Sinai Immuno
@sinaiimmuno.bsky.social
PrIISM at Icahn Mount Sinai | powering immunology research from human profiling through mechanistic studies in preclinical models, towards the development & testing of new immunotherapies
Pinned
Sinai Immuno
@sinaiimmuno.bsky.social
· Nov 17
Frontiers of Medical Research: Immunology
How are scientists rethinking immunotherapy?
www.science.org
What do immunologists get up to at Icahn Mount Sinai? Find out in our recent Science supplement, with essays on the big, open Qs in neuroimmunology, aging, cancer and more that our scientists are pursuing 🧐 www.science.org/content/reso...
For an expert opinion on the recent report that mRNA COVID vaccines may help immune checkpoint blockade work in patients with advanced lung cancer and metastatic melanoma, read this News & Views in @natrevclinonc.nature.com by Sacha Gnjatic FREE >>> rdcu.be/eQYcu
Could a COVID-19 vaccine improve the effectiveness of cancer immunotherapy?
Nature Reviews Clinical Oncology - A recent Nature article reports that mRNA vaccines against SARS-CoV-2 confer improved survival among patients with advanced-stage non-small-cell lung cancer or...
rdcu.be
November 20, 2025 at 3:15 PM
For an expert opinion on the recent report that mRNA COVID vaccines may help immune checkpoint blockade work in patients with advanced lung cancer and metastatic melanoma, read this News & Views in @natrevclinonc.nature.com by Sacha Gnjatic FREE >>> rdcu.be/eQYcu
In Dermatology Times, @itchdoctor.bsky.social
highlights that inflammation is a common thread across diseases throughout the body.
Studying how it goes awry in one organ—like the skin—can reveal why it misfires elsewhere.
www.dermatologytimes.com/view/brian-k...
highlights that inflammation is a common thread across diseases throughout the body.
Studying how it goes awry in one organ—like the skin—can reveal why it misfires elsewhere.
www.dermatologytimes.com/view/brian-k...
Brian Kim, MD, MTR, FAAD, on the Power of Focus in Research | Dermatology Times
Kim explores the significance of inflammation in dermatology, revealing its connections to various diseases and the importance of focused research.
www.dermatologytimes.com
November 14, 2025 at 4:19 PM
In Dermatology Times, @itchdoctor.bsky.social
highlights that inflammation is a common thread across diseases throughout the body.
Studying how it goes awry in one organ—like the skin—can reveal why it misfires elsewhere.
www.dermatologytimes.com/view/brian-k...
highlights that inflammation is a common thread across diseases throughout the body.
Studying how it goes awry in one organ—like the skin—can reveal why it misfires elsewhere.
www.dermatologytimes.com/view/brian-k...
📣 NEW STUDY 📣 @cp-immunity.bsky.social by Maria Lafaille's lab shows how long-lived IgE-producing plasma cells survive & sustain allergy without continued allergen exposure: maturing in spleen & bone marrow with a unique survival program that resists cell-death signals 🧐 www.cell.com/immunity/abs...
Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response
Allergies can persist even in the absence of allergen exposure. Miranda-Waldetario
et al. find that IgE-producing plasma cells mature, acquire survival adaptations,
and persist for extended periods of...
www.cell.com
November 3, 2025 at 7:47 PM
📣 NEW STUDY 📣 @cp-immunity.bsky.social by Maria Lafaille's lab shows how long-lived IgE-producing plasma cells survive & sustain allergy without continued allergen exposure: maturing in spleen & bone marrow with a unique survival program that resists cell-death signals 🧐 www.cell.com/immunity/abs...
Reposted by Sinai Immuno
Excited to share our LongTrack study out in
@natmicrobiol.nature.com today!
Fecal microbiota transplant (FMT), donor 💩 => patients' gut, is an effective treatment for recurrent C. difficile infection & is being evaluated for Inflammatory Bowel Diseases (IBD) & other conditions 1/
📄 rdcu.be/eL8mR
@natmicrobiol.nature.com today!
Fecal microbiota transplant (FMT), donor 💩 => patients' gut, is an effective treatment for recurrent C. difficile infection & is being evaluated for Inflammatory Bowel Diseases (IBD) & other conditions 1/
📄 rdcu.be/eL8mR
Long-read metagenomics for strain tracking after faecal microbiota transplant
Nature Microbiology - A long-read metagenomics method empowers faecal microbiota transplantation studies by precisely tracking bacteria from donors to recipients, distinguishing co-existing strains...
rdcu.be
October 22, 2025 at 3:39 PM
Excited to share our LongTrack study out in
@natmicrobiol.nature.com today!
Fecal microbiota transplant (FMT), donor 💩 => patients' gut, is an effective treatment for recurrent C. difficile infection & is being evaluated for Inflammatory Bowel Diseases (IBD) & other conditions 1/
📄 rdcu.be/eL8mR
@natmicrobiol.nature.com today!
Fecal microbiota transplant (FMT), donor 💩 => patients' gut, is an effective treatment for recurrent C. difficile infection & is being evaluated for Inflammatory Bowel Diseases (IBD) & other conditions 1/
📄 rdcu.be/eL8mR
Reposted by Sinai Immuno
Also tomorrow, Cindy Xintong Li from the University of Oxford will present a preprint about how TCR activation impairs CAR-T cytotoxicity against separate target cells. @kischober.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 21, 2025 at 3:52 PM
Also tomorrow, Cindy Xintong Li from the University of Oxford will present a preprint about how TCR activation impairs CAR-T cytotoxicity against separate target cells. @kischober.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sinai Immuno
Tomorrow, Annie Khamhoung from Mt.Sinai will present a pre-print on the role of brain infiltrating T-cells in microglial dysregulation and neuronal loss following subarachnoid haemorrhage. @ElisaEzanier @MarioNegriIRCCS
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Brain infiltrating T cells mediate microglial dysregulation and neuronal loss following SAH
The contribution of T cells to neuroinflammation after aneurysmal subarachnoid hemorrhage (SAH) remains poorly understood. Using a murine pre-chiasmatic injection model of SAH we demonstrate that T ce...
www.biorxiv.org
October 21, 2025 at 3:48 PM
Tomorrow, Annie Khamhoung from Mt.Sinai will present a pre-print on the role of brain infiltrating T-cells in microglial dysregulation and neuronal loss following subarachnoid haemorrhage. @ElisaEzanier @MarioNegriIRCCS
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sinai Immuno
Our new review in @natbiomedeng.nature.com is out!
RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits.
free to read 🔗 rdcu.be/eLxGs
RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits.
free to read 🔗 rdcu.be/eLxGs
Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level
Nature Biomedical Engineering - This Review explores strategies for targeting and tracking RNA-LNP drugs, monitoring their in vivo behaviour, enhancing tissue-specific delivery, and using synthetic...
rdcu.be
October 17, 2025 at 5:16 PM
Our new review in @natbiomedeng.nature.com is out!
RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits.
free to read 🔗 rdcu.be/eLxGs
RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits.
free to read 🔗 rdcu.be/eLxGs
Reposted by Sinai Immuno
Immunotherapy researcher Miriam Merad from Icahn Mount Sinai says the reason that cancer research has slowed is because of funding issues, which is something taxpayers don’t have to accept.
“We fight for patients, we fight for science, and we have to fight for progress.”
#STATSummit
“We fight for patients, we fight for science, and we have to fight for progress.”
#STATSummit
October 15, 2025 at 8:36 PM
Immunotherapy researcher Miriam Merad from Icahn Mount Sinai says the reason that cancer research has slowed is because of funding issues, which is something taxpayers don’t have to accept.
“We fight for patients, we fight for science, and we have to fight for progress.”
#STATSummit
“We fight for patients, we fight for science, and we have to fight for progress.”
#STATSummit
Reposted by Sinai Immuno
Add your name ✍ at www.nycures.org so Albany sees 10,000 scientists calling for the future of biomedical research to be built right here in New York.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
October 15, 2025 at 12:55 PM
Add your name ✍ at www.nycures.org so Albany sees 10,000 scientists calling for the future of biomedical research to be built right here in New York.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
Reposted by Sinai Immuno
Looking forward to this live episode of @microbetv.bsky.social with my dear friend and rockstar immunologist @diehllab-mskcc.bsky.social #holidayfun #immune100
Celebrate Immune 100 with us!
Join a live recording and audience event at The Incubator, NYC
📅 December 22 | 8 PM
Featuring:
Gretchen Diehl, Ph.D. – Diehl Lab, Immunology Program
Shruti Naik, Ph.D. – Naik Lab of Tissue Immunity and Regeneration, NYU
🎟️ Get tickets: immune100nyc.eventbrite.com
Join a live recording and audience event at The Incubator, NYC
📅 December 22 | 8 PM
Featuring:
Gretchen Diehl, Ph.D. – Diehl Lab, Immunology Program
Shruti Naik, Ph.D. – Naik Lab of Tissue Immunity and Regeneration, NYU
🎟️ Get tickets: immune100nyc.eventbrite.com
IMMUNE 100 — LIVE IN NYC
Join us at The Incubator for Immune’s 100th episode — a live recording with guests, science conversation, and celebration!
immune100nyc.eventbrite.com
October 11, 2025 at 6:57 PM
Looking forward to this live episode of @microbetv.bsky.social with my dear friend and rockstar immunologist @diehllab-mskcc.bsky.social #holidayfun #immune100
Reposted by Sinai Immuno
Wondering what *exactly* we’re up to?
Our first coalition email is about to go out—introducing the statewide biomedical institute we’re proposing and how you can help power it forward THIS WEEK!
Sign up now so you don’t miss it: www.nycures.org/
Our first coalition email is about to go out—introducing the statewide biomedical institute we’re proposing and how you can help power it forward THIS WEEK!
Sign up now so you don’t miss it: www.nycures.org/
October 9, 2025 at 1:18 PM
Wondering what *exactly* we’re up to?
Our first coalition email is about to go out—introducing the statewide biomedical institute we’re proposing and how you can help power it forward THIS WEEK!
Sign up now so you don’t miss it: www.nycures.org/
Our first coalition email is about to go out—introducing the statewide biomedical institute we’re proposing and how you can help power it forward THIS WEEK!
Sign up now so you don’t miss it: www.nycures.org/
Sleep is very good for the immune system!
We are all Dr. Brunkow 😴
“Dr. Brunkow said she did not expect to win a Nobel Prize. ‘My phone rang, and I saw a number from Sweden and thought, well that’s just spam of some sort, so I disabled the phone and went back to sleep,’“ www.nytimes.com/2025/10/06/h...
“Dr. Brunkow said she did not expect to win a Nobel Prize. ‘My phone rang, and I saw a number from Sweden and thought, well that’s just spam of some sort, so I disabled the phone and went back to sleep,’“ www.nytimes.com/2025/10/06/h...
Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems
www.nytimes.com
October 7, 2025 at 9:48 PM
Sleep is very good for the immune system!
Reposted by Sinai Immuno
🧪Excited to co-present this @standupforscience.bsky.social event next week with UW's Dr. Ryan Kelly
We'll cover how to effectively engage in public comments, to help shape public policy at all levels, federal to local. Attend in person or virtually!
RSVP: act.standupforscience.net/events/power...
We'll cover how to effectively engage in public comments, to help shape public policy at all levels, federal to local. Attend in person or virtually!
RSVP: act.standupforscience.net/events/power...
October 7, 2025 at 3:36 PM
🧪Excited to co-present this @standupforscience.bsky.social event next week with UW's Dr. Ryan Kelly
We'll cover how to effectively engage in public comments, to help shape public policy at all levels, federal to local. Attend in person or virtually!
RSVP: act.standupforscience.net/events/power...
We'll cover how to effectively engage in public comments, to help shape public policy at all levels, federal to local. Attend in person or virtually!
RSVP: act.standupforscience.net/events/power...
The immune system is a formidable defense that can destroy our own cells to keep us safe from viruses and cancer.
That power demands effective checks & balances to prevent autoimmunity.
Like the regulatory T cells discovered by this year's Nobel Prize winners! www.newscientist.com/article/2498...
That power demands effective checks & balances to prevent autoimmunity.
Like the regulatory T cells discovered by this year's Nobel Prize winners! www.newscientist.com/article/2498...
Nobel prize for medicine goes to trio for work on immune tolerance
The 2025 Nobel prize in physiology or medicine has gone to Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi for their discoveries around how we keep our immune system under control
www.newscientist.com
October 7, 2025 at 3:24 PM
The immune system is a formidable defense that can destroy our own cells to keep us safe from viruses and cancer.
That power demands effective checks & balances to prevent autoimmunity.
Like the regulatory T cells discovered by this year's Nobel Prize winners! www.newscientist.com/article/2498...
That power demands effective checks & balances to prevent autoimmunity.
Like the regulatory T cells discovered by this year's Nobel Prize winners! www.newscientist.com/article/2498...
Reposted by Sinai Immuno
The BIGGEST impact you can have with 1 minute today ⏱️
Add your name to show NY is ready for a statewide biomedical institute.
CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York.
✍️ www.nycures.org/
Add your name to show NY is ready for a statewide biomedical institute.
CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York.
✍️ www.nycures.org/
New York Cures – NY-CURESNew York Cures Website
NY-CURES is working to advance bold, state-backed investment in biomedical research—on the scale of successful initiatives in California and Texas—to grow New York’s leadership in science, innovation, and health.
www.nycures.org
October 2, 2025 at 4:23 PM
The BIGGEST impact you can have with 1 minute today ⏱️
Add your name to show NY is ready for a statewide biomedical institute.
CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York.
✍️ www.nycures.org/
Add your name to show NY is ready for a statewide biomedical institute.
CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York.
✍️ www.nycures.org/
Reposted by Sinai Immuno
“States like New York have an opportunity to position ourselves as real leaders in so many different areas.” @governor.ny.gov
Like her, we believe NY is ready for revitalization—by launching a state-wide biomedical institute that boosts jobs, the economy & cures. www.youtube.com/watch?v=WVtF...
Like her, we believe NY is ready for revitalization—by launching a state-wide biomedical institute that boosts jobs, the economy & cures. www.youtube.com/watch?v=WVtF...
A Conversation with New York Governor Kathy Hochul | 2025 Concordia Annual Summit
YouTube video by Concordia
www.youtube.com
September 29, 2025 at 4:50 PM
“States like New York have an opportunity to position ourselves as real leaders in so many different areas.” @governor.ny.gov
Like her, we believe NY is ready for revitalization—by launching a state-wide biomedical institute that boosts jobs, the economy & cures. www.youtube.com/watch?v=WVtF...
Like her, we believe NY is ready for revitalization—by launching a state-wide biomedical institute that boosts jobs, the economy & cures. www.youtube.com/watch?v=WVtF...
Reposted by Sinai Immuno
Check out our latest in @cp-trendscancer.bsky.social where rockstar PhD student @laurarosenberg.bsky.social reviews cancer therapies known to induce innate immune responses through the reactivation of Transposable Elements.
September 30, 2025 at 1:21 AM
Check out our latest in @cp-trendscancer.bsky.social where rockstar PhD student @laurarosenberg.bsky.social reviews cancer therapies known to induce innate immune responses through the reactivation of Transposable Elements.
Reposted by Sinai Immuno
The new #NSF #GRFP application now excludes 1000’s of students, including those who were told they could apply this year, or who planned to apply next year.
We have a new specific petition urging #NSFGRFP undo this harmful action. If you are impacted sign here: laurenkuehne.github.io/grfpChanges/
We have a new specific petition urging #NSFGRFP undo this harmful action. If you are impacted sign here: laurenkuehne.github.io/grfpChanges/
September 29, 2025 at 5:47 PM
The new #NSF #GRFP application now excludes 1000’s of students, including those who were told they could apply this year, or who planned to apply next year.
We have a new specific petition urging #NSFGRFP undo this harmful action. If you are impacted sign here: laurenkuehne.github.io/grfpChanges/
We have a new specific petition urging #NSFGRFP undo this harmful action. If you are impacted sign here: laurenkuehne.github.io/grfpChanges/
Reposted by Sinai Immuno
We're excited to share our latest work: "Targeting neoantigens conserved across organs and species overcomes tumor immune escape"!
Thanks to the team at @sinaiimmuno.bsky.social !
www.biorxiv.org/content/10.1...
Thanks to the team at @sinaiimmuno.bsky.social !
www.biorxiv.org/content/10.1...
Targeting neoantigens conserved across organs and species overcomes tumor immune escape
Neoantigen-targeted immunotherapies hold promise for cancer treatment, but current personalized approaches are time-consuming and costly. Here, we identify neoantigens encoded by Ptprs and Igf2r that ...
www.biorxiv.org
September 29, 2025 at 12:24 PM
We're excited to share our latest work: "Targeting neoantigens conserved across organs and species overcomes tumor immune escape"!
Thanks to the team at @sinaiimmuno.bsky.social !
www.biorxiv.org/content/10.1...
Thanks to the team at @sinaiimmuno.bsky.social !
www.biorxiv.org/content/10.1...
