Alexander Pietras Lab
@pietraslab.bsky.social
We're the Alexander Pietras Lab, exploring the complexities of the brain tumor microenvironment. We study how therapies like radiotherapy reshape it and seek innovative ways to outsmart tumors.
AP posts @ Lund University
trained @ MSKCC and @ Fred Hutch
AP posts @ Lund University
trained @ MSKCC and @ Fred Hutch
Reposted by Alexander Pietras Lab
New paper out from the @kpietraslab.bsky.social lab.
I am happy to share that my first-author paper is now published. We map the spatial and temporal dynamics of cancer-associated fibroblasts in breast cancer using integrated spatial proteomics and transcriptomics.
link.springer.com/article/10.1...
I am happy to share that my first-author paper is now published. We map the spatial and temporal dynamics of cancer-associated fibroblasts in breast cancer using integrated spatial proteomics and transcriptomics.
link.springer.com/article/10.1...
Spatial and temporal dynamics of cancer-associated fibroblast niches in breast cancer - Breast Cancer Research
Breast Cancer Research - Cancer-associated fibroblasts (CAFs) are the main constituents of the tumor microenvironment. Several studies have delineated CAF heterogeneity in different types of...
link.springer.com
January 17, 2026 at 12:04 PM
New paper out from the @kpietraslab.bsky.social lab.
I am happy to share that my first-author paper is now published. We map the spatial and temporal dynamics of cancer-associated fibroblasts in breast cancer using integrated spatial proteomics and transcriptomics.
link.springer.com/article/10.1...
I am happy to share that my first-author paper is now published. We map the spatial and temporal dynamics of cancer-associated fibroblasts in breast cancer using integrated spatial proteomics and transcriptomics.
link.springer.com/article/10.1...
Reposted by Alexander Pietras Lab
📣 PREPRINT ALERT! Glioblastoma (GBM) often responds to radiotherapy, yet almost always recurs, frequently within high-dose radiation fields. www.biorxiv.org/content/10.6...
Coevolution of neoplastic and non-neoplastic reactive astrocyte states converges on mesenchymal-like and injury-response programs during murine glioblastoma progression and post-radiotherapy recurrenc...
Glioblastomas initially respond to radiotherapy but invariably recur, often within high-dose radiation treatment fields. Although stromal radiation responses are incompletely understood, evidence sugg...
www.biorxiv.org
December 22, 2025 at 9:22 AM
📣 PREPRINT ALERT! Glioblastoma (GBM) often responds to radiotherapy, yet almost always recurs, frequently within high-dose radiation fields. www.biorxiv.org/content/10.6...
Reposted by Alexander Pietras Lab
Check this out👇
Our neighbors @pietraslab.bsky.social has just published a new preprint detailing high-resolution profiling of the irradiated GBM microenvironment. ❄️Cool reading for the holidays❄️ Thanks for including us!
Our neighbors @pietraslab.bsky.social has just published a new preprint detailing high-resolution profiling of the irradiated GBM microenvironment. ❄️Cool reading for the holidays❄️ Thanks for including us!
📣 PREPRINT ALERT! Glioblastoma (GBM) often responds to radiotherapy, yet almost always recurs, frequently within high-dose radiation fields. www.biorxiv.org/content/10.6...
Coevolution of neoplastic and non-neoplastic reactive astrocyte states converges on mesenchymal-like and injury-response programs during murine glioblastoma progression and post-radiotherapy recurrenc...
Glioblastomas initially respond to radiotherapy but invariably recur, often within high-dose radiation treatment fields. Although stromal radiation responses are incompletely understood, evidence sugg...
www.biorxiv.org
December 22, 2025 at 10:46 AM
Check this out👇
Our neighbors @pietraslab.bsky.social has just published a new preprint detailing high-resolution profiling of the irradiated GBM microenvironment. ❄️Cool reading for the holidays❄️ Thanks for including us!
Our neighbors @pietraslab.bsky.social has just published a new preprint detailing high-resolution profiling of the irradiated GBM microenvironment. ❄️Cool reading for the holidays❄️ Thanks for including us!
📣 PREPRINT ALERT! Glioblastoma (GBM) often responds to radiotherapy, yet almost always recurs, frequently within high-dose radiation fields. www.biorxiv.org/content/10.6...
Coevolution of neoplastic and non-neoplastic reactive astrocyte states converges on mesenchymal-like and injury-response programs during murine glioblastoma progression and post-radiotherapy recurrenc...
Glioblastomas initially respond to radiotherapy but invariably recur, often within high-dose radiation treatment fields. Although stromal radiation responses are incompletely understood, evidence sugg...
www.biorxiv.org
December 22, 2025 at 9:22 AM
📣 PREPRINT ALERT! Glioblastoma (GBM) often responds to radiotherapy, yet almost always recurs, frequently within high-dose radiation fields. www.biorxiv.org/content/10.6...
Reposted by Alexander Pietras Lab
New paper alert 🚨
We are delighted to present our latest paper in @natcomms.nature.com through fabulous work from co-first authors Sebastian Braun and Paulina Bolivar! Big thanks to all expert collaborators for taking this long journey with us!
Tweetorial in comments 🧵
www.nature.com/articles/s41...
We are delighted to present our latest paper in @natcomms.nature.com through fabulous work from co-first authors Sebastian Braun and Paulina Bolivar! Big thanks to all expert collaborators for taking this long journey with us!
Tweetorial in comments 🧵
www.nature.com/articles/s41...
Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma - Nature Communications
Improved understanding of the tumor ecosystem in glioblastoma is critical for developing new treatment strategies for the disease. Here, the authors identify pericytes as an active paracrine signaling...
www.nature.com
December 9, 2025 at 5:05 PM
New paper alert 🚨
We are delighted to present our latest paper in @natcomms.nature.com through fabulous work from co-first authors Sebastian Braun and Paulina Bolivar! Big thanks to all expert collaborators for taking this long journey with us!
Tweetorial in comments 🧵
www.nature.com/articles/s41...
We are delighted to present our latest paper in @natcomms.nature.com through fabulous work from co-first authors Sebastian Braun and Paulina Bolivar! Big thanks to all expert collaborators for taking this long journey with us!
Tweetorial in comments 🧵
www.nature.com/articles/s41...
Reposted by Alexander Pietras Lab
Really excited to see this new paper from our friends & neighbors in the other Pietras lab @kpietraslab.bsky.social, uncovering surprising (?) roles of pericytes in the GBM microenvironment. Congrats all, and thanks for including us! www.nature.com/articles/s41...
Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma - Nature Communications
Improved understanding of the tumor ecosystem in glioblastoma is critical for developing new treatment strategies for the disease. Here, the authors identify pericytes as an active paracrine signaling...
www.nature.com
December 5, 2025 at 3:14 PM
Really excited to see this new paper from our friends & neighbors in the other Pietras lab @kpietraslab.bsky.social, uncovering surprising (?) roles of pericytes in the GBM microenvironment. Congrats all, and thanks for including us! www.nature.com/articles/s41...
Really excited to see this new paper from our friends & neighbors in the other Pietras lab @kpietraslab.bsky.social, uncovering surprising (?) roles of pericytes in the GBM microenvironment. Congrats all, and thanks for including us! www.nature.com/articles/s41...
Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma - Nature Communications
Improved understanding of the tumor ecosystem in glioblastoma is critical for developing new treatment strategies for the disease. Here, the authors identify pericytes as an active paracrine signaling...
www.nature.com
December 5, 2025 at 3:14 PM
Really excited to see this new paper from our friends & neighbors in the other Pietras lab @kpietraslab.bsky.social, uncovering surprising (?) roles of pericytes in the GBM microenvironment. Congrats all, and thanks for including us! www.nature.com/articles/s41...
Reposted by Alexander Pietras Lab
Excited to share I’ve received a #SSMF #Consolidator grant!
