Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
@guillaumehummel.bsky.social
RNA biologist and physiologist studying how plants regulate the expression of invasive and foreign DNA elements, and how this regulation shapes tissue identity
IBMP-CNRS @ibmp-cnrs.bsky.social, University of Strasbourg.
https://tinyurl.com/ghummel
IBMP-CNRS @ibmp-cnrs.bsky.social, University of Strasbourg.
https://tinyurl.com/ghummel
Pinned
I am honoured to share that my postdoctoral work is now out in The Plant Cell @theplantcell.bsky.social !
doi.org/10.1093/plce...
doi.org/10.1093/plce...
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
Two M. tuberculosis RelE toxins don’t cut mRNA, they slice 16S rRNA itself, shutting down translation in a totally unexpected way, new study reveals.
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
November 18, 2025 at 8:56 AM
Two M. tuberculosis RelE toxins don’t cut mRNA, they slice 16S rRNA itself, shutting down translation in a totally unexpected way, new study reveals.
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
This work is now officially published
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
November 15, 2025 at 9:51 AM
This work is now officially published
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
This is a remarkable study describing a new fungal species in a 407 million year old plant - Rugososporomyces lavoisierae Strullu-Derrien and Schornack sp. nov - using some amazing technology. Worth a read 👇
Confocal scanning laser microscopy, fluorescence lifetime imaging & Raman analyses allowed @nhm-london.bsky.social, @slcuplants.bsky.social & @cambridge-ee.bsky.social researchers to resolve plant & fungal structures fossil
Read in @newphyt.bsky.social
doi.org/10.1111/nph....
@dromius.bsky.social
Read in @newphyt.bsky.social
doi.org/10.1111/nph....
@dromius.bsky.social
November 14, 2025 at 9:37 AM
This is a remarkable study describing a new fungal species in a 407 million year old plant - Rugososporomyces lavoisierae Strullu-Derrien and Schornack sp. nov - using some amazing technology. Worth a read 👇
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
We are looking for a PhD student to work on an exciting plastid endosymbiosis in microbial eukaryotes. This position involves sampling, exciting microscopy such as CARDFISH, ExM and FIBSEM, single-cell transcriptomics and more. #protistsonsky 1/2
November 12, 2025 at 9:50 AM
We are looking for a PhD student to work on an exciting plastid endosymbiosis in microbial eukaryotes. This position involves sampling, exciting microscopy such as CARDFISH, ExM and FIBSEM, single-cell transcriptomics and more. #protistsonsky 1/2
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/...
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Recurrent acquisition of nuclease-protease pairs in antiviral immunity
Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin...
www.science.org
November 13, 2025 at 10:15 PM
Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/...
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
Beyond the niche - unlocking the full potential of synthetic riboswitches
doi.org/10.1038/s414...
doi.org/10.1038/s414...
November 13, 2025 at 5:44 AM
Beyond the niche - unlocking the full potential of synthetic riboswitches
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
The worst thing about the book is that it creates the impression that this hypercompetitive, no respect for rules or others, approach to science is normal or desirable.
21/41
21/41
November 8, 2025 at 1:58 PM
The worst thing about the book is that it creates the impression that this hypercompetitive, no respect for rules or others, approach to science is normal or desirable.
21/41
21/41
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
Watson was an opportunist. He took advantage of Crick’s command of crystallography and managed to get access to Franklin’s experimental data including the famous Photography 51 which reveal a simple cross-like diffraction pattern of DNA in high humidity.
15/41
15/41
November 8, 2025 at 1:58 PM
Watson was an opportunist. He took advantage of Crick’s command of crystallography and managed to get access to Franklin’s experimental data including the famous Photography 51 which reveal a simple cross-like diffraction pattern of DNA in high humidity.
15/41
15/41
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
Yes, some people's legacies are complicated. For example, Watson. After all, though he was racist, don't forget his other traits. For example, he was also sexist. And also anti-semitic. And a data / idea thief. So let's not forget all the different facets.
November 8, 2025 at 12:52 AM
Yes, some people's legacies are complicated. For example, Watson. After all, though he was racist, don't forget his other traits. For example, he was also sexist. And also anti-semitic. And a data / idea thief. So let's not forget all the different facets.
