Michael Honigberg
@mchonig.bsky.social
Cardiologist and researcher at Mass General / Broad Institute / Harvard Med. Preventive cardiology, women’s health, genomics. https://honigberglab.mgh.harvard.edu/
Reposted by Michael Honigberg
💬 Invited Commentary: Flynn et al find non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) mutations most strongly associated with heart failure risk in UK Biobank data, supporting gene-specific risk assessment.
#AHA25 @ahascience.bsky.social
ja.ma/4p56SeB
#AHA25 @ahascience.bsky.social
ja.ma/4p56SeB
November 9, 2025 at 6:10 PM
💬 Invited Commentary: Flynn et al find non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) mutations most strongly associated with heart failure risk in UK Biobank data, supporting gene-specific risk assessment.
#AHA25 @ahascience.bsky.social
ja.ma/4p56SeB
#AHA25 @ahascience.bsky.social
ja.ma/4p56SeB
Reposted by Michael Honigberg
Non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) subtypes—including TET2, ASXL1, JAK2, and spliceosome genes—demonstrated higher association with incident heart failure compared to DNMT3A.
#AHA25 @ahascience.bsky.social
ja.ma/3JQSveI
#AHA25 @ahascience.bsky.social
ja.ma/3JQSveI
November 9, 2025 at 6:05 PM
Non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) subtypes—including TET2, ASXL1, JAK2, and spliceosome genes—demonstrated higher association with incident heart failure compared to DNMT3A.
#AHA25 @ahascience.bsky.social
ja.ma/3JQSveI
#AHA25 @ahascience.bsky.social
ja.ma/3JQSveI
Reposted by Michael Honigberg
November issue now live, with Reviews on:
-Clonal haematopoiesis in cardiovascular disease
-Regulators of cardiomyocyte proliferation
-Extracellular vesicles in cardiovascular homeostasis and disease
-Factor XI inhibitors for venous and arterial thromboembolism
www.nature.com/nrcardio/vol...
-Clonal haematopoiesis in cardiovascular disease
-Regulators of cardiomyocyte proliferation
-Extracellular vesicles in cardiovascular homeostasis and disease
-Factor XI inhibitors for venous and arterial thromboembolism
www.nature.com/nrcardio/vol...
October 14, 2025 at 9:36 AM
November issue now live, with Reviews on:
-Clonal haematopoiesis in cardiovascular disease
-Regulators of cardiomyocyte proliferation
-Extracellular vesicles in cardiovascular homeostasis and disease
-Factor XI inhibitors for venous and arterial thromboembolism
www.nature.com/nrcardio/vol...
-Clonal haematopoiesis in cardiovascular disease
-Regulators of cardiomyocyte proliferation
-Extracellular vesicles in cardiovascular homeostasis and disease
-Factor XI inhibitors for venous and arterial thromboembolism
www.nature.com/nrcardio/vol...
Reposted by Michael Honigberg
In this exploratory analysis, treatment with low-dose colchicine was associated with an attenuated annual clonal growth in TET2 CH. These findings suggest the potential for colchicine to curb the proliferative advantage of key CH driver mutations https://bit.ly/3HWJL5M
#ESCCongress #WCCardio #JACC
#ESCCongress #WCCardio #JACC
August 29, 2025 at 7:35 AM
In this exploratory analysis, treatment with low-dose colchicine was associated with an attenuated annual clonal growth in TET2 CH. These findings suggest the potential for colchicine to curb the proliferative advantage of key CH driver mutations https://bit.ly/3HWJL5M
#ESCCongress #WCCardio #JACC
#ESCCongress #WCCardio #JACC
Reposted by Michael Honigberg
Among middle-aged adults, clonal hematopoiesis of indeterminate potential (CHIP) was linked to an increased risk of developing myocarditis and pericarditis.
#ESCCongress #WCCardio
ja.ma/45RBaJG
#ESCCongress #WCCardio
ja.ma/45RBaJG
August 30, 2025 at 3:00 PM
Among middle-aged adults, clonal hematopoiesis of indeterminate potential (CHIP) was linked to an increased risk of developing myocarditis and pericarditis.
#ESCCongress #WCCardio
ja.ma/45RBaJG
#ESCCongress #WCCardio
ja.ma/45RBaJG
Reposted by Michael Honigberg
New report that CHIP (clonal hematopoiesis of indeterminate potential, blood stem cell clones that increase with age) is an independent risk factor for myocarditis and pericarditis, promoting inflammation #ESC2025
@jama.com
jamanetwork.com/journals/jam...
@jama.com
jamanetwork.com/journals/jam...
August 30, 2025 at 3:40 PM
New report that CHIP (clonal hematopoiesis of indeterminate potential, blood stem cell clones that increase with age) is an independent risk factor for myocarditis and pericarditis, promoting inflammation #ESC2025
@jama.com
jamanetwork.com/journals/jam...
@jama.com
jamanetwork.com/journals/jam...
The lab's first sim pub of #ESC2025 is now online in
@jaccjournals.bsky.social #JACC!
jacc.org/doi/10.1016/...
Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study
👇
(1/X)
@jaccjournals.bsky.social #JACC!
jacc.org/doi/10.1016/...
Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study
👇
(1/X)
August 27, 2025 at 2:35 PM
The lab's first sim pub of #ESC2025 is now online in
@jaccjournals.bsky.social #JACC!
jacc.org/doi/10.1016/...
Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study
👇
(1/X)
@jaccjournals.bsky.social #JACC!
jacc.org/doi/10.1016/...
Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study
👇
(1/X)
Fantastic joint lab retreat today w/ @pnatarajanmd.bsky.social @zhiyu.bsky.social & Akl Fahed labs
Honigberg lab is rapidly growing 📈 👇
@mghcvrc.bsky.social @mgbwomenheart.bsky.social @mgbresearch.bsky.social
Honigberg lab is rapidly growing 📈 👇
@mghcvrc.bsky.social @mgbwomenheart.bsky.social @mgbresearch.bsky.social
August 21, 2025 at 10:10 PM
Fantastic joint lab retreat today w/ @pnatarajanmd.bsky.social @zhiyu.bsky.social & Akl Fahed labs
Honigberg lab is rapidly growing 📈 👇
@mghcvrc.bsky.social @mgbwomenheart.bsky.social @mgbresearch.bsky.social
Honigberg lab is rapidly growing 📈 👇
@mghcvrc.bsky.social @mgbwomenheart.bsky.social @mgbresearch.bsky.social
Reposted by Michael Honigberg
Now accepting applications for the 2026-2027 Women's Heart Health Program Fellowship!🫀Click here for details: massgeneral.org/heart-center...
@mdharringtonc.bsky.social @emilyswlau.bsky.social @mchonig.bsky.social
@mdharringtonc.bsky.social @emilyswlau.bsky.social @mchonig.bsky.social
Women's Heart Health Fellowship Program
The Women’s Heart Health Fellowship Program at Massachusetts General Hospital provides advanced training in the prevention, diagnosis, and treatment of heart disease in women.
massgeneral.org
August 6, 2025 at 2:30 PM
Now accepting applications for the 2026-2027 Women's Heart Health Program Fellowship!🫀Click here for details: massgeneral.org/heart-center...
@mdharringtonc.bsky.social @emilyswlau.bsky.social @mchonig.bsky.social
@mdharringtonc.bsky.social @emilyswlau.bsky.social @mchonig.bsky.social
Reposted by Michael Honigberg
Registration is now open!📣We're co-hosting a patient SCAD Symposium with @scadalliance.bsky.social in October 🫀
Please click on the event page to register & for all of the details! massgeneral.org/heart-center...
@emilyswlau.bsky.social @mdharringtonc.bsky.social @mchonig.bsky.social
Please click on the event page to register & for all of the details! massgeneral.org/heart-center...
@emilyswlau.bsky.social @mdharringtonc.bsky.social @mchonig.bsky.social
SCAD Patient Symposium: Your Heart, Your Story
Join us October 18, 2025 for a day of building community with your peers, and hearing from renowned experts about all things SCAD.
massgeneral.org
July 30, 2025 at 3:29 PM
Registration is now open!📣We're co-hosting a patient SCAD Symposium with @scadalliance.bsky.social in October 🫀
Please click on the event page to register & for all of the details! massgeneral.org/heart-center...
@emilyswlau.bsky.social @mdharringtonc.bsky.social @mchonig.bsky.social
Please click on the event page to register & for all of the details! massgeneral.org/heart-center...
@emilyswlau.bsky.social @mdharringtonc.bsky.social @mchonig.bsky.social
The latest from our @americanheart.bsky.social -funded BUSY-BP study, led by MGH medicine resident Lulu Belak, now in Obstet Gynecol @greenjrnl.bsky.social
In Black + Latina 👭, burden of health-related social needs in pregnancy was associated w/ adverse 🤰 outcomes
journals.lww.com/greenjournal...
In Black + Latina 👭, burden of health-related social needs in pregnancy was associated w/ adverse 🤰 outcomes
journals.lww.com/greenjournal...
July 3, 2025 at 9:42 PM
The latest from our @americanheart.bsky.social -funded BUSY-BP study, led by MGH medicine resident Lulu Belak, now in Obstet Gynecol @greenjrnl.bsky.social
In Black + Latina 👭, burden of health-related social needs in pregnancy was associated w/ adverse 🤰 outcomes
journals.lww.com/greenjournal...
In Black + Latina 👭, burden of health-related social needs in pregnancy was associated w/ adverse 🤰 outcomes
journals.lww.com/greenjournal...
Reposted by Michael Honigberg
Missed the deadline? Plot twist: You didn't!
Deadlines extended! 🗓️
#AHA25 & #ReSS25 abstracts now due 6/9 at 10am ET.
Award applications due 6/9 at 7pm ET.
Submit here:
🔹 AHA: bit.ly/2025Extension
🔹 ReSS: bit.ly/ReSSExtension
@ahascience.bsky.social #CardioSky
Deadlines extended! 🗓️
#AHA25 & #ReSS25 abstracts now due 6/9 at 10am ET.
Award applications due 6/9 at 7pm ET.
Submit here:
🔹 AHA: bit.ly/2025Extension
🔹 ReSS: bit.ly/ReSSExtension
@ahascience.bsky.social #CardioSky
Scientific Sessions
Join us for FOUR days of programming, November 7–10, 2025, for AHA's Scientific Sessions (#AHA25) at the Ernest N. Morial Convention Center in New Orleans, Louisiana. It's AHA's biggest cardiova...
bit.ly
June 6, 2025 at 8:13 PM
Missed the deadline? Plot twist: You didn't!
Deadlines extended! 🗓️
#AHA25 & #ReSS25 abstracts now due 6/9 at 10am ET.
Award applications due 6/9 at 7pm ET.
Submit here:
🔹 AHA: bit.ly/2025Extension
🔹 ReSS: bit.ly/ReSSExtension
@ahascience.bsky.social #CardioSky
Deadlines extended! 🗓️
#AHA25 & #ReSS25 abstracts now due 6/9 at 10am ET.
Award applications due 6/9 at 7pm ET.
Submit here:
🔹 AHA: bit.ly/2025Extension
🔹 ReSS: bit.ly/ReSSExtension
@ahascience.bsky.social #CardioSky
Reposted by Michael Honigberg
The inaugural MGB & Inova YIA was a huge success 🎉Please join us in congratulating 👏👏
Basic & Translational category:
Winner: Maria Pabon (BWH)
Honorable Mention: Amelie Vromman (BWH)
Clinical Research category:
Winner: Meesha Vullikanti (Yale)
Honorable Mention: Izza Shahid (Houston Methodist)
Basic & Translational category:
Winner: Maria Pabon (BWH)
Honorable Mention: Amelie Vromman (BWH)
Clinical Research category:
Winner: Meesha Vullikanti (Yale)
Honorable Mention: Izza Shahid (Houston Methodist)
June 5, 2025 at 9:05 PM
The inaugural MGB & Inova YIA was a huge success 🎉Please join us in congratulating 👏👏
Basic & Translational category:
Winner: Maria Pabon (BWH)
Honorable Mention: Amelie Vromman (BWH)
Clinical Research category:
Winner: Meesha Vullikanti (Yale)
Honorable Mention: Izza Shahid (Houston Methodist)
Basic & Translational category:
Winner: Maria Pabon (BWH)
Honorable Mention: Amelie Vromman (BWH)
Clinical Research category:
Winner: Meesha Vullikanti (Yale)
Honorable Mention: Izza Shahid (Houston Methodist)
Huge congrats to @massgeneralbrigham.bsky.social MGH medicine resident Amanda Jowell for receiving a top resident abstract award for her analysis of female-specific CVD risk factors in severe hypercholesterolemia 🏆 @mgbwomenheart.bsky.social @mghcvrc.bsky.social
May 29, 2025 at 2:10 PM
Huge congrats to @massgeneralbrigham.bsky.social MGH medicine resident Amanda Jowell for receiving a top resident abstract award for her analysis of female-specific CVD risk factors in severe hypercholesterolemia 🏆 @mgbwomenheart.bsky.social @mghcvrc.bsky.social
Big congrats to Maria Pabon for winning the inaugural @mgbwomenheart.bsky.social / @ishvnews.bsky.social Young Investigators' Award (basic/translational category) for her work on endothelial cell transcriptomics in preeclampsia (www.ahajournals.org/doi/10.1161/...)! 🏆 @cardioob.bsky.social
May 10, 2025 at 5:38 PM
Big congrats to Maria Pabon for winning the inaugural @mgbwomenheart.bsky.social / @ishvnews.bsky.social Young Investigators' Award (basic/translational category) for her work on endothelial cell transcriptomics in preeclampsia (www.ahajournals.org/doi/10.1161/...)! 🏆 @cardioob.bsky.social
Reposted by Michael Honigberg
Genetic Risk & 1st-Trimester CV Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women
#CardioObstetrics #CardioSky #JACC
www.jacc.org/doi/10.1016/...
@mchonig.bsky.social @garimasharmamd.bsky.social @jaccjournals.bsky.social @csilvers.bsky.social @mdharringtonc.bsky.social
#CardioObstetrics #CardioSky #JACC
www.jacc.org/doi/10.1016/...
@mchonig.bsky.social @garimasharmamd.bsky.social @jaccjournals.bsky.social @csilvers.bsky.social @mdharringtonc.bsky.social
April 28, 2025 at 4:10 PM
Genetic Risk & 1st-Trimester CV Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women
#CardioObstetrics #CardioSky #JACC
www.jacc.org/doi/10.1016/...
@mchonig.bsky.social @garimasharmamd.bsky.social @jaccjournals.bsky.social @csilvers.bsky.social @mdharringtonc.bsky.social
#CardioObstetrics #CardioSky #JACC
www.jacc.org/doi/10.1016/...
@mchonig.bsky.social @garimasharmamd.bsky.social @jaccjournals.bsky.social @csilvers.bsky.social @mdharringtonc.bsky.social
Our latest on 🫀 health, 🧬, and 🤰 now out in @jaccjournals.bsky.social #JACC
First-trimester cardiovascular health strongly associates with development of hypertensive disorders of 🤰 (HDP)
overall and across levels of HDP genetic risk
www.jacc.org/doi/10.1016/...
#CardioObstetrics #CardioSky
First-trimester cardiovascular health strongly associates with development of hypertensive disorders of 🤰 (HDP)
overall and across levels of HDP genetic risk
www.jacc.org/doi/10.1016/...
#CardioObstetrics #CardioSky
April 8, 2025 at 1:43 AM
Our latest on 🫀 health, 🧬, and 🤰 now out in @jaccjournals.bsky.social #JACC
First-trimester cardiovascular health strongly associates with development of hypertensive disorders of 🤰 (HDP)
overall and across levels of HDP genetic risk
www.jacc.org/doi/10.1016/...
#CardioObstetrics #CardioSky
First-trimester cardiovascular health strongly associates with development of hypertensive disorders of 🤰 (HDP)
overall and across levels of HDP genetic risk
www.jacc.org/doi/10.1016/...
#CardioObstetrics #CardioSky
Reposted by Michael Honigberg
We love our team ❤️ Check out @mchonig.bsky.social's latest review!
Check out our latest review on clonal hematopoiesis🩸🧬 and cardiovascular disease 💔 now out in @natrevcardiol.bsky.social
www.nature.com/articles/s41...
Full text link: rdcu.be/ef9VW
@mgbresearch.bsky.social @mgbwomenheart.bsky.social
www.nature.com/articles/s41...
Full text link: rdcu.be/ef9VW
@mgbresearch.bsky.social @mgbwomenheart.bsky.social
Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target - Nature Reviews Cardiology
In this Review, Schuermans and Honigberg highlight the involvement of clonal haematopoiesis of indeterminate potential (CHIP) in cardiovascular diseases, such as atherosclerosis and heart failure, and...
www.nature.com
April 2, 2025 at 8:16 PM
We love our team ❤️ Check out @mchonig.bsky.social's latest review!
Check out our latest review on clonal hematopoiesis🩸🧬 and cardiovascular disease 💔 now out in @natrevcardiol.bsky.social
www.nature.com/articles/s41...
Full text link: rdcu.be/ef9VW
@mgbresearch.bsky.social @mgbwomenheart.bsky.social
www.nature.com/articles/s41...
Full text link: rdcu.be/ef9VW
@mgbresearch.bsky.social @mgbwomenheart.bsky.social
Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target - Nature Reviews Cardiology
In this Review, Schuermans and Honigberg highlight the involvement of clonal haematopoiesis of indeterminate potential (CHIP) in cardiovascular diseases, such as atherosclerosis and heart failure, and...
www.nature.com
April 2, 2025 at 6:29 PM
Check out our latest review on clonal hematopoiesis🩸🧬 and cardiovascular disease 💔 now out in @natrevcardiol.bsky.social
www.nature.com/articles/s41...
Full text link: rdcu.be/ef9VW
@mgbresearch.bsky.social @mgbwomenheart.bsky.social
www.nature.com/articles/s41...
Full text link: rdcu.be/ef9VW
@mgbresearch.bsky.social @mgbwomenheart.bsky.social
Check out our latest episode of HeartBEATS from the @americanheart.bsky.social focused on peripartum cardiomyopathy 🤰🫀 #PPCM ! @cardioob.bsky.social
professional.heart.org/en/education...
professional.heart.org/en/education...
Role of Cardiovascular Health in Maternal Health
Explore the role of cardiovascular health in maternal well-being. Learn warning signs, improve communication, and access life-saving tools.
professional.heart.org
April 2, 2025 at 3:41 PM
Check out our latest episode of HeartBEATS from the @americanheart.bsky.social focused on peripartum cardiomyopathy 🤰🫀 #PPCM ! @cardioob.bsky.social
professional.heart.org/en/education...
professional.heart.org/en/education...
Reposted by Michael Honigberg
Our team is gearing up for #ACC25! We'd love to see you! Come find us at one of our sessions! 🩺♥️
@mchonig.bsky.social @mdharringtonc.bsky.social @accintouch.bsky.social
@mchonig.bsky.social @mdharringtonc.bsky.social @accintouch.bsky.social
March 27, 2025 at 9:11 PM
Our team is gearing up for #ACC25! We'd love to see you! Come find us at one of our sessions! 🩺♥️
@mchonig.bsky.social @mdharringtonc.bsky.social @accintouch.bsky.social
@mchonig.bsky.social @mdharringtonc.bsky.social @accintouch.bsky.social
Reposted by Michael Honigberg
Getting ready for #ACC25?
✅ Download #ACC25 app
apps.apple.com/us/app/acc-2...
✅ Follow #ACC25 ambassadors
bsky.app/profile/did:...
#CardioSky @accintouch.bsky.social @jaccjournals.bsky.social @saraersozlu.bsky.social @thornsberryjd.bsky.social @cathlabedu.bsky.social @bakhshihooman.bsky.social
✅ Download #ACC25 app
apps.apple.com/us/app/acc-2...
✅ Follow #ACC25 ambassadors
bsky.app/profile/did:...
#CardioSky @accintouch.bsky.social @jaccjournals.bsky.social @saraersozlu.bsky.social @thornsberryjd.bsky.social @cathlabedu.bsky.social @bakhshihooman.bsky.social
March 19, 2025 at 1:04 PM
Getting ready for #ACC25?
✅ Download #ACC25 app
apps.apple.com/us/app/acc-2...
✅ Follow #ACC25 ambassadors
bsky.app/profile/did:...
#CardioSky @accintouch.bsky.social @jaccjournals.bsky.social @saraersozlu.bsky.social @thornsberryjd.bsky.social @cathlabedu.bsky.social @bakhshihooman.bsky.social
✅ Download #ACC25 app
apps.apple.com/us/app/acc-2...
✅ Follow #ACC25 ambassadors
bsky.app/profile/did:...
#CardioSky @accintouch.bsky.social @jaccjournals.bsky.social @saraersozlu.bsky.social @thornsberryjd.bsky.social @cathlabedu.bsky.social @bakhshihooman.bsky.social
Important trial of CAC scoring-guided CVD prevention (CAUGHT-CAD) out in @jama.com today:
jamanetwork.com/journals/jam...
In Australians w/ intermediate CVD risk (+ FHx) w/o clear statin indication, CAC score-guided prevention yielded reduced progression of total and non-calcified plaque over 3 y
jamanetwork.com/journals/jam...
In Australians w/ intermediate CVD risk (+ FHx) w/o clear statin indication, CAC score-guided prevention yielded reduced progression of total and non-calcified plaque over 3 y
Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease
This clinical trial evaluates the efficacy of combining coronary artery calcium scoring with a prevention strategy to limit plaque progression in intermediate-risk patients with a family history of pr...
jamanetwork.com
March 6, 2025 at 2:05 AM
Important trial of CAC scoring-guided CVD prevention (CAUGHT-CAD) out in @jama.com today:
jamanetwork.com/journals/jam...
In Australians w/ intermediate CVD risk (+ FHx) w/o clear statin indication, CAC score-guided prevention yielded reduced progression of total and non-calcified plaque over 3 y
jamanetwork.com/journals/jam...
In Australians w/ intermediate CVD risk (+ FHx) w/o clear statin indication, CAC score-guided prevention yielded reduced progression of total and non-calcified plaque over 3 y
Reposted by Michael Honigberg
Danish Analysis Updates Stroke and MI Risks of Contemporary Contraceptives
Danish Analysis Updates Stroke and MI Risks of Contemporary Contraceptives
Danish Analysis Updates Stroke and MI Risks of Contemporary Contraceptives
hdellabella@crf.org
Mon, 03/03/2025 - 15:41
L.A. McKeown
Though arterial thrombotic risk was higher with hormonal contraception use, the absolute excess risks were low.
www.tctmd.com
March 3, 2025 at 8:53 PM
Danish Analysis Updates Stroke and MI Risks of Contemporary Contraceptives