BrownLab @Mt.Sinai
@brownlab1.bsky.social
Our new review in @natbiomedeng.nature.com is out!
RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits.
free to read 🔗 rdcu.be/eLxGs
RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits.
free to read 🔗 rdcu.be/eLxGs
Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level
Nature Biomedical Engineering - This Review explores strategies for targeting and tracking RNA-LNP drugs, monitoring their in vivo behaviour, enhancing tissue-specific delivery, and using synthetic...
rdcu.be
October 17, 2025 at 5:16 PM
Our new review in @natbiomedeng.nature.com is out!
RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits.
free to read 🔗 rdcu.be/eLxGs
RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits.
free to read 🔗 rdcu.be/eLxGs
Reposted by BrownLab @Mt.Sinai
E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.
Read more: e11.bio/blog/prism
Read more: e11.bio/blog/prism
October 1, 2025 at 2:16 PM
E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.
Read more: e11.bio/blog/prism
Read more: e11.bio/blog/prism
Reposted by BrownLab @Mt.Sinai
Add your name ✍ at www.nycures.org so Albany sees 10,000 scientists calling for the future of biomedical research to be built right here in New York.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
October 15, 2025 at 12:55 PM
Add your name ✍ at www.nycures.org so Albany sees 10,000 scientists calling for the future of biomedical research to be built right here in New York.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
Reposted by BrownLab @Mt.Sinai
Wondering what *exactly* we’re up to?
Our first coalition email is about to go out—introducing the statewide biomedical institute we’re proposing and how you can help power it forward THIS WEEK!
Sign up now so you don’t miss it: www.nycures.org/
Our first coalition email is about to go out—introducing the statewide biomedical institute we’re proposing and how you can help power it forward THIS WEEK!
Sign up now so you don’t miss it: www.nycures.org/
October 9, 2025 at 1:18 PM
Wondering what *exactly* we’re up to?
Our first coalition email is about to go out—introducing the statewide biomedical institute we’re proposing and how you can help power it forward THIS WEEK!
Sign up now so you don’t miss it: www.nycures.org/
Our first coalition email is about to go out—introducing the statewide biomedical institute we’re proposing and how you can help power it forward THIS WEEK!
Sign up now so you don’t miss it: www.nycures.org/
Reposted by BrownLab @Mt.Sinai
From patient to scientist: Sergei German beat cancer thanks to clinical trials, inspiring him to leave his career in finance and drive research @nygenome.org
A NY statewide biomedical institute will make more incredible stories like his possible.
Help make this happen, sign up at www.nycures.org/
A NY statewide biomedical institute will make more incredible stories like his possible.
Help make this happen, sign up at www.nycures.org/
New York Cures – NY-CURESNew York Cures Website
NY-CURES is working to advance bold, state-backed investment in biomedical research—on the scale of successful initiatives in California and Texas—to grow New York’s leadership in science, innovation, and health.
www.nycures.org
October 8, 2025 at 3:20 PM
From patient to scientist: Sergei German beat cancer thanks to clinical trials, inspiring him to leave his career in finance and drive research @nygenome.org
A NY statewide biomedical institute will make more incredible stories like his possible.
Help make this happen, sign up at www.nycures.org/
A NY statewide biomedical institute will make more incredible stories like his possible.
Help make this happen, sign up at www.nycures.org/
Reposted by BrownLab @Mt.Sinai
Scientists—let’s use our agency!
NY-CURES is championing a landmark statewide biomedical institute for New York, built to restore and grow science for all
Working FOR a brighter future gives us hope, purpose, and momentum.
Want to be part of it? Follow us + DM—we’ve got many ways to get involved.
NY-CURES is championing a landmark statewide biomedical institute for New York, built to restore and grow science for all
Working FOR a brighter future gives us hope, purpose, and momentum.
Want to be part of it? Follow us + DM—we’ve got many ways to get involved.
October 7, 2025 at 3:00 PM
Scientists—let’s use our agency!
NY-CURES is championing a landmark statewide biomedical institute for New York, built to restore and grow science for all
Working FOR a brighter future gives us hope, purpose, and momentum.
Want to be part of it? Follow us + DM—we’ve got many ways to get involved.
NY-CURES is championing a landmark statewide biomedical institute for New York, built to restore and grow science for all
Working FOR a brighter future gives us hope, purpose, and momentum.
Want to be part of it? Follow us + DM—we’ve got many ways to get involved.
Reposted by BrownLab @Mt.Sinai
The BIGGEST impact you can have with 1 minute today ⏱️
Add your name to show NY is ready for a statewide biomedical institute.
CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York.
✍️ www.nycures.org/
Add your name to show NY is ready for a statewide biomedical institute.
CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York.
✍️ www.nycures.org/
New York Cures – NY-CURESNew York Cures Website
NY-CURES is working to advance bold, state-backed investment in biomedical research—on the scale of successful initiatives in California and Texas—to grow New York’s leadership in science, innovation, and health.
www.nycures.org
October 2, 2025 at 4:23 PM
The BIGGEST impact you can have with 1 minute today ⏱️
Add your name to show NY is ready for a statewide biomedical institute.
CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York.
✍️ www.nycures.org/
Add your name to show NY is ready for a statewide biomedical institute.
CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York.
✍️ www.nycures.org/
Reposted by BrownLab @Mt.Sinai
“States like New York have an opportunity to position ourselves as real leaders in so many different areas.” @governor.ny.gov
Like her, we believe NY is ready for revitalization—by launching a state-wide biomedical institute that boosts jobs, the economy & cures. www.youtube.com/watch?v=WVtF...
Like her, we believe NY is ready for revitalization—by launching a state-wide biomedical institute that boosts jobs, the economy & cures. www.youtube.com/watch?v=WVtF...
A Conversation with New York Governor Kathy Hochul | 2025 Concordia Annual Summit
YouTube video by Concordia
www.youtube.com
September 29, 2025 at 4:50 PM
“States like New York have an opportunity to position ourselves as real leaders in so many different areas.” @governor.ny.gov
Like her, we believe NY is ready for revitalization—by launching a state-wide biomedical institute that boosts jobs, the economy & cures. www.youtube.com/watch?v=WVtF...
Like her, we believe NY is ready for revitalization—by launching a state-wide biomedical institute that boosts jobs, the economy & cures. www.youtube.com/watch?v=WVtF...
Reposted by BrownLab @Mt.Sinai
Behind every scientist is an army of workers who keep the biomedical research ecosystem running. Hear from these workers and how they contribute at www.nycures.org/ and SIGN UP to have your voice heard!
September 25, 2025 at 12:16 AM
Behind every scientist is an army of workers who keep the biomedical research ecosystem running. Hear from these workers and how they contribute at www.nycures.org/ and SIGN UP to have your voice heard!
Reposted by BrownLab @Mt.Sinai
🔬Our paper from the @miriammerad.bsky.social lab is now online! This is a story shaped over years of cross-disciplinary endeavor at @sinaiimmuno.bsky.social and labs across the world. 🧵:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature
An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...
www.nature.com
September 22, 2025 at 12:41 PM
🔬Our paper from the @miriammerad.bsky.social lab is now online! This is a story shaped over years of cross-disciplinary endeavor at @sinaiimmuno.bsky.social and labs across the world. 🧵:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by BrownLab @Mt.Sinai
Research powerhouses 💪 in @forbes.com Best-in-State list with @roswellpark.bsky.social in NY top10 🏆.
Also listed: @stonybrooku.bsky.social @mskcancercenter.bsky.social @northwellhealth.bsky.social.
To keep more talent here we must invest statewide in biomedicine. www.forbes.com/lists/best-e...
Also listed: @stonybrooku.bsky.social @mskcancercenter.bsky.social @northwellhealth.bsky.social.
To keep more talent here we must invest statewide in biomedicine. www.forbes.com/lists/best-e...
Forbes Best Employers By State 2025 List - Best Companies To Work For
Forbes ranks the best employers to work for in each state. Discover companies with great benefits, excellent workplace culture, and high employee satisfaction.
www.forbes.com
September 18, 2025 at 6:23 PM
Research powerhouses 💪 in @forbes.com Best-in-State list with @roswellpark.bsky.social in NY top10 🏆.
Also listed: @stonybrooku.bsky.social @mskcancercenter.bsky.social @northwellhealth.bsky.social.
To keep more talent here we must invest statewide in biomedicine. www.forbes.com/lists/best-e...
Also listed: @stonybrooku.bsky.social @mskcancercenter.bsky.social @northwellhealth.bsky.social.
To keep more talent here we must invest statewide in biomedicine. www.forbes.com/lists/best-e...
Reposted by BrownLab @Mt.Sinai
New York leads in science & medicine but without state investment, we risk losing talent, cures, jobs, & billions in economic return.
Every $1 California invested in biomedical research returned $4 to the state economy. This isn’t just science—it’s smart economics: www.cirm.ca.gov/our-impact/
Every $1 California invested in biomedical research returned $4 to the state economy. This isn’t just science—it’s smart economics: www.cirm.ca.gov/our-impact/
Impact Across California – CIRM
For two decades, CIRM has been at the forefront of regenerative medicine, funding over 100 clinical trials and building the infrastructure that drives innovation in stem cell and gene therapies.
www.cirm.ca.gov
September 16, 2025 at 4:02 PM
New York leads in science & medicine but without state investment, we risk losing talent, cures, jobs, & billions in economic return.
Every $1 California invested in biomedical research returned $4 to the state economy. This isn’t just science—it’s smart economics: www.cirm.ca.gov/our-impact/
Every $1 California invested in biomedical research returned $4 to the state economy. This isn’t just science—it’s smart economics: www.cirm.ca.gov/our-impact/
Science transforms lives and now New York has a chance to lead with NY-CURES!
This new coalition is pushing for statewide commitment to research that fuels discoveries, therapies, and opportunity.
Learn more & sign up today to help make it happen: nycures.org
This new coalition is pushing for statewide commitment to research that fuels discoveries, therapies, and opportunity.
Learn more & sign up today to help make it happen: nycures.org
September 15, 2025 at 7:13 PM
Science transforms lives and now New York has a chance to lead with NY-CURES!
This new coalition is pushing for statewide commitment to research that fuels discoveries, therapies, and opportunity.
Learn more & sign up today to help make it happen: nycures.org
This new coalition is pushing for statewide commitment to research that fuels discoveries, therapies, and opportunity.
Learn more & sign up today to help make it happen: nycures.org
Reposted by BrownLab @Mt.Sinai
🚨 Our new #preprint is out!
doi.org/10.1101/2025...
We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)
doi.org/10.1101/2025...
We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)
doi.org
June 18, 2025 at 1:29 PM
🚨 Our new #preprint is out!
doi.org/10.1101/2025...
We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)
doi.org/10.1101/2025...
We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)
We need to let elected Reps know how destructive White House policies are for medical science. American Institute for Medical & Bio Eng has a link to send your senators and representatives an email (below). Easy to do. make your voice heard and share with colleagues.
aimbe.org/advocate/wri...
aimbe.org/advocate/wri...
Write Your Lawmakers - AIMBE
aimbe.org
February 12, 2025 at 12:35 AM
We need to let elected Reps know how destructive White House policies are for medical science. American Institute for Medical & Bio Eng has a link to send your senators and representatives an email (below). Easy to do. make your voice heard and share with colleagues.
aimbe.org/advocate/wri...
aimbe.org/advocate/wri...
Reposted by BrownLab @Mt.Sinai
First lab Bluesky post! Happy to share new papers:
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
Ovarian cancer-derived IL-4 promotes immunotherapy resistance
Cancer-derived paracrine factors create distinct “neighborhoods” in the tumor microenvironment,
promoting clonal selection and tumor heterogeneity. In ovarian cancer, IL-4 originating
from a minority ...
www.cell.com
January 15, 2025 at 5:34 PM
First lab Bluesky post! Happy to share new papers:
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
First lab Bluesky post! Happy to share new papers:
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
Ovarian cancer-derived IL-4 promotes immunotherapy resistance
Cancer-derived paracrine factors create distinct “neighborhoods” in the tumor microenvironment,
promoting clonal selection and tumor heterogeneity. In ovarian cancer, IL-4 originating
from a minority ...
www.cell.com
January 15, 2025 at 5:34 PM
First lab Bluesky post! Happy to share new papers:
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...