Harsha Gouda
@harshagouda.bsky.social
Post-doc at Dorrestein lab. Interested in all things metabolism, microbes and enzymes.
Get your paper reviewed before peer review at www.qedscience.com
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
www.qedscience.com
October 31, 2025 at 6:46 PM
Get your paper reviewed before peer review at www.qedscience.com
Reposted by Harsha Gouda
The mass spectrometry of microbiome-mediated metabolism of food: challenges and opportunities
#CurrOpinMicrobiol by @harshagouda.bsky.social et al from @pieterdorrestein.bsky.social
www.sciencedirect.com/science/arti...
#CurrOpinMicrobiol by @harshagouda.bsky.social et al from @pieterdorrestein.bsky.social
www.sciencedirect.com/science/arti...
The mass spectrometry of microbiome-mediated metabolism of food: challenges and opportunities
With the exception of molecules acquired through the lungs, skin absorption, or part of a medication regime, nearly all molecules in our bodies origin…
www.sciencedirect.com
August 9, 2025 at 12:45 PM
The mass spectrometry of microbiome-mediated metabolism of food: challenges and opportunities
#CurrOpinMicrobiol by @harshagouda.bsky.social et al from @pieterdorrestein.bsky.social
www.sciencedirect.com/science/arti...
#CurrOpinMicrobiol by @harshagouda.bsky.social et al from @pieterdorrestein.bsky.social
www.sciencedirect.com/science/arti...
The interactions between food, microbiome and host that modulate health can be complex. Here, we offer a perspective on how mass spectrometry can be leveraged to address some of these challenges to understand host and microbial metabolism of food. A step closer to personalized health and nutrition.
The mass spectrometry of microbiome-mediated metabolism of food: challenges and opportunities
With the exception of molecules acquired through the lungs, skin absorption, or part of a medication regime, nearly all molecules in our bodies origin…
www.sciencedirect.com
August 8, 2025 at 6:14 PM
The interactions between food, microbiome and host that modulate health can be complex. Here, we offer a perspective on how mass spectrometry can be leveraged to address some of these challenges to understand host and microbial metabolism of food. A step closer to personalized health and nutrition.
Reposted by Harsha Gouda
Molecules in urine and blood can reveal how much of a person’s diet comes from ultra-processed foods
https://go.nature.com/4kybHea
https://go.nature.com/4kybHea
How much ultra-processed food do you eat? Blood and urine record it
Samples could provide an objective measure of diets and help to unravel their contribution to disease.
go.nature.com
May 21, 2025 at 8:54 AM
Molecules in urine and blood can reveal how much of a person’s diet comes from ultra-processed foods
https://go.nature.com/4kybHea
https://go.nature.com/4kybHea
Reposted by Harsha Gouda
New @science.org
Exposomics. We're not doing nearly enough to understand and mitigate our toxic environmental exposures. A very insightful perspective
www.science.org/doi/10.1126/...
Exposomics. We're not doing nearly enough to understand and mitigate our toxic environmental exposures. A very insightful perspective
www.science.org/doi/10.1126/...
April 24, 2025 at 6:23 PM
New @science.org
Exposomics. We're not doing nearly enough to understand and mitigate our toxic environmental exposures. A very insightful perspective
www.science.org/doi/10.1126/...
Exposomics. We're not doing nearly enough to understand and mitigate our toxic environmental exposures. A very insightful perspective
www.science.org/doi/10.1126/...
Reposted by Harsha Gouda
Should you return home after earning your PhD abroad? This Nature article explores the dilemmas faced by international researchers considering a move back to their home countries. A thought-provoking read for anyone navigating global academic careers. 
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Should I return to my home country after my PhD abroad?
A graduate student from southeast Asia, now based in a European country and missing her homeland, agonizes over her next career move.
www.nature.com
April 17, 2025 at 6:14 AM
Should you return home after earning your PhD abroad? This Nature article explores the dilemmas faced by international researchers considering a move back to their home countries. A thought-provoking read for anyone navigating global academic careers. 
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Harsha Gouda
QC:MXP version 2.0 is now available to download for free from my GitHub page: www.qcmxp.org
Repeat-injection-based Quality Control, Batch Correction, Exploration & Data Cleaning. #Metabolomics #AnalyticalChemistry #Matlab
Repeat-injection-based Quality Control, Batch Correction, Exploration & Data Cleaning. #Metabolomics #AnalyticalChemistry #Matlab
April 17, 2025 at 5:33 AM
QC:MXP version 2.0 is now available to download for free from my GitHub page: www.qcmxp.org
Repeat-injection-based Quality Control, Batch Correction, Exploration & Data Cleaning. #Metabolomics #AnalyticalChemistry #Matlab
Repeat-injection-based Quality Control, Batch Correction, Exploration & Data Cleaning. #Metabolomics #AnalyticalChemistry #Matlab
Reposted by Harsha Gouda
Individuals who were conceived in colder seasons are more likely to show higher brown adipose tissue activity, increased energy expenditure and a lower BMI, and lower fat accumulation around internal organs, suggests a study in Nature Metabolism. https://go.nature.com/4i3EYM0 🧪
April 7, 2025 at 7:04 PM
Individuals who were conceived in colder seasons are more likely to show higher brown adipose tissue activity, increased energy expenditure and a lower BMI, and lower fat accumulation around internal organs, suggests a study in Nature Metabolism. https://go.nature.com/4i3EYM0 🧪
Reposted by Harsha Gouda
New blog post! In which I explain the issue with mediation analysis and sketch out one way to deal with the underlying causal inference problem -- in just a bit over 1,000 words!
