The Gene Lay Institute of Immunology and Inflammation
@genelayinstitute.bsky.social
Immunology-focused research in cancer & aging | understanding immune evasion & resilience | improving health outcomes. 🔗 https://genelayinstitute.org/
#Brigham&WomensHospital #MassGeneralHospital @HarvardMed.bsky.social
#Brigham&WomensHospital #MassGeneralHospital @HarvardMed.bsky.social
Pinned
$100 million gift establishes The Gene Lay Institute of Immunology and Inflammation
The largest gift in the Brigham’s history is furthering investigations of immune-mediated diseases, immune system aging, and cancers that are unresponsive to cancer immunotherapies.
give.brighamandwomens.org
The Gene Lay Institute of Immunology and Inflammation was founded on a generous gift #BrighamandWomensHospital #MassGeneralHospital & @harvardmed.bsky.social
give.brighamandwomens.org/gene-lay-ins...
give.brighamandwomens.org/gene-lay-ins...
The most detailed roadmap to date of how the gut’s nervous system responds to different environmental challenges.
Exciting new 🧪study from @thexavierlab.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
| Science www.science.org/doi/10.1126/...
Exciting new 🧪study from @thexavierlab.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
| Science www.science.org/doi/10.1126/...
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation
Enteric neurons are essential regulators of intestinal physiology, yet their responses to varying microbial and immune environments along the intestinal tract and or during challenges remain poorly un...
www.science.org
November 3, 2025 at 8:03 PM
The most detailed roadmap to date of how the gut’s nervous system responds to different environmental challenges.
Exciting new 🧪study from @thexavierlab.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
| Science www.science.org/doi/10.1126/...
Exciting new 🧪study from @thexavierlab.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
| Science www.science.org/doi/10.1126/...
Reposted by The Gene Lay Institute of Immunology and Inflammation
Check out our new study in @ScienceMagazine! Using single-cell transcriptomics, we profile enteric nervous system responses to the microbiota and inflammation, identifying regulators of motor #neuron states and #gut transit time.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation
Enteric neurons are essential regulators of intestinal physiology, yet their responses to varying microbial and immune environments along the intestinal tract and or during challenges remain poorly un...
www.science.org
October 30, 2025 at 8:34 PM
Check out our new study in @ScienceMagazine! Using single-cell transcriptomics, we profile enteric nervous system responses to the microbiota and inflammation, identifying regulators of motor #neuron states and #gut transit time.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by The Gene Lay Institute of Immunology and Inflammation
Great summary from the @mgbresearch.bsky.social team on our new Science paper about ENS–immune system interactions! Check it out: www.massgeneralbrigham.org/en/about/new...
Research Spotlight: Mapping How Gut Neurons Respond to Bacteria, Parasites and Food Allergy | Mass General Brigham
The enteric nervous system is a vast network of nerves built into the walls of the intestine. A new study adds to accumulating evidence showing that the ENS works closely with the immune system to hel...
www.massgeneralbrigham.org
October 31, 2025 at 2:07 PM
Great summary from the @mgbresearch.bsky.social team on our new Science paper about ENS–immune system interactions! Check it out: www.massgeneralbrigham.org/en/about/new...
Reposted by The Gene Lay Institute of Immunology and Inflammation
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation @science.org @thexavierlab.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 31, 2025 at 1:28 AM
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation @science.org @thexavierlab.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by The Gene Lay Institute of Immunology and Inflammation
Excited to share new work in @NatureMicrobio! Using metagenomics, we show how #HIV infection and treatment shape the gut microbiome across geographic regions & find ART-induced phageome changes linked to inflammation and atherosclerosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Human immunodeficiency virus and antiretroviral therapies exert distinct influences across diverse gut microbiomes - Nature Microbiology
Metagenomic analysis of the gut microbiome of people with human immunodeficiency virus (HIV), from three distinct cohorts, revealed infection- and antiretroviral drug-linked alterations, which may con...
www.nature.com
October 30, 2025 at 4:18 PM
Excited to share new work in @NatureMicrobio! Using metagenomics, we show how #HIV infection and treatment shape the gut microbiome across geographic regions & find ART-induced phageome changes linked to inflammation and atherosclerosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by The Gene Lay Institute of Immunology and Inflammation
Another 🌏 #KuchrooLabReunion in Kyoto with Norio Chihara, VKK, & Kimitoshi Kimura 🇯🇵
October 16, 2025 at 2:39 AM
Another 🌏 #KuchrooLabReunion in Kyoto with Norio Chihara, VKK, & Kimitoshi Kimura 🇯🇵
Reposted by The Gene Lay Institute of Immunology and Inflammation
For those of you joining us for the editors panel at #RTN2025, please bring your questions! We have more editors than I've ever seen at a single meeting, so this is your chance to get answers to all of your burning questions! @genelayinstitute.bsky.social @rtnconference.bsky.social
October 15, 2025 at 1:30 PM
For those of you joining us for the editors panel at #RTN2025, please bring your questions! We have more editors than I've ever seen at a single meeting, so this is your chance to get answers to all of your burning questions! @genelayinstitute.bsky.social @rtnconference.bsky.social
Reposted by The Gene Lay Institute of Immunology and Inflammation
We are proud to sponsor #ReThink Neuroimmunology 2025. A conference focusing on the biggest discoveries and breakthroughs in neuroimmunology, single cell genomics, immunology & neuroscience. The Gene Lay Institute of Immunology and Inflammation
#RTN2025 RTN Conference Beth Stevens Jonathan Kipnis
#RTN2025 RTN Conference Beth Stevens Jonathan Kipnis
October 15, 2025 at 3:34 PM
We are proud to sponsor #ReThink Neuroimmunology 2025. A conference focusing on the biggest discoveries and breakthroughs in neuroimmunology, single cell genomics, immunology & neuroscience. The Gene Lay Institute of Immunology and Inflammation
#RTN2025 RTN Conference Beth Stevens Jonathan Kipnis
#RTN2025 RTN Conference Beth Stevens Jonathan Kipnis
Reposted by The Gene Lay Institute of Immunology and Inflammation
Looking forward to #RTN2025 today! Excited for some #neuroimmunology! If you'll be there, please look for me and say hello! @genelayinstitute.bsky.social @rtnconference.bsky.social
genelayinstitute.org/rtn/#program
genelayinstitute.org/rtn/#program
October 14, 2025 at 2:25 PM
Looking forward to #RTN2025 today! Excited for some #neuroimmunology! If you'll be there, please look for me and say hello! @genelayinstitute.bsky.social @rtnconference.bsky.social
genelayinstitute.org/rtn/#program
genelayinstitute.org/rtn/#program
Reposted by The Gene Lay Institute of Immunology and Inflammation
Hou, Sun et al from @kuchroolab.bsky.social 2024 in @natureportfolio.nature.com
"Neuropeptide signalling orchestrates T cell differentiation"
www.nature.com/articles/s41...
"Neuropeptide signalling orchestrates T cell differentiation"
www.nature.com/articles/s41...
Neuropeptide signalling orchestrates T cell differentiation - Nature
RAMP3, a component of the receptor for the neuropeptide CGRP, has a cell-intrinsic role in T helper type 1 cell fate determination.
www.nature.com
October 13, 2025 at 12:27 AM
Hou, Sun et al from @kuchroolab.bsky.social 2024 in @natureportfolio.nature.com
"Neuropeptide signalling orchestrates T cell differentiation"
www.nature.com/articles/s41...
"Neuropeptide signalling orchestrates T cell differentiation"
www.nature.com/articles/s41...
Reposted by The Gene Lay Institute of Immunology and Inflammation
Reposted by The Gene Lay Institute of Immunology and Inflammation
Reposted by The Gene Lay Institute of Immunology and Inflammation
Reposted by The Gene Lay Institute of Immunology and Inflammation
Reposted by The Gene Lay Institute of Immunology and Inflammation
We're less than a week away from #ReThinkNeuroimmunology — a groundbreaking conference hosted by the @genelayinstitute.bsky.social!
We’re thrilled to welcome experts, ignite new ideas, & push the field forward.
Huge thanks to our incredible sponsors for making #RTN2025 possible!
🧵👇
We’re thrilled to welcome experts, ignite new ideas, & push the field forward.
Huge thanks to our incredible sponsors for making #RTN2025 possible!
🧵👇
October 10, 2025 at 12:39 PM
We're less than a week away from #ReThinkNeuroimmunology — a groundbreaking conference hosted by the @genelayinstitute.bsky.social!
We’re thrilled to welcome experts, ignite new ideas, & push the field forward.
Huge thanks to our incredible sponsors for making #RTN2025 possible!
🧵👇
We’re thrilled to welcome experts, ignite new ideas, & push the field forward.
Huge thanks to our incredible sponsors for making #RTN2025 possible!
🧵👇
The @genelayinstitute.bsky.social
is excited to host its third #ReThinkNeuroimmunology meeting from October 14-16th, 2025. This year will focus on discussing major discoveries & breakthroughs in neuroimmunology, single cell genomics, immunology, & neuroscience.
genelayinstitute.org/rtn/
is excited to host its third #ReThinkNeuroimmunology meeting from October 14-16th, 2025. This year will focus on discussing major discoveries & breakthroughs in neuroimmunology, single cell genomics, immunology, & neuroscience.
genelayinstitute.org/rtn/
September 23, 2025 at 11:27 PM
Reposted by The Gene Lay Institute of Immunology and Inflammation
Our latest effort to translate genetic risk variants to disease mechanisms revealed that the R448G missense mutation in nuclear receptor coregulator NRIP1 promotes tissue inflammation via inefficient repression of a retinoic acid-mediated T cell gut-homing program. www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
September 18, 2025 at 6:21 PM
Our latest effort to translate genetic risk variants to disease mechanisms revealed that the R448G missense mutation in nuclear receptor coregulator NRIP1 promotes tissue inflammation via inefficient repression of a retinoic acid-mediated T cell gut-homing program. www.pnas.org/doi/10.1073/...
Reposted by The Gene Lay Institute of Immunology and Inflammation
ANKRD55 is associated with risk for multiple autoimmune diseases, but without a clear mechanism. In a new @jem.org study, we show that ANKRD55 promotes differentiation of inflammatory T cells via mitochondrial regulation, suggesting a new target for autoimmunity: rupress.org/jem/article-...
Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation
The ANKRD55 locus has been associated with multiple autoimmune diseases. Using murine models of inflammation, Xu et al. demonstrate an important role of th
rupress.org
September 11, 2025 at 9:11 PM
ANKRD55 is associated with risk for multiple autoimmune diseases, but without a clear mechanism. In a new @jem.org study, we show that ANKRD55 promotes differentiation of inflammatory T cells via mitochondrial regulation, suggesting a new target for autoimmunity: rupress.org/jem/article-...
Reposted by The Gene Lay Institute of Immunology and Inflammation
Antibiotics unleash #neuroinflammation. Jessica Kenison and Francisco Quintana (@quintanalabhms.bsky.social) @genelayinstitute.bsky.social @broadinstitute.org discuss new work from Chatterjee et al. (doi.org/10.1084/jem....) in Insights: rupress.org/jem/article/...
#Microbiome
#Microbiome
August 26, 2025 at 2:31 PM
Antibiotics unleash #neuroinflammation. Jessica Kenison and Francisco Quintana (@quintanalabhms.bsky.social) @genelayinstitute.bsky.social @broadinstitute.org discuss new work from Chatterjee et al. (doi.org/10.1084/jem....) in Insights: rupress.org/jem/article/...
#Microbiome
#Microbiome
New insights from @quintanalabhms.bsky.social @jem.org
In @jem.org, Kenison and Quintana @harvardmed.bsky.social discuss work by Chatterjee et al. (doi.org/10.1084/jem....) demonstrating that disruption of the gut microbiota promotes #neuroinflammation and cognitive decline through the loss of #microbiome-derived metabolites. rupress.org/jem/article/...
August 26, 2025 at 12:12 AM
New insights from @quintanalabhms.bsky.social @jem.org
Reposted by The Gene Lay Institute of Immunology and Inflammation
#ReThinkNeuroimmunology!
3 days
27 speakers
7 selected talks
2 panel discussions
>400 registered
Submit your abstract by August 28th for #RTN2025.
🔗 genelayinstitute.org/rtn/ 🧪
@quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
3 days
27 speakers
7 selected talks
2 panel discussions
>400 registered
Submit your abstract by August 28th for #RTN2025.
🔗 genelayinstitute.org/rtn/ 🧪
@quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
August 25, 2025 at 10:21 PM
#ReThinkNeuroimmunology!
3 days
27 speakers
7 selected talks
2 panel discussions
>400 registered
Submit your abstract by August 28th for #RTN2025.
🔗 genelayinstitute.org/rtn/ 🧪
@quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
3 days
27 speakers
7 selected talks
2 panel discussions
>400 registered
Submit your abstract by August 28th for #RTN2025.
🔗 genelayinstitute.org/rtn/ 🧪
@quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua