Broad Institute
@broadinstitute.org
A multidisciplinary community of researchers with the mission to better understand the roots of disease and narrow the gap between new biological insights and impact for patients. Broadinstitute.org
On Wednesday, November 19 at 6PM ET, join us in Cambridge, MA (or online) for a Broad Discovery Series talk with Niall Lennon, “Entering the Genomic Medicine era: How technology, data, and biology can improve healthcare throughout our lives.” Register: broadinstitute.swoogo.com/Discovery25
November 7, 2025 at 7:03 PM
On Wednesday, November 19 at 6PM ET, join us in Cambridge, MA (or online) for a Broad Discovery Series talk with Niall Lennon, “Entering the Genomic Medicine era: How technology, data, and biology can improve healthcare throughout our lives.” Register: broadinstitute.swoogo.com/Discovery25
Reposted by Broad Institute
Announcing our new preprint! We built SPICE, a framework that combines large-scale experiments and generative AI to design RNA sequences that control cell type-specific gene expression using alternative splicing – a powerful, underexplored modality.
Preprint: www.biorxiv.org/content/10.1...
(1/10)
Preprint: www.biorxiv.org/content/10.1...
(1/10)
Generative Design of Cell Type-Specific RNA Splicing Elements for Programmable Gene Regulation
Programmable control of gene expression in specific cell types is essential for both basic discovery and therapeutic intervention, yet current strategies lack scalability across diverse cellular conte...
www.biorxiv.org
November 6, 2025 at 6:59 PM
Announcing our new preprint! We built SPICE, a framework that combines large-scale experiments and generative AI to design RNA sequences that control cell type-specific gene expression using alternative splicing – a powerful, underexplored modality.
Preprint: www.biorxiv.org/content/10.1...
(1/10)
Preprint: www.biorxiv.org/content/10.1...
(1/10)
Reposted by Broad Institute
New research published in @natchembio.nature.com by @danafarber.bsky.social’s William Gibson, MD, PhD, reveals a general strategy for TP53 missense mutant cancers (majority) with prototype small molecules. @broadinstitute.org
Read more at bit.ly/4onnFJO
Read more at bit.ly/4onnFJO
November 6, 2025 at 7:30 PM
New research published in @natchembio.nature.com by @danafarber.bsky.social’s William Gibson, MD, PhD, reveals a general strategy for TP53 missense mutant cancers (majority) with prototype small molecules. @broadinstitute.org
Read more at bit.ly/4onnFJO
Read more at bit.ly/4onnFJO
Reposted by Broad Institute
We’re proud to be part of this new @broadinstitute.org effort! In this Q&A Picower researchers Sara Prescott and Ravi Raju describe the project, how they’re involved, and the research they’re doing: picower.mit.edu/news/qa-pico...
November 4, 2025 at 4:29 PM
We’re proud to be part of this new @broadinstitute.org effort! In this Q&A Picower researchers Sara Prescott and Ravi Raju describe the project, how they’re involved, and the research they’re doing: picower.mit.edu/news/qa-pico...
Broad has launched the Biology of Adversity Project, led by
@jbuenrostro.bsky.social a 2023 @macfound.org fellow, to uncover how adverse life experiences can inflict molecular “scars” in the genome and body and increase risk of heart disease and other disorders. Learn more: broad.io/BAP
@jbuenrostro.bsky.social a 2023 @macfound.org fellow, to uncover how adverse life experiences can inflict molecular “scars” in the genome and body and increase risk of heart disease and other disorders. Learn more: broad.io/BAP
November 4, 2025 at 4:26 PM
Broad has launched the Biology of Adversity Project, led by
@jbuenrostro.bsky.social a 2023 @macfound.org fellow, to uncover how adverse life experiences can inflict molecular “scars” in the genome and body and increase risk of heart disease and other disorders. Learn more: broad.io/BAP
@jbuenrostro.bsky.social a 2023 @macfound.org fellow, to uncover how adverse life experiences can inflict molecular “scars” in the genome and body and increase risk of heart disease and other disorders. Learn more: broad.io/BAP
Reposted by Broad Institute
Congrats to Jinjin Xu & co-authors – an image from their recent @jem.org article that describes Ankrd55 as a modulator of T cell metabolism impacting Th17 responses was selected for the cover!
