George Sflomos
@georgesflomos.bsky.social
Cancer Researcher passionate about Lobular Carcinoma, Preclinical Oncology, Discovery Science & Advocacy @LobularBCA, EACR ECR Council Member @helloeacr.bsky.social
Pinned
George Sflomos
@georgesflomos.bsky.social
· Feb 28
This month we express gratitude to the six presenters who contributed to our highlights presentation of the 2024 ILC Symposium. LBCA SAB members Dr. Muhktar and Dr. Sflomos plus Dr. Covington, Lounes Djerroudi, Dr. Di Meglio and Dr. Sandoval #volunteerappreciation #lobularbreastcancer #ilc
I’m honored to have contributed to the highlights presentation of the 2024 ILC Symposium alongside an incredible group of researchers. Thank you to the organizers and@lobularbca.bsky.social I am grateful to be part of this effort to raise awareness and drive progress in lobular breast cancer!
EACR Career Masterclass 2026 website is now live!
An exceptional virtual programme for early-career cancer researchers with practical career insights.
🗓 17–18 November 2026 | 🌍 Online eacr.org/conference/c...
#EACR #CancerResearch #EarlyCareerResearchers
An exceptional virtual programme for early-career cancer researchers with practical career insights.
🗓 17–18 November 2026 | 🌍 Online eacr.org/conference/c...
#EACR #CancerResearch #EarlyCareerResearchers
Introduction | Career Masterclass for Early Career Cancer Researchers | The European Association for Cancer Research
eacr.org
January 14, 2026 at 4:54 PM
EACR Career Masterclass 2026 website is now live!
An exceptional virtual programme for early-career cancer researchers with practical career insights.
🗓 17–18 November 2026 | 🌍 Online eacr.org/conference/c...
#EACR #CancerResearch #EarlyCareerResearchers
An exceptional virtual programme for early-career cancer researchers with practical career insights.
🗓 17–18 November 2026 | 🌍 Online eacr.org/conference/c...
#EACR #CancerResearch #EarlyCareerResearchers
Reposted by George Sflomos
Got some down time before the New Year? Catch up with The Cancer Researcher Podcast, where we dive into the inspiring and challenging world of being a cancer researcher.
Explore topics from navigating imposter syndrome to mastering scientific communication: magazine.eacr.org/podcast/
Explore topics from navigating imposter syndrome to mastering scientific communication: magazine.eacr.org/podcast/
December 26, 2025 at 12:01 PM
Got some down time before the New Year? Catch up with The Cancer Researcher Podcast, where we dive into the inspiring and challenging world of being a cancer researcher.
Explore topics from navigating imposter syndrome to mastering scientific communication: magazine.eacr.org/podcast/
Explore topics from navigating imposter syndrome to mastering scientific communication: magazine.eacr.org/podcast/
Reposted by George Sflomos
Registration is now OPEN for the cancer research community to join us for the #EACR2026 Congress! 🥳
Don't miss the opportunity to take advantage of our discounted early registration rate to attend, available until 21 April.
2026.eacr.org
Don't miss the opportunity to take advantage of our discounted early registration rate to attend, available until 21 April.
2026.eacr.org
January 7, 2026 at 1:02 PM
Registration is now OPEN for the cancer research community to join us for the #EACR2026 Congress! 🥳
Don't miss the opportunity to take advantage of our discounted early registration rate to attend, available until 21 April.
2026.eacr.org
Don't miss the opportunity to take advantage of our discounted early registration rate to attend, available until 21 April.
2026.eacr.org
I was pleased to contribute as a speaker to the first European Association for Cancer Research (EACR) – Organisation of European Cancer Institutes (OECI) virtual event on Patient Involvement in Cancer Research.
We’ve pulled together the key takeaways from our recent Patient Involvement in Cancer Research event, from powerful patient perspectives to practical guidance for researchers on meaningful patient involvement.
Catch up on the highlights:
magazine.eacr.org/highlights-f...
Catch up on the highlights:
magazine.eacr.org/highlights-f...
December 22, 2025 at 2:27 PM
I was pleased to contribute as a speaker to the first European Association for Cancer Research (EACR) – Organisation of European Cancer Institutes (OECI) virtual event on Patient Involvement in Cancer Research.
Reposted by George Sflomos
Check this out👇
Our neighbors @pietraslab.bsky.social has just published a new preprint detailing high-resolution profiling of the irradiated GBM microenvironment. ❄️Cool reading for the holidays❄️ Thanks for including us!
Our neighbors @pietraslab.bsky.social has just published a new preprint detailing high-resolution profiling of the irradiated GBM microenvironment. ❄️Cool reading for the holidays❄️ Thanks for including us!
📣 PREPRINT ALERT! Glioblastoma (GBM) often responds to radiotherapy, yet almost always recurs, frequently within high-dose radiation fields. www.biorxiv.org/content/10.6...
Coevolution of neoplastic and non-neoplastic reactive astrocyte states converges on mesenchymal-like and injury-response programs during murine glioblastoma progression and post-radiotherapy recurrenc...
Glioblastomas initially respond to radiotherapy but invariably recur, often within high-dose radiation treatment fields. Although stromal radiation responses are incompletely understood, evidence sugg...
www.biorxiv.org
December 22, 2025 at 10:46 AM
Check this out👇
Our neighbors @pietraslab.bsky.social has just published a new preprint detailing high-resolution profiling of the irradiated GBM microenvironment. ❄️Cool reading for the holidays❄️ Thanks for including us!
Our neighbors @pietraslab.bsky.social has just published a new preprint detailing high-resolution profiling of the irradiated GBM microenvironment. ❄️Cool reading for the holidays❄️ Thanks for including us!
Reposted by George Sflomos
Nature research paper: Whole-genome landscapes of 1,364 breast cancers
go.nature.com/48PM7Or
go.nature.com/48PM7Or
Whole-genome landscapes of 1,364 breast cancers - Nature
Whole-genome and transcriptome analysis of 1,364 cases of breast cancer from South Korea broadens our understanding of breast cancer biology and reveals genomic features that connect tumour biology with treatment responses and clinical outcomes.
go.nature.com
December 4, 2025 at 12:56 PM
Nature research paper: Whole-genome landscapes of 1,364 breast cancers
go.nature.com/48PM7Or
go.nature.com/48PM7Or
Reposted by George Sflomos
Registration for our next edition of Liquid Biopsies is now open 🎉
Join world-leading experts and emerging investigators to explore the latest advances in circulating nucleic acids, circulating tumour cells & extracellular vesicles across the cancer continuum.
eacr.org/conference/l...
Join world-leading experts and emerging investigators to explore the latest advances in circulating nucleic acids, circulating tumour cells & extracellular vesicles across the cancer continuum.
eacr.org/conference/l...
November 18, 2025 at 9:01 AM
Registration for our next edition of Liquid Biopsies is now open 🎉
Join world-leading experts and emerging investigators to explore the latest advances in circulating nucleic acids, circulating tumour cells & extracellular vesicles across the cancer continuum.
eacr.org/conference/l...
Join world-leading experts and emerging investigators to explore the latest advances in circulating nucleic acids, circulating tumour cells & extracellular vesicles across the cancer continuum.
eacr.org/conference/l...
Reposted by George Sflomos
You have until 15 December to register for our upcoming virtual conference! We will explore a seemingly paradoxical approach to cancer therapy, based on the deliberate hyper-activation of cancer-relevant signalling pathways.
Register from €60: eacr.org/conference/o...
Register from €60: eacr.org/conference/o...
November 21, 2025 at 9:01 AM
You have until 15 December to register for our upcoming virtual conference! We will explore a seemingly paradoxical approach to cancer therapy, based on the deliberate hyper-activation of cancer-relevant signalling pathways.
Register from €60: eacr.org/conference/o...
Register from €60: eacr.org/conference/o...
Reposted by George Sflomos
There's no better day than #WorldCancerResearchDay to register for our next virtual conference, Patient Involvement in Cancer Research! Learn how to make your research better and more impactful. Registration closes on Monday.
Learn more: eacr.org/conference/p...
Learn more: eacr.org/conference/p...
September 24, 2025 at 12:20 PM
There's no better day than #WorldCancerResearchDay to register for our next virtual conference, Patient Involvement in Cancer Research! Learn how to make your research better and more impactful. Registration closes on Monday.
Learn more: eacr.org/conference/p...
Learn more: eacr.org/conference/p...
Reposted by George Sflomos
EACR members! Join us for an interactive workshop on scientific publishing, where expert scientific editors will guide you through the essential steps of getting your research into the academic spotlight.
📅 29 September, 14:00-15:30 CEST
🌍 Zoom
us02web.zoom.us/meeting/regi...
📅 29 September, 14:00-15:30 CEST
🌍 Zoom
us02web.zoom.us/meeting/regi...
September 4, 2025 at 8:00 AM
EACR members! Join us for an interactive workshop on scientific publishing, where expert scientific editors will guide you through the essential steps of getting your research into the academic spotlight.
📅 29 September, 14:00-15:30 CEST
🌍 Zoom
us02web.zoom.us/meeting/regi...
📅 29 September, 14:00-15:30 CEST
🌍 Zoom
us02web.zoom.us/meeting/regi...
Reposted by George Sflomos
Stand out in your career & boost your research impact 💥
Funders & journals now expect real patient involvement. Join this event to get practical insights to collaborate better & future-proof your research.
Registration closes 29 Sept - don’t miss it! 👉 eacr.org/conference/p...
Funders & journals now expect real patient involvement. Join this event to get practical insights to collaborate better & future-proof your research.
Registration closes 29 Sept - don’t miss it! 👉 eacr.org/conference/p...
September 17, 2025 at 6:01 PM
Stand out in your career & boost your research impact 💥
Funders & journals now expect real patient involvement. Join this event to get practical insights to collaborate better & future-proof your research.
Registration closes 29 Sept - don’t miss it! 👉 eacr.org/conference/p...
Funders & journals now expect real patient involvement. Join this event to get practical insights to collaborate better & future-proof your research.
Registration closes 29 Sept - don’t miss it! 👉 eacr.org/conference/p...
Reposted by George Sflomos
New @dev-journal.bsky.social editorial
We know we have high standards - but we're committed to making publishing with us constructive
From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science
journals.biologists.com/dev/article/...
We know we have high standards - but we're committed to making publishing with us constructive
From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science
journals.biologists.com/dev/article/...
Constructive Critics: Development's approach to peer review
We're all familiar with complaints about peer review. Some think it's biased – editors (especially from ‘those’ journals) seem to have too much power to decide what gets published. It can be opaque – ...
journals.biologists.com
December 2, 2024 at 9:19 AM
New @dev-journal.bsky.social editorial
We know we have high standards - but we're committed to making publishing with us constructive
From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science
journals.biologists.com/dev/article/...
We know we have high standards - but we're committed to making publishing with us constructive
From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science
journals.biologists.com/dev/article/...
Reposted by George Sflomos
Nature Careers reports on how a new generation of researchers are using Substack as a way to build audiences and monetize their knowledge. #Academicsky 🧪
Why scientists are flocking to Substack
A new generation of researchers is using the platform to build audiences and monetize their knowledge.
go.nature.com
September 8, 2025 at 4:03 PM
Nature Careers reports on how a new generation of researchers are using Substack as a way to build audiences and monetize their knowledge. #Academicsky 🧪
Reposted by George Sflomos
Join us this November in Bergamo to help shape the future of early-onset cancer research!
We're excited to bring you this brand new conference topic, exploring the biology, causes and detection of cancer in younger patients.
In partnership with @themarkfdn.bsky.social 💙
eacr.org/conference/m...
We're excited to bring you this brand new conference topic, exploring the biology, causes and detection of cancer in younger patients.
In partnership with @themarkfdn.bsky.social 💙
eacr.org/conference/m...
March 12, 2025 at 2:49 PM
Join us this November in Bergamo to help shape the future of early-onset cancer research!
We're excited to bring you this brand new conference topic, exploring the biology, causes and detection of cancer in younger patients.
In partnership with @themarkfdn.bsky.social 💙
eacr.org/conference/m...
We're excited to bring you this brand new conference topic, exploring the biology, causes and detection of cancer in younger patients.
In partnership with @themarkfdn.bsky.social 💙
eacr.org/conference/m...
Reposted by George Sflomos
Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers
Chien-Chu Lin et al. reveal the structure of the histone demethylase KDM6B bound to
the nucleosome. The study shows how KDM6B is positioned for H3K27 demethylation and
how heterochromatin features suc...
www.cell.com
July 21, 2025 at 10:20 PM
Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by George Sflomos
We used ~normal human mammary epithelial cells (HMECs) to test CDH1 loss (modeling ILC) vs inhibiting E-cadherin, i.e. genetic suppression vs signaling block, to define how CDH1 loss is fundamentally different that 'simply' losing E-cadh mediated cell contacts. I.e. is this ~EMT, or not? 2/n
June 25, 2025 at 5:26 PM
We used ~normal human mammary epithelial cells (HMECs) to test CDH1 loss (modeling ILC) vs inhibiting E-cadherin, i.e. genetic suppression vs signaling block, to define how CDH1 loss is fundamentally different that 'simply' losing E-cadh mediated cell contacts. I.e. is this ~EMT, or not? 2/n
Reposted by George Sflomos
As we learn more re CDH1 loss-induced lineage reprogramming, we can develop new risk assessment strategies for benign ILC precursors, build prevention strategies, and target "truncal" effects of CDH1 loss in overt ILC to target the changes that likely are important in every single cancer cell. 5/5
June 25, 2025 at 5:26 PM
As we learn more re CDH1 loss-induced lineage reprogramming, we can develop new risk assessment strategies for benign ILC precursors, build prevention strategies, and target "truncal" effects of CDH1 loss in overt ILC to target the changes that likely are important in every single cancer cell. 5/5
Reposted by George Sflomos
So CDH1 loss causes a lineage remodeling in normal HMEC, locking cells in a new luminal progenitor-like state. This may explain why nearly all ILC are luminal-type (i.e. ER+) and point to CDH1 loss as a critical "bottleneck" in breast oncogenesis specific to ILC. 4/n
June 25, 2025 at 5:26 PM
So CDH1 loss causes a lineage remodeling in normal HMEC, locking cells in a new luminal progenitor-like state. This may explain why nearly all ILC are luminal-type (i.e. ER+) and point to CDH1 loss as a critical "bottleneck" in breast oncogenesis specific to ILC. 4/n
Reposted by George Sflomos
We did a thing w @jostrander.bsky.social!
Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n
Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n
CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells https://www.biorxiv.org/content/10.1101/2025.06.20.660633v1
June 25, 2025 at 5:26 PM
We did a thing w @jostrander.bsky.social!
Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n
Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n
Reposted by George Sflomos
🚨 New podcast episode!
In this insightful and honest conversation, award winners Karin de Visser, Ido Amit and @martakova.bsky.social talk about their research, career journeys, and excitement for the future of cancer research:
magazine.eacr.org/curiosity-op...
In this insightful and honest conversation, award winners Karin de Visser, Ido Amit and @martakova.bsky.social talk about their research, career journeys, and excitement for the future of cancer research:
magazine.eacr.org/curiosity-op...
May 14, 2025 at 7:01 AM
🚨 New podcast episode!
In this insightful and honest conversation, award winners Karin de Visser, Ido Amit and @martakova.bsky.social talk about their research, career journeys, and excitement for the future of cancer research:
magazine.eacr.org/curiosity-op...
In this insightful and honest conversation, award winners Karin de Visser, Ido Amit and @martakova.bsky.social talk about their research, career journeys, and excitement for the future of cancer research:
magazine.eacr.org/curiosity-op...
Reposted by George Sflomos
If you're traveling this weekend (like I will for the EACR Congress in Lisbon) this is a great way to learn something new while waiting on trains and airports. The Cancer Researcher Podcast is available on all major podcast platforms!
Tune into episode 23 of The Cancer Researcher Podcast 🎙️
We chat with Chiara Pozzato & Georgia Konstantinidou (University of Bern) on FAK signalling in KRAS-driven NSCLC and a novel treatment angle.
🎧 Dive in: magazine.eacr.org/novel-approa...
We chat with Chiara Pozzato & Georgia Konstantinidou (University of Bern) on FAK signalling in KRAS-driven NSCLC and a novel treatment angle.
🎧 Dive in: magazine.eacr.org/novel-approa...
June 12, 2025 at 11:44 AM
If you're traveling this weekend (like I will for the EACR Congress in Lisbon) this is a great way to learn something new while waiting on trains and airports. The Cancer Researcher Podcast is available on all major podcast platforms!
Reposted by George Sflomos
As part of the Cancer Researchers to Watch – An Early Career Showcase, the EACR Early Career Researchers Council took a moment to brainstorm with the early-career EACR members in the audience strategies that would better support the next-generation cancer scientists.
#EACR2025
#EACR2025
June 15, 2025 at 5:13 PM
As part of the Cancer Researchers to Watch – An Early Career Showcase, the EACR Early Career Researchers Council took a moment to brainstorm with the early-career EACR members in the audience strategies that would better support the next-generation cancer scientists.
#EACR2025
#EACR2025
Reposted by George Sflomos
New online! The evolutionary foundations of transcriptional regulation in animals
The evolutionary foundations of transcriptional regulation in animals
Nature Reviews Genetics, Published online: 09 July 2025; doi:10.1038/s41576-025-00864-9In this Review, Coyle and King explore how genomic and functional data from diverse species are providing new insights into the types of mechanistic changes that accompanied the evolutionary origin of animals.
www.nature.com
July 9, 2025 at 11:28 AM
New online! The evolutionary foundations of transcriptional regulation in animals
Reposted by George Sflomos
What a wonderful week we’ve had here together in Lisbon for #EACR2025! Thank you to everyone who attended, presented at and helped organise this fantastic event. Sign up here for updates about EACR 2026 in Budapest… 👀 eacr.us5.list-manage.com/subscribe?u=...
June 19, 2025 at 1:08 PM
What a wonderful week we’ve had here together in Lisbon for #EACR2025! Thank you to everyone who attended, presented at and helped organise this fantastic event. Sign up here for updates about EACR 2026 in Budapest… 👀 eacr.us5.list-manage.com/subscribe?u=...
Reposted by George Sflomos
Participants, speakers and exhibitors have been taking the chance to relax and mingle with a drink at the #EACR2025 Welcome Reception here in Lisbon.
June 16, 2025 at 6:20 PM
Participants, speakers and exhibitors have been taking the chance to relax and mingle with a drink at the #EACR2025 Welcome Reception here in Lisbon.