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kuchroolab.bsky.social
Kuchroo Lab
@kuchroolab.bsky.social
950 followers 140 following 18 posts
Lab of Vijay Kuchroo at @GeneLayInstitute.bsky.social @MGBResearch.bsky.social @HarvardMed.bsky.social @BroadInstitute.org
🧪 #Immunosky
🔗 kuchroolab.bwh.harvard.edu
Posts by lab members unless signed by VKK. Views are our own.
Posts Replies Media Videos
Reposted by Kuchroo Lab
genelayinstitute.bsky.social
By reprogramming the tumor microenvironment with an engineered virus, @quintanalabhms.bsky.social boost anti-tumor immunity against glioblastoma.
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social www.massgeneralbrigham.org/en/about/new...
Engineered Virus Boosts Immune Response Against Glioblastoma in Preclinical Models | Mass General Brigham
Mass General Brigham researchers engineered a virus that destroys brain tumor cells while avoiding healthy brain tissue.
www.massgeneralbrigham.org
December 9, 2025 at 12:16 AM
Reposted by Kuchroo Lab
immunologypodcast.com
🔔 New episode alert!

Dr. Ana Anderson from Harvard Medical School talks about her work on #ImmuneRegulation in cancer.

▶️ https://bit.ly/4pJvw4u
December 3, 2025 at 12:32 AM
Reposted by Kuchroo Lab
immunologypodcast.com
Join us next week for an episode with Dr. Ana Anderson from Harvard Medical School!

Her research focuses on understanding the pathways and mechanisms that regulate the #AntiTumor immune response.
November 28, 2025 at 9:08 PM
Reposted by Kuchroo Lab
labwaggoner.bsky.social
Review @natrevneuro.nature.com
Immune dysfunction in Alzheimer disease
www.nature.com/articles/s41...
November 29, 2025 at 1:43 AM
Reposted by Kuchroo Lab
natrevneuro.nature.com
Immune dysfunction in Alzheimer disease — a Review by Oleg Butovsky, Neta Rosenzweig, Kilian L. Kleemann, Mehdi Jorfi, Vijay K. Kuchroo, Rudolph E. Tanzi & Howard L. Weiner

#neuroscience #neuroskyence

www.nature.com/articles/s41...
Immune dysfunction in Alzheimer disease - Nature Reviews Neuroscience
The importance of peripheral immunity in Alzheimer disease has gained much traction in recent years, mainly due to multiple genome-wide association studies identifying risk loci associated with genes ...
www.nature.com
December 1, 2025 at 9:47 AM
kuchroolab.bsky.social
Beautiful work!
November 3, 2025 at 8:07 PM
Reposted by Kuchroo Lab
genelayinstitute.bsky.social
The most detailed roadmap to date of how the gut’s nervous system responds to different environmental challenges.

Exciting new 🧪study from @thexavierlab.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
| Science www.science.org/doi/10.1126/...
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation
Enteric neurons are essential regulators of intestinal physiology, yet their responses to varying microbial and immune environments along the intestinal tract and or during challenges remain poorly un...
www.science.org
November 3, 2025 at 8:03 PM
Reposted by Kuchroo Lab
immunoboys.bsky.social
Hou, Sun et al from @kuchroolab.bsky.social 2024 in @natureportfolio.nature.com
"Neuropeptide signalling orchestrates T cell differentiation"

