Jaehyuk Choi
@jaehyukchoimd.bsky.social
Physician scientist at UTSW. T cell biologist geneticist dermatologist. Passionate about cancer and autoimmune disease. Co founder moonlight bio.
Reposted by Jaehyuk Choi
Good news keeps coming! Excited to share our latest preprint expanding myeloid cell editing capabilities: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by Hyuncheol Jung and Pascal Devant joint with @juliacarnevale.bsky.social
December 15, 2025 at 2:02 PM
Good news keeps coming! Excited to share our latest preprint expanding myeloid cell editing capabilities: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by Hyuncheol Jung and Pascal Devant joint with @juliacarnevale.bsky.social
We have an active search for tenure-track faculty interested in #ImmuneEngineering #ProteinEngineering #GenomeEngineering & #CancerImmunology. Join the newly formed Center for Cellular Therapies and Cancer Immunology #CCTCI. Learn more at apply.interfolio.com/173562. #facultyjobs
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September 20, 2025 at 12:48 AM
We have an active search for tenure-track faculty interested in #ImmuneEngineering #ProteinEngineering #GenomeEngineering & #CancerImmunology. Join the newly formed Center for Cellular Therapies and Cancer Immunology #CCTCI. Learn more at apply.interfolio.com/173562. #facultyjobs
Reposted by Jaehyuk Choi
People With Severe Diabetes Are Cured in Small Trial of New Drug
www.nytimes.com
June 21, 2025 at 1:26 AM
Reposted by Jaehyuk Choi
☕Have you read this study from our journal (@naturecellbiology.bsky.social) yet?
Studies of endolysosomes and #proteostasis suggest a role for lysosomal quality control in #Alzheimers disease pathology.
bit.ly/4lSORPV
Studies of endolysosomes and #proteostasis suggest a role for lysosomal quality control in #Alzheimers disease pathology.
bit.ly/4lSORPV
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease - Nature Cell Biology
Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with Alzheimer’s disease. Studies of endolysosomes and proteostasis suggest a role f...
bit.ly
April 17, 2025 at 6:34 PM
☕Have you read this study from our journal (@naturecellbiology.bsky.social) yet?
Studies of endolysosomes and #proteostasis suggest a role for lysosomal quality control in #Alzheimers disease pathology.
bit.ly/4lSORPV
Studies of endolysosomes and #proteostasis suggest a role for lysosomal quality control in #Alzheimers disease pathology.
bit.ly/4lSORPV
Reposted by Jaehyuk Choi
Ohio Medicaid got rid of big middlemen. Says it paid pharmacies a lot more — and saved $140M ohiocapitaljournal.com/2025/04/17/o...
Ohio Medicaid got rid of big middlemen. Says it paid pharmacies a lot more — and saved $140M • Ohio Capital Journal
The Ohio Department of Medicaid department in 2022 gave powerful prescription drug middlemen the boot and created a new system. The result: Fees paid to pharmacies were boosted more than 1,200% while ...
ohiocapitaljournal.com
April 17, 2025 at 1:29 PM
Ohio Medicaid got rid of big middlemen. Says it paid pharmacies a lot more — and saved $140M ohiocapitaljournal.com/2025/04/17/o...
some GD T cell lymphomas are addicted to JAK-STAT signaling and relapse with new JAK-STAT mutations, much like melanomas to BRAF inhibitors. ? new approach ? to treating these aggressive diseases. cell of origin (GD cells) important but unclear why. stay tuned for more.
www.jci.org/articles/vie...
www.jci.org/articles/vie...
JCI -
Addiction of primary cutaneous γδ T cell lymphomas to JAK/STAT signaling
www.jci.org
April 16, 2025 at 11:45 PM
some GD T cell lymphomas are addicted to JAK-STAT signaling and relapse with new JAK-STAT mutations, much like melanomas to BRAF inhibitors. ? new approach ? to treating these aggressive diseases. cell of origin (GD cells) important but unclear why. stay tuned for more.
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Reposted by Jaehyuk Choi
DNMT1 inhibition reprograms T cells to NK-like cells with potent antitumor activity www.science.org/doi/10.1126...
March 23, 2025 at 1:45 PM
DNMT1 inhibition reprograms T cells to NK-like cells with potent antitumor activity www.science.org/doi/10.1126...
Reposted by Jaehyuk Choi
Review @jimmunol.bsky.social
Can autoimmune disease be cured by deep CD19+ cell depletion?
doi.org/10.1093/jimm...
Can autoimmune disease be cured by deep CD19+ cell depletion?
doi.org/10.1093/jimm...
March 21, 2025 at 5:58 PM
Review @jimmunol.bsky.social
Can autoimmune disease be cured by deep CD19+ cell depletion?
doi.org/10.1093/jimm...
Can autoimmune disease be cured by deep CD19+ cell depletion?
doi.org/10.1093/jimm...
Reposted by Jaehyuk Choi
Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 21, 2025 at 6:50 PM
Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jaehyuk Choi
Thanks to Dr. Syal & @nbcnews.com for visiting our #CARTcell program to highlight one of our courageous little patients with #DIPG #DMG. So much work left to do but thankful for the support of Seattle Children’s and our brave families. ❤️
www.nbcnews.com/now/video/ex...
www.nbcnews.com/now/video/ex...
Experimental brain tumor treatment shows promise for pediatric brain cancer
Gavin Nielsen, who was 2 years old when he was diagnosed with a rare brain cancer, met Dr. Nicholas Vitanza who is part of a growing group of researchers exploring CAR-T therapy. The treatment program...
www.nbcnews.com
March 20, 2025 at 12:17 AM
Thanks to Dr. Syal & @nbcnews.com for visiting our #CARTcell program to highlight one of our courageous little patients with #DIPG #DMG. So much work left to do but thankful for the support of Seattle Children’s and our brave families. ❤️
www.nbcnews.com/now/video/ex...
www.nbcnews.com/now/video/ex...
Reposted by Jaehyuk Choi
AGO2 mediates immunotherapy failure via suppressing tumor IFN-gamma response-dependent CD8+ T cell immunity
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
March 19, 2025 at 6:01 PM
AGO2 mediates immunotherapy failure via suppressing tumor IFN-gamma response-dependent CD8+ T cell immunity
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
Reposted by Jaehyuk Choi
New #ScienceImmunology research involving mice and human tissues demonstrates how different immune cell types modify expression of stimulator of interferon genes (STING) to support their normal development and function. scim.ag/4idx7wn
Dynamic STING repression orchestrates immune cell development and function
Repression of STING expression in neutrophils and T lymphocytes is required for immune homeostasis and tumor response.
scim.ag
March 19, 2025 at 3:38 PM
New #ScienceImmunology research involving mice and human tissues demonstrates how different immune cell types modify expression of stimulator of interferon genes (STING) to support their normal development and function. scim.ag/4idx7wn
Reposted by Jaehyuk Choi
How does sleep protect against neurodegenerative disease? A review, open-access
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
March 19, 2025 at 3:44 PM
How does sleep protect against neurodegenerative disease? A review, open-access
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Congratulations! Great talk at keystone
March 19, 2025 at 7:23 PM
Congratulations! Great talk at keystone
Reposted by Jaehyuk Choi
Regulatory T cells with engineered specificity for HLA-DQ2.5–restricted deamidated gluten peptides exert bystander suppression in vivo
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
March 19, 2025 at 6:16 PM
Regulatory T cells with engineered specificity for HLA-DQ2.5–restricted deamidated gluten peptides exert bystander suppression in vivo
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Jaehyuk Choi
#InterferonPower! Hongbo Chi &co @stjude.bsky.social @stjuderesearch.bsky.social show @nature.com that VDAC2 deficiency facilitates tumor destruction by T cell-driven IFNgamma by causing mitochondrial (mt) damage & mtDNA sensing by cGAS–STING, which drives type I IFNs & tumor death!
VDAC2 loss elicits tumour destruction and inflammation for cancer therapy - Nature
VDAC2 deficiency elicits uncontrolled IFNγ-induced BAK activation and mitochondrial damage for improved cancer therapy.
www.nature.com
March 19, 2025 at 7:11 PM
#InterferonPower! Hongbo Chi &co @stjude.bsky.social @stjuderesearch.bsky.social show @nature.com that VDAC2 deficiency facilitates tumor destruction by T cell-driven IFNgamma by causing mitochondrial (mt) damage & mtDNA sensing by cGAS–STING, which drives type I IFNs & tumor death!
Reposted by Jaehyuk Choi
Congratulations!
Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U
March 13, 2025 at 2:21 AM
Congratulations!
Reposted by Jaehyuk Choi
#ScienceSaturday 🧵
❓ Are B cells important to eliminate cancers? T cells, capable of directly killing cancers, have been widely studied in tumor immunology.
❓ Are B cells important to eliminate cancers? T cells, capable of directly killing cancers, have been widely studied in tumor immunology.
March 1, 2025 at 4:31 PM
#ScienceSaturday 🧵
❓ Are B cells important to eliminate cancers? T cells, capable of directly killing cancers, have been widely studied in tumor immunology.
❓ Are B cells important to eliminate cancers? T cells, capable of directly killing cancers, have been widely studied in tumor immunology.
Reposted by Jaehyuk Choi
🎉 Congratulations 🥳 to our Director, @miriammerad.bsky.social, on winning this year’s Sjöberg Prize! Check out the video announcement below 🔽
🌟Sjöberg Laureate Miriam Merad has studied how cells in the innate immune system affect the body’s ability to fight tumours. Her discoveries have hugely contributed to making these cells a promising target for the development of new cancer therapies.
www.kva.se/en/news/sjob...
#Science #Academicsky
www.kva.se/en/news/sjob...
#Science #Academicsky
Sjöberg Prize 2025
Miriam Merad is awarded the Sjöberg Prize 2025 for discovering new targets for cancer therapies in the immune system.
www.kva.se
February 13, 2025 at 4:38 PM
🎉 Congratulations 🥳 to our Director, @miriammerad.bsky.social, on winning this year’s Sjöberg Prize! Check out the video announcement below 🔽
Reposted by Jaehyuk Choi
Review @nature.com @quintanalab.bsky.social
The neuroimmune connectome in health and disease
www.nature.com/articles/s41...
The neuroimmune connectome in health and disease
www.nature.com/articles/s41...
February 12, 2025 at 10:51 PM
Review @nature.com @quintanalab.bsky.social
The neuroimmune connectome in health and disease
www.nature.com/articles/s41...
The neuroimmune connectome in health and disease
www.nature.com/articles/s41...
Reposted by Jaehyuk Choi
Repair Drive enables in vivo expansion of gene-targeted hepatocytes in adult mice
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
February 12, 2025 at 11:00 PM
Repair Drive enables in vivo expansion of gene-targeted hepatocytes in adult mice
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Jaehyuk Choi
PD-L1 from tumor extracellular vesicles induces T cell senescence through lipid metabolism
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
February 12, 2025 at 11:01 PM
PD-L1 from tumor extracellular vesicles induces T cell senescence through lipid metabolism
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Jaehyuk Choi
In chaotic times, it is important to emphasize how much i appreciate my fellow scientists and the science they do. Inspired countless times each day by my colleagues in the field.
February 1, 2025 at 12:53 PM
In chaotic times, it is important to emphasize how much i appreciate my fellow scientists and the science they do. Inspired countless times each day by my colleagues in the field.
Reposted by Jaehyuk Choi
The best part of science for me is when someone in the lab or a former lab member has awesome new data and rushes to share it. everything else pales in comparison.
February 6, 2025 at 1:55 PM
The best part of science for me is when someone in the lab or a former lab member has awesome new data and rushes to share it. everything else pales in comparison.