Karim Almahayni 🍉
@karimalmahayni.bsky.social
Microscopy🔬| Glycans🍭| Pharmacology 💊@MPI_Light |@uniofoxford ‘20, @sheffielduni ‘19
Pinned
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🍬🍭🔬
For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology! #glycotime
Preprint and #bluetorial below!!
For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology! #glycotime
Preprint and #bluetorial below!!
Reposted by Karim Almahayni 🍉
Our article "Ångström-resolution imaging of cell-surface glycans" made it to the cover of Nature Nanotechnology! 🤩 @natnano.nature.com
www.nature.com/nnano/volume...
www.nature.com/nnano/volume...
October 18, 2025 at 2:32 PM
Our article "Ångström-resolution imaging of cell-surface glycans" made it to the cover of Nature Nanotechnology! 🤩 @natnano.nature.com
www.nature.com/nnano/volume...
www.nature.com/nnano/volume...
Reposted by Karim Almahayni 🍉
Now online: October 2025 Issue.
- Focus Issue on #biosensing,
- DNA moiré superlattices,
- Sugars at Ångström-resolution,
- Solid-state #nanopores,
- Non-aqueous Li #batteries, -
- Neuromorphic vision,
- Peptide #hydrogels,
- Deep learning for #LNPs and more...
www.nature.com/nnano/volume...
- Focus Issue on #biosensing,
- DNA moiré superlattices,
- Sugars at Ångström-resolution,
- Solid-state #nanopores,
- Non-aqueous Li #batteries, -
- Neuromorphic vision,
- Peptide #hydrogels,
- Deep learning for #LNPs and more...
www.nature.com/nnano/volume...
October 17, 2025 at 6:45 PM
Now online: October 2025 Issue.
- Focus Issue on #biosensing,
- DNA moiré superlattices,
- Sugars at Ångström-resolution,
- Solid-state #nanopores,
- Non-aqueous Li #batteries, -
- Neuromorphic vision,
- Peptide #hydrogels,
- Deep learning for #LNPs and more...
www.nature.com/nnano/volume...
- Focus Issue on #biosensing,
- DNA moiré superlattices,
- Sugars at Ångström-resolution,
- Solid-state #nanopores,
- Non-aqueous Li #batteries, -
- Neuromorphic vision,
- Peptide #hydrogels,
- Deep learning for #LNPs and more...
www.nature.com/nnano/volume...
Reposted by Karim Almahayni 🍉
With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
October 8, 2025 at 1:26 PM
With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
Reposted by Karim Almahayni 🍉
We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...
DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells
The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...
www.biorxiv.org
October 7, 2025 at 1:22 PM
We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...
Reposted by Karim Almahayni 🍉
Excited to see this one out in JACS! We analyzed how molecular interactions lead to self-organization of glycolipids down to microseconds and nanometer spatiotemporal scales. Amazing collaboration with the Sandoghdar lab, @biomemphys.bsky.social, and Thisbe Lindhorst!
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Bottom-up Investigation of Spatiotemporal Glycocalyx Dynamics with Interferometric Scattering Microscopy
Over recent decades, the glycocalyx, an extracellular organelle composed of a multitude of glycolipids, glycoproteins, proteoglycans, and glycoRNA, has gained considerable interest in cellular biology...
pubs.acs.org
August 28, 2025 at 10:53 AM
Excited to see this one out in JACS! We analyzed how molecular interactions lead to self-organization of glycolipids down to microseconds and nanometer spatiotemporal scales. Amazing collaboration with the Sandoghdar lab, @biomemphys.bsky.social, and Thisbe Lindhorst!
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Reposted by Karim Almahayni 🍉
Research Briefing:
"Visualizing the nanostructure of the cell’s sugar coat."
Here, the author's views, expert opinion, and insights behind the recently published paper "Ångström-resolution imaging of cell-surface glycans" are presented.
#Glycotime
www.nature.com/articles/s41...
"Visualizing the nanostructure of the cell’s sugar coat."
Here, the author's views, expert opinion, and insights behind the recently published paper "Ångström-resolution imaging of cell-surface glycans" are presented.
#Glycotime
www.nature.com/articles/s41...
August 6, 2025 at 10:54 AM
Research Briefing:
"Visualizing the nanostructure of the cell’s sugar coat."
Here, the author's views, expert opinion, and insights behind the recently published paper "Ångström-resolution imaging of cell-surface glycans" are presented.
#Glycotime
www.nature.com/articles/s41...
"Visualizing the nanostructure of the cell’s sugar coat."
Here, the author's views, expert opinion, and insights behind the recently published paper "Ångström-resolution imaging of cell-surface glycans" are presented.
#Glycotime
www.nature.com/articles/s41...
Reposted by Karim Almahayni 🍉
Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes
go.nature.com/40I9Ewv
go.nature.com/40I9Ewv
Cell's sugar coating mapped at below-nanometre resolution
Nature - Super-resolution technique works with off-the-shelf optical microscopes.
go.nature.com
August 3, 2025 at 8:59 AM
Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes
go.nature.com/40I9Ewv
go.nature.com/40I9Ewv
Reposted by Karim Almahayni 🍉
Ångström-resolution imaging of cell-surface glycans
Now published in Nature Nanotechnology! 🤩
@natnano.nature.com
www.nature.com/articles/s41...
Now published in Nature Nanotechnology! 🤩
@natnano.nature.com
www.nature.com/articles/s41...
July 30, 2025 at 2:58 PM
Ångström-resolution imaging of cell-surface glycans
Now published in Nature Nanotechnology! 🤩
@natnano.nature.com
www.nature.com/articles/s41...
Now published in Nature Nanotechnology! 🤩
@natnano.nature.com
www.nature.com/articles/s41...
Reposted by Karim Almahayni 🍉
Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes
go.nature.com/4l2wVjS
go.nature.com/4l2wVjS
Cell's sugar coating mapped at below-nanometre resolution
Super-resolution technique works with off-the-shelf optical microscopes.
go.nature.com
July 30, 2025 at 7:57 AM
Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes
go.nature.com/4l2wVjS
go.nature.com/4l2wVjS
Reposted by Karim Almahayni 🍉
News article @nature.com covering a recent study published
@natnano.nature.com
Cell's sugar coating mapped at below-nanometre resolution.
"Super-resolution technique works with off-the-shelf optical microscopes."
#Glycotime
www.nature.com/articles/d41...
@natnano.nature.com
Cell's sugar coating mapped at below-nanometre resolution.
"Super-resolution technique works with off-the-shelf optical microscopes."
#Glycotime
www.nature.com/articles/d41...
Cell's sugar coating mapped at below-nanometre resolution
Super-resolution technique works with off-the-shelf optical microscopes.
www.nature.com
July 30, 2025 at 7:30 AM
News article @nature.com covering a recent study published
@natnano.nature.com
Cell's sugar coating mapped at below-nanometre resolution.
"Super-resolution technique works with off-the-shelf optical microscopes."
#Glycotime
www.nature.com/articles/d41...
@natnano.nature.com
Cell's sugar coating mapped at below-nanometre resolution.
"Super-resolution technique works with off-the-shelf optical microscopes."
#Glycotime
www.nature.com/articles/d41...
Reposted by Karim Almahayni 🍉
New paper online:
Ångström-resolution imaging of cell-surface glycans.
The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
Ångström-resolution imaging of cell-surface glycans.
The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
Ångström-resolution imaging of cell-surface glycans - Nature Nanotechnology
By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...
www.nature.com
July 29, 2025 at 1:11 PM
Reposted by Karim Almahayni 🍉
New paper online:
Ångström-resolution imaging of cell-surface glycans.
The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
Ångström-resolution imaging of cell-surface glycans.
The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
Ångström-resolution imaging of cell-surface glycans - Nature Nanotechnology
By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...
www.nature.com
July 28, 2025 at 9:44 AM
New paper online:
Ångström-resolution imaging of cell-surface glycans.
