@ghazeskandari.bsky.social
Microglia and protein misfolding enthusiast. Postdoctoral fellow @Burton-Johes lab @UCI MIND 🇺🇸, LLHF and Brightfocus Fellow
UAlberta alumni 🇨🇦, studying microglia and human iMG in health and disease 🧠🧫🔬 🧬🧪
UAlberta alumni 🇨🇦, studying microglia and human iMG in health and disease 🧠🧫🔬 🧬🧪
Pinned
alz-journals.onlinelibrary.wiley.com
Really excited to share this work from @blurtonjoneslab.bsky.social lab, “Human microglia differentially respond to β‐amyloid, tau, and combined Alzheimer's disease pathologies in vivo” - Coburn - Eskandari-Sedighi, 2025 - Alzheimer's & Dementia alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted
Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo
alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social
November 21, 2025 at 2:24 PM
Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo
alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social
Really excited to share this work from @blurtonjoneslab.bsky.social lab, “Human microglia differentially respond to β‐amyloid, tau, and combined Alzheimer's disease pathologies in vivo” - Coburn - Eskandari-Sedighi, 2025 - Alzheimer's & Dementia alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com
November 21, 2025 at 1:43 PM
Really excited to share this work from @blurtonjoneslab.bsky.social lab, “Human microglia differentially respond to β‐amyloid, tau, and combined Alzheimer's disease pathologies in vivo” - Coburn - Eskandari-Sedighi, 2025 - Alzheimer's & Dementia alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted
new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface
Knockout of Perilipin 2 in Microglia Alters Lipid Droplet Accumulation and Response to Alzheimer's Disease Stimuli https://www.biorxiv.org/content/10.1101/2025.09.02.673815v1
September 7, 2025 at 12:40 PM
new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface
Thanks for putting together such a fantastic meeting, and for the opportunity to present! It was great to be part of the conversation with the rest of speakers.
👏 Great start to NextGen 2025!
S1: Cellular Immune Responses in the Pathogenesis of #AlzheimersDisease
Hosts: Kristine Freude & Marion Kadlecová
Speakers
🔹 Ghazaleh Eskandari-Sedighi
🔹 Lukas Busch
🔹 Johannes Schlachetzki
🔹 Zhiyuan Ning
🔹 Guoyan Zhao
S1: Cellular Immune Responses in the Pathogenesis of #AlzheimersDisease
Hosts: Kristine Freude & Marion Kadlecová
Speakers
🔹 Ghazaleh Eskandari-Sedighi
🔹 Lukas Busch
🔹 Johannes Schlachetzki
🔹 Zhiyuan Ning
🔹 Guoyan Zhao
August 25, 2025 at 2:51 PM
Thanks for putting together such a fantastic meeting, and for the opportunity to present! It was great to be part of the conversation with the rest of speakers.
Reposted
👏 Great start to NextGen 2025!
S1: Cellular Immune Responses in the Pathogenesis of #AlzheimersDisease
Hosts: Kristine Freude & Marion Kadlecová
Speakers
🔹 Ghazaleh Eskandari-Sedighi
🔹 Lukas Busch
🔹 Johannes Schlachetzki
🔹 Zhiyuan Ning
🔹 Guoyan Zhao
S1: Cellular Immune Responses in the Pathogenesis of #AlzheimersDisease
Hosts: Kristine Freude & Marion Kadlecová
Speakers
🔹 Ghazaleh Eskandari-Sedighi
🔹 Lukas Busch
🔹 Johannes Schlachetzki
🔹 Zhiyuan Ning
🔹 Guoyan Zhao
August 25, 2025 at 2:18 PM
👏 Great start to NextGen 2025!
S1: Cellular Immune Responses in the Pathogenesis of #AlzheimersDisease
Hosts: Kristine Freude & Marion Kadlecová
Speakers
🔹 Ghazaleh Eskandari-Sedighi
🔹 Lukas Busch
🔹 Johannes Schlachetzki
🔹 Zhiyuan Ning
🔹 Guoyan Zhao
S1: Cellular Immune Responses in the Pathogenesis of #AlzheimersDisease
Hosts: Kristine Freude & Marion Kadlecová
Speakers
🔹 Ghazaleh Eskandari-Sedighi
🔹 Lukas Busch
🔹 Johannes Schlachetzki
🔹 Zhiyuan Ning
🔹 Guoyan Zhao
Reposted
Are you an ATP!?!
We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs).
Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY.
Apply here! rb.gy/3zk4cm
We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs).
Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY.
Apply here! rb.gy/3zk4cm
August 18, 2025 at 8:45 PM
Are you an ATP!?!
We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs).
Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY.
Apply here! rb.gy/3zk4cm
We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs).
Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY.
Apply here! rb.gy/3zk4cm
Reposted
Identification of CD33m as a new protective factor in Alzheimer’s Disease development. Read about this research by Brain Star Award winner Ghazaleh Eskandari-Sedighi can-acn.org/brain-star-a... @ualberta.bsky.social @ghazeskandari.bsky.social
August 5, 2025 at 3:03 PM
Identification of CD33m as a new protective factor in Alzheimer’s Disease development. Read about this research by Brain Star Award winner Ghazaleh Eskandari-Sedighi can-acn.org/brain-star-a... @ualberta.bsky.social @ghazeskandari.bsky.social
Reposted
Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...
Post-Translational Modifications Remodel Proteome-Wide Ligandability
Post-translational modifications (PTMs) vastly expand the diversity of human proteome, dynamically reshaping protein activity, interactions, and localization in response to environmental, pharmacologi...
www.biorxiv.org
August 3, 2025 at 2:36 PM
Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...
Reposted
Join us for the next GTA webinar on Siglecs and their glycan ligands, featuring Dr. @siglecdude.bsky.social (U of A) and Dr. Edward Schmidt. Learn how their team is developing novel tools to uncover the biological roles of Siglecs across systems.
Register: canadianglycomics.ca/training/web...
Register: canadianglycomics.ca/training/web...
July 21, 2025 at 9:34 PM
Join us for the next GTA webinar on Siglecs and their glycan ligands, featuring Dr. @siglecdude.bsky.social (U of A) and Dr. Edward Schmidt. Learn how their team is developing novel tools to uncover the biological roles of Siglecs across systems.
Register: canadianglycomics.ca/training/web...
Register: canadianglycomics.ca/training/web...
Reposted
So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…
www.sciencedirect.com
June 24, 2025 at 6:04 PM
So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
Reposted
For #fluorescencefriday the Mesoscopic Integrated NeuroImaging Data (MIND) platform @westernu.bsky.social presents abeta plaques and blood vessels in the 🧠 of our ApoE4 mouse model of AD. 🧪 #clearing #lightsheet 🔬 Courtesy of Arash Salahinejad, Luke Smolders and @shahrzadbahrampour.bsky.social
June 13, 2025 at 5:35 PM
For #fluorescencefriday the Mesoscopic Integrated NeuroImaging Data (MIND) platform @westernu.bsky.social presents abeta plaques and blood vessels in the 🧠 of our ApoE4 mouse model of AD. 🧪 #clearing #lightsheet 🔬 Courtesy of Arash Salahinejad, Luke Smolders and @shahrzadbahrampour.bsky.social
Reposted
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease
In this issue, Chadarevian et al. showed that engraftment of human iPSC-derived microglia
(iMG) engineered to express secreted neprilysin (sNEP) under the plaque-responsive
CD9 promoter reduces amyloi...
www.cell.com
June 5, 2025 at 2:45 PM
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...
Reposted
Just out, recent work from the Plemel lab by the talented Brady Hammond. We sought to understand the factors that regulate microglial proliferation during development.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation
Summary: In vitro and in vivo investigations indicate that CSF1 and IL34 may partially regulate the developmental proliferation of microglia in the mouse hippocampus and cortex, but an additional laye...
journals.biologists.com
June 3, 2025 at 4:14 PM
Just out, recent work from the Plemel lab by the talented Brady Hammond. We sought to understand the factors that regulate microglial proliferation during development.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Reposted
What does the APOE 'lipid droplet-ome' look like???
Check out our new paper to find out!
www.sciencedirect.com/science/arti...
Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social
+help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs
Check out our new paper to find out!
www.sciencedirect.com/science/arti...
Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social
+help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs
APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses
Excess lipid droplet (LD) accumulation is implicated in various diseases, including Alzheimer's disease (AD), yet the mechanisms underlying this accum…
www.sciencedirect.com
June 3, 2025 at 1:09 AM
What does the APOE 'lipid droplet-ome' look like???
Check out our new paper to find out!
www.sciencedirect.com/science/arti...
Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social
+help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs
Check out our new paper to find out!
www.sciencedirect.com/science/arti...
Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social
+help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs
The registration for the second round of 2025 Canadian Neuroscience Series are open now. This was a fantastic opportunity for me to learn about the impressive work of other #postdocs and share mine with them. Highly recommend it to anyone eligible in the field of #Neuroscience.
🇨🇦 🧠 Are you a #Postdoc in #Canada or #Canadian abroad? We are selecting #speakers for the (second round of the) 2025 Canadian #Neuroscience #Seminars: Postdoctoral Series. Apply by July 6th, 2025 @ 23:59PT.
Find more details here: tinyurl.com/56m946jh
Apply through this form: tinyurl.com/42cwhae3
Find more details here: tinyurl.com/56m946jh
Apply through this form: tinyurl.com/42cwhae3
May 19, 2025 at 6:22 PM
The registration for the second round of 2025 Canadian Neuroscience Series are open now. This was a fantastic opportunity for me to learn about the impressive work of other #postdocs and share mine with them. Highly recommend it to anyone eligible in the field of #Neuroscience.
Reposted
🇨🇦 🧠 Are you a #Postdoc in #Canada or #Canadian abroad? We are selecting #speakers for the (second round of the) 2025 Canadian #Neuroscience #Seminars: Postdoctoral Series. Apply by July 6th, 2025 @ 23:59PT.
Find more details here: tinyurl.com/56m946jh
Apply through this form: tinyurl.com/42cwhae3
Find more details here: tinyurl.com/56m946jh
Apply through this form: tinyurl.com/42cwhae3
May 19, 2025 at 3:29 PM
🇨🇦 🧠 Are you a #Postdoc in #Canada or #Canadian abroad? We are selecting #speakers for the (second round of the) 2025 Canadian #Neuroscience #Seminars: Postdoctoral Series. Apply by July 6th, 2025 @ 23:59PT.
Find more details here: tinyurl.com/56m946jh
Apply through this form: tinyurl.com/42cwhae3
Find more details here: tinyurl.com/56m946jh
Apply through this form: tinyurl.com/42cwhae3
Reposted
Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social
All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...
All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...
Inflammasome signaling in astrocytes modulates hippocampal plasticity
The function of immune pathways in homeostatic neurobiology remains underexplored.
Zengeler et al. find that the inflammasome complex, typically associated with immune
responses, is involved in memory...
www.cell.com
May 3, 2025 at 1:45 AM
Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social
All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...
All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...
Thanks to @canacn.bsky.social and #CIHR for choosing my work on human CD33 isoforms in Alzheimer’s disease for a #brainstar_award. I share the credit with Matt Macauley lab @siglecdude.bsky.social and all the amazing co-authors whose tremendous help was a huge contribution to this project.
Very proud to announce the winners of the 2024 Brain Star Awards! can-acn.org/congratulati...
Très fiers d'annoncer les gagnants des prix Cerveau en tête 2024! can-acn.org/fr/bravo-aux...
Très fiers d'annoncer les gagnants des prix Cerveau en tête 2024! can-acn.org/fr/bravo-aux...
May 1, 2025 at 7:32 PM
Thanks to @canacn.bsky.social and #CIHR for choosing my work on human CD33 isoforms in Alzheimer’s disease for a #brainstar_award. I share the credit with Matt Macauley lab @siglecdude.bsky.social and all the amazing co-authors whose tremendous help was a huge contribution to this project.
Reposted
Very proud to announce the winners of the 2024 Brain Star Awards! can-acn.org/congratulati...
Très fiers d'annoncer les gagnants des prix Cerveau en tête 2024! can-acn.org/fr/bravo-aux...
Très fiers d'annoncer les gagnants des prix Cerveau en tête 2024! can-acn.org/fr/bravo-aux...
May 1, 2025 at 3:04 PM
Very proud to announce the winners of the 2024 Brain Star Awards! can-acn.org/congratulati...
Très fiers d'annoncer les gagnants des prix Cerveau en tête 2024! can-acn.org/fr/bravo-aux...
Très fiers d'annoncer les gagnants des prix Cerveau en tête 2024! can-acn.org/fr/bravo-aux...
Reposted
Meet our first speaker 🗣️ Ghazaleh will be presenting at our webinar THIS Thursday! You can register here: zoom.us/webinar/regi...
And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h
And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h
April 29, 2025 at 12:49 PM
Meet our first speaker 🗣️ Ghazaleh will be presenting at our webinar THIS Thursday! You can register here: zoom.us/webinar/regi...
And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h
And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h
Reposted
Happening THIS week!
Register here: zoom.us/webinar/regi...
Stay up to date by subscribing to our mailing list: t.co/Oa9dLowy1h
Register here: zoom.us/webinar/regi...
Stay up to date by subscribing to our mailing list: t.co/Oa9dLowy1h
April 28, 2025 at 10:58 PM
Happening THIS week!
Register here: zoom.us/webinar/regi...
Stay up to date by subscribing to our mailing list: t.co/Oa9dLowy1h
Register here: zoom.us/webinar/regi...
Stay up to date by subscribing to our mailing list: t.co/Oa9dLowy1h
The Alzforum note on the newest publication from Blurton-Jones lab: "Delivery Courier? Microglia Drop Neprilysin Off Near Plaques in Brain"
www.alzforum.org/news/researc...
www.alzforum.org/news/researc...
Delivery Courier? Microglia Drop Neprilysin Off Near Plaques in Brain | ALZFORUM
www.alzforum.org
April 28, 2025 at 3:30 PM
The Alzforum note on the newest publication from Blurton-Jones lab: "Delivery Courier? Microglia Drop Neprilysin Off Near Plaques in Brain"
www.alzforum.org/news/researc...
www.alzforum.org/news/researc...
Reposted
We are back next Thursday (May 1st) with two wonderful presentations 📅 Register now: zoom.us/webinar/regi...
And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h
And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h
April 24, 2025 at 5:02 PM
We are back next Thursday (May 1st) with two wonderful presentations 📅 Register now: zoom.us/webinar/regi...
And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h
And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h
Reposted
Exciting work from @blurtonjoneslab.bsky.social + Spitale labs -- new examples of how iPSC-microglia can be used as a long-term, in vivo platform for a therapeutic protein payload in models of Alzheimer’s disease
@cp-cellstemcell.bsky.social
sciencedirect.com/science/article/pii/S1934590925000992
@cp-cellstemcell.bsky.social
sciencedirect.com/science/article/pii/S1934590925000992
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins
Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…
sciencedirect.com
April 18, 2025 at 3:03 PM
Exciting work from @blurtonjoneslab.bsky.social + Spitale labs -- new examples of how iPSC-microglia can be used as a long-term, in vivo platform for a therapeutic protein payload in models of Alzheimer’s disease
@cp-cellstemcell.bsky.social
sciencedirect.com/science/article/pii/S1934590925000992
@cp-cellstemcell.bsky.social
sciencedirect.com/science/article/pii/S1934590925000992
Reposted
Nice media coverage of our recent study on how Tim-3 regulates microglial activity. #ButovskyLab @genelayinstitute.bsky.social.
Researchers @massgenbrigham.bsky.social @harvardmed.bsky.social gaining ground on Alzheimer’s disease whdh.com/news/researc... via @7NEWS
Researchers @massgenbrigham.bsky.social @harvardmed.bsky.social gaining ground on Alzheimer’s disease whdh.com/news/researc... via @7NEWS
Researchers at Mass. General Brigham gaining ground on Alzheimer’s disease - Boston News, Weather, Sports | WHDH 7News
BOSTON (WHDH) - Some talented researchers at Mass General Brigham are gaining ground in the fight against Alzheimer’s through a new approach that manipulates molecules<a class="excerpt-read-more" href...
whdh.com
April 15, 2025 at 11:55 PM
Nice media coverage of our recent study on how Tim-3 regulates microglial activity. #ButovskyLab @genelayinstitute.bsky.social.
Researchers @massgenbrigham.bsky.social @harvardmed.bsky.social gaining ground on Alzheimer’s disease whdh.com/news/researc... via @7NEWS
Researchers @massgenbrigham.bsky.social @harvardmed.bsky.social gaining ground on Alzheimer’s disease whdh.com/news/researc... via @7NEWS