Karreth Lab
@karrethlab.bsky.social
We study how melanomas progress and metastasize at Moffitt Cancer Center. Current focus on TFs and ncRNAs. Account managed by Florian.
From the biology on melanocytes to pigmentation conditions and melanoma - we have it all! Join us in Tampa in March 2026 to learn the latest in the pigment cell field (and escape the cold) at the Annual Meeting of the Pan-American Society for Pigment Cell Research
October 5, 2025 at 3:07 PM
From the biology on melanocytes to pigmentation conditions and melanoma - we have it all! Join us in Tampa in March 2026 to learn the latest in the pigment cell field (and escape the cold) at the Annual Meeting of the Pan-American Society for Pigment Cell Research
Interested in anti sense #RNA functions and their contribution to #melanoma formation? Check out our latest paper: CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma: Cell Reports www.cell.com/cell-reports...
CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma
Chadourne et al. identify CDH3-AS1 as a downregulated antisense RNA in melanoma that
enhances P-cadherin translation through a SINEUP-like mechanism. CDH3-AS1 overexpression
suppresses melanoma growth...
www.cell.com
October 4, 2025 at 12:57 AM
Interested in anti sense #RNA functions and their contribution to #melanoma formation? Check out our latest paper: CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma: Cell Reports www.cell.com/cell-reports...
Reposted by Karreth Lab
Just like there are good and bad macrophages..., there are good and bad NK cells!! This has profound therapeutic implications, far beyond oncology! Thanks to CD for highlighting both papers and the superb and efficient editorial work! Thanks to our collaborators (especially Zihai Li) and funders!
Now online in Cancer Discovery for the #EACR2025 presentation by @marinelab.bsky.social: Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype doi.org/10.1158/2159... @vib-ccb.bsky.social @pozniakjoanna.bsky.social
September 9, 2025 at 6:27 PM
Just like there are good and bad macrophages..., there are good and bad NK cells!! This has profound therapeutic implications, far beyond oncology! Thanks to CD for highlighting both papers and the superb and efficient editorial work! Thanks to our collaborators (especially Zihai Li) and funders!
Reposted by Karreth Lab
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Mechanical confinement governs phenotypic plasticity in melanoma - Nature
Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...
www.nature.com
August 27, 2025 at 5:18 PM
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
With the NCI payline lowered to 4th percentile, this unfortunately did not age well
Fundable R01 score 🥳
August 20, 2025 at 10:06 PM
With the NCI payline lowered to 4th percentile, this unfortunately did not age well
Fundable R01 score 🥳
June 30, 2025 at 3:43 PM
Fundable R01 score 🥳
Another preprint from our group. Here we show that FRA1 is a potent driver of #melanoma metastasis and inhibiting some of FRA1's transcriptional targets diminishes dissemination
FRA1 drives melanoma metastasis through an actionable transcriptional network https://www.biorxiv.org/content/10.1101/2025.06.07.658418v1
June 10, 2025 at 10:52 PM
Another preprint from our group. Here we show that FRA1 is a potent driver of #melanoma metastasis and inhibiting some of FRA1's transcriptional targets diminishes dissemination
Preprint alert: check out our new genetically engineered mouse model of uveal melanoma, which recapitulates many aspects of the human disease including phenotypic plasticity
A multi-step immune-competent genetic mouse model reveals phenotypic plasticity in uveal melanoma https://www.biorxiv.org/content/10.1101/2025.06.04.657841v1
June 7, 2025 at 3:07 PM
Preprint alert: check out our new genetically engineered mouse model of uveal melanoma, which recapitulates many aspects of the human disease including phenotypic plasticity
Indeed, fucked we are
May 23, 2025 at 5:37 PM
Indeed, fucked we are
Reposted by Karreth Lab
ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
the word alert is in a purple circle
ALT: the word alert is in a purple circle
media.tenor.com
April 23, 2025 at 6:03 PM
ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Gave a talk at the University of Louisville a few weeks ago and received this thank you gift in the mail today. My first Louisville Slugger - so cool!