The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
Ångström-resolution imaging of cell-surface glycans.
The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
Reposted by Karim Almahayni 🍉
Very happy to see this one out - the first molecular-resolution imaging of glycocalyx components in their native environment! Great collaboration with @jungmannlab.bsky.social - congrats to first authors @karimalmahayni.bsky.social and @lumasullo.bsky.social and to the whole team!
New paper online:
Ångström-resolution imaging of cell-surface glycans.
The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
Ångström-resolution imaging of cell-surface glycans.
The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
Ångström-resolution imaging of cell-surface glycans - Nature Nanotechnology
By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...
www.nature.com
July 28, 2025 at 12:38 PM
Very happy to see this one out - the first molecular-resolution imaging of glycocalyx components in their native environment! Great collaboration with @jungmannlab.bsky.social - congrats to first authors @karimalmahayni.bsky.social and @lumasullo.bsky.social and to the whole team!
Reposted by Karim Almahayni 🍉
GLYCAN ATLASSING: NANOSCALE ANALYSIS OF GLYCOCALYX ARCHITECTURE ENABLES FUNCTIONAL TRACING OF CELL STATE 🍭🔬🧬
Don’t judge a book by its cover - judge a cell by its cover! We can now trace how cell state is encoded in glycocalyx state. #glycotime #microscopy
www.biorxiv.org/content/10.1...
Don’t judge a book by its cover - judge a cell by its cover! We can now trace how cell state is encoded in glycocalyx state. #glycotime #microscopy
www.biorxiv.org/content/10.1...
May 2, 2025 at 8:52 AM
GLYCAN ATLASSING: NANOSCALE ANALYSIS OF GLYCOCALYX ARCHITECTURE ENABLES FUNCTIONAL TRACING OF CELL STATE 🍭🔬🧬
Don’t judge a book by its cover - judge a cell by its cover! We can now trace how cell state is encoded in glycocalyx state. #glycotime #microscopy
www.biorxiv.org/content/10.1...
Don’t judge a book by its cover - judge a cell by its cover! We can now trace how cell state is encoded in glycocalyx state. #glycotime #microscopy
www.biorxiv.org/content/10.1...
Reposted by Karim Almahayni 🍉
My daughter died from AML and I don’t want any other parent to go through what we did. This type of vital research must be funded.
Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology
An RNA-binding protein on leukemia cells provides an effective target in mouse models.
www.nature.com
April 26, 2025 at 3:04 AM
My daughter died from AML and I don’t want any other parent to go through what we did. This type of vital research must be funded.
Reposted by Karim Almahayni 🍉
A new druggable cancer target: RNA-binding proteins on the cell surface #NBTintheNews answers.childrenshospital.org/aml-cancer-t...
A druggable target for AML: cell-surface RNA-binding proteins - Boston Children's Answers
Researchers have found a readily druggable target on the surface of acute myeloid leukemia (AML) cells — but not normal blood cells.
answers.childrenshospital.org
April 25, 2025 at 2:21 PM
A new druggable cancer target: RNA-binding proteins on the cell surface #NBTintheNews answers.childrenshospital.org/aml-cancer-t...
Reposted by Karim Almahayni 🍉
Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology
An RNA-binding protein on leukemia cells provides an effective target in mouse models.
www.nature.com
April 25, 2025 at 5:19 AM
Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Karim Almahayni 🍉
A wonderful study, published today in Nature Biotech.: NPM1 is a marker of AML and can be targeted for efficient therapy! @karimalmahayni.bsky.social created the first SR reconstructions of NPM1 on the cell surface. Great collaborative work, spearheaded by @raflynn5.bsky.social and Kostas Tzelepis!
Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically
connecting ‘cell surface RNA biology’ to cancer biology
@natbiotech.nature.com
www.nature.com/articles/s41...
connecting ‘cell surface RNA biology’ to cancer biology
@natbiotech.nature.com
www.nature.com/articles/s41...
