Joe Longo
@joelongo.bsky.social
Postdoctoral Fellow at Van Andel Institute studying cancer and immunometabolism. Previously at the Princess Margaret Cancer Centre and McMaster University 🇨🇦
Pinned
Joe Longo
@joelongo.bsky.social
· Aug 6
I'm delighted to share that this story is now published in Cell Metabolism @cp-cellmetabolism.bsky.social - Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control: www.cell.com/cell-metabol...
Reposted by Joe Longo
Congrats to Dr. Russell Jones for being named to this year’s @clarivate.com Highly Cited Researchers list — a distinction marking him as a leader in his field.
Read more: vai.org/hcr-2025
#HighlyCited2025 @clarivateag.bsky.social
Read more: vai.org/hcr-2025
#HighlyCited2025 @clarivateag.bsky.social
November 12, 2025 at 6:56 PM
Congrats to Dr. Russell Jones for being named to this year’s @clarivate.com Highly Cited Researchers list — a distinction marking him as a leader in his field.
Read more: vai.org/hcr-2025
#HighlyCited2025 @clarivateag.bsky.social
Read more: vai.org/hcr-2025
#HighlyCited2025 @clarivateag.bsky.social
Welcome to VAI, @jdlicht.bsky.social!
I am excited to announce that after a decade of service to the U of Florida during which the @ufhealthcancer.bsky.social received NCI designation, in January 2026 I will be assuming the role of President and Chief Scientific Officer of the @vai.org.
www.vai.org/article/emin...
www.vai.org/article/emin...
Eminent physician-scientist Dr. Jonathan D. Licht to serve as next president and chief scientific officer of Van Andel Institute – Van Andel Institute
Dr. Jonathan D. Licht has been selected as the next president and chief scientific officer of Van Andel Institute, effective January 2026.
www.vai.org
October 29, 2025 at 7:50 PM
Welcome to VAI, @jdlicht.bsky.social!
Reposted by Joe Longo
🪰Finally our study is in print — and we’re thrilled to see it featured on the cover of @natmetabolism.nature.com ! 🎉 #Drosophila #DevBio
✨New issue✨
Check out the latest in #Metabolism research from across all disciplines 🧪
Read about #DietarySugars, #Drosophila development, #Exenatide, #Ketone metabolism, #Neurolipids, #NAD+, #RedoxPathways, and many more topics!
www.nature.com/natmetab/vol...
Check out the latest in #Metabolism research from across all disciplines 🧪
Read about #DietarySugars, #Drosophila development, #Exenatide, #Ketone metabolism, #Neurolipids, #NAD+, #RedoxPathways, and many more topics!
www.nature.com/natmetab/vol...
October 27, 2025 at 4:09 PM
🪰Finally our study is in print — and we’re thrilled to see it featured on the cover of @natmetabolism.nature.com ! 🎉 #Drosophila #DevBio
Reposted by Joe Longo
Congratulations to the 7 recipients of the CRS’ 2025 Next Generation of Scientists Awards! They represent the future of cancer research in Canada.
🔬 Learn more: loom.ly/K8h1z4E
#Cancer #Research #NextGenerationOfScientistsAwards
🔬 Learn more: loom.ly/K8h1z4E
#Cancer #Research #NextGenerationOfScientistsAwards
October 23, 2025 at 3:10 PM
Congratulations to the 7 recipients of the CRS’ 2025 Next Generation of Scientists Awards! They represent the future of cancer research in Canada.
🔬 Learn more: loom.ly/K8h1z4E
#Cancer #Research #NextGenerationOfScientistsAwards
🔬 Learn more: loom.ly/K8h1z4E
#Cancer #Research #NextGenerationOfScientistsAwards
Reposted by Joe Longo
Online now: Nutrient allocation fuels T cell-mediated immunity
Nutrient allocation fuels T cell-mediated immunity
Glucose has traditionally been considered the primary fuel for T cells. Longo et al. present evidence for a revised, “nutrient allocation” model, in which effector T cells channel diverse nutrient sources into specific metabolic pathways to fuel T cell-mediated immunity.
dlvr.it
October 15, 2025 at 3:42 PM
Online now: Nutrient allocation fuels T cell-mediated immunity
Reposted by Joe Longo
It's National Postdoc Appreciation Week! We are proud to recognize our stellar postdocs, whose curiosity and dedication help drive our mission to improve health and enhance lives. Thank you for your outstanding work! 💙 #NPAW2025
www.vai.org/research/pos...
www.vai.org/research/pos...
