Pim Huis in 't Veld
@huis.bsky.social
Chromosome biology and genome stability | lab started 2023 @maxperutzlabs.bsky.social @vienabiocenter, Vienna, Austria
Reposted by Pim Huis in 't Veld
Big news! Group leader Sascha Martens has been awarded a prestigious @erc.europa.eu Synergy Grant for the collaborative project DegrAbility to explore how cells can better recycle harmful protein aggregates linked to diseases like Alzheimer’s ➡️ tinyurl.com/2zuz9jcf
@univie.ac.at
@meduniwien.ac.at
@univie.ac.at
@meduniwien.ac.at
November 6, 2025 at 11:00 AM
Big news! Group leader Sascha Martens has been awarded a prestigious @erc.europa.eu Synergy Grant for the collaborative project DegrAbility to explore how cells can better recycle harmful protein aggregates linked to diseases like Alzheimer’s ➡️ tinyurl.com/2zuz9jcf
@univie.ac.at
@meduniwien.ac.at
@univie.ac.at
@meduniwien.ac.at
Saruman talking. Palantir running.
Please help everyone around you to stop paying attention to him and X! If within reach, please alarm employers, politicians, and news agencies (again and again)..
Please help everyone around you to stop paying attention to him and X! If within reach, please alarm employers, politicians, and news agencies (again and again)..
Elon Musk, "These lovely small towns in England, Scotland and Ireland, they've been living their lives quietly. They're like hobbits"
"And so one day, 1,000 people show up in your village of 500 and start raping the kids"
"This has now happened, God knows how many times in Britain"
"And so one day, 1,000 people show up in your village of 500 and start raping the kids"
"This has now happened, God knows how many times in Britain"
November 3, 2025 at 9:50 AM
Saruman talking. Palantir running.
Please help everyone around you to stop paying attention to him and X! If within reach, please alarm employers, politicians, and news agencies (again and again)..
Please help everyone around you to stop paying attention to him and X! If within reach, please alarm employers, politicians, and news agencies (again and again)..
Reposted by Pim Huis in 't Veld
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Reposted by Pim Huis in 't Veld
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
PhD student position in the Cell Signaling and Cell Cycle group at the Danish Cancer Institute.
The Cell Signaling and Cell Cycle group, headed by Prof. Jakob Nilsson, is looking for a highly motivated and enthusiastic PhD student to establish novel CRISPR
candidate.hr-manager.net
October 23, 2025 at 4:18 PM
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
Reposted by Pim Huis in 't Veld
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Reposted by Pim Huis in 't Veld
WHAT THE F*CK‼️‼️‼️‼️‼️
Chicago’s Reverend David Black of First Presbyterian has been assaulted multiple times by ICE agents during peaceful protest in the city‼️They shot a some kind of non lethal bullet at his head‼️
#PepperBall
Chicago’s Reverend David Black of First Presbyterian has been assaulted multiple times by ICE agents during peaceful protest in the city‼️They shot a some kind of non lethal bullet at his head‼️
#PepperBall
October 8, 2025 at 2:13 PM
WHAT THE F*CK‼️‼️‼️‼️‼️
Chicago’s Reverend David Black of First Presbyterian has been assaulted multiple times by ICE agents during peaceful protest in the city‼️They shot a some kind of non lethal bullet at his head‼️
#PepperBall
Chicago’s Reverend David Black of First Presbyterian has been assaulted multiple times by ICE agents during peaceful protest in the city‼️They shot a some kind of non lethal bullet at his head‼️
#PepperBall
Reposted by Pim Huis in 't Veld
I will not back down.
Trump is now calling for the arrest of elected representatives checking his power.
What else is left on the path to full-blown authoritarianism?
Trump is now calling for the arrest of elected representatives checking his power.
What else is left on the path to full-blown authoritarianism?
October 8, 2025 at 1:44 PM
I will not back down.
Trump is now calling for the arrest of elected representatives checking his power.
What else is left on the path to full-blown authoritarianism?
Trump is now calling for the arrest of elected representatives checking his power.
What else is left on the path to full-blown authoritarianism?
Reposted by Pim Huis in 't Veld
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre
The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…
www.jic.ac.uk
October 3, 2025 at 4:06 PM
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Reposted by Pim Huis in 't Veld
I can’t quite put it into words yet, but something is happening, a kind of global singularity—a fusion of tech/media/news/government/employment which allows the global elite to push single agendas: “You WILL care about Charlie Kirk. You will NOT care about Palestine. You WILL fear cancel culture.”
Think we are up to 8 bbc news alerts about charlie kirk.
September 12, 2025 at 6:10 AM
I can’t quite put it into words yet, but something is happening, a kind of global singularity—a fusion of tech/media/news/government/employment which allows the global elite to push single agendas: “You WILL care about Charlie Kirk. You will NOT care about Palestine. You WILL fear cancel culture.”
Reposted by Pim Huis in 't Veld
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 4, 2025 at 1:10 PM
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
Reposted by Pim Huis in 't Veld
Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!
Full Professorship in Molecular Mechanisms of Disease
The Max Perutz Labs - one of Europe’s leading institutes for basic research in the life sciences - invite applications for a Full Professorship in Molecular Mechanisms of Disease. We are seeking outst...
www.maxperutzlabs.ac.at
September 4, 2025 at 10:25 AM
Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!
Reposted by Pim Huis in 't Veld
Child mortality used to be 50%. As recently as 1950, 25% of children died globally. Now it’s 4% globally, and 0.3% in some rich countries. A large part of that is better public health and vaccines.
Republicans are trying to take us back to the past.
ourworldindata.org/child-mortal...
Republicans are trying to take us back to the past.
ourworldindata.org/child-mortal...
September 4, 2025 at 6:50 AM
Child mortality used to be 50%. As recently as 1950, 25% of children died globally. Now it’s 4% globally, and 0.3% in some rich countries. A large part of that is better public health and vaccines.
Republicans are trying to take us back to the past.
ourworldindata.org/child-mortal...
Republicans are trying to take us back to the past.
ourworldindata.org/child-mortal...
Reposted by Pim Huis in 't Veld
Please re-post: If you know (or are!) somebody who might fancy doing a PhD (Oct 2026 start) in my group @oxfordbiochemistry.bsky.social, working on chromatin evolution in prokaryotes (or other things we're interested in), please have a look at www.bioch.ox.ac.uk/supervisors-...
Supervisors and Projects
www.bioch.ox.ac.uk
September 1, 2025 at 9:27 AM
Please re-post: If you know (or are!) somebody who might fancy doing a PhD (Oct 2026 start) in my group @oxfordbiochemistry.bsky.social, working on chromatin evolution in prokaryotes (or other things we're interested in), please have a look at www.bioch.ox.ac.uk/supervisors-...
Reposted by Pim Huis in 't Veld
This will break you
August 23, 2025 at 1:59 PM
This will break you
OG FPLC - unexpected suprise hidden in a drawer
August 17, 2025 at 2:23 PM
OG FPLC - unexpected suprise hidden in a drawer
Reposted by Pim Huis in 't Veld
Instead of regurgitating the bromide that LLMs are just "autocomplete on steroids" (even by people who know better), maybe we can actually engage in some public education. The problem with genAI is better expressed through a classic computer science concept, known as SYMBOL GROUNDING. 🧵
August 12, 2025 at 4:33 PM
Instead of regurgitating the bromide that LLMs are just "autocomplete on steroids" (even by people who know better), maybe we can actually engage in some public education. The problem with genAI is better expressed through a classic computer science concept, known as SYMBOL GROUNDING. 🧵
Reposted by Pim Huis in 't Veld
BREAKING: One of the most important and prominent reporters on the ground in Gaza has been Anas Al Sharif.
He - and several other Al Jazeera journalists - have just been assassinated by Israelis forces whilst in their press tent in central Gaza.
Speechless.
He - and several other Al Jazeera journalists - have just been assassinated by Israelis forces whilst in their press tent in central Gaza.
Speechless.
August 10, 2025 at 8:50 PM
BREAKING: One of the most important and prominent reporters on the ground in Gaza has been Anas Al Sharif.
He - and several other Al Jazeera journalists - have just been assassinated by Israelis forces whilst in their press tent in central Gaza.
Speechless.
He - and several other Al Jazeera journalists - have just been assassinated by Israelis forces whilst in their press tent in central Gaza.
Speechless.
Reposted by Pim Huis in 't Veld
“Maybe the world won’t act, maybe the world won’t help us but there might be a motive to stop this war—every time I document a massacre or event or bombing, I think that maybe through this bombing or this image that the war could stop and this war would end...”
August 10, 2025 at 9:41 PM
“Maybe the world won’t act, maybe the world won’t help us but there might be a motive to stop this war—every time I document a massacre or event or bombing, I think that maybe through this bombing or this image that the war could stop and this war would end...”
Reposted by Pim Huis in 't Veld
Reposted by Pim Huis in 't Veld
Photo of the Day.
Israel threatened reprisals if the press filmed Gaza from above during airdrops.
This is why. A scene of destroyed & burnt out buildings in what is left of Gaza City, the pre-war home to 800,000 people.
Credit to Post photographer Heidi Levine who defied the ban & took this.
Israel threatened reprisals if the press filmed Gaza from above during airdrops.
This is why. A scene of destroyed & burnt out buildings in what is left of Gaza City, the pre-war home to 800,000 people.
Credit to Post photographer Heidi Levine who defied the ban & took this.
August 1, 2025 at 10:09 PM
Photo of the Day.
Israel threatened reprisals if the press filmed Gaza from above during airdrops.
This is why. A scene of destroyed & burnt out buildings in what is left of Gaza City, the pre-war home to 800,000 people.
Credit to Post photographer Heidi Levine who defied the ban & took this.
Israel threatened reprisals if the press filmed Gaza from above during airdrops.
This is why. A scene of destroyed & burnt out buildings in what is left of Gaza City, the pre-war home to 800,000 people.
Credit to Post photographer Heidi Levine who defied the ban & took this.
Reposted by Pim Huis in 't Veld
This is the lowest form of humanity! Nothing justifies this and the response (!) of all the western and Islamic (!) countries: www.theguardian.com/world/2025/j...
The mathematics of starvation: how Israel caused a famine in Gaza
Israel controls the flow of food into Gaza. It has calculated how many calories Palestinians need to stay alive. Its data shows only a fraction has been allowed in
www.theguardian.com
July 31, 2025 at 8:18 PM
This is the lowest form of humanity! Nothing justifies this and the response (!) of all the western and Islamic (!) countries: www.theguardian.com/world/2025/j...
Reposted by Pim Huis in 't Veld
And another opportunity! Any postdocs looking forward to start your lab on a tenure track? Supportive environment, great core facilities and an outstanding PhD program.
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Mechanistic Cell and Developmental Biology. More details ➡️ tinyurl.com/3fbkp89c
July 23, 2025 at 1:42 PM
And another opportunity! Any postdocs looking forward to start your lab on a tenure track? Supportive environment, great core facilities and an outstanding PhD program.
Reposted by Pim Huis in 't Veld
Exciting and rare opportunity to join the @maxperutzlabs.bsky.social and the @viennabiocenter.bsky.social as a Full Professor!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Full Professorship in Molecular Mechanisms of Disease - Vienna BioCenter, Austria job with Max Perutz Labs, University of Vienna | 12841053
Join theMax Perutz Labs as Full Professor to unravel disease mechanisms—from metabolism and stress to RNA regulation, epigenetics, and immunity.
www.nature.com
July 2, 2025 at 7:19 AM
Exciting and rare opportunity to join the @maxperutzlabs.bsky.social and the @viennabiocenter.bsky.social as a Full Professor!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Reposted by Pim Huis in 't Veld
New preprint from the lab - the first paper made (almost) entirely here @qmul.bsky.social
We report how human outer kinetochore complexes Ndc80 and Ska form cooperative oligomers, that together stabilise microtubule ends against shortening.
www.biorxiv.org/content/10.1...
Key results below: (1/7)
We report how human outer kinetochore complexes Ndc80 and Ska form cooperative oligomers, that together stabilise microtubule ends against shortening.
www.biorxiv.org/content/10.1...
Key results below: (1/7)
Microtubule end stabilisation by cooperative oligomers of Ska and Ndc80 complexes
During mitosis, properly aligned chromosomes stabilise microtubule ends with the help of kinetochores to ensure timely segregation of chromosomes. Microtubule-binding components of the human outer kinetochore, such as Ndc80 and Ska complexes, are present in multiple copies and together bind several microtubule ends, creating a highly multivalent binding interface. Whereas Ndc80:Ndc80 and Ndc80:microtubule binding is crucial for interface stability, Ndc80 alone in absence of Ska is unable to support stable kinetochore-attachments. Using cryoET, we demonstrate that oligomeric Ndc80:Ska assemblies stabilise microtubule ends against shortening by strengthening lateral contacts between tubulin protofilaments at microtubule plus-ends. We further identify a point mutation within the SKA1 microtubule-binding domain that does not affect microtubule-binding of individual Ska molecules, but does abolish Ska:Ska interactions. Finally, we report that oligomerisation of Ska, in a cooperative fashion together with the Ndc80, is necessary to maintain stable microtubule attachments both in vivo and in vitro. ### Competing Interest Statement The authors have declared no competing interest. BBSRC, BB/X014975/1, BB/W019698/1 Wellcome Trust, https://ror.org/029chgv08, 308895/Z/23/Z
www.biorxiv.org
July 7, 2025 at 9:39 AM
New preprint from the lab - the first paper made (almost) entirely here @qmul.bsky.social
We report how human outer kinetochore complexes Ndc80 and Ska form cooperative oligomers, that together stabilise microtubule ends against shortening.
www.biorxiv.org/content/10.1...
Key results below: (1/7)
We report how human outer kinetochore complexes Ndc80 and Ska form cooperative oligomers, that together stabilise microtubule ends against shortening.
www.biorxiv.org/content/10.1...
Key results below: (1/7)
Reposted by Pim Huis in 't Veld
For various reasons, photos/videos of this meeting are doing the rounds on news & social media. But my eye is drawn to the background; this is the "DNA salon" installed in the Dutch Royal Palace in 2019, including art representing the sequence of FOXP2, a gene for which I have a certain fondness. 🧬🗣️
June 27, 2025 at 5:46 PM
For various reasons, photos/videos of this meeting are doing the rounds on news & social media. But my eye is drawn to the background; this is the "DNA salon" installed in the Dutch Royal Palace in 2019, including art representing the sequence of FOXP2, a gene for which I have a certain fondness. 🧬🗣️