Sarah Naguib, PhD
@sarahnaguib.bsky.social
Postdoc in @liganlab.bluesky.social at Weill Cornell Medicine interested in resilience and microglia in neurodegeneration • Vanderbilt Neuro PhD ‘22 • Kenyon College ‘17 • 1st gen Egyptian-American
There are many ways to make your voice heard and participate in all that #ISSCR2026 has to offer! Discover how to get involved, including submitting an abstract, proposing a science spotlight, hosting a meet-up hub, and more! invt.io/1bxbscfory3 @ISSCR.org
Join me at the ISSCR 2026 Annual Meeting!
Register now
invt.io
November 3, 2025 at 8:59 PM
There are many ways to make your voice heard and participate in all that #ISSCR2026 has to offer! Discover how to get involved, including submitting an abstract, proposing a science spotlight, hosting a meet-up hub, and more! invt.io/1bxbscfory3 @ISSCR.org
Thrilled to be selected as an #ISSCR2026 Ambassador! The @ISSCR.org 2026 Annual Meeting will take place in Montréal, Canada on 8-11 July 2026 & features 4 days of scientific sessions with talks from global researchers! Explore the scientific program and the ways to participate. invt.io/1bxbah1l97q
I'm an ISSCR 2026 Ambassador, join me!
Register now
invt.io
October 27, 2025 at 5:04 PM
Thrilled to be selected as an #ISSCR2026 Ambassador! The @ISSCR.org 2026 Annual Meeting will take place in Montréal, Canada on 8-11 July 2026 & features 4 days of scientific sessions with talks from global researchers! Explore the scientific program and the ways to participate. invt.io/1bxbah1l97q
Reposted by Sarah Naguib, PhD
🏆🏆🏆 CONGRATULATIONS to the winner of the PBL Assay Science Best Speaker Award Sarah Naguib @sarahnaguib.bsky.social
Title: Elucidating the neuroprotective mechanisms of human microglial replacement therapy in FTD and PD
Thank you PBL Assay Science for sponsoring the award
Title: Elucidating the neuroprotective mechanisms of human microglial replacement therapy in FTD and PD
Thank you PBL Assay Science for sponsoring the award
August 26, 2025 at 6:02 PM
🏆🏆🏆 CONGRATULATIONS to the winner of the PBL Assay Science Best Speaker Award Sarah Naguib @sarahnaguib.bsky.social
Title: Elucidating the neuroprotective mechanisms of human microglial replacement therapy in FTD and PD
Thank you PBL Assay Science for sponsoring the award
Title: Elucidating the neuroprotective mechanisms of human microglial replacement therapy in FTD and PD
Thank you PBL Assay Science for sponsoring the award
Reposted by Sarah Naguib, PhD
Microglia replacement halts the progression of microgliopathy in mice and humans @science.org www.science.org/doi/10.1126/...
Microglia replacement halts the progression of microgliopathy in mice and humans
Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopath...
www.science.org
July 10, 2025 at 7:01 PM
Microglia replacement halts the progression of microgliopathy in mice and humans @science.org www.science.org/doi/10.1126/...
Reposted by Sarah Naguib, PhD
By me: A generation of scientific talent is at the brink of being lost to overseas competitors by the Trump administration’s dismantling of the National Science Foundation (NSF), with unprecedented political interference jeopardizing the future of US enterprise.
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
Scientists warn US will lose a generation of talent because of Trump cuts
Political interference and chaotic cuts to staff, programs and grants at the National Science Foundation are producing ‘devastating consequences’
www.theguardian.com
July 3, 2025 at 11:58 AM
By me: A generation of scientific talent is at the brink of being lost to overseas competitors by the Trump administration’s dismantling of the National Science Foundation (NSF), with unprecedented political interference jeopardizing the future of US enterprise.
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
Could not be more proud and excited for @sadafamin.bsky.social as she begins her own lab at
@washumedicine.bsky.social very soon! Sadaf has been an amazing mentor, colleague and most importantly, friend, in our time in the @liganlab.bsky.social and I can't wait to see her succeed as a PI 🧠🔬❤️🧪😊
@washumedicine.bsky.social very soon! Sadaf has been an amazing mentor, colleague and most importantly, friend, in our time in the @liganlab.bsky.social and I can't wait to see her succeed as a PI 🧠🔬❤️🧪😊
I am thrilled to announce that I will be starting my lab at
@washumedicine.bsky.social, Department of Pathology & Immunology as an Assistant Professor this month. The lab will study the role of innate immunity in neurodegeneration and brain aging. We'll be hiring at all levels. Details soon!
@washumedicine.bsky.social, Department of Pathology & Immunology as an Assistant Professor this month. The lab will study the role of innate immunity in neurodegeneration and brain aging. We'll be hiring at all levels. Details soon!
July 1, 2025 at 8:30 PM
Could not be more proud and excited for @sadafamin.bsky.social as she begins her own lab at
@washumedicine.bsky.social very soon! Sadaf has been an amazing mentor, colleague and most importantly, friend, in our time in the @liganlab.bsky.social and I can't wait to see her succeed as a PI 🧠🔬❤️🧪😊
@washumedicine.bsky.social very soon! Sadaf has been an amazing mentor, colleague and most importantly, friend, in our time in the @liganlab.bsky.social and I can't wait to see her succeed as a PI 🧠🔬❤️🧪😊
So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…
www.sciencedirect.com
June 24, 2025 at 6:04 PM
So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
Reposted by Sarah Naguib, PhD
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…
www.sciencedirect.com
June 24, 2025 at 12:58 PM
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
Reposted by Sarah Naguib, PhD
Online now: The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The APOE3 Christchurch mutation (R136S) reduces tau pathology despite the PSEN1 mutation and high amyloid, though its protective mechanism remains unclear. Naguib et al. show that R136S suppresses microglial cGAS-STING-IFN signaling in tauopathy mice. Inhibiting cGAS preserves synapses and mimics R136S-linked gene expression, suggesting that cGAS suppression is a key part of the underlying protective effects of R136S.
dlvr.it
June 23, 2025 at 2:48 PM
Online now: The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway