Nik Joshi
@joshilabyale.bsky.social
Michigan | JHSPH | YaleIBIO | MIT | yalemed
#cancerimmunology, #immunotherapy and #cancer. Tweets not reflective of my employer.
#cancerimmunology, #immunotherapy and #cancer. Tweets not reflective of my employer.
Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas.
This was a collaboration between Julie Cheung and Brian Hunt
in the lab
Thanks to Cancer Cell for publishing our work.
www.cell.com/cancer-cell/...
This was a collaboration between Julie Cheung and Brian Hunt
in the lab
Thanks to Cancer Cell for publishing our work.
www.cell.com/cancer-cell/...
Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas
Cheung et al. describe efficient T cell control of nascent neoantigen+ and nearby
neoantigen-negative sarcoma cells, underlying a ∼50% reduction in tumor penetrance.
This otherwise imperceptible immun...
www.cell.com
October 2, 2025 at 4:50 PM
Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas.
This was a collaboration between Julie Cheung and Brian Hunt
in the lab
Thanks to Cancer Cell for publishing our work.
www.cell.com/cancer-cell/...
This was a collaboration between Julie Cheung and Brian Hunt
in the lab
Thanks to Cancer Cell for publishing our work.
www.cell.com/cancer-cell/...
Reposted by Nik Joshi
Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig
Kara Marshall PHD-History of Science in America - Trilogy at Tehaleh 04/27/25
YouTube video by Steve Lawson
youtu.be
May 3, 2025 at 7:20 PM
Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig
Reposted by Nik Joshi
I am very excited to share our article on IFNg, stroma and disease tolerance during intestinal helminth infection published today in Cell. This work was lead by the amazing @susanwestfall.bsky.social and supported by many international collaborators.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection
Type 1 immunity mediates host defense through pathogen elimination, but whether this pathway also impacts tissue function is unknown. Here, we demonst…
www.sciencedirect.com
April 22, 2025 at 4:35 PM
I am very excited to share our article on IFNg, stroma and disease tolerance during intestinal helminth infection published today in Cell. This work was lead by the amazing @susanwestfall.bsky.social and supported by many international collaborators.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Nik Joshi
Systemic IL33 following skin damage can mediate sensitizwtion to a bystander antigen in the gut
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Skin damage signals mediate allergic sensitization to spatially unlinked antigen
Skin injury releases damage-encoded systemic signals that can initiate immunity to novel antigens introduced at distal barrier sites.
www.science.org
April 14, 2025 at 12:11 PM
Systemic IL33 following skin damage can mediate sensitizwtion to a bystander antigen in the gut
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
I do not understand how in 2025 we don’t have a calendar/email program that automatically sets up out of office email. There should be an option in any event where you can click and it turns on OOO message that you’ve set up and including the start and end date (if you want).
April 11, 2025 at 12:55 PM
I do not understand how in 2025 we don’t have a calendar/email program that automatically sets up out of office email. There should be an option in any event where you can click and it turns on OOO message that you’ve set up and including the start and end date (if you want).
Reposted by Nik Joshi
They are cutting cancer research. They are cutting cancer research. They can deny it all they want, but they are cutting cancer research. These are the cuts being made the DoD CDMRP cancer funding mechanism www.fightcancer.org/sites/defaul...
March 27, 2025 at 10:11 AM
They are cutting cancer research. They are cutting cancer research. They can deny it all they want, but they are cutting cancer research. These are the cuts being made the DoD CDMRP cancer funding mechanism www.fightcancer.org/sites/defaul...
Reposted by Nik Joshi
The situation at the NIH and for all biomedical and cancer cure research in the United States is MUCH MUCH WORSE than you realize.
Ruining studies and potentially harming research subjects...
Abruptly terminating clinical trials...
Ignorant and evil
www.theatlantic.com/health/archi...
Abruptly terminating clinical trials...
Ignorant and evil
www.theatlantic.com/health/archi...
The NIH’s Most Reckless Cuts Yet
Ending clinical trials with no warning can put patients at risk.
www.theatlantic.com
March 27, 2025 at 11:46 PM
The situation at the NIH and for all biomedical and cancer cure research in the United States is MUCH MUCH WORSE than you realize.
It’s a bit surprising to me we’re not hearing about foundations stepping up to fill the gap on cancelled grants.
These are vetted and ongoing research programs where money can make an immediate impact. Especially for mission aligned goals.
Maybe it’s occurring behind the scenes.
These are vetted and ongoing research programs where money can make an immediate impact. Especially for mission aligned goals.
Maybe it’s occurring behind the scenes.
March 26, 2025 at 10:32 AM
It’s a bit surprising to me we’re not hearing about foundations stepping up to fill the gap on cancelled grants.
These are vetted and ongoing research programs where money can make an immediate impact. Especially for mission aligned goals.
Maybe it’s occurring behind the scenes.
These are vetted and ongoing research programs where money can make an immediate impact. Especially for mission aligned goals.
Maybe it’s occurring behind the scenes.
Reposted by Nik Joshi
Does your child want to go to college, want to go to med or grad school? The new cures for diseases, new technologies that we depend on come out of universities. #Trump, #Musk, #Vought are now killing higher education. If you haven't been paying attention, this would be a good time to wake up.
February 22, 2025 at 10:45 AM
Reposted by Nik Joshi
These NIH funding cuts threaten research happening in Delaware on heart disease, cancer, diabetes, stroke recovery, & more.
This is what this administration is focused on. Not lowering your household costs.
This is what this administration is focused on. Not lowering your household costs.
Delaware’s innovation pipeline could be at risk with new NIH funding policy
With a proposed cap on indirect costs for NIH grants, Delaware's life science sector could be hit the next generation of start-ups and researchers.
delawarebusinesstimes.com
February 21, 2025 at 8:31 PM
These NIH funding cuts threaten research happening in Delaware on heart disease, cancer, diabetes, stroke recovery, & more.
This is what this administration is focused on. Not lowering your household costs.
This is what this administration is focused on. Not lowering your household costs.
Reposted by Nik Joshi
Summary of the infuriating blockade of US medical research
“This crisis...has already consumed one funding cycle” Carole LaBonne said. “But if this block to publishing in the register continues on much longer, it’s going to swallow two funding cycles, and that will put many labs out of business.”🧪⚕️
“This crisis...has already consumed one funding cycle” Carole LaBonne said. “But if this block to publishing in the register continues on much longer, it’s going to swallow two funding cycles, and that will put many labs out of business.”🧪⚕️
Trump Administration Stalls Scientific Research Despite Court Ruling (Gift Article)
Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.
www.nytimes.com
February 22, 2025 at 1:37 AM
Summary of the infuriating blockade of US medical research
“This crisis...has already consumed one funding cycle” Carole LaBonne said. “But if this block to publishing in the register continues on much longer, it’s going to swallow two funding cycles, and that will put many labs out of business.”🧪⚕️
“This crisis...has already consumed one funding cycle” Carole LaBonne said. “But if this block to publishing in the register continues on much longer, it’s going to swallow two funding cycles, and that will put many labs out of business.”🧪⚕️
Reposted by Nik Joshi
I've been seeing lots of super compelling videos of park rangers and federal lawyers and other federal workers telling their stories. Talking about what they did at their job, how it helped the American people, and why they want to keep doing those jobs.
This is the way.
This is the way.
February 21, 2025 at 12:30 AM
I've been seeing lots of super compelling videos of park rangers and federal lawyers and other federal workers telling their stories. Talking about what they did at their job, how it helped the American people, and why they want to keep doing those jobs.
This is the way.
This is the way.
Well @mcuban.bsky.social every NCI grant that has been awarded over the past decade+ has been cut 20% for years, so it’s not that hypothetical of a question for cancer researchers.
Anyone who is a grant recipient who is not getting paid, a question.
Would you take a 30 PCT annual reduction, if it meant you were guaranteed to be paid ?
Would you take a 30 PCT annual reduction, if it meant you were guaranteed to be paid ?
February 21, 2025 at 2:04 AM
Well @mcuban.bsky.social every NCI grant that has been awarded over the past decade+ has been cut 20% for years, so it’s not that hypothetical of a question for cancer researchers.