September 17, 2025 at 5:29 PM
It's National Postdoc Appreciation Week! We are proud to recognize our stellar postdocs, whose curiosity and dedication help drive our mission to improve health and enhance lives. Thank you for your outstanding work! 💙 #NPAW2025
www.vai.org/research/pos...
www.vai.org/research/pos...
Reposted by Joe Longo
Reposted by Joe Longo
Rewiring of cortical glucose metabolism fuels human brain cancer growth
www.nature.com/articles/s41...
Congrats to the many involved, including @lyssiotislab.bsky.social and @dnagrathlab.bsky.social
www.nature.com/articles/s41...
Congrats to the many involved, including @lyssiotislab.bsky.social and @dnagrathlab.bsky.social
Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature
The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...
www.nature.com
September 4, 2025 at 8:20 AM
Rewiring of cortical glucose metabolism fuels human brain cancer growth
www.nature.com/articles/s41...
Congrats to the many involved, including @lyssiotislab.bsky.social and @dnagrathlab.bsky.social
www.nature.com/articles/s41...
Congrats to the many involved, including @lyssiotislab.bsky.social and @dnagrathlab.bsky.social
Reposted by Joe Longo
A new study, led by VAI’s Dr. Russell Jones and published in @cp-cellmetabolism.bsky.social, reveals that glucose, long known as a vital fuel for immune cells, also plays a key role in helping cancer-fighting T cells communicate and function effectively. www.vai.org/article/swee...
‘Sweet’ discovery reveals how glucose fuels cancer-fighting immune cells – Van Andel Institute
Read about ‘Sweet’ discovery reveals how glucose fuels cancer-fighting immune cells on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and health.
www.vai.org
August 20, 2025 at 8:32 PM
A new study, led by VAI’s Dr. Russell Jones and published in @cp-cellmetabolism.bsky.social, reveals that glucose, long known as a vital fuel for immune cells, also plays a key role in helping cancer-fighting T cells communicate and function effectively. www.vai.org/article/swee...
Reposted by Joe Longo
What’s next in metabolism research? VAI’s Metabolism and Nutrition (MeNu) Program recently asked top experts to forecast their bold ideas. Read about six areas they said are primed for discovery: www.vai.org/article/what...
What’s next in metabolism research? – Van Andel Institute
Read about What’s next in metabolism research? on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and health.
www.vai.org
August 14, 2025 at 8:02 PM
What’s next in metabolism research? VAI’s Metabolism and Nutrition (MeNu) Program recently asked top experts to forecast their bold ideas. Read about six areas they said are primed for discovery: www.vai.org/article/what...
Reposted by Joe Longo
🚀 Our new study is out in Nature Metabolism!
We used single-embryo metabolomics and transcriptomics to map the earliest metabolic transitions in Drosophila development, including the onset of zygotic metabolism.
Explore the dataset & findings:
🔗 rdcu.be/eAH12
#DevBio #metabolomics #Drosophila
We used single-embryo metabolomics and transcriptomics to map the earliest metabolic transitions in Drosophila development, including the onset of zygotic metabolism.
Explore the dataset & findings:
🔗 rdcu.be/eAH12
#DevBio #metabolomics #Drosophila
Resolving early embryonic metabolism in Drosophila through single-embryo metabolomics and transcriptomics
Nature Metabolism - By developing a method for single-embryo multi-omics in Drosophila, the authors provide a high-resolution view into the transcriptional and metabolic underpinnings of early...
rdcu.be
August 14, 2025 at 8:24 AM
🚀 Our new study is out in Nature Metabolism!
We used single-embryo metabolomics and transcriptomics to map the earliest metabolic transitions in Drosophila development, including the onset of zygotic metabolism.
Explore the dataset & findings:
🔗 rdcu.be/eAH12
#DevBio #metabolomics #Drosophila
We used single-embryo metabolomics and transcriptomics to map the earliest metabolic transitions in Drosophila development, including the onset of zygotic metabolism.
Explore the dataset & findings:
🔗 rdcu.be/eAH12
#DevBio #metabolomics #Drosophila
Reposted by Joe Longo
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control - cell.com/cell-metabol...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control - cell.com/cell-metabol...
August 11, 2025 at 11:34 AM
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control - cell.com/cell-metabol...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control - cell.com/cell-metabol...
Reposted by Joe Longo
Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control: Cell Metabolism www.cell.com/cell-metabol...
Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
Glucose is required for T cell proliferation and function, but its key metabolic fates
in vivo are not well defined. Longo et al. demonstrate that in CD8+ effector T cells,
glucose metabolism extends ...
www.cell.com
August 7, 2025 at 1:56 PM
Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control: Cell Metabolism www.cell.com/cell-metabol...
Reposted by Joe Longo
Online now: Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
Glucose is required for T cell proliferation and function, but its key metabolic fates in vivo are not well defined. Longo et al. demonstrate that in CD8+ effector T cells, glucose metabolism extends beyond energy production by fueling glycosphingolipid biosynthesis, a pathway critical for T cell expansion and cytotoxic function.
dlvr.it
August 5, 2025 at 3:42 PM
Online now: Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
Reposted by Joe Longo
Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
@cp-cellmetabolism.bsky.social @drrgjoneslab.bsky.social
www.cell.com/cell-metabol...
@cp-cellmetabolism.bsky.social @drrgjoneslab.bsky.social
www.cell.com/cell-metabol...
August 5, 2025 at 5:15 PM
Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
@cp-cellmetabolism.bsky.social @drrgjoneslab.bsky.social
www.cell.com/cell-metabol...
@cp-cellmetabolism.bsky.social @drrgjoneslab.bsky.social
www.cell.com/cell-metabol...
I'm delighted to share that this story is now published in Cell Metabolism @cp-cellmetabolism.bsky.social - Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control: www.cell.com/cell-metabol...
August 6, 2025 at 11:54 AM
I'm delighted to share that this story is now published in Cell Metabolism @cp-cellmetabolism.bsky.social - Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control: www.cell.com/cell-metabol...
Reposted by Joe Longo
Targeting tumour metabolism through ATP citrate lyase can rewire immune function and suppress #cancer progression in #MASH #HCC www.nature.com/articles/s41...
ACLY inhibition promotes tumour immunity and suppresses liver cancer - Nature
Using metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma mouse models, an ATP citrate lyase inhibitor reduces tumour burden and enhances efficacy of current standards of ...
www.nature.com
July 30, 2025 at 4:07 PM
Targeting tumour metabolism through ATP citrate lyase can rewire immune function and suppress #cancer progression in #MASH #HCC www.nature.com/articles/s41...
Reposted by Joe Longo
This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...
www.nature.com/articles/s42...
The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism
This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
www.nature.com
July 28, 2025 at 3:02 PM
This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Joe Longo
Preclinical data reveal that dietary fat sources differentially regulate natural killer and CD8 T cell infiltration and function within the tumour microenvironment, governed by distinct effects on the plasma metabolome and intracellular metabolism. www.nature.com/articles/s42...
The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism
This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
www.nature.com
July 25, 2025 at 10:04 AM
Preclinical data reveal that dietary fat sources differentially regulate natural killer and CD8 T cell infiltration and function within the tumour microenvironment, governed by distinct effects on the plasma metabolome and intracellular metabolism. www.nature.com/articles/s42...
Reposted by Joe Longo
Super excited to share my final postdoc paper from Rabinowitz lab- on how whole-body and tissue metabolism changes in viral infection!
pubmed.ncbi.nlm.nih.gov/40581045/
pubmed.ncbi.nlm.nih.gov/40581045/
pubmed.ncbi.nlm.nih.gov
July 7, 2025 at 8:51 PM
Super excited to share my final postdoc paper from Rabinowitz lab- on how whole-body and tissue metabolism changes in viral infection!
pubmed.ncbi.nlm.nih.gov/40581045/
pubmed.ncbi.nlm.nih.gov/40581045/
Reposted by Joe Longo
The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion @natimmunol.nature.com @drrgjoneslab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 27, 2025 at 6:21 PM
The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion @natimmunol.nature.com @drrgjoneslab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Joe Longo
Sign up for midwest metabolism & Trimad joint meeting! Abstracts are due 9/2/25. The vast majority of talks will come from the abstracts - great opportunity for trainees! www.vai.org/event/2025-m...
2025 Midwest Metabolism Meeting
Join us for 2025 Midwest Metabolism Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.
www.vai.org
June 4, 2025 at 6:21 PM
Sign up for midwest metabolism & Trimad joint meeting! Abstracts are due 9/2/25. The vast majority of talks will come from the abstracts - great opportunity for trainees! www.vai.org/event/2025-m...
Reposted by Joe Longo
1/For over a decade, we’ve been studying tumor metabolism in patients with non-small cell lung cancer
This long-term commitment allowed us to connect tumor metabolic features to patient outcomes
We found that 13C glucose contribution to the TCA cycle predicts overall survival in NSCLC
This long-term commitment allowed us to connect tumor metabolic features to patient outcomes
We found that 13C glucose contribution to the TCA cycle predicts overall survival in NSCLC
Now online in Cancer Discovery: High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients - by Ling Cai, Nia Hammond, Brandon Faubert, @rjdlab.bsky.social, and colleagues doi.org/10.1158/2159...
February 17, 2025 at 8:20 PM
1/For over a decade, we’ve been studying tumor metabolism in patients with non-small cell lung cancer
This long-term commitment allowed us to connect tumor metabolic features to patient outcomes
We found that 13C glucose contribution to the TCA cycle predicts overall survival in NSCLC
This long-term commitment allowed us to connect tumor metabolic features to patient outcomes
We found that 13C glucose contribution to the TCA cycle predicts overall survival in NSCLC
Reposted by Joe Longo
Make sure you, your trainees, and anyone else who might listen to you understands what "indirects" actually are, how they are established, and what Universities contribute. H/T @rodallab.bsky.social
Please share widely!
www.youtube.com/watch?v=yxTD...
Please share widely!
www.youtube.com/watch?v=yxTD...
Facilities and Administrative (F&A) Costs Explainer
YouTube video by Association of American Universities
www.youtube.com
February 11, 2025 at 3:00 PM
Make sure you, your trainees, and anyone else who might listen to you understands what "indirects" actually are, how they are established, and what Universities contribute. H/T @rodallab.bsky.social
Please share widely!
www.youtube.com/watch?v=yxTD...
Please share widely!
www.youtube.com/watch?v=yxTD...
Reposted by Joe Longo
On this Women in Science Day, get inspired by our leading female scientist 🌟Dr. Linda Penn🌟
Dr. Penn has been at the forefront of cancer research, investigating MYC, a powerful oncoprotein/oncogene linked to more than 50 per cent of human cancers.
youtu.be/BtjxySIjwLI
Dr. Penn has been at the forefront of cancer research, investigating MYC, a powerful oncoprotein/oncogene linked to more than 50 per cent of human cancers.
youtu.be/BtjxySIjwLI
Meet Dr. Linda Penn: decoding the master cancer regulator
YouTube video by UHN Research
youtu.be
February 11, 2025 at 5:55 PM
On this Women in Science Day, get inspired by our leading female scientist 🌟Dr. Linda Penn🌟
Dr. Penn has been at the forefront of cancer research, investigating MYC, a powerful oncoprotein/oncogene linked to more than 50 per cent of human cancers.
youtu.be/BtjxySIjwLI
Dr. Penn has been at the forefront of cancer research, investigating MYC, a powerful oncoprotein/oncogene linked to more than 50 per cent of human cancers.
youtu.be/BtjxySIjwLI