Juliet Mwirigi
@julietmwirigi.bsky.social
HHMI Hanna Gray Fellow | PostDoc WashU | PhD UT Dallas | Neuroscience | Pain pathways | Single-cell EVERYTHING | Neurons | Cell culturing | Computational work | human dorsal root ganglia
Reposted by Juliet Mwirigi
🚨New paper from the NIH PRECISION Human Pain Network! We built a human DRG reference atlas: >500K cells from 126 donors to reveal 22 neuronal & 10 non-neuronal cell types. New insights into human sensory biology!
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
biorxiv.org
November 7, 2025 at 4:43 AM
🚨New paper from the NIH PRECISION Human Pain Network! We built a human DRG reference atlas: >500K cells from 126 donors to reveal 22 neuronal & 10 non-neuronal cell types. New insights into human sensory biology!
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
Reposted by Juliet Mwirigi
HL60 cells take on so many fun shapes as they migrate! This #InsightFromImaging data features cells prepared by Leanna and imaged on the @aicjanelia.bsky.social LLSM by @cmhobson.bsky.social
November 4, 2025 at 10:36 PM
HL60 cells take on so many fun shapes as they migrate! This #InsightFromImaging data features cells prepared by Leanna and imaged on the @aicjanelia.bsky.social LLSM by @cmhobson.bsky.social
Reposted by Juliet Mwirigi
Our team is hard at work preparing for #InsightFromImaging 2025! We can't wait to welcome HHMI #HannaGrayFellows to @hhmijanelia.bsky.social next week for lectures, hands-on labs, and activities focused on designing informative and quantitative bioimaging experiments 🔬
October 27, 2025 at 5:24 PM
Our team is hard at work preparing for #InsightFromImaging 2025! We can't wait to welcome HHMI #HannaGrayFellows to @hhmijanelia.bsky.social next week for lectures, hands-on labs, and activities focused on designing informative and quantitative bioimaging experiments 🔬
Reposted by Juliet Mwirigi
New method development work from our lab that I hope will make it easier for labs to work with peripheral nervous system tissues recovered from organ donors, tissue donors, and fast autopsies: www.biorxiv.org/content/10.1... This work was led by the amazing duo of Joe Lesnak and Mandee Schaub
September 13, 2025 at 3:32 PM
New method development work from our lab that I hope will make it easier for labs to work with peripheral nervous system tissues recovered from organ donors, tissue donors, and fast autopsies: www.biorxiv.org/content/10.1... This work was led by the amazing duo of Joe Lesnak and Mandee Schaub
Reposted by Juliet Mwirigi
I agree with this essay and it is why I don’t use AI for much of anything. I have this job because I enjoy thinking.
“Competent prose generated by a machine, I’ve come to realize, might not be what science actually needs.” ?
By Tim Requarth
#neuroskyence
www.thetransmitter.org/from-bench-t...
By Tim Requarth
#neuroskyence
www.thetransmitter.org/from-bench-t...
From bench to bot: Why AI-powered writing may not deliver on its promise
Efficiency isn’t everything. The cognitive work of struggling with prose may be a crucial part of what drives scientific progress.
www.thetransmitter.org
September 2, 2025 at 10:54 PM
I agree with this essay and it is why I don’t use AI for much of anything. I have this job because I enjoy thinking.
Reposted by Juliet Mwirigi
📢We're #hiring Group Leaders!
Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning.
🔹5-year renewable appointment
🔹Pioneer new tools & approaches
🔹Collaborate across disciplines
Apply by Nov. 4👉 https://janelia.link/groupleader
Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning.
🔹5-year renewable appointment
🔹Pioneer new tools & approaches
🔹Collaborate across disciplines
Apply by Nov. 4👉 https://janelia.link/groupleader
August 26, 2025 at 7:00 PM
📢We're #hiring Group Leaders!
Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning.
🔹5-year renewable appointment
🔹Pioneer new tools & approaches
🔹Collaborate across disciplines
Apply by Nov. 4👉 https://janelia.link/groupleader
Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning.
🔹5-year renewable appointment
🔹Pioneer new tools & approaches
🔹Collaborate across disciplines
Apply by Nov. 4👉 https://janelia.link/groupleader
Reposted by Juliet Mwirigi
BOOM! Cool to see the final form of this great work now published. Deep new insight into human peripheral neuropathy. Congrats @mheming.bsky.social and colleagues on a great study.
Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies.
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...
August 24, 2025 at 3:21 PM
BOOM! Cool to see the final form of this great work now published. Deep new insight into human peripheral neuropathy. Congrats @mheming.bsky.social and colleagues on a great study.
Reposted by Juliet Mwirigi
This work is finally online as in-press preview!
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
JCI -
Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy
www.jci.org
August 19, 2025 at 4:55 PM
This work is finally online as in-press preview!
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
Reposted by Juliet Mwirigi
Do you have any questions about the current understanding and treatment of #migraine? Check out the newest episode of the Pain Beat moderated by @julietmwirigi.bsky.social! bit.ly/3GGjCYu #podcast #newepisode #PRF
July 30, 2025 at 7:00 PM
Do you have any questions about the current understanding and treatment of #migraine? Check out the newest episode of the Pain Beat moderated by @julietmwirigi.bsky.social! bit.ly/3GGjCYu #podcast #newepisode #PRF
Reposted by Juliet Mwirigi
Some really great stuff in our new preprint on sympathetic ganglion in humans - confirmation of what I think many suspected on Nav1.7 expression in human sympathetic neurons.
Excited to share our preprint on spatial transcriptomics of human sympathetic chain ganglia and the effect of diabetes. We also compared sympathetic and dorsal root ganglia to identify ganglia-specific signatures. Work led by @marisolmancilla.bsky.social
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Spatial transcriptomic profiling of human paravertebral sympathetic chain ganglia reveals diabetes-induced neuroplasticity
The paravertebral sympathetic chain ganglia (SCG) are autonomic ganglia critical for regulating the fight-or-flight response. Symptoms of sympathetic dysfunction are prevalent in diabetes, affecting u...
doi.org
June 26, 2025 at 2:40 AM
Some really great stuff in our new preprint on sympathetic ganglion in humans - confirmation of what I think many suspected on Nav1.7 expression in human sympathetic neurons.
Reposted by Juliet Mwirigi
🌞 nice day for a workshop at #NAPainSchool with @tedpricethepainguy.bsky.social
June 24, 2025 at 7:30 PM
🌞 nice day for a workshop at #NAPainSchool with @tedpricethepainguy.bsky.social
Reposted by Juliet Mwirigi
We finally have an impact factor at Neurobiology of Pain. Thanks to our editorial team: Michael Burton, @annatheneurosci.bsky.social, and Dave Seminowicz; the editorial board; and all our wonderful authors for submitting such great papers over the past several years.
June 24, 2025 at 12:27 AM
We finally have an impact factor at Neurobiology of Pain. Thanks to our editorial team: Michael Burton, @annatheneurosci.bsky.social, and Dave Seminowicz; the editorial board; and all our wonderful authors for submitting such great papers over the past several years.
Reposted by Juliet Mwirigi
the wonders of GLP1 bump into migraine: www.nature.com/articles/d41...
Obesity drugs show promise for treating a new ailment: migraine
Liraglutide, a member of the family of blockbuster weight-loss drugs, reduces headaches by half in a small study.
www.nature.com
June 24, 2025 at 12:04 AM
the wonders of GLP1 bump into migraine: www.nature.com/articles/d41...
Reposted by Juliet Mwirigi
I’m so honored to be selected as both a 2025 McKnight Scholar and 2025 HHMI Freeman Hrabowski Scholar. And I couldn’t be prouder to share these honors with awesome @ucdavis.bsky.social colleagues 💙💛💙💛
health.ucdavis.edu/news/headlin...
health.ucdavis.edu/news/headlin...
UC Davis researchers honored by McKnight and Howard Hughes Medical Institute
UC Davis faculty Sergey Stavisky, Theanne Griffith and Elisa Zhang receive prestigious early-career recognition from McKnight Endowment Fund and the Howard Hughes Medical Institute.
health.ucdavis.edu
June 19, 2025 at 4:46 PM
I’m so honored to be selected as both a 2025 McKnight Scholar and 2025 HHMI Freeman Hrabowski Scholar. And I couldn’t be prouder to share these honors with awesome @ucdavis.bsky.social colleagues 💙💛💙💛
health.ucdavis.edu/news/headlin...
health.ucdavis.edu/news/headlin...
Reposted by Juliet Mwirigi
Loved this interview from the legendary Eve Marder. I agree when she said many papers today are so poorly written that they are unreadable. And our trainees writing is not good because people dont read anymore; not just science reading, but any book in any genre.
🔥 New episode of the Night Science podcast! The brilliant Eve Marder, professor at Brandeis University, talks with us about how "Recipe Science" ruins creativity.
Apple: podcasts.apple.com/us/podcast/n...
Spotify: open.spotify.com/episode/4mSv...
Apple: podcasts.apple.com/us/podcast/n...
Spotify: open.spotify.com/episode/4mSv...
May 27, 2025 at 11:22 AM
Loved this interview from the legendary Eve Marder. I agree when she said many papers today are so poorly written that they are unreadable. And our trainees writing is not good because people dont read anymore; not just science reading, but any book in any genre.
Reposted by Juliet Mwirigi
If you love satellite glial cells (SGCs) then you have got to read about Ole Ahlgreen's great work, part of which was done while he was a visiting PhD student in our lab: www.biorxiv.org/content/10.1...
Mapping satellite glial cell heterogeneity reveals distinct spatial organization and signifies functional diversity in the dorsal root ganglion
Satellite glial cells (SGCs) envelop the somata, axon hillock, and initial axon segment of sensory neurons in the dorsal root ganglia (DRG), playing a critical role in regulating the neuronal microenv...
www.biorxiv.org
May 22, 2025 at 11:12 PM
If you love satellite glial cells (SGCs) then you have got to read about Ole Ahlgreen's great work, part of which was done while he was a visiting PhD student in our lab: www.biorxiv.org/content/10.1...
Reposted by Juliet Mwirigi
First time we’ve had the honor of the @dallasmorningnews.bsky.social writing about our scientific discoveries, funded by the #NIH www.dallasnews.com/news/2025/05...
UTD scientists solve 100-year-old mystery behind diabetic nerve damage
Nageotte nodules, once overlooked, may hold the key to understanding and treating diabetic peripheral neuropathy.
www.dallasnews.com
May 21, 2025 at 2:53 PM
First time we’ve had the honor of the @dallasmorningnews.bsky.social writing about our scientific discoveries, funded by the #NIH www.dallasnews.com/news/2025/05...
Reposted by Juliet Mwirigi
people need to internalize, very quickly, that federal research grants are a hypercompetitive contracting process not charity, and that what Uncle Sam gets in return for that money is American dominance in the future
May 18, 2025 at 3:31 AM
people need to internalize, very quickly, that federal research grants are a hypercompetitive contracting process not charity, and that what Uncle Sam gets in return for that money is American dominance in the future
Reposted by Juliet Mwirigi
Congrats to the Kolber lab @utdpaincenter.bsky.social and especially Christian Fofie for his terrific work that made this paper come together. www.cell.com/cell-reports...
Profiling human iPSC-derived sensory neurons for analgesic drug screening using a multi-electrode array
Fofie et al. present a high-content screening platform using hiPSC-derived nociceptors
cultured on multi-well multielectrode arrays to identify peripheral analgesics with
diverse mechanisms of action....
www.cell.com
May 14, 2025 at 2:19 AM
Congrats to the Kolber lab @utdpaincenter.bsky.social and especially Christian Fofie for his terrific work that made this paper come together. www.cell.com/cell-reports...
Reposted by Juliet Mwirigi
Reposted by Juliet Mwirigi
BOOM! www.nature.com/articles/s41... I think this is a big step forward for the field. Congrats to Lauren Donovan and @vivtawfik-mdphd.bsky.social and the whole Tawfik lab team.
Aging and injury drive neuronal senescence in the dorsal root ganglia - Nature Neuroscience
The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.
www.nature.com
May 14, 2025 at 1:53 PM
BOOM! www.nature.com/articles/s41... I think this is a big step forward for the field. Congrats to Lauren Donovan and @vivtawfik-mdphd.bsky.social and the whole Tawfik lab team.
Reposted by Juliet Mwirigi
Happening now: NINDS Council public meeting, including presentation of the #HEAL #painresearch recommendations videocast.nih.gov/livew.asp?li...
NIH VideoCast - NINDS Advisory CouncilLock
videocast.nih.gov
May 14, 2025 at 6:27 PM
Happening now: NINDS Council public meeting, including presentation of the #HEAL #painresearch recommendations videocast.nih.gov/livew.asp?li...
Reposted by Juliet Mwirigi
WOOHOOO!!!
And it's unanimous! The NINDS Advisory Council has approved the HEAL pain research priority recommendations.
May 14, 2025 at 8:31 PM
WOOHOOO!!!
Reposted by Juliet Mwirigi
We wrote this Neuroview to get the word out about the extremely exciting and important NIH funded work happening in the pain field and how it has the potential to really change pain treatment in the coming years www.cell.com/neuron/fullt... We did not imagine how rapidly things would be dismantled.
Human pain neuroscience and the next generation of pain therapeutics
The recent approval of suzetrigine for acute pain treatment highlights both the success
of targeting peripheral sensory neurons for pain management and the potential of developing
new pain therapies p...
www.cell.com
May 8, 2025 at 8:25 PM
We wrote this Neuroview to get the word out about the extremely exciting and important NIH funded work happening in the pain field and how it has the potential to really change pain treatment in the coming years www.cell.com/neuron/fullt... We did not imagine how rapidly things would be dismantled.
Reposted by Juliet Mwirigi
This paper is now published in Nature Communications www.nature.com/articles/s41... Huge congrats to Stephanie Shiers on this magnum opus updating our view of Nageotte's legendary pathology work in the early 1900s.
May 5, 2025 at 6:20 PM
This paper is now published in Nature Communications www.nature.com/articles/s41... Huge congrats to Stephanie Shiers on this magnum opus updating our view of Nageotte's legendary pathology work in the early 1900s.