Reposted by Sinai Immuno
Also tomorrow from #PreprintHub1 Shelley Herbrich from MD Anderson will present a #preprint from @LHooperLab on how the gut microbiota regulates intestinal T cell development.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The gut microbiota directs vitamin A flux to regulate intestinal T cell development
The intestinal microbiota shapes adaptive immunity, but the mechanisms remain incompletely defined. Here, we show that the microbiota initiates the movement of retinoids—dietary vitamin A derivatives ...
www.biorxiv.org
September 23, 2025 at 3:36 PM
Also tomorrow from #PreprintHub1 Shelley Herbrich from MD Anderson will present a #preprint from @LHooperLab on how the gut microbiota regulates intestinal T cell development.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sinai Immuno
Tomorrow #PreprintHub1 is starting for the 2025-2026 season! Laura Rosenberg from Mount Sinai will present a #preprint by the @BelkaidLab on how endogenous retroelements promote tolerance to dietary antigens.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
September 23, 2025 at 3:32 PM
Tomorrow #PreprintHub1 is starting for the 2025-2026 season! Laura Rosenberg from Mount Sinai will present a #preprint by the @BelkaidLab on how endogenous retroelements promote tolerance to dietary antigens.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sinai Immuno
🔬Our paper from the @miriammerad.bsky.social lab is now online! This is a story shaped over years of cross-disciplinary endeavor at @sinaiimmuno.bsky.social and labs across the world. 🧵:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature
An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...
www.nature.com
September 22, 2025 at 12:41 PM
🔬Our paper from the @miriammerad.bsky.social lab is now online! This is a story shaped over years of cross-disciplinary endeavor at @sinaiimmuno.bsky.social and labs across the world. 🧵:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
📝NEW STUDY📝 Cancer's first punch when battling the immune system may be rewiring myeloid progenitors in bone marrow so they become suppressive tumor macrophages blunting T-cell attacks. Find out how in @nature.com from @samhegde.bsky.social & @miriammerad.bsky.social 🧐 www.nature.com/articles/s41...
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature
An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...
www.nature.com
September 18, 2025 at 3:16 PM
📝NEW STUDY📝 Cancer's first punch when battling the immune system may be rewiring myeloid progenitors in bone marrow so they become suppressive tumor macrophages blunting T-cell attacks. Find out how in @nature.com from @samhegde.bsky.social & @miriammerad.bsky.social 🧐 www.nature.com/articles/s41...
Reposted by Sinai Immuno
📢 📢📢📢 📢 Mechanosensitive fibroblasts fuel strictures via YAP/TAZ signaling—opening doors to new anti-fibrotic therapies. Grateful to be part of this transformative study with the Longaker lab! 🙏🙏🙏
www.sciencedirect.com/science/arti...
STAY TUNED for more in IBD damage from the #Naiklab
www.sciencedirect.com/science/arti...
STAY TUNED for more in IBD damage from the #Naiklab
Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures
A significant complication of Crohn’s disease (CD) is intestinal fibrosis, which narrows the bowel lumen to form a stricture. Creeping fat (CF) is the…
www.sciencedirect.com
September 17, 2025 at 4:13 PM
📢 📢📢📢 📢 Mechanosensitive fibroblasts fuel strictures via YAP/TAZ signaling—opening doors to new anti-fibrotic therapies. Grateful to be part of this transformative study with the Longaker lab! 🙏🙏🙏
www.sciencedirect.com/science/arti...
STAY TUNED for more in IBD damage from the #Naiklab
www.sciencedirect.com/science/arti...
STAY TUNED for more in IBD damage from the #Naiklab
Reposted by Sinai Immuno
New York leads in science & medicine but without state investment, we risk losing talent, cures, jobs, & billions in economic return.
Every $1 California invested in biomedical research returned $4 to the state economy. This isn’t just science—it’s smart economics: www.cirm.ca.gov/our-impact/
Every $1 California invested in biomedical research returned $4 to the state economy. This isn’t just science—it’s smart economics: www.cirm.ca.gov/our-impact/
Impact Across California – CIRM
For two decades, CIRM has been at the forefront of regenerative medicine, funding over 100 clinical trials and building the infrastructure that drives innovation in stem cell and gene therapies.
www.cirm.ca.gov
September 16, 2025 at 4:02 PM
New York leads in science & medicine but without state investment, we risk losing talent, cures, jobs, & billions in economic return.
Every $1 California invested in biomedical research returned $4 to the state economy. This isn’t just science—it’s smart economics: www.cirm.ca.gov/our-impact/
Every $1 California invested in biomedical research returned $4 to the state economy. This isn’t just science—it’s smart economics: www.cirm.ca.gov/our-impact/