Intermittent Fasting
@ifdiet.bsky.social
Steve Mount on intermittent fasting, metabolic health, aging and longevity, with a focus on the science.
Intermittent fasting is sustainable; I've been at it for over 20 years.
Intermittent fasting is sustainable; I've been at it for over 20 years.
Alternate day fasting (which I've done for 21 yrs) seems best.
"more substantial weight losses ... accompanied by reductions in visceral fat and cardiometabolic improvements." "lowered total cholesterol, triglycerides, and non-high density lipoprotein"
www.bmj.com/content/389/...
"more substantial weight losses ... accompanied by reductions in visceral fat and cardiometabolic improvements." "lowered total cholesterol, triglycerides, and non-high density lipoprotein"
www.bmj.com/content/389/...
Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials
Objective
To assess the effect of intermittent fasting diets, with continuous energy restriction or unrestricted (ad-libitum) diets on intermediate cardiometabolic outcomes from randomised clinical ...
www.bmj.com
June 23, 2025 at 12:51 AM
Alternate day fasting (which I've done for 21 yrs) seems best.
"more substantial weight losses ... accompanied by reductions in visceral fat and cardiometabolic improvements." "lowered total cholesterol, triglycerides, and non-high density lipoprotein"
www.bmj.com/content/389/...
"more substantial weight losses ... accompanied by reductions in visceral fat and cardiometabolic improvements." "lowered total cholesterol, triglycerides, and non-high density lipoprotein"
www.bmj.com/content/389/...
This is a very important story. The government essentially censored news reports about a taxpayer-funded study because they feared that it might reflect badly on RFK Jr.
WATCH: Dr. Kevin Hall is departing NIH after 21 years at his “dream job.” He says his research findings were being censored under RFK Jr.
"What is it going to be like if they want to start actually meddling in the research itself?"
April 18, 2025 at 6:24 PM
This is a very important story. The government essentially censored news reports about a taxpayer-funded study because they feared that it might reflect badly on RFK Jr.
Reposted by Intermittent Fasting
On the cyclic benefits of intermittent fasting and metabolic switching, this is an outstanding new perspective @naturemetabolism.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
March 14, 2025 at 1:56 PM
On the cyclic benefits of intermittent fasting and metabolic switching, this is an outstanding new perspective @naturemetabolism.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Varady remains unconvinced of effects independent of calorie restriction. “... I don’t think that there are any benefits ... beyond weight loss,” she says.
Mattson is equally sure of the opposite: “... considerable evidence of benefits ... that cannot be explained by reduction in calorie intake.”"
Mattson is equally sure of the opposite: “... considerable evidence of benefits ... that cannot be explained by reduction in calorie intake.”"
Intermittent fasting has gained a following, in part because of tantalizing hints that it can boost cognition, fend off cancer and even slow ageing
https://go.nature.com/4iF4Z5u
https://go.nature.com/4iF4Z5u
Fasting for weight loss is all the rage: what are the health benefits?
Intermittent fasting has gained a following, in part because of tantalizing hints that it can boost cognition, fend off cancer and even slow ageing.
go.nature.com
March 26, 2025 at 5:50 PM
Varady remains unconvinced of effects independent of calorie restriction. “... I don’t think that there are any benefits ... beyond weight loss,” she says.
Mattson is equally sure of the opposite: “... considerable evidence of benefits ... that cannot be explained by reduction in calorie intake.”"
Mattson is equally sure of the opposite: “... considerable evidence of benefits ... that cannot be explained by reduction in calorie intake.”"
Reposted by Intermittent Fasting
Everything you ever wanted to know about the science behind intermittent fasting… as always, many questions remain open but there are suggestions that its effects might not be simply a function of calorie restriction…
🧪 @nature.com
www.nature.com/articles/d41...
🧪 @nature.com
www.nature.com/articles/d41...
Fasting for weight loss is all the rage: what are the health benefits?
