Nathanael Caveney
@caveneylab.ca
Assistant Professor, PharmTox, University of Toronto. Signalling, structural biology, protein engineering. 🇨🇦
https://caveneylab.ca
https://caveneylab.ca
Reposted by Nathanael Caveney
It should go without saying that the disclosure of personal demographic information that was promised confidentiality to a government committee by the Tri-Council would be the most fundamental breach of ethics and pose a genuine danger to the safety of Canadian researchers.
October 31, 2025 at 2:39 PM
It should go without saying that the disclosure of personal demographic information that was promised confidentiality to a government committee by the Tri-Council would be the most fundamental breach of ethics and pose a genuine danger to the safety of Canadian researchers.
Reposted by Nathanael Caveney
Launch your independent research career in beautiful Toronto!
Princess Margaret Cancer Centre is recruiting an ECR in cancer biology with appointment to University of Toronto and a generous startup package. Vibrant research community.
Apply now!
www.nature.com/naturecareer...
Princess Margaret Cancer Centre is recruiting an ECR in cancer biology with appointment to University of Toronto and a generous startup package. Vibrant research community.
Apply now!
www.nature.com/naturecareer...
Principal Investigator - Early Career in Cancer Biology - Toronto (City), Ontario (CA) job with Princess Margaret Cancer Centre | 12845320
We are seeking an early-career faculty Scientist at Assistant Professor level to establish an independent research program in Cancer Biology.
www.nature.com
October 10, 2025 at 12:46 PM
Launch your independent research career in beautiful Toronto!
Princess Margaret Cancer Centre is recruiting an ECR in cancer biology with appointment to University of Toronto and a generous startup package. Vibrant research community.
Apply now!
www.nature.com/naturecareer...
Princess Margaret Cancer Centre is recruiting an ECR in cancer biology with appointment to University of Toronto and a generous startup package. Vibrant research community.
Apply now!
www.nature.com/naturecareer...
Reposted by Nathanael Caveney
Our cryo-EM structure of the intermediate state of the KCNQ1 potassium channel is out. Collaborative effort with the David Fedida and Luca Maragliano labs. Cryo-EM work spearheaded by Efthimios Kyriakis, PhD
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 3, 2025 at 6:44 PM
Our cryo-EM structure of the intermediate state of the KCNQ1 potassium channel is out. Collaborative effort with the David Fedida and Luca Maragliano labs. Cryo-EM work spearheaded by Efthimios Kyriakis, PhD
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nathanael Caveney
EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
September 30, 2025 at 9:52 AM
EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
Reposted by Nathanael Caveney
I feel some responsibility, as we develop the software. But helical reconstruction is prone to getting stuck in local minima, and unfortunately still requires a lot of self-criticism. The most important one: if you don't see expected features in the map, don't trust it!
September 26, 2025 at 7:47 AM
I feel some responsibility, as we develop the software. But helical reconstruction is prone to getting stuck in local minima, and unfortunately still requires a lot of self-criticism. The most important one: if you don't see expected features in the map, don't trust it!
Another wild paper from Jan Burian et al! Modern day gold mining w/ cutting edge sequencing tech! ⛏️
@rockefelleruniv.bsky.social
www.nature.com/articles/s41...
@rockefelleruniv.bsky.social
www.nature.com/articles/s41...
Bioactive molecules unearthed by terabase-scale long-read sequencing of a soil metagenome - Nature Biotechnology
Optimized long-read sequencing constructs megabase-scale genome assemblies from complex soil samples.
www.nature.com
September 20, 2025 at 1:37 AM
Another wild paper from Jan Burian et al! Modern day gold mining w/ cutting edge sequencing tech! ⛏️
@rockefelleruniv.bsky.social
www.nature.com/articles/s41...
@rockefelleruniv.bsky.social
www.nature.com/articles/s41...
Reposted by Nathanael Caveney
📢🥳 The #SanterLab is recruiting to have new people join the #IFN fun!
With #CIHR & other 💰:
1) joint tech with Dr Thomas Murooka for more of an immediate start - see umanitoba.ca/careers/ #41169
2) #Immunology PhD student
3) Postdoctoral fellow
Please see our Google lab website + dept website 😀
With #CIHR & other 💰:
1) joint tech with Dr Thomas Murooka for more of an immediate start - see umanitoba.ca/careers/ #41169
2) #Immunology PhD student
3) Postdoctoral fellow
Please see our Google lab website + dept website 😀
September 19, 2025 at 2:56 PM
📢🥳 The #SanterLab is recruiting to have new people join the #IFN fun!
With #CIHR & other 💰:
1) joint tech with Dr Thomas Murooka for more of an immediate start - see umanitoba.ca/careers/ #41169
2) #Immunology PhD student
3) Postdoctoral fellow
Please see our Google lab website + dept website 😀
With #CIHR & other 💰:
1) joint tech with Dr Thomas Murooka for more of an immediate start - see umanitoba.ca/careers/ #41169
2) #Immunology PhD student
3) Postdoctoral fellow
Please see our Google lab website + dept website 😀
Reposted by Nathanael Caveney
In Canada, proposed cuts of 15% across the federal government would have a dramatic effect on already globally decimated research & science.
Join Canada's research & science community and tell PM Mark Carney to preserve the funding promised in 2024.
Send a letter: win.newmode.net/canadianasso...
Join Canada's research & science community and tell PM Mark Carney to preserve the funding promised in 2024.
Send a letter: win.newmode.net/canadianasso...
September 18, 2025 at 9:30 PM
In Canada, proposed cuts of 15% across the federal government would have a dramatic effect on already globally decimated research & science.
Join Canada's research & science community and tell PM Mark Carney to preserve the funding promised in 2024.
Send a letter: win.newmode.net/canadianasso...
Join Canada's research & science community and tell PM Mark Carney to preserve the funding promised in 2024.
Send a letter: win.newmode.net/canadianasso...
Reposted by Nathanael Caveney
Important to remember the theoretical size limit is based on assumptions and a model that may or may not be complete. It isn't some indisputable universal truth.
‘We expect that this approach may be useful for cryo-EM analysis of other small particles near or below the theoretical size limit.’ 🤯
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
September 13, 2025 at 9:07 PM
Important to remember the theoretical size limit is based on assumptions and a model that may or may not be complete. It isn't some indisputable universal truth.
Reposted by Nathanael Caveney
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
September 13, 2025 at 12:05 AM
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
Reposted by Nathanael Caveney
‼️ Notice of upcoming funding opportunity!
Co-led by CIHR-III and CIHR-IIPH, the CIHR Research Excellence, Diversity, and Independence (REDI) Early Career Transition Award (2025) competition will launch in October.
Learn more: cihr-irsc.gc.ca/e/54442.html
Co-led by CIHR-III and CIHR-IIPH, the CIHR Research Excellence, Diversity, and Independence (REDI) Early Career Transition Award (2025) competition will launch in October.
Learn more: cihr-irsc.gc.ca/e/54442.html
August 27, 2025 at 7:36 PM
‼️ Notice of upcoming funding opportunity!
Co-led by CIHR-III and CIHR-IIPH, the CIHR Research Excellence, Diversity, and Independence (REDI) Early Career Transition Award (2025) competition will launch in October.
Learn more: cihr-irsc.gc.ca/e/54442.html
Co-led by CIHR-III and CIHR-IIPH, the CIHR Research Excellence, Diversity, and Independence (REDI) Early Career Transition Award (2025) competition will launch in October.
Learn more: cihr-irsc.gc.ca/e/54442.html
Reposted by Nathanael Caveney
Wow. Check this out.
Politicians actually trying to solve problems can achieve a lot!
www.washingtonpost.com/climate-solu...
Politicians actually trying to solve problems can achieve a lot!
www.washingtonpost.com/climate-solu...
Paris said au revoir to cars. Air pollution maps reveal a dramatic change.
Air pollution fell substantially as the city restricted car traffic and made way for parks and bike lanes.
www.washingtonpost.com
August 30, 2025 at 9:15 PM
Wow. Check this out.
Politicians actually trying to solve problems can achieve a lot!
www.washingtonpost.com/climate-solu...
Politicians actually trying to solve problems can achieve a lot!
www.washingtonpost.com/climate-solu...
Reposted by Nathanael Caveney
Expanding the cytokine receptor alphabet reprograms T cells into diverse states @natmicrobiol.nature.com #GarciaLab @xrtcell.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 13, 2025 at 6:26 PM
Expanding the cytokine receptor alphabet reprograms T cells into diverse states @natmicrobiol.nature.com #GarciaLab @xrtcell.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nathanael Caveney
🇨🇦🚨Job alert🚨🇨🇦
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children
July 25, 2025 at 7:21 PM
🇨🇦🚨Job alert🚨🇨🇦
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children
🚨 Two weeks left to apply! 🚨 #facultyjobs
Reminder we have a Faculty position opening in our Dept in Machine Learning and/or Self Driving Labs applied to Drug Discovery, Pharmacology and/or Toxicology. Closing date, August 5 (two weeks from now). Please RT/Repost. jobs.utoronto.ca/job/Toronto-...
Assistant Professor - Pharmacology and Toxicology
Assistant Professor - Pharmacology and Toxicology
jobs.utoronto.ca
July 21, 2025 at 4:53 PM
🚨 Two weeks left to apply! 🚨 #facultyjobs
Reposted by Nathanael Caveney
Reminder we have a Faculty position opening in our Dept in Machine Learning and/or Self Driving Labs applied to Drug Discovery, Pharmacology and/or Toxicology. Closing date, August 5 (two weeks from now). Please RT/Repost. jobs.utoronto.ca/job/Toronto-...
Assistant Professor - Pharmacology and Toxicology
Assistant Professor - Pharmacology and Toxicology
jobs.utoronto.ca
July 21, 2025 at 4:19 PM
Reminder we have a Faculty position opening in our Dept in Machine Learning and/or Self Driving Labs applied to Drug Discovery, Pharmacology and/or Toxicology. Closing date, August 5 (two weeks from now). Please RT/Repost. jobs.utoronto.ca/job/Toronto-...
Reposted by Nathanael Caveney
Sharing some of my PhD work that just came out today.
TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5)
www.nature.com/articles/s41...
(1/5)
TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5)
www.nature.com/articles/s41...
(1/5)
July 2, 2025 at 9:24 PM
Sharing some of my PhD work that just came out today.
TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5)
www.nature.com/articles/s41...
(1/5)
TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5)
www.nature.com/articles/s41...
(1/5)
Reposted by Nathanael Caveney
Our friends in Pharmacology + Toxicology at the @uoftmedicine.bsky.social @uoft.bsky.social are looking for an assistant professor! The successful candidate will also become a member of the Acceleration Consortium. Apply now: jobs.utoronto.ca/job/Toronto-...
Assistant Professor - Pharmacology and Toxicology
Assistant Professor - Pharmacology and Toxicology
jobs.utoronto.ca
June 19, 2025 at 1:54 PM
Our friends in Pharmacology + Toxicology at the @uoftmedicine.bsky.social @uoft.bsky.social are looking for an assistant professor! The successful candidate will also become a member of the Acceleration Consortium. Apply now: jobs.utoronto.ca/job/Toronto-...
Excited to share that our department at UofT is hiring! We are looking for someone working on "Machine Learning and/or Self Driving Labs applied to Drug Discovery, Pharmacology and/or Toxicology". jobs.utoronto.ca/job/Toronto-...
Assistant Professor - Pharmacology & Toxicology
Assistant Professor - Pharmacology & Toxicology
jobs.utoronto.ca
June 14, 2025 at 2:08 AM
Excited to share that our department at UofT is hiring! We are looking for someone working on "Machine Learning and/or Self Driving Labs applied to Drug Discovery, Pharmacology and/or Toxicology". jobs.utoronto.ca/job/Toronto-...
Reposted by Nathanael Caveney
Setting up a lab has been no joke. Today, I'm stoked to have one more piece of my postdoc work out in the wild.
Several more manuscripts to go, and I don't have a lot of time for a blue-torial(?) today, but enjoy and happy to get any feedback on this story.
www.biorxiv.org/content/10.1...
Several more manuscripts to go, and I don't have a lot of time for a blue-torial(?) today, but enjoy and happy to get any feedback on this story.
www.biorxiv.org/content/10.1...
Membrane phosphoinositides allosterically tune β-arrestin dynamics to facilitate GPCR core engagement
Arrestin proteins bind active G protein-coupled receptors (GPCRs) through coordinated protein-protein, protein-phosphate, and protein-lipid interactions to attenuate G protein signaling and promote GP...
www.biorxiv.org
June 10, 2025 at 12:41 AM
Setting up a lab has been no joke. Today, I'm stoked to have one more piece of my postdoc work out in the wild.
Several more manuscripts to go, and I don't have a lot of time for a blue-torial(?) today, but enjoy and happy to get any feedback on this story.
www.biorxiv.org/content/10.1...
Several more manuscripts to go, and I don't have a lot of time for a blue-torial(?) today, but enjoy and happy to get any feedback on this story.
www.biorxiv.org/content/10.1...
Reposted by Nathanael Caveney
🇨🇦🚨Job Alert🚨🇨🇦
Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget)
U Toronto, Dept of Biochem/LabMedPath
*Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?)
Are you an established PI ready to move to 🇨🇦?
research.utoronto.ca/funding-oppo...
Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget)
U Toronto, Dept of Biochem/LabMedPath
*Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?)
Are you an established PI ready to move to 🇨🇦?
research.utoronto.ca/funding-oppo...