March 14, 2025 at 9:44 PM
Gave a talk at the University of Louisville a few weeks ago and received this thank you gift in the mail today. My first Louisville Slugger - so cool!
Reposted by Karreth Lab
We wrapped up our final day of #AMC25 on Saturday!
Four days of insightful discussions, collaboration, & cutting-edge research. Grateful to everyone who joined us in DR to share insights, engage in conversations & foster collaborations. Until next time!🐭☀️🌴
Four days of insightful discussions, collaboration, & cutting-edge research. Grateful to everyone who joined us in DR to share insights, engage in conversations & foster collaborations. Until next time!🐭☀️🌴
March 4, 2025 at 8:50 AM
We wrapped up our final day of #AMC25 on Saturday!
Four days of insightful discussions, collaboration, & cutting-edge research. Grateful to everyone who joined us in DR to share insights, engage in conversations & foster collaborations. Until next time!🐭☀️🌴
Four days of insightful discussions, collaboration, & cutting-edge research. Grateful to everyone who joined us in DR to share insights, engage in conversations & foster collaborations. Until next time!🐭☀️🌴
Reposted by Karreth Lab
I’ll be in DC March 7th at the StandUpForScience rally. See you there! If you can’t make it to DC there will be a StandUpForScience rally in a city near you. @standupforscience.bsky.social
February 27, 2025 at 2:55 AM
I’ll be in DC March 7th at the StandUpForScience rally. See you there! If you can’t make it to DC there will be a StandUpForScience rally in a city near you. @standupforscience.bsky.social
Anyone else use 'please' and 'thank you' when entering AI prompts? I hope my life will be spared when AI takes over...
February 22, 2025 at 1:05 PM
Anyone else use 'please' and 'thank you' when entering AI prompts? I hope my life will be spared when AI takes over...
Some study sections seemed to have happened this week - one ND (R01) and a 7%ile (R21). But are June council meetings going to be on?
February 20, 2025 at 10:37 PM
Some study sections seemed to have happened this week - one ND (R01) and a 7%ile (R21). But are June council meetings going to be on?
Reposted by Karreth Lab
Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Sign the Petition
Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)
chng.it
February 10, 2025 at 5:49 PM
Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Reposted by Karreth Lab
Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Rhodoquinone carries electrons in the mammalian electron transport chain
Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian
mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal
electron acceptor. The authors de...
www.cell.com
February 4, 2025 at 9:40 PM
Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
4 papers submitted - a busy start to the year. Let's hope 2025 won't be the year of rejections 😁
January 21, 2025 at 10:45 PM
4 papers submitted - a busy start to the year. Let's hope 2025 won't be the year of rejections 😁
New preprint from the lab just posted to bioRxiv. Our first foray into antisense RNAs, led by postdoc Manon Chadourne, with implications for mRNA translation. Great collab with Alex Jaeger and his lab!
CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma https://www.biorxiv.org/content/10.1101/2024.12.26.630428v1
December 27, 2024 at 2:17 PM
New preprint from the lab just posted to bioRxiv. Our first foray into antisense RNAs, led by postdoc Manon Chadourne, with implications for mRNA translation. Great collab with Alex Jaeger and his lab!
Reposted by Karreth Lab
We are recruiting a postdoc to join our team (myself, Boris Bastian, and Iwei Yeh) at UCSF to develop a pre-cancer atlas of skin cancer -- part of the Human Tumor Atlas Network (#HTAN). #CancerEvolution #Bioinformatics. Interested? Email resume and cover letter to me.
December 14, 2024 at 5:43 PM
We are recruiting a postdoc to join our team (myself, Boris Bastian, and Iwei Yeh) at UCSF to develop a pre-cancer atlas of skin cancer -- part of the Human Tumor Atlas Network (#HTAN). #CancerEvolution #Bioinformatics. Interested? Email resume and cover letter to me.
November has been busy, but I'm pleased to finally share our recent paper in Cancer Research: PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability aacrjournals.org/cancerres/ar... Congrats to grad student Neel! A short 🧵 of what we found.
PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability
Abstract. Overexpression of PHGDH, the rate-limiting enzyme in the serine synthesis pathway, promotes melanomagenesis, melanoma cell proliferation, and survival of metastases in serine-low environment...
aacrjournals.org
November 29, 2024 at 3:39 PM
November has been busy, but I'm pleased to finally share our recent paper in Cancer Research: PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability aacrjournals.org/cancerres/ar... Congrats to grad student Neel! A short 🧵 of what we found.
Reposted by Karreth Lab
We are hiring! We are looking for a Project Scientist to be in charge of the day-to-day operation of our tumor organoid pipeline. Come join our team of rare cancer aficionados looking to leverage organoids for functional precision medicine. Apply by November 24th!
recruit.apo.ucla.edu/JPF09960
recruit.apo.ucla.edu/JPF09960
Project Scientist
University of California, Los Angeles is hiring. Apply now!
recruit.apo.ucla.edu
November 23, 2024 at 5:34 PM
We are hiring! We are looking for a Project Scientist to be in charge of the day-to-day operation of our tumor organoid pipeline. Come join our team of rare cancer aficionados looking to leverage organoids for functional precision medicine. Apply by November 24th!
recruit.apo.ucla.edu/JPF09960
recruit.apo.ucla.edu/JPF09960
We're looking to recruit a postdoc with expertise in RNA biology to join our glyco-RNA team. Please share.
moffitt-cancer-center-careers.hctsportals.com/jobs/1808511...
moffitt-cancer-center-careers.hctsportals.com/jobs/1808511...
Postdoctoral Fellow – RNA Modifications in Melanoma in Tampa, FL - Moffitt Cancer Center CareersPostdoctoral Fellow – RNA Modifications in Melanoma in Tampa, FL - Moffitt Cancer Center Careers
Working at Moffitt Cancer Center is both a career and a mission. All employees are dedicated to patient care, research and education to advance our fight against this disease.
moffitt-cancer-center-careers.hctsportals.com
November 24, 2024 at 3:54 AM
We're looking to recruit a postdoc with expertise in RNA biology to join our glyco-RNA team. Please share.
moffitt-cancer-center-careers.hctsportals.com/jobs/1808511...
moffitt-cancer-center-careers.hctsportals.com/jobs/1808511...
Reposted by Karreth Lab
hey everyone! i made a list of some useful starter packs (primarily biology/earth sciences with a few bonus things thrown in) to share with friends who have joined bsky in the last week and thought it may be useful for some people here too! 🌍🧪 #SciSky #BioSky docs.google.com/document/d/1...
Starter packs
BIOLOGY Ecology Macroecology https://go.bsky.app/GBn9pNZ Global ecology https://go.bsky.app/V6tN4cv Trait based ecology and evolution https://go.bsky.app/PThMXeX Invasion biology https://go.b...
docs.google.com
November 11, 2024 at 5:41 PM
hey everyone! i made a list of some useful starter packs (primarily biology/earth sciences with a few bonus things thrown in) to share with friends who have joined bsky in the last week and thought it may be useful for some people here too! 🌍🧪 #SciSky #BioSky docs.google.com/document/d/1...
Reposted by Karreth Lab
🚨 Update for #RNA science fans:
I checked on #Bsky registry, and here is a 'condensate' (😆) of all #RNA #RNAsky starter packs so far:
1. General RNA biology #1
go.bsky.app/RN6HnZp
I checked on #Bsky registry, and here is a 'condensate' (😆) of all #RNA #RNAsky starter packs so far:
1. General RNA biology #1
go.bsky.app/RN6HnZp
November 21, 2024 at 8:08 AM
🚨 Update for #RNA science fans:
I checked on #Bsky registry, and here is a 'condensate' (😆) of all #RNA #RNAsky starter packs so far:
1. General RNA biology #1
go.bsky.app/RN6HnZp
I checked on #Bsky registry, and here is a 'condensate' (😆) of all #RNA #RNAsky starter packs so far:
1. General RNA biology #1
go.bsky.app/RN6HnZp