Reposted by Miguel Soares
@elmiguelche.bsky.social from GIMM and Daniel Costa Gomes from ULSSM and FMUL are leading a project aimed at developing a multi-omics atlas for sepsis patients to identify cellular mechanisms that lead to organ failure.
February 2, 2026 at 3:30 PM
@elmiguelche.bsky.social from GIMM and Daniel Costa Gomes from ULSSM and FMUL are leading a project aimed at developing a multi-omics atlas for sepsis patients to identify cellular mechanisms that lead to organ failure.
Reposted by Miguel Soares
Two days of scientific discussion and networking will be followed by a day open to the public — reinforcing our commitment to sharing research with society.
Secure your ticket!
🔗 Get your ticket: fest.gimm.pt
🎟️ Early bird special rates
Secure your ticket!
🔗 Get your ticket: fest.gimm.pt
🎟️ Early bird special rates
February 6, 2026 at 5:42 PM
Two days of scientific discussion and networking will be followed by a day open to the public — reinforcing our commitment to sharing research with society.
Secure your ticket!
🔗 Get your ticket: fest.gimm.pt
🎟️ Early bird special rates
Secure your ticket!
🔗 Get your ticket: fest.gimm.pt
🎟️ Early bird special rates
Reposted by Miguel Soares
GIMM Fest returns September 17–19 with three days dedicated to the future of science and health, this year focusing on microbes. 🦠
Join researchers and innovators for a programme designed to promote scientific exchange and collaboration.
Join researchers and innovators for a programme designed to promote scientific exchange and collaboration.
February 6, 2026 at 5:42 PM
GIMM Fest returns September 17–19 with three days dedicated to the future of science and health, this year focusing on microbes. 🦠
Join researchers and innovators for a programme designed to promote scientific exchange and collaboration.
Join researchers and innovators for a programme designed to promote scientific exchange and collaboration.
The great Ruslan Medzhitov strikes again!
On the balance of knowledge
Nature Reviews Immunology - Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern...
www.nature.com
February 7, 2026 at 11:12 AM
The great Ruslan Medzhitov strikes again!
Reposted by Miguel Soares
Join us for the 2026 GRC Immunochemistry and Immunobiology "Immune Circuitry and Molecular Pathways in Tissue Homeostasis, Infection, and Disease" in beautiful Barcelona. June 28 - July 3, 2026. Great lineup of speakers! www.grc.org/immunochemis...
2026 Immunochemistry and Immunobiology Conference GRC
The 2026 Gordon Research Conference on Immunochemistry and Immunobiology will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.
www.grc.org
February 4, 2026 at 6:24 AM
Join us for the 2026 GRC Immunochemistry and Immunobiology "Immune Circuitry and Molecular Pathways in Tissue Homeostasis, Infection, and Disease" in beautiful Barcelona. June 28 - July 3, 2026. Great lineup of speakers! www.grc.org/immunochemis...
Incredible science at the CAML-GIMM PhD Meeting 2026! So proud of the outstanding presentations from our GIMM students across both campuses. 🧬
The meeting showcased "home made" cutting-edge research!
Congratulations to Sonia Trikha, Madalena Pereira and Miguel Mesquita!
@gimmfoundation.bsky.social
The meeting showcased "home made" cutting-edge research!
Congratulations to Sonia Trikha, Madalena Pereira and Miguel Mesquita!
@gimmfoundation.bsky.social
January 29, 2026 at 2:08 PM
Incredible science at the CAML-GIMM PhD Meeting 2026! So proud of the outstanding presentations from our GIMM students across both campuses. 🧬
The meeting showcased "home made" cutting-edge research!
Congratulations to Sonia Trikha, Madalena Pereira and Miguel Mesquita!
@gimmfoundation.bsky.social
The meeting showcased "home made" cutting-edge research!
Congratulations to Sonia Trikha, Madalena Pereira and Miguel Mesquita!
@gimmfoundation.bsky.social
Reposted by Miguel Soares
#DirtyIsBetter! @rmedzhitov.bsky.social, Erickson &co show @nature.com that pet shop mice are protected from #allergy thanks to cross reactive type I (or tolerogenic) immune memory that prevents type II allergen-driven responses! doi.org/10.1038/s415...
Environmentally driven immune imprinting protects against allergy - Nature
In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship be...
doi.org
January 28, 2026 at 10:37 PM
#DirtyIsBetter! @rmedzhitov.bsky.social, Erickson &co show @nature.com that pet shop mice are protected from #allergy thanks to cross reactive type I (or tolerogenic) immune memory that prevents type II allergen-driven responses! doi.org/10.1038/s415...
Ageing rewires the body’s tolerance to infection www.nature.com/articles/d41...
Ageing rewires the body’s tolerance to infection
In life-threatening sepsis, the same signalling pathway that protects young mice from succumbing to organ dysfunction exacerbates damage and lethality in older animals.
www.nature.com
January 18, 2026 at 10:20 AM
Ageing rewires the body’s tolerance to infection www.nature.com/articles/d41...
Reposted by Miguel Soares
#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...
TLR4al senses heme as a key damage/danger-associated molecular pattern to activate immune responses in lower vertebrates
Abstract. Toll-like receptor 4 (TLR4), a critical pattern recognition receptor, detects microbe- and damage/danger-associated molecular patterns to trigger
academic.oup.com
January 11, 2026 at 3:58 PM
#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...
This is not an anomaly. It is a method.
Correction becomes harassment
Public discourse becomes “stalking”
Expertise becomes abuse
Evidence is replaced by narrative
Sex and victimhood are instrumentalised
Reputation damage is the objective
Correction becomes harassment
Public discourse becomes “stalking”
Expertise becomes abuse
Evidence is replaced by narrative
Sex and victimhood are instrumentalised
Reputation damage is the objective
Disinformation: When falsehoods become a political identity
How storytelling is used as "investigation".
marcveldhoen.substack.com
January 11, 2026 at 10:39 AM
This is not an anomaly. It is a method.
Correction becomes harassment
Public discourse becomes “stalking”
Expertise becomes abuse
Evidence is replaced by narrative
Sex and victimhood are instrumentalised
Reputation damage is the objective
Correction becomes harassment
Public discourse becomes “stalking”
Expertise becomes abuse
Evidence is replaced by narrative
Sex and victimhood are instrumentalised
Reputation damage is the objective
Reposted by Miguel Soares
New research led by @karinaxavierlab.bsky.social at 🇵🇹 @gimmfoundation.bsky.social demonstrates that a harmless strain of 🦠 #Klebsiella – discovered by chance in 🧫 laboratory experiments – can eliminate #infections and reduce gut inflammation in mouse models of inflammatory bowel disease. #IBD
Klebsiella strain to protect against IBD gut infections
A team of researchers led by Karina Xavier has uncovered a promising new live biotherapeutic agent that may redefine how the medical field approaches microbiota-based therapies.
healthcare-in-europe.com
December 22, 2025 at 8:17 AM
New research led by @karinaxavierlab.bsky.social at 🇵🇹 @gimmfoundation.bsky.social demonstrates that a harmless strain of 🦠 #Klebsiella – discovered by chance in 🧫 laboratory experiments – can eliminate #infections and reduce gut inflammation in mouse models of inflammatory bowel disease. #IBD
1/10 🧵NEW PREPRINT: How does jaundice protect against malaria? We show it's ALL about biliverdin reductase (BVRA) catalytic activity and found the bilirubin threshold needed for protection.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Biliverdin Reductase Catalytic Activity Is Essential for Malaria Resistance
Jaundice, a condition characterized by elevated levels of circulating bilirubin, is an adaptive response to malaria sustained through bilirubin production by biliverdin reductase A (BVRA). Beyond its ...
www.biorxiv.org
December 26, 2025 at 11:25 AM
1/10 🧵NEW PREPRINT: How does jaundice protect against malaria? We show it's ALL about biliverdin reductase (BVRA) catalytic activity and found the bilirubin threshold needed for protection.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Miguel Soares
@EMBO Practical Course
Pipetting scRNA-seq data into computational cells
18 – 23 May 2026 | Oeiras/Lisbon, Portugal @gimmfoundation.bsky.social
Registration open!
Pipetting scRNA-seq data into computational cells
18 – 23 May 2026 | Oeiras/Lisbon, Portugal @gimmfoundation.bsky.social
Registration open!
Pipetting scRNA-seq data into computational cells
Single-cell transcriptomics is transforming biology, uncovering hidden cell states, dynamic transitions, and intricate interactions across systems from immunity to cancer. Yet as these technologies s…
meetings.embo.org
November 23, 2025 at 11:37 AM
@EMBO Practical Course
Pipetting scRNA-seq data into computational cells
18 – 23 May 2026 | Oeiras/Lisbon, Portugal @gimmfoundation.bsky.social
Registration open!
Pipetting scRNA-seq data into computational cells
18 – 23 May 2026 | Oeiras/Lisbon, Portugal @gimmfoundation.bsky.social
Registration open!
Reposted by Miguel Soares
Homeostatic control of energy metabolism by monocyte-derived macrophages
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
November 19, 2025 at 3:20 PM
Homeostatic control of energy metabolism by monocyte-derived macrophages
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism.
www.embopress.org/doi/full/10....
(1/9)
www.embopress.org/doi/full/10....
(1/9)
Homeostatic control of energy metabolism by monocyte-derived macrophages | The EMBO Journal
imageimageMacrophages play critical roles in the homeostatic control systems that maintain vital
parameters within physiological ranges. This study characterizes how mouse monocyte-derived
macrophages...
www.embopress.org
November 19, 2025 at 2:11 PM
🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism.
www.embopress.org/doi/full/10....
(1/9)
www.embopress.org/doi/full/10....
(1/9)
Reposted by Miguel Soares
of the influenza vaccine is low (against infection). What is forgotten is the protection from non-communicable diseases.
What if you could reduce your risk to heart disease by 40%?
What is you could reduce you risk to dementia by at least 10%?
That is what vaccines do!
3/10
What if you could reduce your risk to heart disease by 40%?
What is you could reduce you risk to dementia by at least 10%?
That is what vaccines do!
3/10
September 19, 2025 at 2:15 PM
of the influenza vaccine is low (against infection). What is forgotten is the protection from non-communicable diseases.
What if you could reduce your risk to heart disease by 40%?
What is you could reduce you risk to dementia by at least 10%?
That is what vaccines do!
3/10
What if you could reduce your risk to heart disease by 40%?
What is you could reduce you risk to dementia by at least 10%?
That is what vaccines do!
3/10
Food for thought from:
@lferreiramoita.bsky.social in JCI - Biological and clinical implications of a model of surveillance immunity www.jci.org/articles/vie...
@lferreiramoita.bsky.social in JCI - Biological and clinical implications of a model of surveillance immunity www.jci.org/articles/vie...
JCI -
Biological and clinical implications of a model of surveillance immunity
www.jci.org
August 5, 2025 at 9:37 AM
Food for thought from:
@lferreiramoita.bsky.social in JCI - Biological and clinical implications of a model of surveillance immunity www.jci.org/articles/vie...
@lferreiramoita.bsky.social in JCI - Biological and clinical implications of a model of surveillance immunity www.jci.org/articles/vie...
Reposted by Miguel Soares
Beautiful new work from Maz Divangahi lab about the enhanced anti-tumoral activity of β-glucan + BCG trained neutrophils leading to tumor eradication.
#freshoffthepress @cp-immunity.bsky.social
#freshoffthepress @cp-immunity.bsky.social
Combining BCG with β-glucan reprograms granulopoiesis to generate trained neutrophils with enhanced antitumoral activity, preventing their protumoral conversion and leading to complete tumor eradication @cp-immunity.bsky.social www.cell.com/immunity/ful...
June 23, 2025 at 9:57 PM
Beautiful new work from Maz Divangahi lab about the enhanced anti-tumoral activity of β-glucan + BCG trained neutrophils leading to tumor eradication.
#freshoffthepress @cp-immunity.bsky.social
#freshoffthepress @cp-immunity.bsky.social
Reposted by Miguel Soares
A recent study based on observations in humans and experiments in mice proposes that induction of bilirubin production in response to Plasmodium spp. infection is an evolutionary conserved mechanism against malaria. 🧪 www.science.org/doi/10.1126/...
June 20, 2025 at 3:30 PM
A recent study based on observations in humans and experiments in mice proposes that induction of bilirubin production in response to Plasmodium spp. infection is an evolutionary conserved mechanism against malaria. 🧪 www.science.org/doi/10.1126/...
Reposted by Miguel Soares
Rewring lipid metabolism to sustain thermoregulation during sepsis. Don’t let it get cold! A very interesting piece from Miguel Soares lab @elmiguelche.bsky.social @gimmfoundation.bsky.social
A bioenergetic basis for multiorgan dysfunction in sepsis https://www.biorxiv.org/content/10.1101/2025.06.12.659280v1
June 18, 2025 at 8:34 AM
Rewring lipid metabolism to sustain thermoregulation during sepsis. Don’t let it get cold! A very interesting piece from Miguel Soares lab @elmiguelche.bsky.social @gimmfoundation.bsky.social
Reposted by Miguel Soares
The future of heart health: AI, immunity, and personalized prevention | Science | AAAS www.science.org/content/webi...
The future of heart health: AI, immunity, and personalized prevention
www.science.org
June 20, 2025 at 7:49 PM
The future of heart health: AI, immunity, and personalized prevention | Science | AAAS www.science.org/content/webi...
Reposted by Miguel Soares
Call for our new PhD program is open. Come join one of our labs at Gulbenkian Institute for Molecular Medicine - Lisbon-Oeiras, Portugal. Help us spread the word
Exciting opportunities are now available!
GIMM offers a distinctive PhD Program designed to attract & cultivate highly skilled researchers in biology & biomedicine.
Deadline: July 9
👉 Apply now! gimm.pt/education-and-training/phd-program/
GIMM offers a distinctive PhD Program designed to attract & cultivate highly skilled researchers in biology & biomedicine.
Deadline: July 9
👉 Apply now! gimm.pt/education-and-training/phd-program/
June 17, 2025 at 7:03 PM
Call for our new PhD program is open. Come join one of our labs at Gulbenkian Institute for Molecular Medicine - Lisbon-Oeiras, Portugal. Help us spread the word
Reposted by Miguel Soares
A bioenergetic basis for multiorgan dysfunction in sepsis https://www.biorxiv.org/content/10.1101/2025.06.12.659280v1
June 17, 2025 at 9:00 PM
A bioenergetic basis for multiorgan dysfunction in sepsis https://www.biorxiv.org/content/10.1101/2025.06.12.659280v1
Reposted by Miguel Soares
Check out the paper from our latest collaboration with Miguel Soares's lab:
🦠A metabolite-based resistance mechanism against malaria
Now out in Science: www.science.org/doi/10.1126/...
@gimmfoundation.bsky.social @turkubioscience.bsky.social @inflames-flagship.bsky.social @utu.fi
🦠A metabolite-based resistance mechanism against malaria
Now out in Science: www.science.org/doi/10.1126/...
@gimmfoundation.bsky.social @turkubioscience.bsky.social @inflames-flagship.bsky.social @utu.fi
Turun biotiedekeskuksen tutkijat olivat mukana kansainvälisessä tutkimuksessa, jossa löydettiin uusi puolustuskeino malariaa vastaan.
Tutkimuksessa kävi ilmi, että keltaisuus toimii elimistön luonnollisena suojamekanismina malarialoisen aiheuttamaa infektiota vastaan.
www.utu.fi/fi/ajankohta...
Tutkimuksessa kävi ilmi, että keltaisuus toimii elimistön luonnollisena suojamekanismina malarialoisen aiheuttamaa infektiota vastaan.
www.utu.fi/fi/ajankohta...
Tutkijat löysivät uuden puolustuskeinon malariaa vastaan – keltaisuus toimii elimistön luonnollisena suojamekanismina
Turun yliopiston biotiedekeskuksen tutkijat ovat olleet mukana merkittävässä kansainvälisessä tutkimuksessa, joka paljasti keltaisuuden uudenlaisen roolin elimistön luonnollisena puolustuskeinona m
www.utu.fi
June 13, 2025 at 8:40 AM
Check out the paper from our latest collaboration with Miguel Soares's lab:
🦠A metabolite-based resistance mechanism against malaria
Now out in Science: www.science.org/doi/10.1126/...
@gimmfoundation.bsky.social @turkubioscience.bsky.social @inflames-flagship.bsky.social @utu.fi
🦠A metabolite-based resistance mechanism against malaria
Now out in Science: www.science.org/doi/10.1126/...
@gimmfoundation.bsky.social @turkubioscience.bsky.social @inflames-flagship.bsky.social @utu.fi