If you have never found the time to read up on this, now is your chance.
www.the100.ci/2025/03/20/r...
If you have never found the time to read up on this, now is your chance.
www.the100.ci/2025/03/20/r...
Reviewer notes: That’s a very nice mediation analysis you have there. It would be a shame if something happened to it.
Mediation analysis has gotten a lot of flak, including classic titles such as “Yes, but what’s the mechanism? (Don’t expect an easy answer)” (Bullock et al., 2010), “What mediation analysis can (not) ...
www.the100.ci
March 20, 2025 at 1:40 PM
New blog post! In which I explain the issue with mediation analysis and sketch out one way to deal with the underlying causal inference problem -- in just a bit over 1,000 words!
If you have never found the time to read up on this, now is your chance.
www.the100.ci/2025/03/20/r...
If you have never found the time to read up on this, now is your chance.
www.the100.ci/2025/03/20/r...
Reposted by Harsha Gouda
Reposted by Harsha Gouda
Event organizers often overlook the visa-related difficulties that researchers in low- and middle-income countries face. This must change, says Kara Hanson
https://go.nature.com/3DioEc0
https://go.nature.com/3DioEc0
We moved a conference halfway around the globe to avoid visa discrimination
Event organizers often overlook the visa-related difficulties that researchers in low- and middle-income countries face. This must change.
go.nature.com
March 4, 2025 at 2:20 PM
Event organizers often overlook the visa-related difficulties that researchers in low- and middle-income countries face. This must change, says Kara Hanson
https://go.nature.com/3DioEc0
https://go.nature.com/3DioEc0
Reposted by Harsha Gouda
Discovery of metabolites prevails amid in-source fragmentation #NatMetab www.nature.com/articles/s42...
Discovery of metabolites prevails amid in-source fragmentation - Nature Metabolism
Nature Metabolism - Discovery of metabolites prevails amid in-source fragmentation
www.nature.com
March 1, 2025 at 8:12 PM
Discovery of metabolites prevails amid in-source fragmentation #NatMetab www.nature.com/articles/s42...
Reposted by Harsha Gouda
Another fun paper that was started by a good and important question by Prajit - an undergrad in the lab - about imputation. We then teamed up with the Kelley lab as they are good at such benchmarking in data science. So fun to work woth them. pubs.acs.org/doi/10.1021/...
To Impute or Not To Impute in Untargeted Metabolomics─That is the Compositional Question
Untargeted metabolomics often produce large datasets with missing values. These missing values are derived from biological or technical factors and can undermine statistical analyses and lead to biase...
pubs.acs.org
February 28, 2025 at 9:12 PM
Another fun paper that was started by a good and important question by Prajit - an undergrad in the lab - about imputation. We then teamed up with the Kelley lab as they are good at such benchmarking in data science. So fun to work woth them. pubs.acs.org/doi/10.1021/...
Reposted by Harsha Gouda
The #InternationalSpaceStation is overly sterile; making it “dirtier” could improve astronaut health, microbiologists say. cell.com/cell/fulltex...
Learn more in @cp-cell.bsky.social
@pieterdorrestein.bsky.social, Rob Knight
Learn more in @cp-cell.bsky.social
@pieterdorrestein.bsky.social, Rob Knight
The International Space Station has a unique and extreme microbial and chemical environment driven by use patterns
With long-term space travel and extraterrestrial habitation becoming feasible, understanding
how space environmental exposures, microbial communities, and molecular profiles differ
from Earth is cruci...
cell.com
February 27, 2025 at 5:56 PM
The #InternationalSpaceStation is overly sterile; making it “dirtier” could improve astronaut health, microbiologists say. cell.com/cell/fulltex...
Learn more in @cp-cell.bsky.social
@pieterdorrestein.bsky.social, Rob Knight
Learn more in @cp-cell.bsky.social
@pieterdorrestein.bsky.social, Rob Knight
Reposted by Harsha Gouda
A new resource rating >50,000 foods from 3 grocery stores
(Walmart, Target, and Whole Foods) for degree of processing and breakdown of ingredients
www.nature.com/articles/s43...
Website for consumers www.truefood.tech
(Walmart, Target, and Whole Foods) for degree of processing and breakdown of ingredients
www.nature.com/articles/s43...
Website for consumers www.truefood.tech
January 13, 2025 at 2:29 PM
A new resource rating >50,000 foods from 3 grocery stores
(Walmart, Target, and Whole Foods) for degree of processing and breakdown of ingredients
www.nature.com/articles/s43...
Website for consumers www.truefood.tech
(Walmart, Target, and Whole Foods) for degree of processing and breakdown of ingredients
www.nature.com/articles/s43...
Website for consumers www.truefood.tech
Reposted by Harsha Gouda
Such a wonderful SIMB workshop on @gnps2.bsky.social covering classical mol networking, FBMN, ion identity based mol networking, FBMN-STATS, gnps-dashboard, CMMC-kb, Modifinder, MicrobeMASST, MassQL, and limited ReDU - many were covered at a workshop for the first time. 1/4
January 8, 2025 at 7:18 PM
Such a wonderful SIMB workshop on @gnps2.bsky.social covering classical mol networking, FBMN, ion identity based mol networking, FBMN-STATS, gnps-dashboard, CMMC-kb, Modifinder, MicrobeMASST, MassQL, and limited ReDU - many were covered at a workshop for the first time. 1/4
Reposted by Harsha Gouda
So fun at SIMB teaching the gnps ecosystem.
January 7, 2025 at 10:01 PM
So fun at SIMB teaching the gnps ecosystem.
Reposted by Harsha Gouda
December 17, 2024 at 1:33 PM
Reposted by Harsha Gouda
An accurate IDMS-based method for absolute quantification of phytohemagglutinin, a major antinutritional component in common bean #JFoodSci ift.onlinelibrary.wiley.com/doi/10.1111/...
An accurate IDMS‐based method for absolute quantification of phytohemagglutinin, a major antinutritional component in common bean
Abstract Phytohemagglutinin (PHA), a natural tetramer comprising PHA-E and PHA-L subunits that preferentially bind to red and white blood cells, respectively, constitutes a significant antinutrition...
ift.onlinelibrary.wiley.com
December 20, 2024 at 7:48 PM
An accurate IDMS-based method for absolute quantification of phytohemagglutinin, a major antinutritional component in common bean #JFoodSci ift.onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Harsha Gouda
Welcome to the wonderful #mzmine @mzmine.bsky.social team in Bluesky @bsky.app .
So nice to have you in #ICTC13 metabolomics workshop !
Check it out at www.ictc13.gr
So nice to have you in #ICTC13 metabolomics workshop !
Check it out at www.ictc13.gr
December 19, 2024 at 7:49 AM
Welcome to the wonderful #mzmine @mzmine.bsky.social team in Bluesky @bsky.app .
So nice to have you in #ICTC13 metabolomics workshop !
Check it out at www.ictc13.gr
So nice to have you in #ICTC13 metabolomics workshop !
Check it out at www.ictc13.gr
Reposted by Harsha Gouda
New tensor factorization paper out today — a fun collaboration with Pixu Shi, Liat Shenhav, Rob Knight, & Anru_Zhang! 🎉 Check it out here: genomebiology.biomedcentral.com/articles/10....
TEMPTED: time-informed dimensionality reduction for longitudinal microbiome studies - Genome Biology
Longitudinal studies are crucial for understanding complex microbiome dynamics and their link to health. We introduce TEMPoral TEnsor Decomposition (TEMPTED), a time-informed dimensionality reduction ...
genomebiology.biomedcentral.com
December 19, 2024 at 8:17 PM
New tensor factorization paper out today — a fun collaboration with Pixu Shi, Liat Shenhav, Rob Knight, & Anru_Zhang! 🎉 Check it out here: genomebiology.biomedcentral.com/articles/10....
HAHAHA 🤯
All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is. 🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Why probability probably doesn’t exist (but it is useful to act like it does)
All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.
www.nature.com
December 19, 2024 at 11:55 PM
HAHAHA 🤯
I’m starting to fall in love with math again. It was enzyme kinetics in grad school, now it’s testing different models on clinical data.
December 18, 2024 at 1:38 AM
I’m starting to fall in love with math again. It was enzyme kinetics in grad school, now it’s testing different models on clinical data.
Reposted by Harsha Gouda
What if I told you that if you have coyote "problems" (as in, you feel there are too many), killing them...can make it WORSE?
Me on @rolandkays.com 's latest paper, so glad his lab is studying this!
teamtrash.substack.com/p/hunt-more-...
Me on @rolandkays.com 's latest paper, so glad his lab is studying this!
teamtrash.substack.com/p/hunt-more-...
Hunt more coyote, get more coyote
Humans often assume killing will solve the problem. Here's yet another example of why we are wrong.
teamtrash.substack.com
December 15, 2024 at 9:35 PM
What if I told you that if you have coyote "problems" (as in, you feel there are too many), killing them...can make it WORSE?
Me on @rolandkays.com 's latest paper, so glad his lab is studying this!
teamtrash.substack.com/p/hunt-more-...
Me on @rolandkays.com 's latest paper, so glad his lab is studying this!
teamtrash.substack.com/p/hunt-more-...