Jackson Cahn
@jkbcahn.bsky.social
Learning from evolution to make drugs with enzymes.
Reposted by Jackson Cahn
9. Directed evolution campaigns yield new lipid-binding domains from a variety of protein scaffold precursors, from @takinishimura.bsky.social and Noboru Mizushima, on @biorxiv-cellbio.bsky.social www.biorxiv.org/content/10.1...
Rational engineering of lipid-binding probes via high-throughput protein-lipid interaction screening
Lipid-binding domains, originally isolated from natural proteins, are useful tools essential for analyzing membrane lipids in cells, and their applications are varied. Yet, there is no general strateg...
www.biorxiv.org
January 5, 2026 at 2:48 PM
9. Directed evolution campaigns yield new lipid-binding domains from a variety of protein scaffold precursors, from @takinishimura.bsky.social and Noboru Mizushima, on @biorxiv-cellbio.bsky.social www.biorxiv.org/content/10.1...
Reposted by Jackson Cahn
amazing how the entire machine can pivot within 24 hours. no need to slowly upsell the argument; just issue new marching orders
January 5, 2026 at 6:50 AM
amazing how the entire machine can pivot within 24 hours. no need to slowly upsell the argument; just issue new marching orders
Reposted by Jackson Cahn
this is your mission. our pedophile president needs you to jump out of a helicopter to kidnap a head of state and his wife so some oil ceos can make a lot of money. we’ll be watching from a resort in florida that still serves wedge salad and checking how many retweets we get. good luck soldier
January 3, 2026 at 10:57 PM
this is your mission. our pedophile president needs you to jump out of a helicopter to kidnap a head of state and his wife so some oil ceos can make a lot of money. we’ll be watching from a resort in florida that still serves wedge salad and checking how many retweets we get. good luck soldier
Reposted by Jackson Cahn
Maduro is a brutal and oppressive dictator of Venezuela.
Trump has no legitimate legal basis for military action against Venezuela under United States or international law.
Both of those facts are simultaneously true.
Trump has no legitimate legal basis for military action against Venezuela under United States or international law.
Both of those facts are simultaneously true.
January 3, 2026 at 9:00 AM
Maduro is a brutal and oppressive dictator of Venezuela.
Trump has no legitimate legal basis for military action against Venezuela under United States or international law.
Both of those facts are simultaneously true.
Trump has no legitimate legal basis for military action against Venezuela under United States or international law.
Both of those facts are simultaneously true.
Did we just do a fucking coup in Venezuela?
January 3, 2026 at 10:48 AM
Did we just do a fucking coup in Venezuela?
Reposted by Jackson Cahn
In 2005 Benedict became Pope and the Seahawks won 13 games and went to the Super Bowl
In 2013 Francis became Pope and the Seahawks won 13 games and went to the Super Bowl
In 2025 Leo became Pope and the Seahawks have won 13 games...
In 2013 Francis became Pope and the Seahawks won 13 games and went to the Super Bowl
In 2025 Leo became Pope and the Seahawks have won 13 games...
December 29, 2025 at 6:13 AM
In 2005 Benedict became Pope and the Seahawks won 13 games and went to the Super Bowl
In 2013 Francis became Pope and the Seahawks won 13 games and went to the Super Bowl
In 2025 Leo became Pope and the Seahawks have won 13 games...
In 2013 Francis became Pope and the Seahawks won 13 games and went to the Super Bowl
In 2025 Leo became Pope and the Seahawks have won 13 games...
December 29, 2025 at 6:07 AM
Reposted by Jackson Cahn
Per NY Times’s Michael Grynbaum on X, this is Sharyn Alfonsi’s email to her “60 Minutes” colleagues in full:
December 22, 2025 at 3:37 AM
Per NY Times’s Michael Grynbaum on X, this is Sharyn Alfonsi’s email to her “60 Minutes” colleagues in full:
Demon escapes because you didn't have enough wizards to form a binding circle? Problematic mage gap.
You need to treat a bunch of dysentery patients but you don't have enough viruses that lyse bacterial cells? Problematic phage gap.
Angry person yelling at chill person who is responding by being calm, which makes the angry person even more mad? Problematic rage gap.
November 20, 2025 at 2:44 AM
Demon escapes because you didn't have enough wizards to form a binding circle? Problematic mage gap.
Reposted by Jackson Cahn
Alternate between AlphaFold3 "hallucinations" and fixed-backbone sequence design to generate or optimize proteins.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 18, 2025 at 10:39 PM
Alternate between AlphaFold3 "hallucinations" and fixed-backbone sequence design to generate or optimize proteins.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jackson Cahn
The shutdown delayed applications opening for the NIST Summer Undergraduate Research Fellowship (SURF) program, but their website says they will start accepting applications 12/1. www.nist.gov/surf #chemsummer
There’s an example of a project from last year in the quoted post
There’s an example of a project from last year in the quoted post
November 17, 2025 at 1:13 PM
The shutdown delayed applications opening for the NIST Summer Undergraduate Research Fellowship (SURF) program, but their website says they will start accepting applications 12/1. www.nist.gov/surf #chemsummer
There’s an example of a project from last year in the quoted post
There’s an example of a project from last year in the quoted post
Reposted by Jackson Cahn
NEW pub in @science.org 🥳
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
November 13, 2025 at 8:34 PM
NEW pub in @science.org 🥳
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Nearly ten years in the making and finally out in print!
www.nature.com/articles/s41...
Entotheonella are insanely biosynthetically rich bacteria, but few genomes were available.
Working with far-flung collaborators, we obtained genomes for 14 candidate species from 8 sponges.
www.nature.com/articles/s41...
Entotheonella are insanely biosynthetically rich bacteria, but few genomes were available.
Working with far-flung collaborators, we obtained genomes for 14 candidate species from 8 sponges.
Chemical richness and diversity of uncultivated ‘Entotheonella’ symbionts in marine sponges - Nature Chemical Biology
Marine sponges host bacteria that produce diverse bioactive compounds. Here, the authors conduct a large-scale metagenomic, single-bacterial and biochemical study to reveal the untapped biosynthetic p...
www.nature.com
November 14, 2025 at 12:48 PM
Nearly ten years in the making and finally out in print!
www.nature.com/articles/s41...
Entotheonella are insanely biosynthetically rich bacteria, but few genomes were available.
Working with far-flung collaborators, we obtained genomes for 14 candidate species from 8 sponges.
www.nature.com/articles/s41...
Entotheonella are insanely biosynthetically rich bacteria, but few genomes were available.
Working with far-flung collaborators, we obtained genomes for 14 candidate species from 8 sponges.
Reposted by Jackson Cahn
Atropisomers are popular as chiral ligands and have been showing up in drugs and drug candidates. Making just one atropisomer isn’t trivial, though. That could change, thanks to @alisonnarayan.bsky.social and @narayanlab.bsky.social. My latest for @cenmag.bsky.social
cen.acs.org/synthesis/bi...
cen.acs.org/synthesis/bi...
An enzyme gives atropisomers a specific twist
Biocatalytic approach could be used to make chiral ligands and drugs
cen.acs.org
November 12, 2025 at 4:48 PM
Atropisomers are popular as chiral ligands and have been showing up in drugs and drug candidates. Making just one atropisomer isn’t trivial, though. That could change, thanks to @alisonnarayan.bsky.social and @narayanlab.bsky.social. My latest for @cenmag.bsky.social
cen.acs.org/synthesis/bi...
cen.acs.org/synthesis/bi...
Imagine being part of one of the most important scientific discoveries of all time, and then when you die all anyone wants to talk about is what a huge piece of shit you were. I think there's a lesson there.
November 8, 2025 at 11:49 PM
Imagine being part of one of the most important scientific discoveries of all time, and then when you die all anyone wants to talk about is what a huge piece of shit you were. I think there's a lesson there.
Today they're going to ask Mike Johnson about the election results and he'll say that he hasn't heard about them yet.
November 5, 2025 at 12:34 PM
Today they're going to ask Mike Johnson about the election results and he'll say that he hasn't heard about them yet.
I love going to my polling place on Election Day and seeing it packed, especially with families bringing their kids. Democracy is beautiful you guys, and we should hang on to it.
November 4, 2025 at 11:16 PM
I love going to my polling place on Election Day and seeing it packed, especially with families bringing their kids. Democracy is beautiful you guys, and we should hang on to it.
Reposted by Jackson Cahn
New online! De novo design and evolution of an artificial metathase for cytoplasmic olefin metathesis
De novo design and evolution of an artificial metathase for cytoplasmic olefin metathesis
Nature Catalysis, Published online: 03 November 2025; doi:10.1038/s41929-025-01436-0The creation of artificial metalloenzymes compatible with complex biological settings could enable broad applications. Now a de novo-designed artificial metalloenzyme containing an abiological ruthenium cofactor is reported and optimized for ring-closing metathesis in the cytoplasm of whole cells.
bit.ly
November 3, 2025 at 10:51 AM
New online! De novo design and evolution of an artificial metathase for cytoplasmic olefin metathesis
That was a great game but ooof. Maybe in another 25 years we'll get another shot.
October 21, 2025 at 3:19 AM
That was a great game but ooof. Maybe in another 25 years we'll get another shot.
Reposted by Jackson Cahn
a tyrant is ignoring the constitution, firing live artillery at americans, invading our cities, and tearing down the white house to build himself a palace
our institutions won't react because they're lost in a digital dreamstate, unable to decide what is true because of social media poisoning
our institutions won't react because they're lost in a digital dreamstate, unable to decide what is true because of social media poisoning
October 20, 2025 at 9:41 PM
a tyrant is ignoring the constitution, firing live artillery at americans, invading our cities, and tearing down the white house to build himself a palace
our institutions won't react because they're lost in a digital dreamstate, unable to decide what is true because of social media poisoning
our institutions won't react because they're lost in a digital dreamstate, unable to decide what is true because of social media poisoning
Reposted by Jackson Cahn
Somehow people who found the goals of the “Tea Party” crystal clear just can’t wrap their heads around what “No Kings” is getting at.
October 20, 2025 at 5:30 AM
Somehow people who found the goals of the “Tea Party” crystal clear just can’t wrap their heads around what “No Kings” is getting at.
Reposted by Jackson Cahn
"Tyranny, like hell, is not easily conquered, but we have this consolation: The harder the struggle, the more glorious the triumph." —Tom Paine
October 19, 2025 at 12:24 AM
"Tyranny, like hell, is not easily conquered, but we have this consolation: The harder the struggle, the more glorious the triumph." —Tom Paine
Reposted by Jackson Cahn
Honestly if we were a real country anymore this video would start an armed revolution
ICE arrested comedian Robby Roadsteamer for singing a parody of Rod Stewart’s “Do Ya Think I’m Sexy” in a Jeffrey Epstein the Giraffe costume outside their facility.
He sings “If you hate brown people / and you are a Nazi” and ICE thugs grab him and drag him into detention. No violence—just speech.
He sings “If you hate brown people / and you are a Nazi” and ICE thugs grab him and drag him into detention. No violence—just speech.
October 15, 2025 at 5:48 PM
Honestly if we were a real country anymore this video would start an armed revolution
Reposted by Jackson Cahn
A bit of chemistry to start your day! Sharing our latest review on sponge peptides 🧪 Surprisingly, we know so little about them...
www.publish.csiro.au/CH/CH25100
www.publish.csiro.au/CH/CH25100
Ribosomally synthesised and post-translationally modified peptides (RiPPs) from marine demosponges and their microsymbionts
Marine sponges are among the oldest animals to have emerged on Earth. They are metazoan holobionts that host diverse microbial symbionts, which constitute more than 40% of their biomass. Despite their...
www.publish.csiro.au
October 8, 2025 at 6:18 AM
A bit of chemistry to start your day! Sharing our latest review on sponge peptides 🧪 Surprisingly, we know so little about them...
www.publish.csiro.au/CH/CH25100
www.publish.csiro.au/CH/CH25100
Reposted by Jackson Cahn
Ric Grenell, Kennedy Center president, organized a claque of Republicans to heckle a musician critical of Trump. It's like junior high school
www.washingtonian.com/2025/09/23/l...
www.washingtonian.com/2025/09/23/l...
Log Cabin Republicans Disrupted Yasmin Williams’s Kennedy Center Performance - Washingtonian
Staffers say center president Ric Grenell's office set aside passes for the group, which booed and heckled the musician.
www.washingtonian.com
September 24, 2025 at 5:32 PM
Ric Grenell, Kennedy Center president, organized a claque of Republicans to heckle a musician critical of Trump. It's like junior high school
www.washingtonian.com/2025/09/23/l...
www.washingtonian.com/2025/09/23/l...