Alan Gerber
@alangerber.bsky.social
Assistant Professor at Amsterdam UMC | Cancer Center Amsterdam. Interested in regulation of gene expression, particularly #tRNA and other RNA Pol III-transcribed genes in glioma.
ORCID: https://orcid.org/0000-0003-3909-3606
Lab website: alangerberlab.com
ORCID: https://orcid.org/0000-0003-3909-3606
Lab website: alangerberlab.com
Reposted by Alan Gerber
And it's out!
Our paper on the optimization of smFISH to quantify cytokine mRNAs in T cells is published in EMBO Journal.
Using this protocol, we gathered interesting insights on cytokine mRNAs co-expression and localization in these teeny tiny human cells.
www.embopress.org/doi/full/10....
Our paper on the optimization of smFISH to quantify cytokine mRNAs in T cells is published in EMBO Journal.
Using this protocol, we gathered interesting insights on cytokine mRNAs co-expression and localization in these teeny tiny human cells.
www.embopress.org/doi/full/10....
October 15, 2025 at 9:31 PM
And it's out!
Our paper on the optimization of smFISH to quantify cytokine mRNAs in T cells is published in EMBO Journal.
Using this protocol, we gathered interesting insights on cytokine mRNAs co-expression and localization in these teeny tiny human cells.
www.embopress.org/doi/full/10....
Our paper on the optimization of smFISH to quantify cytokine mRNAs in T cells is published in EMBO Journal.
Using this protocol, we gathered interesting insights on cytokine mRNAs co-expression and localization in these teeny tiny human cells.
www.embopress.org/doi/full/10....
Reposted by Alan Gerber
Reposted by Alan Gerber
It's out!
Beautiful work led by Loreto Oyarte Gálvez & @cbisot.bsky.social!
Do you want to learn more about how Mycorrhizal fungi extraordinary networks form and function? Read the open-access publication! Link below 👇
Beautiful work led by Loreto Oyarte Gálvez & @cbisot.bsky.social!
Do you want to learn more about how Mycorrhizal fungi extraordinary networks form and function? Read the open-access publication! Link below 👇
Our newest research on plant-fungal trade published today in @nature.com.
The work, led by scientists from Vrije Universiteit, Princeton University, SPUN & AMOLF combines robotics, mycology & biophysics to reveal underground supply-chain dynamics.
Open access:
www.nature.com/articles/s41...
The work, led by scientists from Vrije Universiteit, Princeton University, SPUN & AMOLF combines robotics, mycology & biophysics to reveal underground supply-chain dynamics.
Open access:
www.nature.com/articles/s41...
February 26, 2025 at 8:42 PM
It's out!
Beautiful work led by Loreto Oyarte Gálvez & @cbisot.bsky.social!
Do you want to learn more about how Mycorrhizal fungi extraordinary networks form and function? Read the open-access publication! Link below 👇
Beautiful work led by Loreto Oyarte Gálvez & @cbisot.bsky.social!
Do you want to learn more about how Mycorrhizal fungi extraordinary networks form and function? Read the open-access publication! Link below 👇
Reposted by Alan Gerber
I am giving a lecture at the EMBO practical course: "FISHing for RNAs: classical to single molecule approaches"
Check out this hands-on EMBO course!
Check out this hands-on EMBO course!
Hi Bluesky community! 👋
Are you looking forward to 2025 as much as we are? 👀
We just updated our 2025 Annual Poster to include even more events for you to join, so go and have a look!
➡️ s.embl.org/poster-bl
#EMBLEvents #molecularbiology #lifesciencetraining
Are you looking forward to 2025 as much as we are? 👀
We just updated our 2025 Annual Poster to include even more events for you to join, so go and have a look!
➡️ s.embl.org/poster-bl
#EMBLEvents #molecularbiology #lifesciencetraining
December 21, 2024 at 10:59 AM
I am giving a lecture at the EMBO practical course: "FISHing for RNAs: classical to single molecule approaches"
Check out this hands-on EMBO course!
Check out this hands-on EMBO course!
Reposted by Alan Gerber
Excited to share @domenicnarducci.bsky.social 's paper now out in Mol Cell published back-to-back with the paper from @dewitlab.bsky.social - despite lots of prior work, we find that ZNF143 has no looping function
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 20, 2024 at 4:32 PM
Excited to share @domenicnarducci.bsky.social 's paper now out in Mol Cell published back-to-back with the paper from @dewitlab.bsky.social - despite lots of prior work, we find that ZNF143 has no looping function
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
MDPI & Frontiers journals blacklisted in Finland, I wonder if this will indeed spread further? Never considered any of these journals for publication, but MDPI surely send funny emails... Maybe I will introduce myself like this 👇 from now on 😂.
December 20, 2024 at 2:21 PM
MDPI & Frontiers journals blacklisted in Finland, I wonder if this will indeed spread further? Never considered any of these journals for publication, but MDPI surely send funny emails... Maybe I will introduce myself like this 👇 from now on 😂.
Reposted by Alan Gerber
"We report that numerous “miRNAs” previously reported in EMT and cancer contexts are not incorporated into RISC and are not capable of endogenously silencing target genes, despite the fact that hundreds of publications in the cancer field describe their roles"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
December 12, 2024 at 10:21 PM
"We report that numerous “miRNAs” previously reported in EMT and cancer contexts are not incorporated into RISC and are not capable of endogenously silencing target genes, despite the fact that hundreds of publications in the cancer field describe their roles"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alan Gerber
Not easy to describe the emotions of seeing our work published in @cellpress.bsky.social ! We explored how novel isoforms emerge during evolution through the exonization of Transposable Elements. Exonized TEs modify the functions and structures of host proteins.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Transposable element exonization generates a reservoir of evolving and functional protein isoforms
Transposable element exonization by unannotated splicing events produces stable protein isoforms with acquired functions that are subject to evolutionary selection.
www.cell.com
December 12, 2024 at 3:29 PM
Not easy to describe the emotions of seeing our work published in @cellpress.bsky.social ! We explored how novel isoforms emerge during evolution through the exonization of Transposable Elements. Exonized TEs modify the functions and structures of host proteins.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Alan Gerber
📢We're recruiting📢
Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!
Please share
#uridine #cancermetabolism #immunometabolism
@unil.bsky.social
🔗(PDF): www.jourdainlab.org/wp-content/u...
Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!
Please share
#uridine #cancermetabolism #immunometabolism
@unil.bsky.social
🔗(PDF): www.jourdainlab.org/wp-content/u...
December 16, 2024 at 11:13 AM
📢We're recruiting📢
Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!
Please share
#uridine #cancermetabolism #immunometabolism
@unil.bsky.social
🔗(PDF): www.jourdainlab.org/wp-content/u...
Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!
Please share
#uridine #cancermetabolism #immunometabolism
@unil.bsky.social
🔗(PDF): www.jourdainlab.org/wp-content/u...
Reposted by Alan Gerber
Excited to share our new work on the earliest steps of Pol-III transcription: We provide structural and kinetic insights into tRNA promoter engagement by yeast transcription factor TFIIIC !
Cool collaboration with the Müller and Eustermann Labs @embl.org !
academic.oup.com/nar/advance-...
Cool collaboration with the Müller and Eustermann Labs @embl.org !
academic.oup.com/nar/advance-...
Structural and kinetic insights into tRNA promoter engagement by yeast general transcription factor TFIIIC
Abstract. Transcription of transfer RNA (tRNA) genes by RNA polymerase (Pol) III requires the general transcription factor IIIC (TFIIIC), which recognizes
academic.oup.com
December 11, 2024 at 7:39 AM
Excited to share our new work on the earliest steps of Pol-III transcription: We provide structural and kinetic insights into tRNA promoter engagement by yeast transcription factor TFIIIC !
Cool collaboration with the Müller and Eustermann Labs @embl.org !
academic.oup.com/nar/advance-...
Cool collaboration with the Müller and Eustermann Labs @embl.org !
academic.oup.com/nar/advance-...
Reposted by Alan Gerber
🧪 Your eyes may deceive you. A study of 3,387 life-science papers from 2023 found nearly 1/3 of bar charts distorted data, often by not starting the y-axis at zero or misusing log scales.
Bad bar charts are pervasive across biology
Scientific ‘shorthand’ could be introducing data distortions into published papers.
www.nature.com
December 9, 2024 at 3:14 PM
🧪 Your eyes may deceive you. A study of 3,387 life-science papers from 2023 found nearly 1/3 of bar charts distorted data, often by not starting the y-axis at zero or misusing log scales.
Reposted by Alan Gerber
🎉Excited to share our new preprint on Biorxiv 🥳
We uncover how RNA Polymerase III (Pol3) dynamically regulates tRNA transcription during heat shock (HS) stress!
So what did we find? 🧵
www.biorxiv.org/content/10.1...
We uncover how RNA Polymerase III (Pol3) dynamically regulates tRNA transcription during heat shock (HS) stress!
So what did we find? 🧵
www.biorxiv.org/content/10.1...
Dynamic regulation of RNA Polymerase III transcription in mouse embryonic stem cells during heat shock stress
Cells respond to many different types of stresses by overhauling gene expression patterns, both at the transcriptional and translational level. Under heat stress, global transcription and translation ...
www.biorxiv.org
November 30, 2024 at 5:21 PM
🎉Excited to share our new preprint on Biorxiv 🥳
We uncover how RNA Polymerase III (Pol3) dynamically regulates tRNA transcription during heat shock (HS) stress!
So what did we find? 🧵
www.biorxiv.org/content/10.1...
We uncover how RNA Polymerase III (Pol3) dynamically regulates tRNA transcription during heat shock (HS) stress!
So what did we find? 🧵
www.biorxiv.org/content/10.1...
Reposted by Alan Gerber
Reposted by Alan Gerber
Paired CRISPR screens to map gene regulation in cis and trans https://www.biorxiv.org/content/10.1101/2024.11.27.625752v1
Paired CRISPR screens to map gene regulation in cis and trans https://www.biorxiv.org/content/10.1101/2024.11.27.625752v1
Recent massively-parallel approaches to decipher gene regulatory circuits have focused on the discov
www.biorxiv.org
November 28, 2024 at 2:33 AM
Paired CRISPR screens to map gene regulation in cis and trans https://www.biorxiv.org/content/10.1101/2024.11.27.625752v1
Reposted by Alan Gerber
Epromoters bind key stress-related transcription factors to regulate clusters of stress response genes https://www.biorxiv.org/content/10.1101/2024.11.26.625372v1
Epromoters bind key stress-related transcription factors to regulate clusters of stress response genes https://www.biorxiv.org/content/10.1101/2024.11.26.625372v1
Stress insults trigger the rapid and global reprogramming of gene transcription by coordinated recru
www.biorxiv.org
November 27, 2024 at 8:32 AM
Epromoters bind key stress-related transcription factors to regulate clusters of stress response genes https://www.biorxiv.org/content/10.1101/2024.11.26.625372v1
Reposted by Alan Gerber
Very cool - snoRNA73 acts as a bridge between mRNAs and 7SL (i.e. the SRP ncRNA) to facilitate the synthesis of the encoded secreted protein.
November 26, 2024 at 1:45 PM
Very cool - snoRNA73 acts as a bridge between mRNAs and 7SL (i.e. the SRP ncRNA) to facilitate the synthesis of the encoded secreted protein.
Reposted by Alan Gerber
A Versatile Anti-CRISPR Platform for Opto- and Chemogenetic Control of CRISPR-Cas9 and Cas12 across a Wide Range of Orthologs https://www.biorxiv.org/content/10.1101/2024.11.25.625186v1
A Versatile Anti-CRISPR Platform for Opto- and Chemogenetic Control of CRISPR-Cas9 and Cas12 across a Wide Range of Orthologs https://www.biorxiv.org/content/10.1101/2024.11.25.625186v1
CRISPR-Cas technologies have revolutionized life sciences by enabling programmable genome editing ac
www.biorxiv.org
November 26, 2024 at 5:04 AM
A Versatile Anti-CRISPR Platform for Opto- and Chemogenetic Control of CRISPR-Cas9 and Cas12 across a Wide Range of Orthologs https://www.biorxiv.org/content/10.1101/2024.11.25.625186v1
Reposted by Alan Gerber
Did you know that at our conference, we record our Keynote Lectures and make them freely available? You can find them all in our Youtube page!
To get started, check out the 2023 IUBMB Jubilee Lecture, given by Prof. Rachel Green.
To get started, check out the 2023 IUBMB Jubilee Lecture, given by Prof. Rachel Green.
Rachel Green - IUBMB Jubilee Lecture - 3rd Molecular Biosystems Conference (2023)
YouTube video by Molecular Biosystems Conference
www.youtube.com
November 25, 2024 at 4:22 PM
Did you know that at our conference, we record our Keynote Lectures and make them freely available? You can find them all in our Youtube page!
To get started, check out the 2023 IUBMB Jubilee Lecture, given by Prof. Rachel Green.
To get started, check out the 2023 IUBMB Jubilee Lecture, given by Prof. Rachel Green.
Reposted by Alan Gerber
Post a non-religious photo you think of as holy.
Not necessarily holy, just cool contrast between "then and now" in ribosome assembly landscape understanding. Nierhaus map from the 80s / AV Broeck & Sebastian Clinge in Science 2023.
Not necessarily holy, just cool contrast between "then and now" in ribosome assembly landscape understanding. Nierhaus map from the 80s / AV Broeck & Sebastian Clinge in Science 2023.
November 25, 2024 at 7:17 PM
Post a non-religious photo you think of as holy.
Not necessarily holy, just cool contrast between "then and now" in ribosome assembly landscape understanding. Nierhaus map from the 80s / AV Broeck & Sebastian Clinge in Science 2023.
Not necessarily holy, just cool contrast between "then and now" in ribosome assembly landscape understanding. Nierhaus map from the 80s / AV Broeck & Sebastian Clinge in Science 2023.
Reposted by Alan Gerber
This 👇 is happening. Change is coming!
Sign of the times, no more bluebird on the biorxiv engagement tab..
November 24, 2024 at 10:03 AM
This 👇 is happening. Change is coming!
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 by Ueli Laemmli! The paper which introduced SDS-page to the world!!! 💯
Post a non-religious photo you think as holy
November 24, 2024 at 12:30 PM
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 by Ueli Laemmli! The paper which introduced SDS-page to the world!!! 💯
Reposted by Alan Gerber
💯
February 14th 1969, RNA polymerases' day.
The pioneering experiment that laid the foundation for the eukaryotic transcription field by Robert Roeder.
February 14th 1969, RNA polymerases' day.
The pioneering experiment that laid the foundation for the eukaryotic transcription field by Robert Roeder.
Post a non-religious photo you think of as holy.
November 24, 2024 at 10:31 AM
💯
February 14th 1969, RNA polymerases' day.
The pioneering experiment that laid the foundation for the eukaryotic transcription field by Robert Roeder.
February 14th 1969, RNA polymerases' day.
The pioneering experiment that laid the foundation for the eukaryotic transcription field by Robert Roeder.
Reposted by Alan Gerber
Post a non-religious photo you think of as holy
November 24, 2024 at 10:48 AM
Post a non-religious photo you think of as holy
Post a non-religious photo you think of as holy.
November 23, 2024 at 9:03 PM
Post a non-religious photo you think of as holy.
Reposted by Alan Gerber
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function https://www.biorxiv.org/content/10.1101/2024.11.21.624739v1
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function https://www.biorxiv.org/content/10.1101/2024.11.21.624739v1
Phase separation explains the exquisite spatial and temporal regulation of many biological processes
www.biorxiv.org
November 23, 2024 at 1:49 AM
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function https://www.biorxiv.org/content/10.1101/2024.11.21.624739v1