Preprint Club - Immunology
@preprintclub.bsky.social
Cross-Institutional Journal Club. We review immunology #preprints and highlight our favourites. Check our website 👉 https://www.preprintclub.com/
Pinned
#PreprintClub is now on Bluesky!
Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬
Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬
Also tomorrow from the University of Toronto, Maye Cheng will present a #preprint from @jhelisseeff.bsky.social lab on how γδ17 T-cell-stromal networks modulate matrix composition and vascularity in foreign body response.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
December 2, 2025 at 5:52 PM
Also tomorrow from the University of Toronto, Maye Cheng will present a #preprint from @jhelisseeff.bsky.social lab on how γδ17 T-cell-stromal networks modulate matrix composition and vascularity in foreign body response.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tomorrow, Rob Crozier from the University of Toronto will present a #preprint from the Morais da Fonseca lab about how Escherichia coli-induced gut IL-33 release inhibits lung type 2 allergic responses.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Escherichia coli-induced gut IL-33 release inhibits lung type 2 allergic responses
Background The incidence of lung allergies is reduced in countries with higher prevalence of infection and environmental exposure to microbes. However, enteric bacterial infections do not always corre...
www.biorxiv.org
December 2, 2025 at 5:51 PM
Tomorrow, Rob Crozier from the University of Toronto will present a #preprint from the Morais da Fonseca lab about how Escherichia coli-induced gut IL-33 release inhibits lung type 2 allergic responses.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Today at #preprinthub2, Freya from Vienna will present
Tomas Pachano and He Leng’s preprint “Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways”, from the labs coordinated by @alex-stark.bsky.social and @miketilapia.bsky.social
www.biorxiv.org/content/10.1...
Tomas Pachano and He Leng’s preprint “Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways”, from the labs coordinated by @alex-stark.bsky.social and @miketilapia.bsky.social
www.biorxiv.org/content/10.1...
Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways
Pathogens deploy effector proteins to exploit host cell biology, and most pathogen open reading frames (ORFs) are rapidly evolving and lack functional annotation. We developed the eORFeome, a scalable...
www.biorxiv.org
December 2, 2025 at 2:52 PM
Today at #preprinthub2, Freya from Vienna will present
Tomas Pachano and He Leng’s preprint “Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways”, from the labs coordinated by @alex-stark.bsky.social and @miketilapia.bsky.social
www.biorxiv.org/content/10.1...
Tomas Pachano and He Leng’s preprint “Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways”, from the labs coordinated by @alex-stark.bsky.social and @miketilapia.bsky.social
www.biorxiv.org/content/10.1...
Today at #preprinthub2, Maria and Öykü from Vienna will present Maud Mayoux's preprint “CD4 memory T cells orchestrate therapy-responsive immune niches in colorectal cancer liver metastases” from the labs of Dr. Sonia Tugues and Dr. Bettina Sobottka 💯✅
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
CD4 memory T cells orchestrate therapy-responsive immune niches in colorectal cancer liver metastases
Colorectal cancer frequently progresses to liver metastases (CRLM), a stage with limited treatment options and poor prognosis. Neoadjuvant chemotherapy is used to control tumor growth and enable resec...
www.biorxiv.org
November 25, 2025 at 1:26 PM
Today at #preprinthub2, Maria and Öykü from Vienna will present Maud Mayoux's preprint “CD4 memory T cells orchestrate therapy-responsive immune niches in colorectal cancer liver metastases” from the labs of Dr. Sonia Tugues and Dr. Bettina Sobottka 💯✅
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Congrats on the publication — we discussed the study published as a preprint here 🤗 bsky.app/profile/prep...
🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism.
www.embopress.org/doi/full/10....
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www.embopress.org/doi/full/10....
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Homeostatic control of energy metabolism by monocyte-derived macrophages | The EMBO Journal
imageimageMacrophages play critical roles in the homeostatic control systems that maintain vital
parameters within physiological ranges. This study characterizes how mouse monocyte-derived
macrophages...
www.embopress.org
November 19, 2025 at 3:24 PM
Congrats on the publication — we discussed the study published as a preprint here 🤗 bsky.app/profile/prep...
Also today at #PreprintHub1, Frederika Rentzeperis from Mt.Sinai will present a #preprint by Xueping Zhu from Professor Sokol's lab on how "Sensory neuronal mTORC1 signaling establishes neuroimmune memory that initiates allergic immunity"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 19, 2025 at 6:59 AM
Also today at #PreprintHub1, Frederika Rentzeperis from Mt.Sinai will present a #preprint by Xueping Zhu from Professor Sokol's lab on how "Sensory neuronal mTORC1 signaling establishes neuroimmune memory that initiates allergic immunity"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Today at #PreprintHub1, Sara Lamorte from the University of Toronto will present a #preprint by @diniscalado.bsky.social, titled “Lactate Blocks Tertiary Lymphoid Structure Formation by Inhibiting B Cell Chemotaxis"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 19, 2025 at 6:55 AM
Today at #PreprintHub1, Sara Lamorte from the University of Toronto will present a #preprint by @diniscalado.bsky.social, titled “Lactate Blocks Tertiary Lymphoid Structure Formation by Inhibiting B Cell Chemotaxis"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Today at #PreprintHub2, Felix and Joel from the Medical University of Vienna will present a #preprint by Jake N. Lichterman from Professor Koh’s lab, titled “Timing of immune checkpoint blockade shapes anti-tumor immunity via a clock-dependent chemokine axis.” 🧫🧪
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 18, 2025 at 2:54 PM
Today at #PreprintHub2, Felix and Joel from the Medical University of Vienna will present a #preprint by Jake N. Lichterman from Professor Koh’s lab, titled “Timing of immune checkpoint blockade shapes anti-tumor immunity via a clock-dependent chemokine axis.” 🧫🧪
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Preprint Club - Immunology
by Aglaia Skolariki & @eileenparkes.bsky.social
Single-cell proteomics sheds light on neutrophil diversity in glioblastoma - Nature Reviews Immunology
A preprint by Sadiku et al. characterizes neutrophil diversity in glioblastoma using a new workflow for single-cell proteomic profiling.
www.nature.com
November 11, 2025 at 4:39 PM
by Aglaia Skolariki & @eileenparkes.bsky.social
Reposted by Preprint Club - Immunology
by Alisa Iakupova & @theonlylabever.bsky.social
The OCR369 cis-regulatory element controls gut peacekeeping cells - Nature Reviews Immunology
A preprint by Guo et al. reports a mechanism of transcriptional control of RORγt expression in intestinal antigen-presenting cells that are important for oral tolerance involving the cis-regulatory re...
www.nature.com
November 11, 2025 at 4:39 PM
by Alisa Iakupova & @theonlylabever.bsky.social
Reposted by Preprint Club - Immunology
Today at #PreprintHub2, Meredith from Virginia will present a #preprint by Cecilia Pessoa Rodrigues from the Daniel Regan-Komito Lab, with the title "IFNAR1⁺ Neutrophils Orchestrate Chronic Inflammatory Damage Through Mitochondrial Remodeling" 🔬🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
IFNAR1⁺ Neutrophils Orchestrate Chronic Inflammatory Damage Through Mitochondrial Remodeling
Neutrophils are abundant innate effector cells that drive mucosal inflammation, yet the mechanisms by which they contribute to chronic inflammatory diseases across distinct tissues remain incompletely...
www.biorxiv.org
November 11, 2025 at 11:38 AM
Today at #PreprintHub2, Meredith from Virginia will present a #preprint by Cecilia Pessoa Rodrigues from the Daniel Regan-Komito Lab, with the title "IFNAR1⁺ Neutrophils Orchestrate Chronic Inflammatory Damage Through Mitochondrial Remodeling" 🔬🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Also tomorrow in #PreprintHub1, Mehdi Chaib from MD Anderson will present a #preprint from the DuPage lab about how intratumoral Treg ablation is sufficient to mediate tumor control without systemic autoimmunity.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Intratumoral Treg ablation is sufficient to mediate tumor control systemically without autoimmunity
Regulatory T cells (Tregs) infiltrate most tumors, yet whether they suppress immune responses directly within tumor tissues is not clear. We used intratumoral (IT) delivery of diphtheria toxin (DT) in...
www.biorxiv.org
November 5, 2025 at 1:06 AM
Also tomorrow in #PreprintHub1, Mehdi Chaib from MD Anderson will present a #preprint from the DuPage lab about how intratumoral Treg ablation is sufficient to mediate tumor control without systemic autoimmunity.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tomorrow in #preprintHub1, Meredith Ramba from
Mt.Sinai will present a #preprint from @maxkonigmd.bsky.social about targeting autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells.
biorxiv.org/content/10.1...
Mt.Sinai will present a #preprint from @maxkonigmd.bsky.social about targeting autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells.
biorxiv.org/content/10.1...
November 5, 2025 at 1:05 AM
Tomorrow in #preprintHub1, Meredith Ramba from
Mt.Sinai will present a #preprint from @maxkonigmd.bsky.social about targeting autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells.
biorxiv.org/content/10.1...
Mt.Sinai will present a #preprint from @maxkonigmd.bsky.social about targeting autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells.
biorxiv.org/content/10.1...
Tomorrow, @kiel_olumuyide from @IcahnMountSinai
will present a #preprint by Dr.Zhejie Li from @Zhu_Lab
titled “Somatic TYK2 activating mutations in tumor-infiltrating T cells promote anti-cancer immunity."
www.biorxiv.org/content/10.1...
will present a #preprint by Dr.Zhejie Li from @Zhu_Lab
titled “Somatic TYK2 activating mutations in tumor-infiltrating T cells promote anti-cancer immunity."
www.biorxiv.org/content/10.1...
Somatic TYK2 activating mutations in tumor-infiltrating T cells promote anti-cancer immunity
Cancer cells evolve to increase fitness and evade the immune system, but it is not clear if tumor infiltrating lymphocytes (TILs) undergo selection for somatic mutations that augment anti-cancer immun...
www.biorxiv.org
October 28, 2025 at 10:41 PM
Tomorrow, @kiel_olumuyide from @IcahnMountSinai
will present a #preprint by Dr.Zhejie Li from @Zhu_Lab
titled “Somatic TYK2 activating mutations in tumor-infiltrating T cells promote anti-cancer immunity."
www.biorxiv.org/content/10.1...
will present a #preprint by Dr.Zhejie Li from @Zhu_Lab
titled “Somatic TYK2 activating mutations in tumor-infiltrating T cells promote anti-cancer immunity."
www.biorxiv.org/content/10.1...
Tomorrow at #PreprintHub2, @lmgail.bsky.social from @cemm.oeaw.ac.at and Lea Heinzl from Uni Wien/MUW will present a #preprint by Thomas N. Burn from Professor Laura Mackay Lab: "Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours
CD8+ T cells are a key weapon in the therapeutic armamentarium against cancer. While CD8+CD103+ T cells with a tissue-resident memory T (TRM) cell phenotype have been favourably correlated with patien...
www.biorxiv.org
October 27, 2025 at 6:58 PM
Tomorrow at #PreprintHub2, @lmgail.bsky.social from @cemm.oeaw.ac.at and Lea Heinzl from Uni Wien/MUW will present a #preprint by Thomas N. Burn from Professor Laura Mackay Lab: "Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Also tomorrow, Cindy Xintong Li from the University of Oxford will present a preprint about how TCR activation impairs CAR-T cytotoxicity against separate target cells. @kischober.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 21, 2025 at 3:52 PM
Also tomorrow, Cindy Xintong Li from the University of Oxford will present a preprint about how TCR activation impairs CAR-T cytotoxicity against separate target cells. @kischober.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tomorrow, Annie Khamhoung from Mt.Sinai will present a pre-print on the role of brain infiltrating T-cells in microglial dysregulation and neuronal loss following subarachnoid haemorrhage. @ElisaEzanier @MarioNegriIRCCS
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Brain infiltrating T cells mediate microglial dysregulation and neuronal loss following SAH
The contribution of T cells to neuroinflammation after aneurysmal subarachnoid hemorrhage (SAH) remains poorly understood. Using a murine pre-chiasmatic injection model of SAH we demonstrate that T ce...
www.biorxiv.org
October 21, 2025 at 3:48 PM
Tomorrow, Annie Khamhoung from Mt.Sinai will present a pre-print on the role of brain infiltrating T-cells in microglial dysregulation and neuronal loss following subarachnoid haemorrhage. @ElisaEzanier @MarioNegriIRCCS
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tomorrow at #PreprintHub2, Raisa Brito from @mdc-berlin.bsky.social will present a #preprint by Prof. Dr. Karsten Kretschmer titled “Functional Dichotomy of Developmental Foxp3+ Treg Cell Subsets in the Visceral Adipose Tissue of Lean and Obese Mice”
October 20, 2025 at 7:02 PM
Tomorrow at #PreprintHub2, Raisa Brito from @mdc-berlin.bsky.social will present a #preprint by Prof. Dr. Karsten Kretschmer titled “Functional Dichotomy of Developmental Foxp3+ Treg Cell Subsets in the Visceral Adipose Tissue of Lean and Obese Mice”
Today from MD Anderson Cancer Center, Dr. Priyanshu Srivastava presented a preprint about tumor instrinsic regulation of PD-L1 and type I IFN by the mitochondrial citrate carrier SLC25A1 @Georgetown #Avantaggiatilab
October 17, 2025 at 1:27 AM
Today from MD Anderson Cancer Center, Dr. Priyanshu Srivastava presented a preprint about tumor instrinsic regulation of PD-L1 and type I IFN by the mitochondrial citrate carrier SLC25A1 @Georgetown #Avantaggiatilab
Izabella Valdez from Mount Sinai will present a preprint from the Moriarity lab at @UMN on FAS and TGFβR2 base editing in primary T cells
October 8, 2025 at 4:42 AM
Izabella Valdez from Mount Sinai will present a preprint from the Moriarity lab at @UMN on FAS and TGFβR2 base editing in primary T cells
Today, Nicolas Ruffin from Karolinska will present a preprint from @josephsunlab.bsky.social on how STAT3 operates as an inflammation-dependent transcriptional switch!
October 8, 2025 at 4:25 AM
Today, Nicolas Ruffin from Karolinska will present a preprint from @josephsunlab.bsky.social on how STAT3 operates as an inflammation-dependent transcriptional switch!
Today at #PreprintHub2, Teresa Neuwirth from
@cemm.oeaw.ac.at will present a #preprint by
@retickerflynn.bsky.social on how Type I interferon signaling drives divergent metastatic phenotypes and immunotherapy responses 🧬🔬
www.biorxiv.org/content/10.1...
@cemm.oeaw.ac.at will present a #preprint by
@retickerflynn.bsky.social on how Type I interferon signaling drives divergent metastatic phenotypes and immunotherapy responses 🧬🔬
www.biorxiv.org/content/10.1...
Type I interferon signaling instills divergent metastatic phenotypes and immunotherapy responses
Metastatic colonization of distant tissues is responsible for most cancer deaths, yet while this colonization is typically preceded by lymph node (LN) metastasis, the clonal and functional relationshi...
www.biorxiv.org
October 7, 2025 at 11:55 AM
Today at #PreprintHub2, Teresa Neuwirth from
@cemm.oeaw.ac.at will present a #preprint by
@retickerflynn.bsky.social on how Type I interferon signaling drives divergent metastatic phenotypes and immunotherapy responses 🧬🔬
www.biorxiv.org/content/10.1...
@cemm.oeaw.ac.at will present a #preprint by
@retickerflynn.bsky.social on how Type I interferon signaling drives divergent metastatic phenotypes and immunotherapy responses 🧬🔬
www.biorxiv.org/content/10.1...
Also tomorrow from #PreprintHub1 Shelley Herbrich from MD Anderson will present a #preprint from @LHooperLab on how the gut microbiota regulates intestinal T cell development.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The gut microbiota directs vitamin A flux to regulate intestinal T cell development
The intestinal microbiota shapes adaptive immunity, but the mechanisms remain incompletely defined. Here, we show that the microbiota initiates the movement of retinoids—dietary vitamin A derivatives ...
www.biorxiv.org
September 23, 2025 at 3:36 PM
Also tomorrow from #PreprintHub1 Shelley Herbrich from MD Anderson will present a #preprint from @LHooperLab on how the gut microbiota regulates intestinal T cell development.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tomorrow #PreprintHub1 is starting for the 2025-2026 season! Laura Rosenberg from Mount Sinai will present a #preprint by the @BelkaidLab on how endogenous retroelements promote tolerance to dietary antigens.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
September 23, 2025 at 3:32 PM
Tomorrow #PreprintHub1 is starting for the 2025-2026 season! Laura Rosenberg from Mount Sinai will present a #preprint by the @BelkaidLab on how endogenous retroelements promote tolerance to dietary antigens.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...