Intermittent fasting has gained a following, in part because of tantalizing hints that it can boost cognition, fend off cancer and even slow ageing.
www.nature.com
March 26, 2025 at 7:07 AM
Everything you ever wanted to know about the science behind intermittent fasting… as always, many questions remain open but there are suggestions that its effects might not be simply a function of calorie restriction…
🧪 @nature.com
www.nature.com/articles/d41...
🧪 @nature.com
www.nature.com/articles/d41...
If you are a scientist, or a nutritionist who follows the science, and you think beef tallow is healthier than seed oils, or if you just avoid seed oils, tell me why.
I'm looking for citations.
I'm looking for citations.
March 21, 2025 at 8:23 PM
If you are a scientist, or a nutritionist who follows the science, and you think beef tallow is healthier than seed oils, or if you just avoid seed oils, tell me why.
I'm looking for citations.
I'm looking for citations.
Wake up and drink your coffee!
"Lower risks of all-cause mortality and cardiovascular mortality were observed in people who mostly drank coffee in the morning."
If you keep drinking coffee all day, not so much.
www.medpagetoday.com/primarycare/...
"Lower risks of all-cause mortality and cardiovascular mortality were observed in people who mostly drank coffee in the morning."
If you keep drinking coffee all day, not so much.
www.medpagetoday.com/primarycare/...
Coffee Drinking Tied to Better Survival, but Timing Matters
Lower risk of all-cause and cardiovascular mortality observed only among morning drinkers
www.medpagetoday.com
January 11, 2025 at 2:22 PM
Wake up and drink your coffee!
"Lower risks of all-cause mortality and cardiovascular mortality were observed in people who mostly drank coffee in the morning."
If you keep drinking coffee all day, not so much.
www.medpagetoday.com/primarycare/...
"Lower risks of all-cause mortality and cardiovascular mortality were observed in people who mostly drank coffee in the morning."
If you keep drinking coffee all day, not so much.
www.medpagetoday.com/primarycare/...
Reposted by Intermittent Fasting
There is no scenario where RFK Jr should be anywhere near HHS. Reporters, pundits and politicians trying to normalize this nomination are complicit in the coming disaster his rise represents. www.nbcnews.com/news/amp/rcn...
Thousands of doctors urge Senate to block RFK Jr. as health secretary for Trump administration
Their letter calls the choice of Robert F. Kennedy Jr., who is known for promoting false medical claims, “a slap in the face” to health care professionals.
www.nbcnews.com
January 9, 2025 at 11:04 PM
There is no scenario where RFK Jr should be anywhere near HHS. Reporters, pundits and politicians trying to normalize this nomination are complicit in the coming disaster his rise represents. www.nbcnews.com/news/amp/rcn...
The short-chain fatty acids (SCFAs) have beneficial health effects, are produced by microbial metabolism and are unique acyl lysine histone marks. These papers show that the last bit is important; it's a mechanism by which the microbiome alters gene expression.
How eating fiber->short-chain fatty acid (SCFA) metabolites->anti-cancer effects
nature.com/articles/s42...
nature.com/articles/s42...
nature.com/articles/s42...
nature.com/articles/s42...
January 9, 2025 at 3:30 PM
The short-chain fatty acids (SCFAs) have beneficial health effects, are produced by microbial metabolism and are unique acyl lysine histone marks. These papers show that the last bit is important; it's a mechanism by which the microbiome alters gene expression.
Interest in intermittent fasting appears to be lessening. There is an annual peak in Google searches right around this time of year, with the highest being 2020. Maybe this reflects the fact that most people already know what they want to know.
January 8, 2025 at 4:20 PM
Interest in intermittent fasting appears to be lessening. There is an annual peak in Google searches right around this time of year, with the highest being 2020. Maybe this reflects the fact that most people already know what they want to know.
I would favor allowing states to decide. Maybe Illinois wants to be Eastern with no time change, Alaska wants a time change, Florida wants Atlantic time (aka Eastern with permanent daylight savings). Let them.
This does not scare me in the slightest. Bring it on! www.washingtonpost.com/nation/inter...
No daylight saving time? See how early or late you would be in the dark.
Would you be okay if the sun rose before 4 a.m., or after 10? Not changing clocks is a popular idea, but we’d have to live with the extremes.
www.washingtonpost.com
December 15, 2024 at 4:41 PM
I would favor allowing states to decide. Maybe Illinois wants to be Eastern with no time change, Alaska wants a time change, Florida wants Atlantic time (aka Eastern with permanent daylight savings). Let them.
Reposted by Intermittent Fasting
And you want something to do? WRITE AND CALL YOUR SENATORS NOW.
So in November, there were a few Democrats (e.g., Polis, Booker), some pundits (e.g. Wen, Oster, Bedard) doing maybe-he's-got-a-point-two-step with RFK Jr. How's your guy doing now? It was a mistake to indulge him then and still is now. www.reuters.com/world/us/tru...
Trump to discuss ending childhood vaccination programs with RFK Jr.
U.S. President-elect Donald Trump in an interview published on Thursday said he will be talking to Robert F. Kennedy Jr., his nominee to run the Department of Health and Human Services, about ending childhood vaccination programs.
www.reuters.com
December 13, 2024 at 11:59 AM
And you want something to do? WRITE AND CALL YOUR SENATORS NOW.
The cardioprotective and anti-arthritic consequences of fasting are reported to depend on spermidine, acting via autophagy induction and hypusination of the translation regulator eIF5A.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Spermidine is essential for fasting-mediated autophagy and longevity - Nature Cell Biology
Hofer et al. show that fasting promotes the synthesis of spermidine, which stimulates eIF5A hypusination to induce autophagy and increase lifespan in various species in a conserved manner.
www.nature.com
December 13, 2024 at 9:44 PM
The cardioprotective and anti-arthritic consequences of fasting are reported to depend on spermidine, acting via autophagy induction and hypusination of the translation regulator eIF5A.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Intermittent Fasting
And now this. My father had polio when he was a child in the 1930s. He thankfully survived. Many did not. This is, well, evil. Let's not mince words. www.nytimes.com/2024/12/13/h...
Kennedy’s Lawyer Has Asked the F.D.A. to Revoke Approval of the Polio Vaccine
Aaron Siri, who specializes in vaccine lawsuits, has been at Robert F. Kennedy Jr.’s side reviewing candidates for top jobs at the Department of Health and Human Services.
www.nytimes.com
December 13, 2024 at 11:49 AM
And now this. My father had polio when he was a child in the 1930s. He thankfully survived. Many did not. This is, well, evil. Let's not mince words. www.nytimes.com/2024/12/13/h...
Reposted by Intermittent Fasting
Changes in RNA structure (3' UTR, alternative splicing) and base modifications with age in C. elegans, a new paper from Schiksnis et al. (Pasquinelli lab)
This new paper is at the intersection of my core scientific interest (RNA processing) and aging.
academic.oup.com/nar/advance-...
This new paper is at the intersection of my core scientific interest (RNA processing) and aging.
academic.oup.com/nar/advance-...
Full-length direct RNA sequencing reveals extensive remodeling of RNA expression, processing and modification in aging Caenorhabditis elegans
Abstract. Organismal aging is marked by decline in cellular function and anatomy, ultimately resulting in death. To inform our understanding of the mechani
academic.oup.com
December 2, 2024 at 1:53 AM
Changes in RNA structure (3' UTR, alternative splicing) and base modifications with age in C. elegans, a new paper from Schiksnis et al. (Pasquinelli lab)
This new paper is at the intersection of my core scientific interest (RNA processing) and aging.
academic.oup.com/nar/advance-...
This new paper is at the intersection of my core scientific interest (RNA processing) and aging.
academic.oup.com/nar/advance-...
This was on the first page of the print Washington Post today. It's a long article about research into the way different organs age at different rates. These ages can be inferred from plasma proteins. People are described as 'heart agers' or 'brain youthers'.
The first in a series of Post stories I'm writing about the science of aging. I hope we all turn out to be 'brain youthers'
wapo.st/3V5DTut
wapo.st/3V5DTut
Inside your body, aging unfolds at remarkably different rates
New research shows aging is not a uniform process. Parts of our bodies start aging earlier than others, right down to our organs and cells.
wapo.st
November 28, 2024 at 2:50 PM
This was on the first page of the print Washington Post today. It's a long article about research into the way different organs age at different rates. These ages can be inferred from plasma proteins. People are described as 'heart agers' or 'brain youthers'.
This is striking:
"the effect of combined lifestyle interventions on type 2 diabetes risk partly persisted for many years after the intervention was withdrawn"
"the effect of combined lifestyle interventions on type 2 diabetes risk partly persisted for many years after the intervention was withdrawn"
Lifestyle interventions to reduce cardiovascular and metabolic diseases, a new comprehensive review
nature.com/articles/s41...
nature.com/articles/s41...
November 27, 2024 at 3:44 PM
This is striking:
"the effect of combined lifestyle interventions on type 2 diabetes risk partly persisted for many years after the intervention was withdrawn"
"the effect of combined lifestyle interventions on type 2 diabetes risk partly persisted for many years after the intervention was withdrawn"
Reposted by Intermittent Fasting
Pleased to announce the publication of our new manuscript, "Late-life protein or isoleucine restriction
impacts physiological and molecular
signatures of aging" in Nature Aging today! www.nature.com/articles/s43... Free link: rdcu.be/d1DGk
impacts physiological and molecular
signatures of aging" in Nature Aging today! www.nature.com/articles/s43... Free link: rdcu.be/d1DGk
Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging - Nature Aging
Yeh et al. explore the effects of restricting dietary protein, or isoleucine specifically, in aged mice. They uncover benefits to metabolic health and certain indicators of aging and a sexually dimorp...
www.nature.com
November 27, 2024 at 2:42 PM
Pleased to announce the publication of our new manuscript, "Late-life protein or isoleucine restriction
impacts physiological and molecular
signatures of aging" in Nature Aging today! www.nature.com/articles/s43... Free link: rdcu.be/d1DGk
impacts physiological and molecular
signatures of aging" in Nature Aging today! www.nature.com/articles/s43... Free link: rdcu.be/d1DGk
Reposted by Intermittent Fasting
SHADES OF BLUE
Blue zones, supposed havens of longevity, have become a global brand. But skeptics think they rest on shaky science
www.science.org/content/arti...
Blue zones, supposed havens of longevity, have become a global brand. But skeptics think they rest on shaky science
www.science.org/content/arti...
Do ‘blue zones,’ supposed havens of longevity, rest on shaky science?
Critics say extraordinary life spans reflect faulty record keeping, not healthy lifestyles
www.science.org
November 26, 2024 at 7:31 AM
SHADES OF BLUE
Blue zones, supposed havens of longevity, have become a global brand. But skeptics think they rest on shaky science
www.science.org/content/arti...
Blue zones, supposed havens of longevity, have become a global brand. But skeptics think they rest on shaky science
www.science.org/content/arti...
Reposted by Intermittent Fasting
Post a non-religious photo you think of as holy.
November 23, 2024 at 9:03 PM
Post a non-religious photo you think of as holy.
Reposted by Intermittent Fasting
New review from grad student Stacy Li, postdoc Manny Vazquez, and I www.cell.com/trends/genet... - super proud of their hard work!
September 16, 2023 at 3:47 PM
New review from grad student Stacy Li, postdoc Manny Vazquez, and I www.cell.com/trends/genet... - super proud of their hard work!