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
November 7, 2025 at 11:43 PM
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
Guillaume Hummel, David Pflieger, Alexandre Berr, Laurence Drouard: From the RNA world to land plants: Evolutionary insights from tRNA genes https://arxiv.org/abs/2511.01943 https://arxiv.org/pdf/2511.01943 https://arxiv.org/html/2511.01943
November 5, 2025 at 6:50 AM
Guillaume Hummel, David Pflieger, Alexandre Berr, Laurence Drouard: From the RNA world to land plants: Evolutionary insights from tRNA genes https://arxiv.org/abs/2511.01943 https://arxiv.org/pdf/2511.01943 https://arxiv.org/html/2511.01943
Thrilled to share our new preprint on the evolution of transfer RNA (tRNA) genes in photosynthetic organisms, together with David Pflieger, Alexandre Berr, and Laurence Drouard!
#PlantGenomics #Evolution #tRNA
@ibmp-cnrs.bsky.social
arxiv.org/abs/2511.01943
#PlantGenomics #Evolution #tRNA
@ibmp-cnrs.bsky.social
arxiv.org/abs/2511.01943
From the RNA world to land plants: Evolutionary insights from tRNA genes
Transfer RNAs (tRNAs) are universal adaptors of the genetic code, yet their evolutionary dynamics across photosynthetic eukaryotes remain underexplored. Here, we present the largest comparative re-ana...
arxiv.org
November 5, 2025 at 7:39 AM
Thrilled to share our new preprint on the evolution of transfer RNA (tRNA) genes in photosynthetic organisms, together with David Pflieger, Alexandre Berr, and Laurence Drouard!
#PlantGenomics #Evolution #tRNA
@ibmp-cnrs.bsky.social
arxiv.org/abs/2511.01943
#PlantGenomics #Evolution #tRNA
@ibmp-cnrs.bsky.social
arxiv.org/abs/2511.01943
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
How sodium gets sequestered in the vacuoles of salinized plants? #opinion #MolecularPlant cell.com/molecular-pl...
November 1, 2025 at 11:53 AM
How sodium gets sequestered in the vacuoles of salinized plants? #opinion #MolecularPlant cell.com/molecular-pl...
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
November 1, 2025 at 5:56 AM
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
Cool work by @microberna.bsky.social & Kai Papenfort, presenting the first RNA-RNA map in C. crescentus using RIL-seq, revealing an RNA sponge that controls the transition from nutrient abundance to starvation; new insights into RNA networks and stress responses!
#RNA
www.nature.com/articles/s41...
#RNA
www.nature.com/articles/s41...
An RNA sponge directs the transition from feast to famine in Caulobacter crescentus - Nature Communications
In bacteria, many small regulatory RNAs (sRNAs) associate with the RNA chaperone Hfq to modulate gene expression at the post-transcriptional level. Here, the authors identify global Hfq-mediated RNA-R...
www.nature.com
October 30, 2025 at 1:43 PM
Cool work by @microberna.bsky.social & Kai Papenfort, presenting the first RNA-RNA map in C. crescentus using RIL-seq, revealing an RNA sponge that controls the transition from nutrient abundance to starvation; new insights into RNA networks and stress responses!
#RNA
www.nature.com/articles/s41...
#RNA
www.nature.com/articles/s41...
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
Plant cell wall signaling is indeed a very dynamic process 🌱
You can read what our very own Sebastian Wolf says about pectin in this news feature 👇
You can read what our very own Sebastian Wolf says about pectin in this news feature 👇
Scientists long thought the plant cell wall to be dead, but it's an active, even chatty participant in cellular growth, reproduction and responses to infection
go.nature.com/4nqhFhU
go.nature.com/4nqhFhU
Plants have a secret language that scientists are only now starting to decipher
Signals from the plant cell wall help to orchestrate growth, reproduction and immune function. Can harnessing this molecular cross talk help in creating better crops?
go.nature.com
October 29, 2025 at 8:21 AM
Plant cell wall signaling is indeed a very dynamic process 🌱
You can read what our very own Sebastian Wolf says about pectin in this news feature 👇
You can read what our very own Sebastian Wolf says about pectin in this news feature 👇
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
www.nature.com
October 28, 2025 at 4:02 PM
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
Been working on a really strange retron bacterial immune system, here's the preprint: www.biorxiv.org/content/10.1...
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
October 23, 2025 at 6:49 PM
Been working on a really strange retron bacterial immune system, here's the preprint: www.biorxiv.org/content/10.1...
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
Here, we show that the unique regulatory landscape of ecDNA enables an ancient LINE to resurrect and act as an enhancer of Myc. This was so fun with @katerinakraft.bsky.social and @mattjones.bsky.social and others. www.nature.com/articles/s41...
Enhancer activation from transposable elements in extrachromosomal DNA - Nature Cell Biology
Kraft, Murphy, Jones et al. identify extrachromosomal DNA (ecDNA)-interacting elements (EIEs) enriched for transposable elements within ecDNA in colorectal cancer cells. They show that EIE 14 integrat...
www.nature.com
October 21, 2025 at 9:43 AM
Here, we show that the unique regulatory landscape of ecDNA enables an ancient LINE to resurrect and act as an enhancer of Myc. This was so fun with @katerinakraft.bsky.social and @mattjones.bsky.social and others. www.nature.com/articles/s41...
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
#Intercropping & #CropRotation are ancient #agricultural practices that increase yield & #DiseaseResistance in #crops. This Essay discusses the role of plant-derived metabolites & microbes in these systems and how they can contribute to #SustainableAgriculture @plosbiology.org 🧪 plos.io/4op7k6W
October 17, 2025 at 4:40 PM
#Intercropping & #CropRotation are ancient #agricultural practices that increase yield & #DiseaseResistance in #crops. This Essay discusses the role of plant-derived metabolites & microbes in these systems and how they can contribute to #SustainableAgriculture @plosbiology.org 🧪 plos.io/4op7k6W
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
Our paper on the evolution (duplicated) gene expression divergence in spatially resolved plant transcriptomes is now out @theplantcell.bsky.social
w/ @yvdp.bsky.social
#PlantSci #Evolution
academic.oup.com/plcell/advan...
w/ @yvdp.bsky.social
#PlantSci #Evolution
academic.oup.com/plcell/advan...
Gene expression divergence following gene and genome duplications in spatially resolved plant transcriptomes
After gene and genome duplications, expression divergence across cell types is not random, and it can be explained by a combination of gene age, gene funct
academic.oup.com
October 16, 2025 at 11:20 AM
Our paper on the evolution (duplicated) gene expression divergence in spatially resolved plant transcriptomes is now out @theplantcell.bsky.social
w/ @yvdp.bsky.social
#PlantSci #Evolution
academic.oup.com/plcell/advan...
w/ @yvdp.bsky.social
#PlantSci #Evolution
academic.oup.com/plcell/advan...
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Antiviral reverse transcriptases reveal the evolutionary origin of telomerase
Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...
www.biorxiv.org
October 17, 2025 at 5:22 PM
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
New Article: "Pan-centromere landscape and dynamic evolution in Brassica plants" rdcu.be/eLtOL
Pan-centromere landscape and evolutionary dynamics in Brassica. T2T genome assemblies of multiple morphotypes shedding light on centromere evolution during domestication.
Pan-centromere landscape and evolutionary dynamics in Brassica. T2T genome assemblies of multiple morphotypes shedding light on centromere evolution during domestication.
October 17, 2025 at 10:23 AM
New Article: "Pan-centromere landscape and dynamic evolution in Brassica plants" rdcu.be/eLtOL
Pan-centromere landscape and evolutionary dynamics in Brassica. T2T genome assemblies of multiple morphotypes shedding light on centromere evolution during domestication.
Pan-centromere landscape and evolutionary dynamics in Brassica. T2T genome assemblies of multiple morphotypes shedding light on centromere evolution during domestication.
Reposted by Guillaume Hummel 🌱 🇪🇺 🇫🇷 🥨 🇮🇹
The role of post-translational modifications in the dynamics of cytoplasmic biomolecular condensates in #plants
A #ResearchReview by Legoux et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
A #ResearchReview by Legoux et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
October 16, 2025 at 2:35 PM
The role of post-translational modifications in the dynamics of cytoplasmic biomolecular condensates in #plants
A #ResearchReview by Legoux et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
A #ResearchReview by Legoux et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience