Michael D Kornberg
@mdkornberg.bsky.social
Clinician-Scientist, Neurologist, Multiple Sclerosis Specialist. Interests in neuroimmunology, remyelination, CNS innate immunity, diet, and metabolism. Johns Hopkins University. https://kornberglab.com/
Pinned
The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelination
Protein kinase C modulation with bryostatin-1 enables innate immune cells in the central nervous system to promote myelin repair and regeneration.
www.science.org
Excited to share our new work identifying PKC as a druggable target for modulating microglia in order to enhance myelin repair. 🧵 #remyelination #multiplesclerosis www.science.org/doi/10.1126/...
Reposted by Michael D Kornberg
📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠
tinyurl.com/3wvmm8v3
tinyurl.com/3wvmm8v3
Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
Microglia replacement holds great promise for the study and treatment of neurological diseases. We previously achieved high-efficiency replacement by …
tinyurl.com
November 12, 2025 at 10:41 PM
📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠
tinyurl.com/3wvmm8v3
tinyurl.com/3wvmm8v3
Reposted by Michael D Kornberg
Reposted by Michael D Kornberg
How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
October 29, 2025 at 3:01 PM
How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
At least once per year I see someone with debilitating MS-related tremor, usually cerebellar or rubral. This is a study I was hoping would be done... journals.sagepub.com/doi/10.1177/...
October 28, 2025 at 12:03 PM
At least once per year I see someone with debilitating MS-related tremor, usually cerebellar or rubral. This is a study I was hoping would be done... journals.sagepub.com/doi/10.1177/...
Reposted by Michael D Kornberg
Reposted by Michael D Kornberg
Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis
Progressive multiple sclerosis (PMS), which is characterized by relentless disease progression, lacks effective treatment. While recent studies have h…
www.sciencedirect.com
October 15, 2025 at 3:04 PM
Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Michael D Kornberg
Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions
Single-cell immunoprofiling uncovered systemic immune cell signatures of neurological MOG antibody–associated disease.
www.science.org
October 8, 2025 at 7:04 PM
Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis | Science Translational Medicine www.science.org/doi/10.1126/...
SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis
SV2A-PET reveals cortical synapse loss in multiple sclerosis (MS), highlighting a potential approach for unmasking gray matter pathology.
www.science.org
October 3, 2025 at 1:52 PM
SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis | Science Translational Medicine www.science.org/doi/10.1126/...
Reposted by Michael D Kornberg
Notch3+ Treg induced in the gut by microbiota translocate to CNS, outcompete protective NPY1R+-resident Treg, and degenerate into pathogenic Th17 in MS/EAE @cp-immunity.bsky.social @bostonchildrens.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
October 2, 2025 at 4:52 PM
Notch3+ Treg induced in the gut by microbiota translocate to CNS, outcompete protective NPY1R+-resident Treg, and degenerate into pathogenic Th17 in MS/EAE @cp-immunity.bsky.social @bostonchildrens.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Michael D Kornberg
This is a really excellent review of the knowns and unknowns of the role of EBV in MS. Congrats @jsabatino37.bsky.social - this is fantastic www.neurology.org/doi/10.1212/...
Epstein-Barr Virus in Multiple Sclerosis | Neurology Neuroimmunology & Neuroinflammation
Epstein-Barr virus (EBV) is a very common herpesvirus that infects more than 90% of
the general population. Epidemiologic data indicate that EBV is a requisite risk factor
for the development of multi...
www.neurology.org
September 16, 2025 at 12:18 PM
This is a really excellent review of the knowns and unknowns of the role of EBV in MS. Congrats @jsabatino37.bsky.social - this is fantastic www.neurology.org/doi/10.1212/...
Reposted by Michael D Kornberg
PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 4, 2025 at 5:09 AM
PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Michael D Kornberg
#Throwback 🧪
PERSPECTIVE | The emerging role of protein l-lactylation in metabolic regulation and cell signalling
H Ren, Y Tang & D Zhang
PERSPECTIVE | The emerging role of protein l-lactylation in metabolic regulation and cell signalling
H Ren, Y Tang & D Zhang
The emerging role of protein l-lactylation in metabolic regulation and cell signalling - Nature Metabolism
In this Perspective, the functions of the recently identified post-translational-modification protein l-lactylation in the regulation of cellular metabolism and signalling are discussed, highlighting the potential of l-lactylation as a therapeutic target.
bit.ly
August 31, 2025 at 8:02 PM
#Throwback 🧪
PERSPECTIVE | The emerging role of protein l-lactylation in metabolic regulation and cell signalling
H Ren, Y Tang & D Zhang
PERSPECTIVE | The emerging role of protein l-lactylation in metabolic regulation and cell signalling
H Ren, Y Tang & D Zhang
Reposted by Michael D Kornberg
Reposted by Michael D Kornberg
New review from Carson Moseley and Scott Zamvil on B cell antigen presentation in CNS autoimmunity
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
B-cell antigen presentation in central nervous system autoimmunity
The role of B cells in central nervous system (CNS) autoimmunity was initially highlighted by successful clinical trials of anti-CD20 monoclonal antib…
www.sciencedirect.com
August 25, 2025 at 5:22 PM
New review from Carson Moseley and Scott Zamvil on B cell antigen presentation in CNS autoimmunity
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Michael D Kornberg
Dysregulated cytokine networks have an important role in neuroinflammatory diseases such as multiple sclerosis. Read about progress and challenges in targeting these networks therapeutically in this review
www.nature.com/articles/s41...
rdcu.be/eBzvu
www.nature.com/articles/s41...
rdcu.be/eBzvu
Targeting cytokine networks in neuroinflammatory diseases - Nature Reviews Drug Discovery
Dysregulated cytokine networks are important in the pathogenesis of neuroinflammation. This Review discusses targeting cytokines and their receptors in non-infectious central nervous system inflammato...
www.nature.com
August 20, 2025 at 2:31 PM
Dysregulated cytokine networks have an important role in neuroinflammatory diseases such as multiple sclerosis. Read about progress and challenges in targeting these networks therapeutically in this review
www.nature.com/articles/s41...
rdcu.be/eBzvu
www.nature.com/articles/s41...
rdcu.be/eBzvu
Reposted by Michael D Kornberg
Systematic characterization of cell type-specific master metabolic regulators in Alzheimer's disease
Systematic characterization of cell type-specific master metabolic regulators in Alzheimer's disease #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-7207381/latest
https://www.researchsquare.com/article/rs-7207381/latest
August 19, 2025 at 8:36 AM
Systematic characterization of cell type-specific master metabolic regulators in Alzheimer's disease
Reposted by Michael D Kornberg
Brain myelin as a deficient energy source in aging and disease www.cell.com/trends/endoc... Excellent discussion on how myelin fatty acid reserves may be reallocated during aging and neurodegeneration
Brain myelin as a deficient energy source in aging and disease
Central nervous system (CNS) myelin may act as a dynamic energy store that supports
brain metabolism; its consumption and replenishment is a newly recognized form of
metabolic plasticity aimed at main...
www.cell.com
August 13, 2025 at 12:01 PM
Brain myelin as a deficient energy source in aging and disease www.cell.com/trends/endoc... Excellent discussion on how myelin fatty acid reserves may be reallocated during aging and neurodegeneration
Reposted by Michael D Kornberg
#Throwback 🧪
COMMENT | A call for accessible tools to unlock single-cell immunometabolism research
J Van den Bossche et al.
COMMENT | A call for accessible tools to unlock single-cell immunometabolism research
J Van den Bossche et al.
A call for accessible tools to unlock single-cell immunometabolism research - Nature Metabolism
Recent technological advances permit the profiling of metabolic changes in single cells, which sheds light on how metabolism regulates immune responses. We advocate for accessible and standardized tools to reduce the barrier of entry to immunometabolism studies and facilitate the translation of fundamental findings towards clinical applications.
bit.ly
August 6, 2025 at 4:02 PM
#Throwback 🧪
COMMENT | A call for accessible tools to unlock single-cell immunometabolism research
J Van den Bossche et al.
COMMENT | A call for accessible tools to unlock single-cell immunometabolism research
J Van den Bossche et al.
Reposted by Michael D Kornberg
Review @jem.org
Lipid metabolism and neuroinflammation: What is the link?
rupress.org/jem/article/...
Lipid metabolism and neuroinflammation: What is the link?
rupress.org/jem/article/...
August 5, 2025 at 3:03 PM
Review @jem.org
Lipid metabolism and neuroinflammation: What is the link?
rupress.org/jem/article/...
Lipid metabolism and neuroinflammation: What is the link?
rupress.org/jem/article/...
Reposted by Michael D Kornberg
We’re excited to announce the Young Investigators Special Issue in the Journal of Neuroimmunology! We will spotlight early-career researchers and support the next generation of discovery. Submit your original research and let your work be seen and recognized.
#CallForPaper
#CallForPaper
Journal of Neuroimmunology | Early career investigators in Neuroimmunology | ScienceDirect.com by Elsevier
Historically, many established investigators in the field of neuroimmunology published early work from their laboratories in the Journal of Neuroimmunology. Our mission is to bring important work in t...
www.sciencedirect.com
August 4, 2025 at 1:28 AM
We’re excited to announce the Young Investigators Special Issue in the Journal of Neuroimmunology! We will spotlight early-career researchers and support the next generation of discovery. Submit your original research and let your work be seen and recognized.
#CallForPaper
#CallForPaper