Preprint Club - Immunology
@preprintclub.bsky.social
Cross-Institutional Journal Club. We review immunology #preprints and highlight our favourites. Check our website 👉 https://www.preprintclub.com/
Pinned
#PreprintClub is now on Bluesky!
Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬
Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬
Reposted by Preprint Club - Immunology
by Aglaia Skolariki & @eileenparkes.bsky.social
Single-cell proteomics sheds light on neutrophil diversity in glioblastoma - Nature Reviews Immunology
A preprint by Sadiku et al. characterizes neutrophil diversity in glioblastoma using a new workflow for single-cell proteomic profiling.
www.nature.com
November 11, 2025 at 4:39 PM
by Aglaia Skolariki & @eileenparkes.bsky.social
Reposted by Preprint Club - Immunology
by Alisa Iakupova & @theonlylabever.bsky.social
The OCR369 cis-regulatory element controls gut peacekeeping cells - Nature Reviews Immunology
A preprint by Guo et al. reports a mechanism of transcriptional control of RORγt expression in intestinal antigen-presenting cells that are important for oral tolerance involving the cis-regulatory re...
www.nature.com
November 11, 2025 at 4:39 PM
by Alisa Iakupova & @theonlylabever.bsky.social
Reposted by Preprint Club - Immunology
Today at #PreprintHub2, Meredith from Virginia will present a #preprint by Cecilia Pessoa Rodrigues from the Daniel Regan-Komito Lab, with the title "IFNAR1⁺ Neutrophils Orchestrate Chronic Inflammatory Damage Through Mitochondrial Remodeling" 🔬🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
IFNAR1⁺ Neutrophils Orchestrate Chronic Inflammatory Damage Through Mitochondrial Remodeling
Neutrophils are abundant innate effector cells that drive mucosal inflammation, yet the mechanisms by which they contribute to chronic inflammatory diseases across distinct tissues remain incompletely...
www.biorxiv.org
November 11, 2025 at 11:38 AM
Today at #PreprintHub2, Meredith from Virginia will present a #preprint by Cecilia Pessoa Rodrigues from the Daniel Regan-Komito Lab, with the title "IFNAR1⁺ Neutrophils Orchestrate Chronic Inflammatory Damage Through Mitochondrial Remodeling" 🔬🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Also tomorrow in #PreprintHub1, Mehdi Chaib from MD Anderson will present a #preprint from the DuPage lab about how intratumoral Treg ablation is sufficient to mediate tumor control without systemic autoimmunity.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Intratumoral Treg ablation is sufficient to mediate tumor control systemically without autoimmunity
Regulatory T cells (Tregs) infiltrate most tumors, yet whether they suppress immune responses directly within tumor tissues is not clear. We used intratumoral (IT) delivery of diphtheria toxin (DT) in...
www.biorxiv.org
November 5, 2025 at 1:06 AM
Also tomorrow in #PreprintHub1, Mehdi Chaib from MD Anderson will present a #preprint from the DuPage lab about how intratumoral Treg ablation is sufficient to mediate tumor control without systemic autoimmunity.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tomorrow in #preprintHub1, Meredith Ramba from
Mt.Sinai will present a #preprint from @maxkonigmd.bsky.social about targeting autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells.
biorxiv.org/content/10.1...
Mt.Sinai will present a #preprint from @maxkonigmd.bsky.social about targeting autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells.
biorxiv.org/content/10.1...
November 5, 2025 at 1:05 AM
Tomorrow in #preprintHub1, Meredith Ramba from
Mt.Sinai will present a #preprint from @maxkonigmd.bsky.social about targeting autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells.
biorxiv.org/content/10.1...
Mt.Sinai will present a #preprint from @maxkonigmd.bsky.social about targeting autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells.
biorxiv.org/content/10.1...
Tomorrow, @kiel_olumuyide from @IcahnMountSinai
will present a #preprint by Dr.Zhejie Li from @Zhu_Lab
titled “Somatic TYK2 activating mutations in tumor-infiltrating T cells promote anti-cancer immunity."
www.biorxiv.org/content/10.1...
will present a #preprint by Dr.Zhejie Li from @Zhu_Lab
titled “Somatic TYK2 activating mutations in tumor-infiltrating T cells promote anti-cancer immunity."
www.biorxiv.org/content/10.1...