2026 Canada Excellence Research Chair Opportunities | Research & Innovation
research.utoronto.ca
May 31, 2025 at 12:46 PM
🇨🇦🚨Job Alert🚨🇨🇦
Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget)
U Toronto, Dept of Biochem/LabMedPath
*Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?)
Are you an established PI ready to move to 🇨🇦?
research.utoronto.ca/funding-oppo...
Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget)
U Toronto, Dept of Biochem/LabMedPath
*Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?)
Are you an established PI ready to move to 🇨🇦?
research.utoronto.ca/funding-oppo...
Reposted by Nathanael Caveney
Very excited for the “Machines acting on DNA and RNA, a molecular mechanistic perspective” - CNIO-CaixaResearch Frontiers Meeting!
Getting started with the introduction by @oscarllorca.bsky.social
@cniostopcancer.bsky.social
Getting started with the introduction by @oscarllorca.bsky.social
@cniostopcancer.bsky.social
May 28, 2025 at 8:25 AM
Very excited for the “Machines acting on DNA and RNA, a molecular mechanistic perspective” - CNIO-CaixaResearch Frontiers Meeting!
Getting started with the introduction by @oscarllorca.bsky.social
@cniostopcancer.bsky.social
Getting started with the introduction by @oscarllorca.bsky.social
@cniostopcancer.bsky.social
Reposted by Nathanael Caveney
Thrilled to announce my first PhD publication in Nature Comms! We determined structures of the Tad pilus ATPase CpaF from Caulobacter. We use these structures to propose how CpaF employs a rotary mechanism of catalysis to drive Tad pilus assembly.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Conformational changes in the motor ATPase CpaF facilitate a rotary mechanism of Tad pilus assembly - Nature Communications
The bacterial Tad pilus extends and retracts using a single bifunctional ATPase CpaF. Here, the authors employ cryo-EM, fluorescent microscopy, and AlphaFold modelling to propose how a rotary mechanis...
www.nature.com
April 24, 2025 at 3:29 AM
Thrilled to announce my first PhD publication in Nature Comms! We determined structures of the Tad pilus ATPase CpaF from Caulobacter. We use these structures to propose how CpaF employs a rotary mechanism of catalysis to drive Tad pilus assembly.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nathanael Caveney
Recruiting scientists from the US has to be coupled with increases to tricouncil funding, else we will fail both the recruits, & of course Canadian scientists, who are struggling with insufficient funds. Discovery & biomedical research funding (NSERC, CIHR) in Canada is among the lowest in the G7.
“Recruiting U.S. scientists is a fine idea – except we’re barely supporting Canadian scientists as it is”
https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y
https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y
April 19, 2025 at 2:12 PM
Recruiting scientists from the US has to be coupled with increases to tricouncil funding, else we will fail both the recruits, & of course Canadian scientists, who are struggling with insufficient funds. Discovery & biomedical research funding (NSERC, CIHR) in Canada is among the lowest in the G7.
Reposted by Nathanael Caveney
🚨 We’re hiring! 🚨
Exciting opportunity for a Cryo-EM Senior Research Associate at the University of Toronto!
Join a cutting-edge facility supporting groundbreaking, cross-disciplinary research. 🧬🦠🔬
📍 Toronto
🔗 jobs.utoronto.ca/job/Toronto-...
#CryoEM #ElectronMicroscopy #Hiring #UofT #AcademicJobs
Exciting opportunity for a Cryo-EM Senior Research Associate at the University of Toronto!
Join a cutting-edge facility supporting groundbreaking, cross-disciplinary research. 🧬🦠🔬
📍 Toronto
🔗 jobs.utoronto.ca/job/Toronto-...
#CryoEM #ElectronMicroscopy #Hiring #UofT #AcademicJobs
Senior Research Associate
Senior Research Associate
jobs.utoronto.ca
April 8, 2025 at 9:25 PM
🚨 We’re hiring! 🚨
Exciting opportunity for a Cryo-EM Senior Research Associate at the University of Toronto!
Join a cutting-edge facility supporting groundbreaking, cross-disciplinary research. 🧬🦠🔬
📍 Toronto
🔗 jobs.utoronto.ca/job/Toronto-...
#CryoEM #ElectronMicroscopy #Hiring #UofT #AcademicJobs
Exciting opportunity for a Cryo-EM Senior Research Associate at the University of Toronto!
Join a cutting-edge facility supporting groundbreaking, cross-disciplinary research. 🧬🦠🔬
📍 Toronto
🔗 jobs.utoronto.ca/job/Toronto-...
#CryoEM #ElectronMicroscopy #Hiring #UofT #AcademicJobs