Zinder for you
@hoorayforzinder.bsky.social
Principal scientist in the structural biology group at Odyssey Therapeutics and dad to a tiny and very cool human
Everything from biochemistry to chemical biology 🧪
He/him
Everything from biochemistry to chemical biology 🧪
He/him
Reposted by Zinder for you
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Multiscale structure of chromatin condensates explains phase separation and material properties
The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structur...
www.science.org
December 5, 2025 at 5:24 AM
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Just found this slide from a group meeting presentation I gave to my postdoc lab in the height of pre-vaccine COVID lol I was going through it
November 23, 2025 at 7:15 PM
Just found this slide from a group meeting presentation I gave to my postdoc lab in the height of pre-vaccine COVID lol I was going through it
Reposted by Zinder for you
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by Zinder for you
To test how few images we could get away with, I took progressively smaller subsamples of the Aca2-RNA blob-picked stack and repeated HR-HAIR with the same random seed.
Using a 60k stack (<10% of the total), high res features are still easily discernible in the good class (~20k ptcls)
Using a 60k stack (<10% of the total), high res features are still easily discernible in the good class (~20k ptcls)
September 17, 2025 at 1:04 PM
To test how few images we could get away with, I took progressively smaller subsamples of the Aca2-RNA blob-picked stack and repeated HR-HAIR with the same random seed.
Using a 60k stack (<10% of the total), high res features are still easily discernible in the good class (~20k ptcls)
Using a 60k stack (<10% of the total), high res features are still easily discernible in the good class (~20k ptcls)
Reposted by Zinder for you
if you're not from or have never been to new york i cannot stress enough how normal the subway is 99% of the time. kids take it to school. everyone is basically chill. you learn to be in proximity with harmless weirdos or minor irritations pretty quick. for all its issues it's an incredible thing
August 23, 2025 at 9:36 PM
if you're not from or have never been to new york i cannot stress enough how normal the subway is 99% of the time. kids take it to school. everyone is basically chill. you learn to be in proximity with harmless weirdos or minor irritations pretty quick. for all its issues it's an incredible thing
Choose your fighter
August 10, 2025 at 5:15 PM
Choose your fighter
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Losing my grant doesn’t make me worried that having it on my resume will hurt my career. Rather, I worry about what it means for science, I worry about it means for the active work I do and will KEEP doing to uplift, I worry about what it means for upcoming and future scientists.
April 28, 2025 at 12:42 PM
Losing my grant doesn’t make me worried that having it on my resume will hurt my career. Rather, I worry about what it means for science, I worry about it means for the active work I do and will KEEP doing to uplift, I worry about what it means for upcoming and future scientists.
Reposted by Zinder for you
🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome
April 6, 2025 at 9:45 AM
🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome
Reposted by Zinder for you
our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell!
key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity
many are "negative regulators" & misexpressed in cancer
www.sciencedirect.com/science/arti...
key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity
many are "negative regulators" & misexpressed in cancer
www.sciencedirect.com/science/arti...
March 26, 2025 at 5:11 PM
our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell!
key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity
many are "negative regulators" & misexpressed in cancer
www.sciencedirect.com/science/arti...
key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity
many are "negative regulators" & misexpressed in cancer
www.sciencedirect.com/science/arti...
Reposted by Zinder for you
We just had our first grant terminated. This was a U19 AViDD grant (grants.nih.gov/grants/guide...). It was set to end next month, although many in the consortia were hoping for NCEs.
March 25, 2025 at 3:18 PM
We just had our first grant terminated. This was a U19 AViDD grant (grants.nih.gov/grants/guide...). It was set to end next month, although many in the consortia were hoping for NCEs.
Reposted by Zinder for you
Make use of our public database of Postdoc fellowships (private foundations, federal agencies). It's downloadable and free.
We list 290 different fellowships and funding opportunities, along with description, deadline, amount, and eligibility criteria
Download here: research.jhu.edu/rdt/funding-...
We list 290 different fellowships and funding opportunities, along with description, deadline, amount, and eligibility criteria
Download here: research.jhu.edu/rdt/funding-...
March 5, 2025 at 5:12 PM
Make use of our public database of Postdoc fellowships (private foundations, federal agencies). It's downloadable and free.
We list 290 different fellowships and funding opportunities, along with description, deadline, amount, and eligibility criteria
Download here: research.jhu.edu/rdt/funding-...
We list 290 different fellowships and funding opportunities, along with description, deadline, amount, and eligibility criteria
Download here: research.jhu.edu/rdt/funding-...
Reposted by Zinder for you
Join us at Amgen Structural Biology in SoCal! Work on #xray and #cryoEM.
careers.amgen.com/en/job/thous...
careers.amgen.com/en/job/thous...
Senior Scientist Jobs at Amgen in United States of America
Explore the details of a Senior Scientist career in Thousand Oaks. Live. Win. Thrive. Search and apply for a rewarding new career at Amgen.
careers.amgen.com
February 27, 2025 at 9:53 PM
Join us at Amgen Structural Biology in SoCal! Work on #xray and #cryoEM.
careers.amgen.com/en/job/thous...
careers.amgen.com/en/job/thous...
Reposted by Zinder for you
Great advice on transitioning from academia to industry. I would add that you should also be prepared to discuss why you applied to a specific company. Find details in their platform or targets to discuss. Interview teams see you as a flight liability if you’re just looking for any industry position
Because of the alarmingly quick dismantling of our federal funding agencies I imagine some academic scientists are considering a stint in (or fulltime switch to) industry R&D. As someone who recently made this switch I thought it could be useful to share some advice (1/7)
February 25, 2025 at 7:38 PM
Great advice on transitioning from academia to industry. I would add that you should also be prepared to discuss why you applied to a specific company. Find details in their platform or targets to discuss. Interview teams see you as a flight liability if you’re just looking for any industry position
Because of the alarmingly quick dismantling of our federal funding agencies I imagine some academic scientists are considering a stint in (or fulltime switch to) industry R&D. As someone who recently made this switch I thought it could be useful to share some advice (1/7)
February 25, 2025 at 4:33 PM
Because of the alarmingly quick dismantling of our federal funding agencies I imagine some academic scientists are considering a stint in (or fulltime switch to) industry R&D. As someone who recently made this switch I thought it could be useful to share some advice (1/7)
Reposted by Zinder for you
ok i am absolutely SICK of this anticipatory obedience that we're seeing across academic institutions and scientific organizations. miss me with the "oh the white house said xyz we have to stop DEI." EXECUTIVE ORDERS ARE NOT LAW.
February 19, 2025 at 2:05 AM
ok i am absolutely SICK of this anticipatory obedience that we're seeing across academic institutions and scientific organizations. miss me with the "oh the white house said xyz we have to stop DEI." EXECUTIVE ORDERS ARE NOT LAW.
Reposted by Zinder for you
Pretty sad. Just got the email that CZI is canceling the second round of Diversity Leadership Awards. Private industry will definitely not fill the hole that NIH and NSF are leaving. 😢💔
February 19, 2025 at 1:03 AM
Pretty sad. Just got the email that CZI is canceling the second round of Diversity Leadership Awards. Private industry will definitely not fill the hole that NIH and NSF are leaving. 😢💔
Reposted by Zinder for you
I’m not sure if someone has made this thread yet, but I figure there may be some postdocs in the states that are now thinking more seriously about trying to get a PI position in Canada. 🇨🇦 (1/n)
February 16, 2025 at 6:49 PM
I’m not sure if someone has made this thread yet, but I figure there may be some postdocs in the states that are now thinking more seriously about trying to get a PI position in Canada. 🇨🇦 (1/n)
Reposted by Zinder for you
Cryo-EM Faculty position (Assistant or Associate Prof. level) at U de Montréal (in one of the world's great cities)!
Dept of Biochem & Mol Med
www.umontreal.ca/public/www/d...
Deadline March 11, 2025
Contact Pascale Legault, Director (direction@bcm.umontreal.ca)
Dept of Biochem & Mol Med
www.umontreal.ca/public/www/d...
Deadline March 11, 2025
Contact Pascale Legault, Director (direction@bcm.umontreal.ca)
www.umontreal.ca
February 14, 2025 at 5:21 PM
Cryo-EM Faculty position (Assistant or Associate Prof. level) at U de Montréal (in one of the world's great cities)!
Dept of Biochem & Mol Med
www.umontreal.ca/public/www/d...
Deadline March 11, 2025
Contact Pascale Legault, Director (direction@bcm.umontreal.ca)
Dept of Biochem & Mol Med
www.umontreal.ca/public/www/d...
Deadline March 11, 2025
Contact Pascale Legault, Director (direction@bcm.umontreal.ca)
Shameful that an institution with such extraordinary resources and influence caves so quickly. Fucking cowards www.nytimes.com/2025/02/06/u...
NCAA Bars Transgender Athletes From Women’s Sports After Trump Order
The decision, effective immediately, came a day after President Trump signed an order barring transgender girls and women from playing in women’s sports at federally funded educational institutions.
www.nytimes.com
February 7, 2025 at 12:32 AM
Shameful that an institution with such extraordinary resources and influence caves so quickly. Fucking cowards www.nytimes.com/2025/02/06/u...
Here’s Val being a shaggy queen for your enjoyment
February 6, 2025 at 8:57 PM
Here’s Val being a shaggy queen for your enjoyment
Boooooooooooooooooooo
February 5, 2025 at 11:19 PM
Boooooooooooooooooooo
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Just got word that our Howard Hughes Medical Institute (HHMI) Inclusive Excellence 3 (IE3) Grant was being canceled. All 100+ institutions. So even private funding is susceptible to this administration’s unraveling of DEI initiatives
February 5, 2025 at 9:46 PM
Just got word that our Howard Hughes Medical Institute (HHMI) Inclusive Excellence 3 (IE3) Grant was being canceled. All 100+ institutions. So even private funding is susceptible to this administration’s unraveling of DEI initiatives
idk why I wasted so much time making figures from scratch when I could just have ai generate a perfect visual for telomere shartening (from LinkedIn, of course)
February 3, 2025 at 3:57 PM
idk why I wasted so much time making figures from scratch when I could just have ai generate a perfect visual for telomere shartening (from LinkedIn, of course)
Reposted by Zinder for you
Brilliant work by Takeharu Nagai and team: Creating coveted bioluminescence colors for simultaneous multi-color bioimaging
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 24, 2025 at 9:01 PM
Brilliant work by Takeharu Nagai and team: Creating coveted bioluminescence colors for simultaneous multi-color bioimaging
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Damn inflation is crazy I’m heading to Helmholtz
January 20, 2025 at 7:40 PM
Damn inflation is crazy I’m heading to Helmholtz