Reposted by Nik Joshi
Reaching out to all Americans through the media to explain how decreasing funding of the NIH will have irreversible harm for developing therapies for all diseases. Please spread the word to your families and friends and contact your congressional representatives.
www.nbcnews.com/science/scie...
www.nbcnews.com/science/scie...
Science under siege: Trump cuts threaten to undermine decades of research
Sweeping layoffs, funding freezes and executive orders have provoked outcry among federal researchers and their university partners, who fear that science itself is under siege.
www.nbcnews.com
February 20, 2025 at 5:43 PM
Reaching out to all Americans through the media to explain how decreasing funding of the NIH will have irreversible harm for developing therapies for all diseases. Please spread the word to your families and friends and contact your congressional representatives.
www.nbcnews.com/science/scie...
www.nbcnews.com/science/scie...
Reposted by Nik Joshi
The attacks and uncertainty are not just crushing progress for human health, forfeiting the US leadership role in biomedical science, curtaining economic gain, and threatening many livelihoods...but breaking a pipeline of training that will be very hard to rebuild and which will haunt industry too
Biomedical graduate admissions paused or cut back as some universities respond to Trump orders on research - STAT
apple.news/APlQhGHRrSfy...
apple.news/APlQhGHRrSfy...
Graduate student admissions paused and cut back as universities react to Trump orders on research — STAT
Acceptances for biomedical graduate students and postdoctoral scholars are being cut back at some universities and medical centers across the country as many grapple with the potential impact of the T...
apple.news
February 20, 2025 at 2:17 PM
The attacks and uncertainty are not just crushing progress for human health, forfeiting the US leadership role in biomedical science, curtaining economic gain, and threatening many livelihoods...but breaking a pipeline of training that will be very hard to rebuild and which will haunt industry too
Reposted by Nik Joshi
My family knows the pain of Alzheimer’s. It’s devastating. And now we learn Trump’s NIH cuts led to the firing of top researchers working on it --Infuriating. This isn’t “cutting waste”—it’s cutting and gutting life-saving research.
Scoop --> Trump-Musk cuts just resulted in the firing of numerous top researchers at NIH's center for combating Alzheimer's, sources tell me. They predict big setbacks to fighting dementias.
This cause was once championed by *Republicans.*
Details here:
newrepublic.com/article/1917...
This cause was once championed by *Republicans.*
Details here:
newrepublic.com/article/1917...
Oops: Trump-Musk Cuts Just Wrecked an NIH Org Championed by GOPers
Republicans once lavished praise on an NIH center that deals with Alzheimer’s. Donald Trump and Elon Musk are hobbling it. What will they say now?
newrepublic.com
February 19, 2025 at 10:53 PM
My family knows the pain of Alzheimer’s. It’s devastating. And now we learn Trump’s NIH cuts led to the firing of top researchers working on it --Infuriating. This isn’t “cutting waste”—it’s cutting and gutting life-saving research.
Reposted by Nik Joshi
Scoop --> Trump-Musk cuts just resulted in the firing of numerous top researchers at NIH's center for combating Alzheimer's, sources tell me. They predict big setbacks to fighting dementias.
This cause was once championed by *Republicans.*
Details here:
newrepublic.com/article/1917...
This cause was once championed by *Republicans.*
Details here:
newrepublic.com/article/1917...
Oops: Trump-Musk Cuts Just Wrecked an NIH Org Championed by GOPers
Republicans once lavished praise on an NIH center that deals with Alzheimer’s. Donald Trump and Elon Musk are hobbling it. What will they say now?
newrepublic.com
February 19, 2025 at 5:58 PM
Scoop --> Trump-Musk cuts just resulted in the firing of numerous top researchers at NIH's center for combating Alzheimer's, sources tell me. They predict big setbacks to fighting dementias.
This cause was once championed by *Republicans.*
Details here:
newrepublic.com/article/1917...
This cause was once championed by *Republicans.*
Details here:
newrepublic.com/article/1917...
Reposted by Nik Joshi
Very important to get this word out!
I just covered this for @thetransmitter.bsky.social — will keep following! www.thetransmitter.org/funding/fede...
Federal Register hold makes ‘end run’ around court pause on NIH funding freeze
NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...
www.thetransmitter.org
February 19, 2025 at 12:26 PM
Very important to get this word out!
Reposted by Nik Joshi
I expect that most academic biomedical researchers have considered leaving the US—if only in theory for now. What a colossal mess! Our representatives need to hear this. Please amplify so they know this matters. @levin.house.gov @repscottpeters.bsky.social @schiff.senate.gov @padilla.senate.gov
“For the last 75 yrs, the NIH has been the biggest funder of biomedical research in the world. Most advances in medicine were seeded by NIH funding. When we became scientists, we just bought into this system. This is how it works. — @tuthill.bsky.social 🧵
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
Trump cuts threaten a ‘generation of scientists’ as many weigh leaving US
President’s call to ‘Make America Healthy Again’ has led to slashes in NIH funding – endangering jobs and vital research
www.theguardian.com
February 19, 2025 at 9:19 PM
I expect that most academic biomedical researchers have considered leaving the US—if only in theory for now. What a colossal mess! Our representatives need to hear this. Please amplify so they know this matters. @levin.house.gov @repscottpeters.bsky.social @schiff.senate.gov @padilla.senate.gov
So angry to see this.
We are volunteering our time in this system.
Reviewers have better things to do than spend time reviewing grants for a system that doesn’t respect our time.
We are volunteering our time in this system.
Reviewers have better things to do than spend time reviewing grants for a system that doesn’t respect our time.
I’m a standing member on the Chemical Biology and Probes (CBP) NIH study section that was supposed to meet tomorrow. It just got postponed this afternoon with a date yet to be determined….
February 19, 2025 at 11:36 PM
So angry to see this.
We are volunteering our time in this system.
Reviewers have better things to do than spend time reviewing grants for a system that doesn’t respect our time.
We are volunteering our time in this system.
Reviewers have better things to do than spend time reviewing grants for a system that doesn’t respect our time.
Reposted by Nik Joshi
1/ I am seeing a lot of comments on the slashing of NIH support along the lines of “universities should just spend their huge endowments.”
I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.
I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.
February 18, 2025 at 1:48 PM
1/ I am seeing a lot of comments on the slashing of NIH support along the lines of “universities should just spend their huge endowments.”
I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.
I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.
My wife and I were postbac IRTAs 25 years ago. Neither would have pursued a career in research if not for this program
We have PhD students in Yale Immunobiology now who also came from this NIH program including (one amazing student in my lab)
This is a valuable program and has been for decades.
We have PhD students in Yale Immunobiology now who also came from this NIH program including (one amazing student in my lab)
This is a valuable program and has been for decades.
One of the many, many “pauses” and cancellations devastating our next generation of researchers. “The NIH Intramural Program has paused the recruitment of IRTAs, CRTAs, and Visiting Fellows in all training programs pending guidance from Health and Human Services. Check back daily for updates.”
Postbac Program
www.training.nih.gov
February 18, 2025 at 10:58 AM
My wife and I were postbac IRTAs 25 years ago. Neither would have pursued a career in research if not for this program
We have PhD students in Yale Immunobiology now who also came from this NIH program including (one amazing student in my lab)
This is a valuable program and has been for decades.
We have PhD students in Yale Immunobiology now who also came from this NIH program including (one amazing student in my lab)
This is a valuable program and has been for decades.
Reposted by Nik Joshi
I just found out that my first book 📗, LAB GIRL 🌱🌿🌳, was challenged by a parent and subsequently removed from the shelves of the library at Walworth High School in Elkhorn, Wisconsin.
So I decided to write a 🧵 on book 📚 #censorship 🚫 in American 🇺🇸 schools 🚸
1/n
So I decided to write a 🧵 on book 📚 #censorship 🚫 in American 🇺🇸 schools 🚸
1/n
February 17, 2025 at 11:41 AM
I just found out that my first book 📗, LAB GIRL 🌱🌿🌳, was challenged by a parent and subsequently removed from the shelves of the library at Walworth High School in Elkhorn, Wisconsin.
So I decided to write a 🧵 on book 📚 #censorship 🚫 in American 🇺🇸 schools 🚸
1/n
So I decided to write a 🧵 on book 📚 #censorship 🚫 in American 🇺🇸 schools 🚸
1/n
Reposted by Nik Joshi