April 23, 2025 at 2:14 PM
A wonderful study, published today in Nature Biotech.: NPM1 is a marker of AML and can be targeted for efficient therapy! @karimalmahayni.bsky.social created the first SR reconstructions of NPM1 on the cell surface. Great collaborative work, spearheaded by @raflynn5.bsky.social and Kostas Tzelepis!
Reposted by Karim Almahayni 🍉
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - @raflynn5.bsky.social go.nature.com/3YbT1In
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology
An RNA-binding protein on leukemia cells provides an effective target in mouse models.
go.nature.com
April 23, 2025 at 3:11 PM
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - @raflynn5.bsky.social go.nature.com/3YbT1In
Happy to have contributed to this amazing story identifying cell surface NPM1 as a promising therapeutic strategy in acute myeloid leukaemia, check it out!
Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically
connecting ‘cell surface RNA biology’ to cancer biology
@natbiotech.nature.com
www.nature.com/articles/s41...
connecting ‘cell surface RNA biology’ to cancer biology
@natbiotech.nature.com
www.nature.com/articles/s41...
April 23, 2025 at 1:07 PM
Happy to have contributed to this amazing story identifying cell surface NPM1 as a promising therapeutic strategy in acute myeloid leukaemia, check it out!
Thrilled to be part of this masterpiece published today in CELL 🚀🔬!! Check it out!
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered
domains containing glycoRNAs.
www.cell.com
February 27, 2025 at 6:35 PM
Thrilled to be part of this masterpiece published today in CELL 🚀🔬!! Check it out!
Reposted by Karim Almahayni 🍉
This is an amazing achievement - angstrom scale imagine of glycan molecules, what a great time for #glycotime. Congrats Leonhard Möckl!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Angstrom-resolution imaging of cell-surface glycans
Glycobiology is rooted in the study of monosaccharides, Angstrom-sized molecules that are the building blocks of intricate glycosylation patterns. Glycosylated biomolecules form the glycocalyx, a dens...
www.biorxiv.org
February 10, 2025 at 8:30 AM
This is an amazing achievement - angstrom scale imagine of glycan molecules, what a great time for #glycotime. Congrats Leonhard Möckl!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Karim Almahayni 🍉
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS🍬🍬🍬
For the first time, we are able to image the molecular architecture of the glycocalyx at Ångström resolution. A dream come true!
Read the preprint: biorxiv.org/content/10.110…
And find our tweetorial below#glycotimeme
For the first time, we are able to image the molecular architecture of the glycocalyx at Ångström resolution. A dream come true!
Read the preprint: biorxiv.org/content/10.110…
And find our tweetorial below#glycotimeme
February 10, 2025 at 8:36 AM
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS🍬🍬🍬
For the first time, we are able to image the molecular architecture of the glycocalyx at Ångström resolution. A dream come true!
Read the preprint: biorxiv.org/content/10.110…
And find our tweetorial below#glycotimeme
For the first time, we are able to image the molecular architecture of the glycocalyx at Ångström resolution. A dream come true!
Read the preprint: biorxiv.org/content/10.110…
And find our tweetorial below#glycotimeme
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🍬🍭🔬
For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology! #glycotime
Preprint and #bluetorial below!!
For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology! #glycotime
Preprint and #bluetorial below!!
February 11, 2025 at 11:29 AM
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🍬🍭🔬
For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology! #glycotime
Preprint and #bluetorial below!!
For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology! #glycotime
Preprint and #bluetorial below!!
Reposted by Karim Almahayni 🍉
Excited to share the latest work from our lab: www.biorxiv.org/content/10.1...
Biphasic inflammation control by dedifferentiated fibroblasts enables axon regeneration after spinal cord injury in zebrafish
Fibrosis and persistent inflammation are interconnected processes that inhibit axon regeneration in the mammalian central nervous system (CNS). In zebrafish, by contrast, fibroblast-derived extracellu...
www.biorxiv.org
January 27, 2025 at 7:17 PM
Excited to share the latest work from our lab: www.biorxiv.org/content/10.1...