Jason McLellan
@mclellanlab.bsky.social
Structural virology / Structure-based vaccine design
mclellanlab.org
Professor of Molecular Biosciences
The University of Texas at Austin
Opinions are my own and not the views of my employer
mclellanlab.org
Professor of Molecular Biosciences
The University of Texas at Austin
Opinions are my own and not the views of my employer
Excited for Adam Klivans and my other colleagues at UT working in the AI space!
Already among the most powerful artificial intelligence hubs in academia, the UT Center for Generative AI is keeping its foot on the gas. “It’s exciting to accelerate discovery and to create more opportunities for our researchers to push the boundaries of what’s possible.”
UT Doubles Size of One of World’s Most Powerful AI Computing Hubs
AUSTIN, Texas — The Center for Generative AI at The University of Texas at Austin, already among the most powerful artificial intelligence hubs in the
news.utexas.edu
November 10, 2025 at 10:54 PM
Excited for Adam Klivans and my other colleagues at UT working in the AI space!
Happy Halloween! My daughter is dressed as Hornet from Silksong, the game I've spent 60 hours playing the past two months
October 31, 2025 at 10:31 PM
Happy Halloween! My daughter is dressed as Hornet from Silksong, the game I've spent 60 hours playing the past two months
I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow
UT Austin has a new “genius grant” recipient!
Texas Science professor Jason McLellan has been awarded a MacArthur Fellowship — aka the “genius grant” — by The MacArthur Foundation.
#TexasScience @mclellanlab.bsky.social #MacArthurGenius @utaustin.bsky.social
cns.utexas.edu/news/accolad...
Texas Science professor Jason McLellan has been awarded a MacArthur Fellowship — aka the “genius grant” — by The MacArthur Foundation.
#TexasScience @mclellanlab.bsky.social #MacArthurGenius @utaustin.bsky.social
cns.utexas.edu/news/accolad...
Virus Slayer Awarded ‘Genius Grant’ by MacArthur Foundation
The award recognizes Jason McLellan’s work to investigate how viruses infect our cells and to develop new treatments for infectious disease.
cns.utexas.edu
October 8, 2025 at 7:59 PM
I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow
Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.
August 19, 2025 at 6:24 PM
Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
June 18, 2025 at 2:24 PM
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...
May 20, 2025 at 6:19 PM
Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...
Getting ready for the Viruses and Cells GRC in Castelldefels
May 18, 2025 at 12:46 PM
Getting ready for the Viruses and Cells GRC in Castelldefels
New exhibit at the National Inventors Hall of Fame 👀
May 7, 2025 at 5:56 PM
New exhibit at the National Inventors Hall of Fame 👀
Reposted by Jason McLellan
"Angry, disappointed, frustrated"--Scientists were making progress on vaccines and antivirals for the next pandemic--until this week, when the Trump administration abruptly told them to stop. Here's my story with @apoorvanyt.bsky.social Gift link: nyti.ms/43Xz77q
H.H.S. Scraps Studies of Vaccines and Treatments for Future Pandemics (Gift Article)
Federal officials cited the end of the Covid-19 pandemic in halting the research. But much of the work was focused on preventing outbreaks of other pathogens.
nyti.ms
March 26, 2025 at 9:57 PM
"Angry, disappointed, frustrated"--Scientists were making progress on vaccines and antivirals for the next pandemic--until this week, when the Trump administration abruptly told them to stop. Here's my story with @apoorvanyt.bsky.social Gift link: nyti.ms/43Xz77q
We just had our first grant terminated. This was a U19 AViDD grant (grants.nih.gov/grants/guide...). It was set to end next month, although many in the consortia were hoping for NCEs.
March 25, 2025 at 3:18 PM
We just had our first grant terminated. This was a U19 AViDD grant (grants.nih.gov/grants/guide...). It was set to end next month, although many in the consortia were hoping for NCEs.
Reposted by Jason McLellan
Wow! UT Austin’s Jason McLellan will be inducted into the National Inventors Hall of Fame for his work on structure-based vaccine design that led to development of vaccines to fight COVID-19 & RSV.
@mclellanlab.bsky.social @utaustin.bsky.social #COVIDVaccine
cns.utexas.edu/news/announc...
@mclellanlab.bsky.social @utaustin.bsky.social #COVIDVaccine
cns.utexas.edu/news/announc...
UT Vaccine Scientist Will Be Inducted Into National Inventors Hall of Fame
McLellan, who will be inducted in Washington, D.C. on May 8, is among the youngest new inductees in hall of fame history.
cns.utexas.edu
January 17, 2025 at 4:00 PM
Wow! UT Austin’s Jason McLellan will be inducted into the National Inventors Hall of Fame for his work on structure-based vaccine design that led to development of vaccines to fight COVID-19 & RSV.
@mclellanlab.bsky.social @utaustin.bsky.social #COVIDVaccine
cns.utexas.edu/news/announc...
@mclellanlab.bsky.social @utaustin.bsky.social #COVIDVaccine
cns.utexas.edu/news/announc...
Reposted by Jason McLellan
PhDs in biochemistry, structural biology, pharmacology, or similar, located in the US and with strong publication track records and a high motivation to solve Parkinson's, please send CV directly to me at jimhurley@berkeley.edu.
Repost appreciated.
Repost appreciated.
January 9, 2025 at 2:58 AM
PhDs in biochemistry, structural biology, pharmacology, or similar, located in the US and with strong publication track records and a high motivation to solve Parkinson's, please send CV directly to me at jimhurley@berkeley.edu.
Repost appreciated.
Repost appreciated.
Taking the family to their first Red Wings game!
December 29, 2024 at 9:33 PM
Taking the family to their first Red Wings game!
Congratulations Elizabeth! Great collaborative effort with our colleagues Kartik Chandran, Andrew Herbert, Stephanie Monticelli and more!
This is my first, first-author paper of my PhD and is a reminder of my growth over the last several years and the excellent training and mentorship I've received from
@mclellanlab.bsky.social. Thanks to all who contributed to this work!
(3/3)
@mclellanlab.bsky.social. Thanks to all who contributed to this work!
(3/3)
December 20, 2024 at 8:43 PM
Congratulations Elizabeth! Great collaborative effort with our colleagues Kartik Chandran, Andrew Herbert, Stephanie Monticelli and more!
Register now to hear some cool vaccine science! I'll be speaking at this conference, so come hang out!
December 6, 2024 at 5:45 PM
Register now to hear some cool vaccine science! I'll be speaking at this conference, so come hang out!
Time for a name change?
November 30, 2024 at 7:16 AM
Time for a name change?
Let's go Lions!
November 28, 2024 at 6:37 PM
Let's go Lions!
My graduate student Nasim Abdi just won 2nd place for her poster at the International Conference for Pandemic Preparedness in Trieste, Italy! www.pathogen-ri.eu/conference/. Great collaboration with @drjimmydale.bsky.social at Houston Methodist🤝
November 13, 2024 at 6:28 PM
My graduate student Nasim Abdi just won 2nd place for her poster at the International Conference for Pandemic Preparedness in Trieste, Italy! www.pathogen-ri.eu/conference/. Great collaboration with @drjimmydale.bsky.social at Houston Methodist🤝
Austin now has some Michelin-rated restaurants! guide.michelin.com/us/en/articl...
All The Stars From The MICHELIN Guide Texas 2024
15 new One Stars and 2 new Green Stars land in the Lone Star state.
guide.michelin.com
November 12, 2024 at 3:54 AM
Austin now has some Michelin-rated restaurants! guide.michelin.com/us/en/articl...
ACL Music Festival! Teddy Swims on stage.
November 24, 2024 at 2:49 AM
ACL Music Festival! Teddy Swims on stage.
Check out our pre-print describing a CCHFV glycoprotein complex in the pre-fusion conformation! We used several engineering tricks to design our final construct, GP38-GnH-DS-Gc. Great collaborative effort, led by graduate student @Eliza4Science!...
November 24, 2024 at 2:49 AM
Check out our pre-print describing a CCHFV glycoprotein complex in the pre-fusion conformation! We used several engineering tricks to design our final construct, GP38-GnH-DS-Gc. Great collaborative effort, led by graduate student @Eliza4Science!...
View from Austin, TX
November 24, 2024 at 2:49 AM
View from Austin, TX
Saw Road House with the cast at SXSW!
November 24, 2024 at 2:49 AM
Saw Road House with the cast at SXSW!
Promising results for a third PreF-based RSV vaccine: https://www.nejm.org/doi/10.1056/NEJMoa2307079
November 24, 2024 at 2:49 AM
Promising results for a third PreF-based RSV vaccine: https://www.nejm.org/doi/10.1056/NEJMoa2307079