www.nature.com/articles/s41...
Neuropeptide signalling orchestrates T cell differentiation - Nature
RAMP3, a component of the receptor for the neuropeptide CGRP, has a cell-intrinsic role in T helper type 1 cell fate determination.
www.nature.com
October 13, 2025 at 12:27 AM
Reposted by Kuchroo Lab
rtnconference.bsky.social
October 10, 2025 at 12:39 PM
Reposted by Kuchroo Lab
rtnconference.bsky.social
October 10, 2025 at 12:39 PM
Reposted by Kuchroo Lab
rtnconference.bsky.social
October 10, 2025 at 12:39 PM
Reposted by Kuchroo Lab
rtnconference.bsky.social
We're less than a week away from #ReThinkNeuroimmunology — a groundbreaking conference hosted by the @genelayinstitute.bsky.social!
We’re thrilled to welcome experts, ignite new ideas, & push the field forward.
Huge thanks to our incredible sponsors for making #RTN2025 possible!
🧵👇
October 10, 2025 at 12:39 PM
kuchroolab.bsky.social
#KuchrooLabReunion at #CSNeuroimmune25 in NYC with VKK & Manu Rangachari
September 10, 2025 at 11:37 PM
kuchroolab.bsky.social
This conference is going to be great!
Looking forward to it.
August 25, 2025 at 10:22 PM
kuchroolab.bsky.social
This conference is going to be great! Looking forward to it.
August 25, 2025 at 10:18 PM
Reposted by Kuchroo Lab
genelayinstitute.bsky.social
Blockade of STUB1 in T cells boosts anti-tumor immunity. Study from the #SharpeLab led by @martinlafleur.bsky.social & #LaurenMilling @natimmunol.nature.com.
@genelayinstitute.bsky.social @harvardmed.bsky.social @broadinstitute.org
hms.harvard.edu/news/researc...
www.nature.com/articles/s41...
Research Identifies New Ways To Supercharge Cancer Immunotherapy
Findings, based on mouse studies, could pave the way for more effective cancer treatments
hms.harvard.edu
August 18, 2025 at 11:46 PM
Reposted by Kuchroo Lab
labwaggoner.bsky.social
REV-ERBα & REV-ERBβ, which control clock gene expression, also maintain ILC3 in a state that facilitates the maintenance of a balanced and healthy intestine @natimmunol.nature.com #ColonnaLab
www.nature.com/articles/s41...
preview @theonlylabever.bsky.social
www.nature.com/articles/s41...
August 13, 2025 at 6:16 PM
Reposted by Kuchroo Lab
genelayinstitute.bsky.social
🚨 New study from the lab of our Vice Director, Arlene Sharpe, led by @kepauken.bsky.social & #SamuelMarkson in @jem.org.
PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic & a cell-extrinsic fashion🧪
jem.org Journal of Experimental Medicine @jem.org · Jul 24
@kepauken.bsky.social, Markson, Sharpe et al. @harvardmed.bsky.social show that when PD-1–expressing and PD-1 knockout CD8+ T cells are within the same tumor microenvironment, both cell types exhibit similarly enhanced functions. rupress.org/jem/article/...
July 31, 2025 at 1:07 AM
Reposted by Kuchroo Lab
genelayinstitute.bsky.social
Cellular & spatial profiling of fibrosis in Crohn's disease provides new insights into the mechanisms involved.
From the lab of our Vice Director @thexavierlab.bsky.social in collaboration with #SmillieLab.
Study led by #LingjiaKong @broadinstitute.org
July 31, 2025 at 1:35 AM
Reposted by Kuchroo Lab
mdkornberg.bsky.social
New work from the lab - we found a surprising role for the glycolytic enzyme PGAM in Treg function. Whereas most glycolytic enzymes support inflammatory T cells, PGAM has the opposite effect by controlling serine synthesis to regulate the Treg-Th17 axis. #immunometabolism doi.org/10.7554/eLif...
Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism
The glycolytic enzyme phosphoglycerate mutase supports Treg function, identifying a novel therapeutic target for immune modulation and demonstrating that glycolytic regulation of T cells is more nuanc...
doi.org
July 29, 2025 at 1:44 AM
Reposted by Kuchroo Lab
mdkornberg.bsky.social
Gratifyingly, our findings complement and corroborate a very cool recent story from @kuchroolab.bsky.social showing that PGAM activity negatively regulates pathogenic Th17 cells www.sciencedirect.com/science/arti...
The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity
Glucose metabolism is a critical regulator of T cell function, largely thought to support their activation and effector differentiation. Here, we inve…
www.sciencedirect.com
July 29, 2025 at 1:49 AM
Reposted by Kuchroo Lab
genelayinstitute.bsky.social
Our annual symposium on Immunity & Inflammation in Disease & Tissue is on again on August 6th.
🎙️Looking forward to talks from #RafiAhmed, #RichardFlavell, @thefuchslab.bsky.social, #BanaJabri & #LawrenceSteinman.
Joseph B. Martin Conference Center, Boston MA
July 17, 2025 at 12:20 AM
Reposted by Kuchroo Lab
rtnconference.bsky.social
Have you registered yet for #ReThinkNeuroimmunology in October?
Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more
June 12, 2025 at 11:26 PM