Michael Honigberg
@mchonig.bsky.social
Cardiologist and researcher at Mass General / Broad Institute / Harvard Med. Preventive cardiology, women’s health, genomics. https://honigberglab.mgh.harvard.edu/
(6/X)
Our findings suggest CHIP remains relevant into later life & underscore its heterogeneity.
Paper (OA): www.jacc.org/doi/10.1016/...
Editorial: www.jacc.org/doi/10.1016/...
Come see @danielezzat.bsky.social 's presentation #ESC2025 (29 Aug 10:15a)!
@mghcvrc.bsky.social @broadinstitute.org
Our findings suggest CHIP remains relevant into later life & underscore its heterogeneity.
Paper (OA): www.jacc.org/doi/10.1016/...
Editorial: www.jacc.org/doi/10.1016/...
Come see @danielezzat.bsky.social 's presentation #ESC2025 (29 Aug 10:15a)!
@mghcvrc.bsky.social @broadinstitute.org
August 27, 2025 at 2:43 PM
(6/X)
Our findings suggest CHIP remains relevant into later life & underscore its heterogeneity.
Paper (OA): www.jacc.org/doi/10.1016/...
Editorial: www.jacc.org/doi/10.1016/...
Come see @danielezzat.bsky.social 's presentation #ESC2025 (29 Aug 10:15a)!
@mghcvrc.bsky.social @broadinstitute.org
Our findings suggest CHIP remains relevant into later life & underscore its heterogeneity.
Paper (OA): www.jacc.org/doi/10.1016/...
Editorial: www.jacc.org/doi/10.1016/...
Come see @danielezzat.bsky.social 's presentation #ESC2025 (29 Aug 10:15a)!
@mghcvrc.bsky.social @broadinstitute.org
(5/X)
HRs for CHIP were comparable or greater than those for other conventional CVD risk factors (e.g., 👇)
In addition, we examined alternate thresholds of variant allele frequency to define CHIP; associations generally ⬇️ w/ smaller clone size
HRs for CHIP were comparable or greater than those for other conventional CVD risk factors (e.g., 👇)
In addition, we examined alternate thresholds of variant allele frequency to define CHIP; associations generally ⬇️ w/ smaller clone size
August 27, 2025 at 2:39 PM
(5/X)
HRs for CHIP were comparable or greater than those for other conventional CVD risk factors (e.g., 👇)
In addition, we examined alternate thresholds of variant allele frequency to define CHIP; associations generally ⬇️ w/ smaller clone size
HRs for CHIP were comparable or greater than those for other conventional CVD risk factors (e.g., 👇)
In addition, we examined alternate thresholds of variant allele frequency to define CHIP; associations generally ⬇️ w/ smaller clone size
(4/X)
Key CHIP subtypes were associated w/ adverse CV events
Consistent w/ our prior work, TET2 CHIP associated w/ CHD & HFpEF
👀 ASXL1 CHIP ➡️ HFrEF (aHR >3)
Notably, no associations were seen when we lumped all CHIP types together, underscoring its heterogeneity
Key CHIP subtypes were associated w/ adverse CV events
Consistent w/ our prior work, TET2 CHIP associated w/ CHD & HFpEF
👀 ASXL1 CHIP ➡️ HFrEF (aHR >3)
Notably, no associations were seen when we lumped all CHIP types together, underscoring its heterogeneity
August 27, 2025 at 2:39 PM
(4/X)
Key CHIP subtypes were associated w/ adverse CV events
Consistent w/ our prior work, TET2 CHIP associated w/ CHD & HFpEF
👀 ASXL1 CHIP ➡️ HFrEF (aHR >3)
Notably, no associations were seen when we lumped all CHIP types together, underscoring its heterogeneity
Key CHIP subtypes were associated w/ adverse CV events
Consistent w/ our prior work, TET2 CHIP associated w/ CHD & HFpEF
👀 ASXL1 CHIP ➡️ HFrEF (aHR >3)
Notably, no associations were seen when we lumped all CHIP types together, underscoring its heterogeneity
(3/X)
We therefore examined ~6,700 👵👵 from the Women's Health Initiative Long Life Study (median age 80 y) and sequenced blood cells ~4,500x in each participant to accurately detect 🔍 and quantify CHIP
Women were followed for ~10 y for coronary heart disease and several secondary outcomes
👇
We therefore examined ~6,700 👵👵 from the Women's Health Initiative Long Life Study (median age 80 y) and sequenced blood cells ~4,500x in each participant to accurately detect 🔍 and quantify CHIP
Women were followed for ~10 y for coronary heart disease and several secondary outcomes
👇
August 27, 2025 at 2:37 PM
(3/X)
We therefore examined ~6,700 👵👵 from the Women's Health Initiative Long Life Study (median age 80 y) and sequenced blood cells ~4,500x in each participant to accurately detect 🔍 and quantify CHIP
Women were followed for ~10 y for coronary heart disease and several secondary outcomes
👇
We therefore examined ~6,700 👵👵 from the Women's Health Initiative Long Life Study (median age 80 y) and sequenced blood cells ~4,500x in each participant to accurately detect 🔍 and quantify CHIP
Women were followed for ~10 y for coronary heart disease and several secondary outcomes
👇
(2/X)
CHIP = aging-related acquired blood stem cell mutations that predispose to blood cancers
We + others have shown that CHIP also associates w/ ⬆️ CVD risk
But previous work suggested attenuation of associated risk in older adults, who have highest risk of both CHIP + CVD
CHIP = aging-related acquired blood stem cell mutations that predispose to blood cancers
We + others have shown that CHIP also associates w/ ⬆️ CVD risk
But previous work suggested attenuation of associated risk in older adults, who have highest risk of both CHIP + CVD
August 27, 2025 at 2:36 PM
(2/X)
CHIP = aging-related acquired blood stem cell mutations that predispose to blood cancers
We + others have shown that CHIP also associates w/ ⬆️ CVD risk
But previous work suggested attenuation of associated risk in older adults, who have highest risk of both CHIP + CVD
CHIP = aging-related acquired blood stem cell mutations that predispose to blood cancers
We + others have shown that CHIP also associates w/ ⬆️ CVD risk
But previous work suggested attenuation of associated risk in older adults, who have highest risk of both CHIP + CVD
… posted prematurely/in error without acknowledging the awesome work of lead author and overall rockstar @artschuermans.bsky.social !
April 2, 2025 at 6:30 PM
… posted prematurely/in error without acknowledging the awesome work of lead author and overall rockstar @artschuermans.bsky.social !