursed token sequence puts Claude into stupid mode, but it's impossible to recover from it and you have to start a new conversation
August 1, 2025 at 2:53 AM
I don't know what cursed token sequence puts Claude into stupid mode, but it's impossible to recover from it and you have to start a new conversation
First flight lesson survived!
July 20, 2025 at 4:36 PM
First flight lesson survived!
Whoever gets the resolution of raw tomograms to <10 Å within the sampled parts of Fourier space would probably deserve a Nobel. Or they'd get one anyway for the crazy new physics they discovered to achieve that.
“Achieving individual tomograms of cells where any features are at 10 Å resolution or better is well-beyond both current capabilities and reasonable predictions of future improvements.”
:(
:(
Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...
July 1, 2025 at 6:31 PM
Whoever gets the resolution of raw tomograms to <10 Å within the sampled parts of Fourier space would probably deserve a Nobel. Or they'd get one anyway for the crazy new physics they discovered to achieve that.
I had a dream last night where some online store had the 5090 FE in stock at MSRP. It was a happy dream 🥹
May 31, 2025 at 4:05 PM
I had a dream last night where some online store had the 5090 FE in stock at MSRP. It was a happy dream 🥹
He's currently beta-testing “faucet with a sensor that doesn't register your hands until you bring them in the least fortunate position, then sends water full-blast horizontally at them to be deflected to your crotch area to make it look like you peed yourself” in select locations
I’m the guy who invents new bathroom faucet designs for every hotel. You might know me from Knob That Goes The Other Way and Joystick That’s Hard To Turn Off. Lately I’ve been lacking inspiration, even thinking about hanging it up. I’ve had a good run, but — wait, never mind: Ball You Turn Diagonal
May 24, 2025 at 6:26 AM
He's currently beta-testing “faucet with a sensor that doesn't register your hands until you bring them in the least fortunate position, then sends water full-blast horizontally at them to be deflected to your crotch area to make it look like you peed yourself” in select locations
Y'all marketing people need to stop handing out reusable water bottles at every event
April 26, 2025 at 4:21 PM
Y'all marketing people need to stop handing out reusable water bottles at every event
Came for the memes, stayed for the science
Did you know that there is so much DNA packed inside a phage capsid that the pressure is 10X higher than in a bottle of champagne? In our latest preprint, we wondered how that is contained in a phage that lives at extremely high temperatures. /1
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 18, 2025 at 4:30 PM
Came for the memes, stayed for the science
I've got bad news for #teamtomo: earlier today, our resident headcrab attacked @lorenzlamm.bsky.social, turning his Mem🧠 into 🧟♂️🧠
April 7, 2025 at 8:30 PM
I've got bad news for #teamtomo: earlier today, our resident headcrab attacked @lorenzlamm.bsky.social, turning his Mem🧠 into 🧟♂️🧠
When you wake up at 4am because your spouse used the allyourblanketarebelongtous cheat code, and your brain puts on a slideshow to make sure you won't fall asleep again, but you need to make slides for a talk tomorrow so it's a literal slideshow
March 23, 2025 at 2:42 PM
When you wake up at 4am because your spouse used the allyourblanketarebelongtous cheat code, and your brain puts on a slideshow to make sure you won't fall asleep again, but you need to make slides for a talk tomorrow so it's a literal slideshow
Reposted by Dimitry Tegunov
Been thinking of trying WarpTools but worried about having to start processing from scratch? @rasmusjensen.bsky.social wrote this handy guide for moving projects from desktop Warp to the latest version which runs on linux
warpem.github.io/warp/referen...
warpem.github.io/warp/referen...
Desktop Warp → WarpTools - Warp, M and friends
Warp
warpem.github.io
March 17, 2025 at 6:22 PM
Been thinking of trying WarpTools but worried about having to start processing from scratch? @rasmusjensen.bsky.social wrote this handy guide for moving projects from desktop Warp to the latest version which runs on linux
warpem.github.io/warp/referen...
warpem.github.io/warp/referen...
Damn, this is brilliant. But I feel like the authors didn't answer the most important question: can you make tiny soap bubbles with this??
Foam film vitrification for cryo-EM https://www.biorxiv.org/content/10.1101/2025.03.10.642366v1
March 12, 2025 at 9:13 PM
Damn, this is brilliant. But I feel like the authors didn't answer the most important question: can you make tiny soap bubbles with this??