Heidi Creighton
@heidi.bsky.social
Founder & CEO Creighton HealthTech | Life Sciences | Spatial Biology | AI | Former News Reporter, MediaNews Group | Alum, IDG/NetworkWorld | @usouthernmaine.bsky.social | www.creightonhealthtech.com | signal: creighton.92
Pinned
Join the LinkedIn Group "Spatial Biology Pioneers" if you are in the spatial multiomics field #spatialomics #singlecell #multiomics linkedin.com/groups/13906...
Reposted by Heidi Creighton
🧬Appearing today @science.org a Review - From sequence to function: Bridging single-molecule kinetics and molecular diversity | Science 🔬https://www.science.org/doi/10.1126/science.adv4503
From sequence to function: Bridging single-molecule kinetics and molecular diversity
Biological function is fundamentally determined by nucleic acid and protein sequence. Beyond encoding genetic information, nucleic acids also display complex physicochemical parameters that shape stru...
www.science.org
January 29, 2026 at 7:44 PM
🧬Appearing today @science.org a Review - From sequence to function: Bridging single-molecule kinetics and molecular diversity | Science 🔬https://www.science.org/doi/10.1126/science.adv4503
Spatial Biology Update - DeciBio is developing a new report focused on the real-world perspectives of end users of spatial omics technologies. For more information, contact Rebecca Burnham, PhD #spatialbiology #spatialomics #singlecell #multiomics
January 29, 2026 at 10:57 AM
Spatial Biology Update - DeciBio is developing a new report focused on the real-world perspectives of end users of spatial omics technologies. For more information, contact Rebecca Burnham, PhD #spatialbiology #spatialomics #singlecell #multiomics
Reposted by Heidi Creighton
The new cover and feature @nature.com www.nature.com/immersive/d4...
January 21, 2026 at 4:39 PM
The new cover and feature @nature.com www.nature.com/immersive/d4...
Reposted by Heidi Creighton
Presenting data from the largest integrated thyroid cancer single-cell sequencing atlas
@vivianweiss.bsky.social et al. highlight stromal tumor-dynamics occurring across the spatial evolution of thyroid cancer from indolent to lethal disease: doi.org/10.1172/jci....
@vivianweiss.bsky.social et al. highlight stromal tumor-dynamics occurring across the spatial evolution of thyroid cancer from indolent to lethal disease: doi.org/10.1172/jci....
January 19, 2026 at 1:01 PM
Presenting data from the largest integrated thyroid cancer single-cell sequencing atlas
@vivianweiss.bsky.social et al. highlight stromal tumor-dynamics occurring across the spatial evolution of thyroid cancer from indolent to lethal disease: doi.org/10.1172/jci....
@vivianweiss.bsky.social et al. highlight stromal tumor-dynamics occurring across the spatial evolution of thyroid cancer from indolent to lethal disease: doi.org/10.1172/jci....
Reposted by Heidi Creighton
Interested in cutting-edge work in both the development and application of techniques to better understand gene regulation from a systems perspective? Abstract submissions are still open for this CSHL meeting: meetings.cshl.edu/meetings.asp...
Systems Biology: Global Regulation of Gene Expression
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
January 17, 2026 at 4:04 PM
Interested in cutting-edge work in both the development and application of techniques to better understand gene regulation from a systems perspective? Abstract submissions are still open for this CSHL meeting: meetings.cshl.edu/meetings.asp...
Join the LinkedIn Group "Spatial Biology Pioneers" if you are in the spatial multiomics field #spatialomics #singlecell #multiomics linkedin.com/groups/13906...
January 17, 2026 at 5:31 PM
Join the LinkedIn Group "Spatial Biology Pioneers" if you are in the spatial multiomics field #spatialomics #singlecell #multiomics linkedin.com/groups/13906...
Reposted by Heidi Creighton
Spatial Multi-omics
DBiTplus
DBiT-seq + CODEX
Mesmer segmentation
MaxFus multiomic integration
CODEX-informed spatial deconvolution (TACCO vs Cell2location vs RCTD)
Work on FFPE
>1000 genes/25 μm spot
@zongmingma.bsky.social @rongfan8.bsky.social #NatMethods 2025
www.nature.com/articles/s41...
DBiTplus
DBiT-seq + CODEX
Mesmer segmentation
MaxFus multiomic integration
CODEX-informed spatial deconvolution (TACCO vs Cell2location vs RCTD)
Work on FFPE
>1000 genes/25 μm spot
@zongmingma.bsky.social @rongfan8.bsky.social #NatMethods 2025
www.nature.com/articles/s41...
January 16, 2026 at 8:08 PM
Spatial Multi-omics
DBiTplus
DBiT-seq + CODEX
Mesmer segmentation
MaxFus multiomic integration
CODEX-informed spatial deconvolution (TACCO vs Cell2location vs RCTD)
Work on FFPE
>1000 genes/25 μm spot
@zongmingma.bsky.social @rongfan8.bsky.social #NatMethods 2025
www.nature.com/articles/s41...
DBiTplus
DBiT-seq + CODEX
Mesmer segmentation
MaxFus multiomic integration
CODEX-informed spatial deconvolution (TACCO vs Cell2location vs RCTD)
Work on FFPE
>1000 genes/25 μm spot
@zongmingma.bsky.social @rongfan8.bsky.social #NatMethods 2025
www.nature.com/articles/s41...
Reposted by Heidi Creighton
In this episode of the Epigenetics Podcast, we talked with Will Wang from @sbpdiscovery.bsky.social about his work on muscle stem cell repair, regeneration, and aging, exploring spatial-omics and machine learning. #podcast #epigenetics
Listen here: activemotif.com/podcasts-wil...
Listen here: activemotif.com/podcasts-wil...
January 16, 2026 at 8:00 AM
In this episode of the Epigenetics Podcast, we talked with Will Wang from @sbpdiscovery.bsky.social about his work on muscle stem cell repair, regeneration, and aging, exploring spatial-omics and machine learning. #podcast #epigenetics
Listen here: activemotif.com/podcasts-wil...
Listen here: activemotif.com/podcasts-wil...
Reposted by Heidi Creighton
Nature Health, the newest journal in the Nature Portfolio, aims to bridge the ‘implementation gap’ from research to policy and practice
go.nature.com/49Jmm1J
go.nature.com/49Jmm1J
Making progress on global health will need high-quality evidence
Nature Health, the newest journal in the Nature Portfolio, aims to bridge the ‘implementation gap’ from research to policy and practice.
go.nature.com
January 15, 2026 at 6:22 PM
Nature Health, the newest journal in the Nature Portfolio, aims to bridge the ‘implementation gap’ from research to policy and practice
go.nature.com/49Jmm1J
go.nature.com/49Jmm1J
Reposted by Heidi Creighton
Single-cell and spatial profiling highlights #TB-induced myofibroblasts as drivers of lung pathology. From Ian Mbano, Nuo Liu, Paul Elkington @unisouthampton.bsky.social, Alex Shalek @mit.edu, Alasdair Leslie (Africa Health Research Institute) et al: rupress.org/jem/article/...
#Tuberculosis
#Tuberculosis
January 14, 2026 at 8:30 PM
Single-cell and spatial profiling highlights #TB-induced myofibroblasts as drivers of lung pathology. From Ian Mbano, Nuo Liu, Paul Elkington @unisouthampton.bsky.social, Alex Shalek @mit.edu, Alasdair Leslie (Africa Health Research Institute) et al: rupress.org/jem/article/...
#Tuberculosis
#Tuberculosis
Reposted by Heidi Creighton
A large patient study suggests that testing for tau protein in blood can predict post-stroke outcomes, an antibody cocktail shields rodents from RSV while preventing viral escape, and more this week in #ScienceTranslationalMedicine. https://scim.ag/3YHiUQ2
January 14, 2026 at 10:00 PM
A large patient study suggests that testing for tau protein in blood can predict post-stroke outcomes, an antibody cocktail shields rodents from RSV while preventing viral escape, and more this week in #ScienceTranslationalMedicine. https://scim.ag/3YHiUQ2
Reposted by Heidi Creighton
A single cell and spatial profile of visceral and colonic adipose tissue www.cell.com/cell-metabol...
Cytoarchitectural multi-depot profiling reveals immune-metabolic crosstalk in human colon-associated adipose tissue
Jalkanen et al. generate spatial and single-nucleus transcriptomic maps of human subcutaneous
and visceral white adipose depots, revealing distinct cytoarchitectural and immunologic
features. Epiploic...
www.cell.com
January 14, 2026 at 12:29 AM
A single cell and spatial profile of visceral and colonic adipose tissue www.cell.com/cell-metabol...
Reposted by Heidi Creighton
Newly uncovered pathway behind tissue scarring, or fibrosis, in inflammatory bowel disease suggests new treatment strategies for the dangerous condition.
Researchers uncover molecular roots of fibrosis or tissue scarring in inflammatory bowel disease
New study finds a biological pathway responsible for dangerous scarring, which could possibly be targeted by new treatments.
broad.io
January 7, 2026 at 7:34 PM
Newly uncovered pathway behind tissue scarring, or fibrosis, in inflammatory bowel disease suggests new treatment strategies for the dangerous condition.
“We’re at a point,” Sarah Teichmann continued, “where we can start to assemble the data sets and provide reference atlases for different tissues, different organs, different systems around the body.”
www.genengnews.com/topics/omics...
www.genengnews.com/topics/omics...
The Single-Cell Club Is Rapidly Expanding
As single-cell RNA-Seq meets AI, and DNA sequencing prices drop, projects are becoming much (much) larger.
www.genengnews.com
July 9, 2025 at 2:53 PM
“We’re at a point,” Sarah Teichmann continued, “where we can start to assemble the data sets and provide reference atlases for different tissues, different organs, different systems around the body.”
www.genengnews.com/topics/omics...
www.genengnews.com/topics/omics...
Reposted by Heidi Creighton
This project is an unprecedented dataset of high resolution anatomical images of individual cells in mouse visual cortex, mapped on to their responses
https://go.nature.com/3YnGotC
https://go.nature.com/3YnGotC
The MICrONS Project
An unprecedented dataset of high resolution anatomical images of individual cells in mouse visual cortex, mapped on to their responses. This integrated view of function and structure lays a foundation for discovering the computational bases of cortical circuits.
go.nature.com
April 10, 2025 at 8:15 AM
This project is an unprecedented dataset of high resolution anatomical images of individual cells in mouse visual cortex, mapped on to their responses
https://go.nature.com/3YnGotC
https://go.nature.com/3YnGotC
Reposted by Heidi Creighton
Thanks so much to @ddiamond.bsky.social for his excellent, detailed coverage of how medical research is being harmed by federal instability. We need to keep talking about this and help the public understand the scope of damage that is happening and how this will impact future medicine and technology
Also spoke with researchers like
@docsirianni.bsky.social who have turned to Bluesky and other outlets to amplify the situation facing scientists.
Heard story after story about heart-wrenching decisions affecting their labs now — and the consequence of fewer cures for patients and families later.
@docsirianni.bsky.social who have turned to Bluesky and other outlets to amplify the situation facing scientists.
Heard story after story about heart-wrenching decisions affecting their labs now — and the consequence of fewer cures for patients and families later.
March 28, 2025 at 3:51 PM
Thanks so much to @ddiamond.bsky.social for his excellent, detailed coverage of how medical research is being harmed by federal instability. We need to keep talking about this and help the public understand the scope of damage that is happening and how this will impact future medicine and technology
Reposted by Heidi Creighton
🔔 Save the date!
Join us for the next IICD Seminar on April 9 at 2 PM ET with Jean Fan @jef.works from @jhu.edu
🔬 Multi-Sample Comparative Spatial Omics Data Analysis
📍 In person: Schermerhorn 603
💻 Remote: Register 👉 bit.ly/4j0RwEM
Join us for the next IICD Seminar on April 9 at 2 PM ET with Jean Fan @jef.works from @jhu.edu
🔬 Multi-Sample Comparative Spatial Omics Data Analysis
📍 In person: Schermerhorn 603
💻 Remote: Register 👉 bit.ly/4j0RwEM
March 28, 2025 at 6:11 PM
🔔 Save the date!
Join us for the next IICD Seminar on April 9 at 2 PM ET with Jean Fan @jef.works from @jhu.edu
🔬 Multi-Sample Comparative Spatial Omics Data Analysis
📍 In person: Schermerhorn 603
💻 Remote: Register 👉 bit.ly/4j0RwEM
Join us for the next IICD Seminar on April 9 at 2 PM ET with Jean Fan @jef.works from @jhu.edu
🔬 Multi-Sample Comparative Spatial Omics Data Analysis
📍 In person: Schermerhorn 603
💻 Remote: Register 👉 bit.ly/4j0RwEM
Reposted by Heidi Creighton
A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved
March 23, 2025 at 4:17 PM
A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved
Reposted by Heidi Creighton
Perturb-FISH, a method that combines high-throughput imaging spatial transcriptomics with in situ guide RNA detection, allows for the analysis of molecular and functional states, with spatial resolution at the single-cell level @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
March 13, 2025 at 3:33 AM
Perturb-FISH, a method that combines high-throughput imaging spatial transcriptomics with in situ guide RNA detection, allows for the analysis of molecular and functional states, with spatial resolution at the single-cell level @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Heidi Creighton
Cancer recurrence predicted by spatial biology of the immune response nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/s41...
Liver cancer recurrence predicted by immune-cell location and gene expression
Immune cells called natural killer cells can target and eliminate tumours. The gene expression and spatial distribution of the immune cells in the tumour microenvironment indicates whether liver cance...
nature.com
March 12, 2025 at 4:31 PM
Cancer recurrence predicted by spatial biology of the immune response nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/s41...
Join @jlemieux.bsky.social and expert panelists -- Catharine Aquino @biomath.bsky.social @jasmineplummer.bsky.social @jessie-no.bsky.social -- as they cover the latest research and novel technologies. #genomics #NGS #spatial #singlecell #AGBTGM #AGBT25 REGISTER: hubs.li/Q036f_3x0
February 26, 2025 at 3:17 PM
Join @jlemieux.bsky.social and expert panelists -- Catharine Aquino @biomath.bsky.social @jasmineplummer.bsky.social @jessie-no.bsky.social -- as they cover the latest research and novel technologies. #genomics #NGS #spatial #singlecell #AGBTGM #AGBT25 REGISTER: hubs.li/Q036f_3x0
Celebrating All Women in Science this weekend! 🎉🔬🧬#WomeninScience #February11 #WomenAndGirlsInScience #WomenInSTEM #IDWGS #IDWGS2024 #WomenInScienceDay @bsky.app Learn more at www.un.org/en/observanc...
February 10, 2024 at 12:36 PM
Celebrating All Women in Science this weekend! 🎉🔬🧬#WomeninScience #February11 #WomenAndGirlsInScience #WomenInSTEM #IDWGS #IDWGS2024 #WomenInScienceDay @bsky.app Learn more at www.un.org/en/observanc...