Read the study here: rupress.org/jem/article-...
@broadinstitute.org @mgbresearch.bsky.social
Read the study here: rupress.org/jem/article-...
@broadinstitute.org @mgbresearch.bsky.social
November 4, 2025 at 2:47 PM
Congrats to Jinjin Xu & co-authors – an image from their recent @jem.org article that describes Ankrd55 as a modulator of T cell metabolism impacting Th17 responses was selected for the cover!
Read the study here: rupress.org/jem/article-...
@broadinstitute.org @mgbresearch.bsky.social
Read the study here: rupress.org/jem/article-...
@broadinstitute.org @mgbresearch.bsky.social
A new @natgenet.nature.com study by Broad, @mgbresearch.bsky.social, and VA Boston collaborators reveals a genetic variant that helps explain the high dilated cardiomyopathy risk in people of African ancestry.
Genetic variant increases risk of heart muscle disease common in individuals of African ancestry
A single mutation in the CD36 gene, present in 17 percent of people with African ancestry, increases a person's dilated cardiomyopathy risk by 33 percent.
broad.io
October 31, 2025 at 3:28 PM
A new @natgenet.nature.com study by Broad, @mgbresearch.bsky.social, and VA Boston collaborators reveals a genetic variant that helps explain the high dilated cardiomyopathy risk in people of African ancestry.
Reposted by Broad Institute
Excited to share new work in @NatureMicrobio! Using metagenomics, we show how #HIV infection and treatment shape the gut microbiome across geographic regions & find ART-induced phageome changes linked to inflammation and atherosclerosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Human immunodeficiency virus and antiretroviral therapies exert distinct influences across diverse gut microbiomes - Nature Microbiology
Metagenomic analysis of the gut microbiome of people with human immunodeficiency virus (HIV), from three distinct cohorts, revealed infection- and antiretroviral drug-linked alterations, which may con...
www.nature.com
October 30, 2025 at 4:18 PM
Excited to share new work in @NatureMicrobio! Using metagenomics, we show how #HIV infection and treatment shape the gut microbiome across geographic regions & find ART-induced phageome changes linked to inflammation and atherosclerosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Broad Institute
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation @science.org @thexavierlab.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 31, 2025 at 1:28 AM
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation @science.org @thexavierlab.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Broad Institute
Tissue and cellular spatiotemporal dynamics in colon aging - @nygenome.org @flatironinstitute.org @broadinstitute.org @cancerdynamics.bsky.social go.nature.com/47I1RBF
Tissue and cellular spatiotemporal dynamics in colon aging - Nature Biotechnology
cSplotch compares spatial transcriptomics data across ages and regions of mouse colon tissue.
go.nature.com
October 22, 2025 at 2:45 PM
Tissue and cellular spatiotemporal dynamics in colon aging - @nygenome.org @flatironinstitute.org @broadinstitute.org @cancerdynamics.bsky.social go.nature.com/47I1RBF
Now accepting nominations for the 2026 Merkin Prize — a $400,000 international award recognizing advances that improved human health through diagnosis, treatment or prevention of disease. Submit by Dec 5, 2025: merkinprize.org
October 29, 2025 at 7:34 PM
Now accepting nominations for the 2026 Merkin Prize — a $400,000 international award recognizing advances that improved human health through diagnosis, treatment or prevention of disease. Submit by Dec 5, 2025: merkinprize.org
A new drug candidate for a difficult-to-treat type of lung cancer, developed by scientists in the Broad-Bayer oncology research alliance, targets HER2 mutations in lung cancer and shrinks tumors in mice and humans.
Broad-Bayer collaboration leads to drug candidate for a hard-to-treat type of lung cancer
The compound, now under priority review at FDA, targets HER2 mutations in lung cancer and shrinks tumors in mice and humans.
www.broadinstitute.org
October 16, 2025 at 8:43 PM
A new drug candidate for a difficult-to-treat type of lung cancer, developed by scientists in the Broad-Bayer oncology research alliance, targets HER2 mutations in lung cancer and shrinks tumors in mice and humans.
Reposted by Broad Institute
We’re so excited with this accomplishment of fastest genome sequencing. Major efforts from BCL and Roche to make this happen. Can’t wait to launch this service clinically so patients can benefit! Paper here www.nejm.org/doi/full/10....
Toward Same-Day Genome Sequencing in the Critical Care Setting | NEJM
Decisions about critical care are almost always made without access to genetic information. The authors report the application of a new method of DNA sequencing in infants in a neonatal intensive c...
www.nejm.org
October 15, 2025 at 3:05 PM
We’re so excited with this accomplishment of fastest genome sequencing. Major efforts from BCL and Roche to make this happen. Can’t wait to launch this service clinically so patients can benefit! Paper here www.nejm.org/doi/full/10....
Reposted by Broad Institute
Predicting functions of uncharacterized gene products from microbial communities - @hutlab.bsky.social @hsph.harvard.edu @broadinstitute.org go.nature.com/435C4lp
Predicting functions of uncharacterized gene products from microbial communities - Nature Biotechnology
FUGAsseM predicts protein function in microbiomes using coexpression patterns from metatranscriptomes and diverse community-wide data.
go.nature.com
October 16, 2025 at 3:54 PM
Predicting functions of uncharacterized gene products from microbial communities - @hutlab.bsky.social @hsph.harvard.edu @broadinstitute.org go.nature.com/435C4lp
Broad Clinical Labs, Roche Sequencing Systems, and @bostonchildrens.bsky.social have set a new @guinnessworldrecords.com for the sequencing and analysis of the whole human genome in less than 4 hours — potentially enabling faster results in critical medical settings. Learn more: broad.io/BCLGWR
October 15, 2025 at 1:53 PM
Broad Clinical Labs, Roche Sequencing Systems, and @bostonchildrens.bsky.social have set a new @guinnessworldrecords.com for the sequencing and analysis of the whole human genome in less than 4 hours — potentially enabling faster results in critical medical settings. Learn more: broad.io/BCLGWR
Enrollment has now completed for most Count Me In projects, though a few remain open. Patient-partnered research will now be supported through Broad Clinical Labs, and interested researchers can learn more here: broad.io/CMInextphase.
A pioneering effort in patient-partnered cancer research enters a new phase
Count Me In’s legacy of data and resources will usher in a new way of doing research on other diseases and continue to fuel cancer studies around the globe.
broad.io
October 8, 2025 at 6:57 PM
Enrollment has now completed for most Count Me In projects, though a few remain open. Patient-partnered research will now be supported through Broad Clinical Labs, and interested researchers can learn more here: broad.io/CMInextphase.
Leading epigenetics researcher and longtime Broad member
@jbuenrostro.bsky.social has been named core institute member of the Broad. His lab will study how cells change in response to life experiences, and how those alterations affect health and disease.
@jbuenrostro.bsky.social has been named core institute member of the Broad. His lab will study how cells change in response to life experiences, and how those alterations affect health and disease.
Jason Buenrostro named core institute member at Broad
An expert in epigenetics and longtime member of the Broad community, Buenrostro will focus on how life experiences can alter the epigenome and increase risk of disease.
broad.io
September 30, 2025 at 3:40 PM
Leading epigenetics researcher and longtime Broad member
@jbuenrostro.bsky.social has been named core institute member of the Broad. His lab will study how cells change in response to life experiences, and how those alterations affect health and disease.
@jbuenrostro.bsky.social has been named core institute member of the Broad. His lab will study how cells change in response to life experiences, and how those alterations affect health and disease.
Reposted by Broad Institute
New research from Microsoft, Drexel, and the Broad explores how generative AI could support genetic professionals in rare disease diagnosis. msft.it/6019sS3P5
September 24, 2025 at 9:01 PM
New research from Microsoft, Drexel, and the Broad explores how generative AI could support genetic professionals in rare disease diagnosis. msft.it/6019sS3P5
Reposted by Broad Institute
Xu, @thexavierlab.bsky.social et al @harvardmed.bsky.social @broadinstitute.org reveal an important role of the ANKRD55 protein in TH17 biology, where its deletion impairs T cell proliferation & effector cytokine production through metabolic dysregulation. rupress.org/jem/article/...
#Autoimmunity
#Autoimmunity
September 11, 2025 at 5:15 PM
Xu, @thexavierlab.bsky.social et al @harvardmed.bsky.social @broadinstitute.org reveal an important role of the ANKRD55 protein in TH17 biology, where its deletion impairs T cell proliferation & effector cytokine production through metabolic dysregulation. rupress.org/jem/article/...
#Autoimmunity
#Autoimmunity
In her new role as an alliance manager, former drug discovery scientist Gail Guo keeps research projects moving forward for the Broad-Bayer Oncology collaboration. Learn more about her evolving role in a new #WhyIScience Q&A.
#WhyIScience Q&A: A structural biologist adopts a new role catalyzing collaborations
A former drug discovery scientist, Gail Guo now helps advance research into novel cancer drugs as part of Broad’s alliance with Bayer.
broad.io
September 10, 2025 at 6:47 PM
In her new role as an alliance manager, former drug discovery scientist Gail Guo keeps research projects moving forward for the Broad-Bayer Oncology collaboration. Learn more about her evolving role in a new #WhyIScience Q&A.
Reposted by Broad Institute
A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in #lupus #nephritis. New study from Paul Hoover, Nir Hacohen @broadinstitute.org, Anne Davidson @northwellhealth.bsky.social and colleagues: rupress.org/jem/article/...
#InnateImmunity #Autoimmunity
#InnateImmunity #Autoimmunity
September 10, 2025 at 2:45 PM
A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in #lupus #nephritis. New study from Paul Hoover, Nir Hacohen @broadinstitute.org, Anne Davidson @northwellhealth.bsky.social and colleagues: rupress.org/jem/article/...
#InnateImmunity #Autoimmunity
#InnateImmunity #Autoimmunity
Reposted by Broad Institute
Antibody–bottlebrush prodrug conjugates for targeted cancer therapy - @mitchemistry.bsky.social @broadinstitute.org go.nature.com/46d1T3t
Antibody–bottlebrush prodrug conjugates for targeted cancer therapy - Nature Biotechnology
Antibody–bottlebrush conjugates expand the options for drug cargos compared to antibody–drug conjugates.
go.nature.com
September 10, 2025 at 3:56 PM
Antibody–bottlebrush prodrug conjugates for targeted cancer therapy - @mitchemistry.bsky.social @broadinstitute.org go.nature.com/46d1T3t
In a Broad Q&A, Broad scientists Kristin Ardlie and Brad Bernstein talk about AlphaGenome, artificial intelligence, and how foundational datasets like ENCODE and @GTEx are fueling biomedical science in the AI age.
How massive datasets generated at Broad are powering the latest AI models in biology
Broad scientists describe how data resources they helped build over more than a decade now form the foundation for cutting-edge AI and genome biology discoveries.
broad.io
September 3, 2025 at 7:37 PM
In a Broad Q&A, Broad scientists Kristin Ardlie and Brad Bernstein talk about AlphaGenome, artificial intelligence, and how foundational datasets like ENCODE and @GTEx are fueling biomedical science in the AI age.
Reposted by Broad Institute
The lab's first sim pub of #ESC2025 is now online in
@jaccjournals.bsky.social #JACC!
jacc.org/doi/10.1016/...
Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study
👇
(1/X)
@jaccjournals.bsky.social #JACC!
jacc.org/doi/10.1016/...
Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study
👇
(1/X)
August 27, 2025 at 2:35 PM
The lab's first sim pub of #ESC2025 is now online in
@jaccjournals.bsky.social #JACC!
jacc.org/doi/10.1016/...
Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study
👇
(1/X)
@jaccjournals.bsky.social #JACC!
jacc.org/doi/10.1016/...
Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study
👇
(1/X)
Reposted by Broad Institute
Funded by the NIH Common Fund, @smahtnetwrk.bsky.social will map somatic mutations across human tissues with #SingleCell sequencing.
Their work will uncover the causes, patterns, and consequences of somatic mutations in normal cells—providing a vital baseline for disease research.
🧪 🧬
Their work will uncover the causes, patterns, and consequences of somatic mutations in normal cells—providing a vital baseline for disease research.
🧪 🧬
August 14, 2025 at 12:53 PM
Funded by the NIH Common Fund, @smahtnetwrk.bsky.social will map somatic mutations across human tissues with #SingleCell sequencing.
Their work will uncover the causes, patterns, and consequences of somatic mutations in normal cells—providing a vital baseline for disease research.
🧪 🧬
Their work will uncover the causes, patterns, and consequences of somatic mutations in normal cells—providing a vital baseline for disease research.
🧪 🧬