Saad Yousuf PhD
@saadyousuf.bsky.social
Excited to share our preprint on spatial transcriptomics of human sympathetic chain ganglia and the effect of diabetes. We also compared sympathetic and dorsal root ganglia to identify ganglia-specific signatures. Work led by @marisolmancilla.bsky.social
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Spatial transcriptomic profiling of human paravertebral sympathetic chain ganglia reveals diabetes-induced neuroplasticity
The paravertebral sympathetic chain ganglia (SCG) are autonomic ganglia critical for regulating the fight-or-flight response. Symptoms of sympathetic dysfunction are prevalent in diabetes, affecting u...
doi.org
June 26, 2025 at 2:00 AM
Excited to share our preprint on spatial transcriptomics of human sympathetic chain ganglia and the effect of diabetes. We also compared sympathetic and dorsal root ganglia to identify ganglia-specific signatures. Work led by @marisolmancilla.bsky.social
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Saad Yousuf PhD
Our collaborative paper with Isaac Chiu's lab was published today: www.sciencedirect.com/science/arti... It is a really cool finding on how Staphylococcus V8 protease drives the itch-scratch cycle via PAR1 activation. We did the human DRG work. Huge congrats to Liwen Deng, who led this work.
S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis
Itch is an unpleasant sensation that evokes a desire to scratch. The skin barrier is constantly exposed to microbes and their products. However, the r…
www.sciencedirect.com
November 22, 2023 at 3:59 PM
Our collaborative paper with Isaac Chiu's lab was published today: www.sciencedirect.com/science/arti... It is a really cool finding on how Staphylococcus V8 protease drives the itch-scratch cycle via PAR1 activation. We did the human DRG work. Huge congrats to Liwen Deng, who led this work.
Reposted by Saad Yousuf PhD
We received positive reviews on our work on TMEM97 modulators for neuropathic pain and have now posted a revision to our paper on @biorxiv-neursci.bsky.social @biorxiv-bioinfo.bsky.social www.biorxiv.org/content/10.1... led by Saad Yousuf in my lab and Jim Sahn in Stephen Martin's lab at UT Austin
Highly specific σ2R/TMEM97 ligand alleviates neuropathic pain and inhibits the integrated stress re...
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
October 18, 2023 at 10:31 AM
We received positive reviews on our work on TMEM97 modulators for neuropathic pain and have now posted a revision to our paper on @biorxiv-neursci.bsky.social @biorxiv-bioinfo.bsky.social www.biorxiv.org/content/10.1... led by Saad Yousuf in my lab and Jim Sahn in Stephen Martin's lab at UT Austin