Broad Institute
@broadinstitute.org
A multidisciplinary community of researchers with the mission to better understand the roots of disease and narrow the gap between new biological insights and impact for patients. Broadinstitute.org
A team at the Broad Institute co-led by Sarah Pierce, Steven Erwood, and David Liu has developed a new genome-editing strategy that could potentially lead to a one-time treatment for multiple unrelated genetic diseases.
Single prime editing system could potentially treat multiple genetic diseases
Researchers have developed a genome-editing strategy that targets a common cause of roughly 30 percent of rare diseases and could vastly improve access to gene-editing treatments for patients.
www.broadinstitute.org
November 19, 2025 at 6:40 PM
A team at the Broad Institute co-led by Sarah Pierce, Steven Erwood, and David Liu has developed a new genome-editing strategy that could potentially lead to a one-time treatment for multiple unrelated genetic diseases.
Reposted by Broad Institute
The MacArthur Foundation today announced the winner of this year’s 100&Change award: Sentinel at @broadinstitute.org. Sentinel is an outbreak surveillance framework that prevents pandemics through local community empowerment.
Congrats to the Sentinel team, incl. foundation trustee, Pardis Sabeti!
Congrats to the Sentinel team, incl. foundation trustee, Pardis Sabeti!
MacArthur Foundation
The MacArthur Foundation supports creative people and effective institutions committed to building a more just, verdant, and peaceful world. In addition to selecting the MacArthur Fellows, we work to ...
www.macfound.org
November 19, 2025 at 12:36 AM
The MacArthur Foundation today announced the winner of this year’s 100&Change award: Sentinel at @broadinstitute.org. Sentinel is an outbreak surveillance framework that prevents pandemics through local community empowerment.
Congrats to the Sentinel team, incl. foundation trustee, Pardis Sabeti!
Congrats to the Sentinel team, incl. foundation trustee, Pardis Sabeti!
Reposted by Broad Institute
It is a rare thing to be able to award a $100 million grant but today we do so @macfound.org. I’m thrilled to share the Broad Institute’s Sentinel project is @macfound 100&Change Award Recipient!
www.macfound.org/press/press-...
www.macfound.org/press/press-...
Sentinel Awarded $100 Million to Prevent Pandemics
www.macfound.org
November 18, 2025 at 5:07 PM
It is a rare thing to be able to award a $100 million grant but today we do so @macfound.org. I’m thrilled to share the Broad Institute’s Sentinel project is @macfound 100&Change Award Recipient!
www.macfound.org/press/press-...
www.macfound.org/press/press-...
We're thrilled that Sentinel, a pandemic prevention and response program jointly led by @sabetilab.bsky.social and Christian Happi of the Institute of Genomics and Global Health (IGH), Redeemer’s University in Nigeria, is the Award Recipient for @macfound.org’s #100andChange!
MacArthur Foundation’s 100&Change Awards $100 Million to Sentinel to Prevent Pandemics - Lever for Change
CHICAGO, IL — November 18, 2025 — The John D. and Catherine T. MacArthur Foundation has awarded $100 million to the Broad Institute for the…
leverforchange.org
November 18, 2025 at 5:36 PM
We're thrilled that Sentinel, a pandemic prevention and response program jointly led by @sabetilab.bsky.social and Christian Happi of the Institute of Genomics and Global Health (IGH), Redeemer’s University in Nigeria, is the Award Recipient for @macfound.org’s #100andChange!
Join us in Cambridge, MA (or online) on Wednesday, November 19 at 6PM ET for a Broad Discovery Series talk with Niall Lennon, “Entering the Genomic Medicine era: How technology, data, and biology can improve healthcare throughout our lives.” Register: broadinstitute.swoogo.com/Discovery25
November 13, 2025 at 6:28 PM
Join us in Cambridge, MA (or online) on Wednesday, November 19 at 6PM ET for a Broad Discovery Series talk with Niall Lennon, “Entering the Genomic Medicine era: How technology, data, and biology can improve healthcare throughout our lives.” Register: broadinstitute.swoogo.com/Discovery25
The 2026 Merkin Prize is now accepting nominations!
The Prize is a $400,000 award for transformative technologies and pioneering innovators.
The Merkin Prize recognizes:
🔹 Real-world impact
🔹 Innovation
🔹 Teams and individuals
Nominate by December 5, 2025: merkinprize.org
The Prize is a $400,000 award for transformative technologies and pioneering innovators.
The Merkin Prize recognizes:
🔹 Real-world impact
🔹 Innovation
🔹 Teams and individuals
Nominate by December 5, 2025: merkinprize.org
November 12, 2025 at 4:42 PM
The 2026 Merkin Prize is now accepting nominations!
The Prize is a $400,000 award for transformative technologies and pioneering innovators.
The Merkin Prize recognizes:
🔹 Real-world impact
🔹 Innovation
🔹 Teams and individuals
Nominate by December 5, 2025: merkinprize.org
The Prize is a $400,000 award for transformative technologies and pioneering innovators.
The Merkin Prize recognizes:
🔹 Real-world impact
🔹 Innovation
🔹 Teams and individuals
Nominate by December 5, 2025: merkinprize.org
On Wednesday, November 19 at 6PM ET, join us in Cambridge, MA (or online) for a Broad Discovery Series talk with Niall Lennon, “Entering the Genomic Medicine era: How technology, data, and biology can improve healthcare throughout our lives.” Register: broadinstitute.swoogo.com/Discovery25
November 7, 2025 at 7:03 PM
On Wednesday, November 19 at 6PM ET, join us in Cambridge, MA (or online) for a Broad Discovery Series talk with Niall Lennon, “Entering the Genomic Medicine era: How technology, data, and biology can improve healthcare throughout our lives.” Register: broadinstitute.swoogo.com/Discovery25
Reposted by Broad Institute
Announcing our new preprint! We built SPICE, a framework that combines large-scale experiments and generative AI to design RNA sequences that control cell type-specific gene expression using alternative splicing – a powerful, underexplored modality.
Preprint: www.biorxiv.org/content/10.1...
(1/10)
Preprint: www.biorxiv.org/content/10.1...
(1/10)
Generative Design of Cell Type-Specific RNA Splicing Elements for Programmable Gene Regulation
Programmable control of gene expression in specific cell types is essential for both basic discovery and therapeutic intervention, yet current strategies lack scalability across diverse cellular conte...
www.biorxiv.org
November 6, 2025 at 6:59 PM
Announcing our new preprint! We built SPICE, a framework that combines large-scale experiments and generative AI to design RNA sequences that control cell type-specific gene expression using alternative splicing – a powerful, underexplored modality.
Preprint: www.biorxiv.org/content/10.1...
(1/10)
Preprint: www.biorxiv.org/content/10.1...
(1/10)
Reposted by Broad Institute
New research published in @natchembio.nature.com by @danafarber.bsky.social’s William Gibson, MD, PhD, reveals a general strategy for TP53 missense mutant cancers (majority) with prototype small molecules. @broadinstitute.org
Read more at bit.ly/4onnFJO
Read more at bit.ly/4onnFJO
November 6, 2025 at 7:30 PM
New research published in @natchembio.nature.com by @danafarber.bsky.social’s William Gibson, MD, PhD, reveals a general strategy for TP53 missense mutant cancers (majority) with prototype small molecules. @broadinstitute.org
Read more at bit.ly/4onnFJO
Read more at bit.ly/4onnFJO
Reposted by Broad Institute
We’re proud to be part of this new @broadinstitute.org effort! In this Q&A Picower researchers Sara Prescott and Ravi Raju describe the project, how they’re involved, and the research they’re doing: picower.mit.edu/news/qa-pico...
November 4, 2025 at 4:29 PM
We’re proud to be part of this new @broadinstitute.org effort! In this Q&A Picower researchers Sara Prescott and Ravi Raju describe the project, how they’re involved, and the research they’re doing: picower.mit.edu/news/qa-pico...
Broad has launched the Biology of Adversity Project, led by
@jbuenrostro.bsky.social a 2023 @macfound.org fellow, to uncover how adverse life experiences can inflict molecular “scars” in the genome and body and increase risk of heart disease and other disorders. Learn more: broad.io/BAP
@jbuenrostro.bsky.social a 2023 @macfound.org fellow, to uncover how adverse life experiences can inflict molecular “scars” in the genome and body and increase risk of heart disease and other disorders. Learn more: broad.io/BAP
November 4, 2025 at 4:26 PM
Broad has launched the Biology of Adversity Project, led by
@jbuenrostro.bsky.social a 2023 @macfound.org fellow, to uncover how adverse life experiences can inflict molecular “scars” in the genome and body and increase risk of heart disease and other disorders. Learn more: broad.io/BAP
@jbuenrostro.bsky.social a 2023 @macfound.org fellow, to uncover how adverse life experiences can inflict molecular “scars” in the genome and body and increase risk of heart disease and other disorders. Learn more: broad.io/BAP
Reposted by Broad Institute
Congrats to Jinjin Xu & co-authors – an image from their recent @jem.org article that describes Ankrd55 as a modulator of T cell metabolism impacting Th17 responses was selected for the cover!
Read the study here: rupress.org/jem/article-...
@broadinstitute.org @mgbresearch.bsky.social
Read the study here: rupress.org/jem/article-...
@broadinstitute.org @mgbresearch.bsky.social
November 4, 2025 at 2:47 PM
Congrats to Jinjin Xu & co-authors – an image from their recent @jem.org article that describes Ankrd55 as a modulator of T cell metabolism impacting Th17 responses was selected for the cover!
Read the study here: rupress.org/jem/article-...
@broadinstitute.org @mgbresearch.bsky.social
Read the study here: rupress.org/jem/article-...
@broadinstitute.org @mgbresearch.bsky.social
A new @natgenet.nature.com study by Broad, @mgbresearch.bsky.social, and VA Boston collaborators reveals a genetic variant that helps explain the high dilated cardiomyopathy risk in people of African ancestry.
Genetic variant increases risk of heart muscle disease common in individuals of African ancestry
A single mutation in the CD36 gene, present in 17 percent of people with African ancestry, increases a person's dilated cardiomyopathy risk by 33 percent.
broad.io
October 31, 2025 at 3:28 PM
A new @natgenet.nature.com study by Broad, @mgbresearch.bsky.social, and VA Boston collaborators reveals a genetic variant that helps explain the high dilated cardiomyopathy risk in people of African ancestry.
Reposted by Broad Institute
Excited to share new work in @NatureMicrobio! Using metagenomics, we show how #HIV infection and treatment shape the gut microbiome across geographic regions & find ART-induced phageome changes linked to inflammation and atherosclerosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Human immunodeficiency virus and antiretroviral therapies exert distinct influences across diverse gut microbiomes - Nature Microbiology
Metagenomic analysis of the gut microbiome of people with human immunodeficiency virus (HIV), from three distinct cohorts, revealed infection- and antiretroviral drug-linked alterations, which may con...
www.nature.com
October 30, 2025 at 4:18 PM
Excited to share new work in @NatureMicrobio! Using metagenomics, we show how #HIV infection and treatment shape the gut microbiome across geographic regions & find ART-induced phageome changes linked to inflammation and atherosclerosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Broad Institute
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation @science.org @thexavierlab.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 31, 2025 at 1:28 AM
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation @science.org @thexavierlab.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Broad Institute
Tissue and cellular spatiotemporal dynamics in colon aging - @nygenome.org @flatironinstitute.org @broadinstitute.org @cancerdynamics.bsky.social go.nature.com/47I1RBF
Tissue and cellular spatiotemporal dynamics in colon aging - Nature Biotechnology
cSplotch compares spatial transcriptomics data across ages and regions of mouse colon tissue.
go.nature.com
October 22, 2025 at 2:45 PM
Tissue and cellular spatiotemporal dynamics in colon aging - @nygenome.org @flatironinstitute.org @broadinstitute.org @cancerdynamics.bsky.social go.nature.com/47I1RBF
Now accepting nominations for the 2026 Merkin Prize — a $400,000 international award recognizing advances that improved human health through diagnosis, treatment or prevention of disease. Submit by Dec 5, 2025: merkinprize.org
October 29, 2025 at 7:34 PM
Now accepting nominations for the 2026 Merkin Prize — a $400,000 international award recognizing advances that improved human health through diagnosis, treatment or prevention of disease. Submit by Dec 5, 2025: merkinprize.org
A new drug candidate for a difficult-to-treat type of lung cancer, developed by scientists in the Broad-Bayer oncology research alliance, targets HER2 mutations in lung cancer and shrinks tumors in mice and humans.
Broad-Bayer collaboration leads to drug candidate for a hard-to-treat type of lung cancer
The compound, now under priority review at FDA, targets HER2 mutations in lung cancer and shrinks tumors in mice and humans.
www.broadinstitute.org
October 16, 2025 at 8:43 PM
A new drug candidate for a difficult-to-treat type of lung cancer, developed by scientists in the Broad-Bayer oncology research alliance, targets HER2 mutations in lung cancer and shrinks tumors in mice and humans.
Reposted by Broad Institute
We’re so excited with this accomplishment of fastest genome sequencing. Major efforts from BCL and Roche to make this happen. Can’t wait to launch this service clinically so patients can benefit! Paper here www.nejm.org/doi/full/10....
Toward Same-Day Genome Sequencing in the Critical Care Setting | NEJM
Decisions about critical care are almost always made without access to genetic information. The authors report the application of a new method of DNA sequencing in infants in a neonatal intensive c...
www.nejm.org
October 15, 2025 at 3:05 PM
We’re so excited with this accomplishment of fastest genome sequencing. Major efforts from BCL and Roche to make this happen. Can’t wait to launch this service clinically so patients can benefit! Paper here www.nejm.org/doi/full/10....
Reposted by Broad Institute
Predicting functions of uncharacterized gene products from microbial communities - @hutlab.bsky.social @hsph.harvard.edu @broadinstitute.org go.nature.com/435C4lp
Predicting functions of uncharacterized gene products from microbial communities - Nature Biotechnology
FUGAsseM predicts protein function in microbiomes using coexpression patterns from metatranscriptomes and diverse community-wide data.
go.nature.com
October 16, 2025 at 3:54 PM
Predicting functions of uncharacterized gene products from microbial communities - @hutlab.bsky.social @hsph.harvard.edu @broadinstitute.org go.nature.com/435C4lp
Broad Clinical Labs, Roche Sequencing Systems, and @bostonchildrens.bsky.social have set a new @guinnessworldrecords.com for the sequencing and analysis of the whole human genome in less than 4 hours — potentially enabling faster results in critical medical settings. Learn more: broad.io/BCLGWR
October 15, 2025 at 1:53 PM
Broad Clinical Labs, Roche Sequencing Systems, and @bostonchildrens.bsky.social have set a new @guinnessworldrecords.com for the sequencing and analysis of the whole human genome in less than 4 hours — potentially enabling faster results in critical medical settings. Learn more: broad.io/BCLGWR
Enrollment has now completed for most Count Me In projects, though a few remain open. Patient-partnered research will now be supported through Broad Clinical Labs, and interested researchers can learn more here: broad.io/CMInextphase.
A pioneering effort in patient-partnered cancer research enters a new phase
Count Me In’s legacy of data and resources will usher in a new way of doing research on other diseases and continue to fuel cancer studies around the globe.
broad.io
October 8, 2025 at 6:57 PM
Enrollment has now completed for most Count Me In projects, though a few remain open. Patient-partnered research will now be supported through Broad Clinical Labs, and interested researchers can learn more here: broad.io/CMInextphase.
Leading epigenetics researcher and longtime Broad member
@jbuenrostro.bsky.social has been named core institute member of the Broad. His lab will study how cells change in response to life experiences, and how those alterations affect health and disease.
@jbuenrostro.bsky.social has been named core institute member of the Broad. His lab will study how cells change in response to life experiences, and how those alterations affect health and disease.
Jason Buenrostro named core institute member at Broad
An expert in epigenetics and longtime member of the Broad community, Buenrostro will focus on how life experiences can alter the epigenome and increase risk of disease.
broad.io
September 30, 2025 at 3:40 PM
Leading epigenetics researcher and longtime Broad member
@jbuenrostro.bsky.social has been named core institute member of the Broad. His lab will study how cells change in response to life experiences, and how those alterations affect health and disease.
@jbuenrostro.bsky.social has been named core institute member of the Broad. His lab will study how cells change in response to life experiences, and how those alterations affect health and disease.
Reposted by Broad Institute
New research from Microsoft, Drexel, and the Broad explores how generative AI could support genetic professionals in rare disease diagnosis. msft.it/6019sS3P5
September 24, 2025 at 9:01 PM
New research from Microsoft, Drexel, and the Broad explores how generative AI could support genetic professionals in rare disease diagnosis. msft.it/6019sS3P5
Reposted by Broad Institute
Xu, @thexavierlab.bsky.social et al @harvardmed.bsky.social @broadinstitute.org reveal an important role of the ANKRD55 protein in TH17 biology, where its deletion impairs T cell proliferation & effector cytokine production through metabolic dysregulation. rupress.org/jem/article/...
#Autoimmunity
#Autoimmunity
September 11, 2025 at 5:15 PM
Xu, @thexavierlab.bsky.social et al @harvardmed.bsky.social @broadinstitute.org reveal an important role of the ANKRD55 protein in TH17 biology, where its deletion impairs T cell proliferation & effector cytokine production through metabolic dysregulation. rupress.org/jem/article/...
#Autoimmunity
#Autoimmunity