Somatic TYK2 activating mutations in tumor-infiltrating T cells promote anti-cancer immunity
Cancer cells evolve to increase fitness and evade the immune system, but it is not clear if tumor infiltrating lymphocytes (TILs) undergo selection for somatic mutations that augment anti-cancer immun...
www.biorxiv.org
October 28, 2025 at 10:41 PM
Tomorrow, @kiel_olumuyide from @IcahnMountSinai
will present a #preprint by Dr.Zhejie Li from @Zhu_Lab
titled “Somatic TYK2 activating mutations in tumor-infiltrating T cells promote anti-cancer immunity."
www.biorxiv.org/content/10.1...
will present a #preprint by Dr.Zhejie Li from @Zhu_Lab
titled “Somatic TYK2 activating mutations in tumor-infiltrating T cells promote anti-cancer immunity."
www.biorxiv.org/content/10.1...
Tomorrow at #PreprintHub2, @lmgail.bsky.social from @cemm.oeaw.ac.at and Lea Heinzl from Uni Wien/MUW will present a #preprint by Thomas N. Burn from Professor Laura Mackay Lab: "Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours
CD8+ T cells are a key weapon in the therapeutic armamentarium against cancer. While CD8+CD103+ T cells with a tissue-resident memory T (TRM) cell phenotype have been favourably correlated with patien...
www.biorxiv.org
October 27, 2025 at 6:58 PM
Tomorrow at #PreprintHub2, @lmgail.bsky.social from @cemm.oeaw.ac.at and Lea Heinzl from Uni Wien/MUW will present a #preprint by Thomas N. Burn from Professor Laura Mackay Lab: "Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Also tomorrow, Cindy Xintong Li from the University of Oxford will present a preprint about how TCR activation impairs CAR-T cytotoxicity against separate target cells. @kischober.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 21, 2025 at 3:52 PM
Also tomorrow, Cindy Xintong Li from the University of Oxford will present a preprint about how TCR activation impairs CAR-T cytotoxicity against separate target cells. @kischober.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tomorrow, Annie Khamhoung from Mt.Sinai will present a pre-print on the role of brain infiltrating T-cells in microglial dysregulation and neuronal loss following subarachnoid haemorrhage. @ElisaEzanier @MarioNegriIRCCS
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Brain infiltrating T cells mediate microglial dysregulation and neuronal loss following SAH
The contribution of T cells to neuroinflammation after aneurysmal subarachnoid hemorrhage (SAH) remains poorly understood. Using a murine pre-chiasmatic injection model of SAH we demonstrate that T ce...
www.biorxiv.org
October 21, 2025 at 3:48 PM
Tomorrow, Annie Khamhoung from Mt.Sinai will present a pre-print on the role of brain infiltrating T-cells in microglial dysregulation and neuronal loss following subarachnoid haemorrhage. @ElisaEzanier @MarioNegriIRCCS
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tomorrow at #PreprintHub2, Raisa Brito from @mdc-berlin.bsky.social will present a #preprint by Prof. Dr. Karsten Kretschmer titled “Functional Dichotomy of Developmental Foxp3+ Treg Cell Subsets in the Visceral Adipose Tissue of Lean and Obese Mice”
October 20, 2025 at 7:02 PM
Tomorrow at #PreprintHub2, Raisa Brito from @mdc-berlin.bsky.social will present a #preprint by Prof. Dr. Karsten Kretschmer titled “Functional Dichotomy of Developmental Foxp3+ Treg Cell Subsets in the Visceral Adipose Tissue of Lean and Obese Mice”
Today from MD Anderson Cancer Center, Dr. Priyanshu Srivastava presented a preprint about tumor instrinsic regulation of PD-L1 and type I IFN by the mitochondrial citrate carrier SLC25A1 @Georgetown #Avantaggiatilab
October 17, 2025 at 1:27 AM
Today from MD Anderson Cancer Center, Dr. Priyanshu Srivastava presented a preprint about tumor instrinsic regulation of PD-L1 and type I IFN by the mitochondrial citrate carrier SLC25A1 @Georgetown #Avantaggiatilab
Izabella Valdez from Mount Sinai will present a preprint from the Moriarity lab at @UMN on FAS and TGFβR2 base editing in primary T cells
October 8, 2025 at 4:42 AM
Izabella Valdez from Mount Sinai will present a preprint from the Moriarity lab at @UMN on FAS and TGFβR2 base editing in primary T cells
Today, Nicolas Ruffin from Karolinska will present a preprint from @josephsunlab.bsky.social on how STAT3 operates as an inflammation-dependent transcriptional switch!
October 8, 2025 at 4:25 AM
Today, Nicolas Ruffin from Karolinska will present a preprint from @josephsunlab.bsky.social on how STAT3 operates as an inflammation-dependent transcriptional switch!
Today at #PreprintHub2, Teresa Neuwirth from
@cemm.oeaw.ac.at will present a #preprint by
@retickerflynn.bsky.social on how Type I interferon signaling drives divergent metastatic phenotypes and immunotherapy responses 🧬🔬
www.biorxiv.org/content/10.1...
@cemm.oeaw.ac.at will present a #preprint by
@retickerflynn.bsky.social on how Type I interferon signaling drives divergent metastatic phenotypes and immunotherapy responses 🧬🔬
www.biorxiv.org/content/10.1...
Type I interferon signaling instills divergent metastatic phenotypes and immunotherapy responses
Metastatic colonization of distant tissues is responsible for most cancer deaths, yet while this colonization is typically preceded by lymph node (LN) metastasis, the clonal and functional relationshi...
www.biorxiv.org
October 7, 2025 at 11:55 AM
Today at #PreprintHub2, Teresa Neuwirth from
@cemm.oeaw.ac.at will present a #preprint by
@retickerflynn.bsky.social on how Type I interferon signaling drives divergent metastatic phenotypes and immunotherapy responses 🧬🔬
www.biorxiv.org/content/10.1...
@cemm.oeaw.ac.at will present a #preprint by
@retickerflynn.bsky.social on how Type I interferon signaling drives divergent metastatic phenotypes and immunotherapy responses 🧬🔬
www.biorxiv.org/content/10.1...
Also tomorrow from #PreprintHub1 Shelley Herbrich from MD Anderson will present a #preprint from @LHooperLab on how the gut microbiota regulates intestinal T cell development.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The gut microbiota directs vitamin A flux to regulate intestinal T cell development
The intestinal microbiota shapes adaptive immunity, but the mechanisms remain incompletely defined. Here, we show that the microbiota initiates the movement of retinoids—dietary vitamin A derivatives ...
www.biorxiv.org
September 23, 2025 at 3:36 PM
Also tomorrow from #PreprintHub1 Shelley Herbrich from MD Anderson will present a #preprint from @LHooperLab on how the gut microbiota regulates intestinal T cell development.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tomorrow #PreprintHub1 is starting for the 2025-2026 season! Laura Rosenberg from Mount Sinai will present a #preprint by the @BelkaidLab on how endogenous retroelements promote tolerance to dietary antigens.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
September 23, 2025 at 3:32 PM
Tomorrow #PreprintHub1 is starting for the 2025-2026 season! Laura Rosenberg from Mount Sinai will present a #preprint by the @BelkaidLab on how endogenous retroelements promote tolerance to dietary antigens.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tomorrow in #PreprintHub2,
@alisaiakupova.bsky.social from
@mdc-berlin.bsky.social will present a #preprint on tolerance to dietary antigens from the Xiaohuan Guo lab 🧬📷
Preprint: www.researchsquare.com/article/rs-4...
@alisaiakupova.bsky.social from
@mdc-berlin.bsky.social will present a #preprint on tolerance to dietary antigens from the Xiaohuan Guo lab 🧬📷
Preprint: www.researchsquare.com/article/rs-4...
RORγt+ APCs require a distinct cis-regulatory element to instruct tolerance to dietary antigens
Oral tolerance represents a hallmark of intestinal mucosal immunity to prevent inflammatory responses to harmless natural antigens, such as dietary components or commensal organisms. However, the unde...
www.researchsquare.com
September 22, 2025 at 8:29 PM
Tomorrow in #PreprintHub2,
@alisaiakupova.bsky.social from
@mdc-berlin.bsky.social will present a #preprint on tolerance to dietary antigens from the Xiaohuan Guo lab 🧬📷
Preprint: www.researchsquare.com/article/rs-4...
@alisaiakupova.bsky.social from
@mdc-berlin.bsky.social will present a #preprint on tolerance to dietary antigens from the Xiaohuan Guo lab 🧬📷
Preprint: www.researchsquare.com/article/rs-4...
Reposted by Preprint Club - Immunology
pH controls inflammatory response through transcriptional condensates...but how? Read all about the mechanism here ->
@xuzhoulab.bsky.social
www.cell.com/cell/fulltex...
www.nature.com/articles/s41...
www.preprintclub.com/preprint-rev...
@preprintclub.bsky.social
@xuzhoulab.bsky.social
www.cell.com/cell/fulltex...
www.nature.com/articles/s41...
www.preprintclub.com/preprint-rev...
@preprintclub.bsky.social
Regulation of inflammatory responses by pH-dependent transcriptional condensates
BRD4 functions as an intracellular pH sensor through a conserved histidine-rich intrinsically
disordered region. Inflammation-associated acidification triggers a pH-dependent switch
in transcriptional...
www.cell.com
July 17, 2025 at 11:08 PM
pH controls inflammatory response through transcriptional condensates...but how? Read all about the mechanism here ->
@xuzhoulab.bsky.social
www.cell.com/cell/fulltex...
www.nature.com/articles/s41...
www.preprintclub.com/preprint-rev...
@preprintclub.bsky.social
@xuzhoulab.bsky.social
www.cell.com/cell/fulltex...
www.nature.com/articles/s41...
www.preprintclub.com/preprint-rev...
@preprintclub.bsky.social
🙏
Thank you to @amitava-bio.bsky.social and Thomas Weichhart for this really nice summary of our preprint! www.nature.com/articles/s41...
Spatial immunometabolic zonation in tuberculosis granulomas - Nature Reviews Immunology
A preprint by McCaffrey and Delmastro et al. delineates distinct immunometabolic zones of tuberculosis granulomas and reports that hypoxia is a key driver of immune subversion.
www.nature.com
July 9, 2025 at 11:22 AM
🙏
Reposted by Preprint Club - Immunology
Amitava Sinha via the @preprintclub.bsky.social wrote a nice Journal Club article on a preprint by from the Angelo lab @stanfordmedicine.bsky.social that describes spatial immunometabolic zonation in tuberculosis granulomas: www.nature.com/articles/s41...
Spatial immunometabolic zonation in tuberculosis granulomas - Nature Reviews Immunology
A preprint by McCaffrey and Delmastro et al. delineates distinct immunometabolic zones of tuberculosis granulomas and reports that hypoxia is a key driver of immune subversion.
www.nature.com
July 8, 2025 at 7:06 AM
Amitava Sinha via the @preprintclub.bsky.social wrote a nice Journal Club article on a preprint by from the Angelo lab @stanfordmedicine.bsky.social that describes spatial immunometabolic zonation in tuberculosis granulomas: www.nature.com/articles/s41...
Reposted by Preprint Club - Immunology
Another Journal Club article from @preprintclub.bsky.social -
Mehdi Chaib and James Allison @mdanderson.bsky.social report on @biorxiv-immuno.bsky.social preprint by Han et al. that describes a mechanism by which metastatic tumours secure iron in the bone marrow
#immunosky #cancersky
rdcu.be/euBTD
Mehdi Chaib and James Allison @mdanderson.bsky.social report on @biorxiv-immuno.bsky.social preprint by Han et al. that describes a mechanism by which metastatic tumours secure iron in the bone marrow
#immunosky #cancersky
rdcu.be/euBTD
Tumour cells mimic erythroblasts to hijack iron from bone marrow macrophages
Nature Reviews Immunology - A preprint by Han et al. reports that tumour cells acquire iron in the bone marrow through phenotypic mimicry of erythroblasts, which promotes metastasis and leads to...
rdcu.be
July 3, 2025 at 8:25 AM
Another Journal Club article from @preprintclub.bsky.social -
Mehdi Chaib and James Allison @mdanderson.bsky.social report on @biorxiv-immuno.bsky.social preprint by Han et al. that describes a mechanism by which metastatic tumours secure iron in the bone marrow
#immunosky #cancersky
rdcu.be/euBTD
Mehdi Chaib and James Allison @mdanderson.bsky.social report on @biorxiv-immuno.bsky.social preprint by Han et al. that describes a mechanism by which metastatic tumours secure iron in the bone marrow
#immunosky #cancersky
rdcu.be/euBTD
July 2, 2025 at 6:12 PM
This semester’s #preprinthub2 club, led by Carolina Mangana & Alex Deltedesco has concluded with a #preprint on how human chronic inflammation is orchestrated by spatially restricted inflammation-activated #DCs. 🎻🫨🚧 #immunosky
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Human chronic inflammation is orchestrated by spatially restricted inflammation-activated Dendritic cells
Dendritic cells (DCs) form coordinated networks that orchestrate inflammatory responses across tissues. Upon activation, conventional dendritic cells (DCs) undergo changes in their transcriptome, phen...
www.biorxiv.org
July 2, 2025 at 8:14 AM
This semester’s #preprinthub2 club, led by Carolina Mangana & Alex Deltedesco has concluded with a #preprint on how human chronic inflammation is orchestrated by spatially restricted inflammation-activated #DCs. 🎻🫨🚧 #immunosky
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Happy to share with you another excellent preprint highlight. #immunosky
NEW Journal Club article from @boyantsankovsci.bsky.social & Dana Philpott @preprintclub.bsky.social highlights a @biorxiv-immuno.bsky.social paper by Srivastava et al. that identifies a previously unknown C19S-modified insulin neoantigen.
rdcu.be/et76Z
rdcu.be/et76Z
Insulin neoantigen elicits memory T cell activation in diabetes
Nature Reviews Immunology - A preprint by Srivastava et al. reports that C19S modification of insulin, which occurs in response to a stressed microenvironment, promotes pro-inflammatory T cell...
rdcu.be
June 30, 2025 at 2:25 PM
Happy to share with you another excellent preprint highlight. #immunosky