📣 Recruiting a #postdoc to study #cancer #neuroscience #3Dgenomics #multiomics #singlecellomics
🔬How neural inputs shape #3Dgenome and #cellplasticity in #glioblastoma #GBM
Interested? Apply now 👇
rb.gy/m7xz7b
📣 Recruiting a #postdoc to study #cancer #neuroscience #3Dgenomics #multiomics #singlecellomics
🔬How neural inputs shape #3Dgenome and #cellplasticity in #glioblastoma #GBM
Interested? Apply now 👇
rb.gy/m7xz7b
Postdoctoral Researcher in "Cancer Neuroscience: the impact of neural activity on 3D genome organization and cellular plasticity in glioblastoma”
rb.gy
November 14, 2025 at 11:00 AM
Excited to share I’ve received a #SSMF #Consolidator grant!
📣 Recruiting a #postdoc to study #cancer #neuroscience #3Dgenomics #multiomics #singlecellomics
🔬How neural inputs shape #3Dgenome and #cellplasticity in #glioblastoma #GBM
Interested? Apply now 👇
rb.gy/m7xz7b
📣 Recruiting a #postdoc to study #cancer #neuroscience #3Dgenomics #multiomics #singlecellomics
🔬How neural inputs shape #3Dgenome and #cellplasticity in #glioblastoma #GBM
Interested? Apply now 👇
rb.gy/m7xz7b
Reposted by Alexander Pietras Lab
How can senescent cells, which are damaged and growth arrested, both block tumor initiation as well as fuel its growth? A recent study published in Cancer Discovery @aacrjournals.bsky.social from Lin Zhou in the lab uncovered some new insights into this puzzle.
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
P21-positive senescent stromal cells promote prostate cancer immune suppression and progression that can be reversed by senolytic therapy
Abstract. Cellular senescence is a well-established tumor-suppressive cell cycle arrest program. However, chronic inflammation through the senescence-associated secretory phenotype (SASP) can alternat...
aacrjournals.org
October 29, 2025 at 2:40 PM
How can senescent cells, which are damaged and growth arrested, both block tumor initiation as well as fuel its growth? A recent study published in Cancer Discovery @aacrjournals.bsky.social from Lin Zhou in the lab uncovered some new insights into this puzzle.
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
Had a blast hosting the Brain Tumor Plasticity symposium at the Royal Swedish Academy of Sciences this week! Here's @leilaakkari.bsky.social with an outstanding talk on the evolving brain tumor microenvironment 🤩
September 19, 2025 at 5:50 AM
Had a blast hosting the Brain Tumor Plasticity symposium at the Royal Swedish Academy of Sciences this week! Here's @leilaakkari.bsky.social with an outstanding talk on the evolving brain tumor microenvironment 🤩
Reposted by Alexander Pietras Lab
Thrilled to share our latest work - we describe a novel and therapeutically relevant mechanism underlying dysregulation of innate immune receptor C5aR1 in the tumour microenvironment. Thanks and congratulations to all authors!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 24, 2025 at 8:45 PM
Thrilled to share our latest work - we describe a novel and therapeutically relevant mechanism underlying dysregulation of innate immune receptor C5aR1 in the tumour microenvironment. Thanks and congratulations to all authors!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alexander Pietras Lab
To this day, even the strongest treatments fail when the brain’s own healing turns against it. Flunarizine, a migraine drug, may help stop astrocytes from nurturing #glioblastoma back to life.
Read ⤵️
Read ⤵️
📣 Preprint alert! Happy to share our latest work, in which we identify Flunarizine as an inhibitor of astrocyte reactivity with therapeutic potential in glioblastoma (GBM). Details in 🧵:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Phenotypic Screening Identifies Flunarizine as an Inhibitor of Radiotherapy-Induced Astrocyte Reactivity with Therapeutic Potential in Glioblastoma
Radiotherapy is part of the standard-of-care for glioblastoma, yet tumors invariably recur as incurable lesions post-treatment. Recent studies suggest that radiation-induced astrocyte reactivity foste...
www.biorxiv.org
July 22, 2025 at 4:35 PM
To this day, even the strongest treatments fail when the brain’s own healing turns against it. Flunarizine, a migraine drug, may help stop astrocytes from nurturing #glioblastoma back to life.
Read ⤵️
Read ⤵️
Reposted by Alexander Pietras Lab
📣 Preprint alert! Happy to share our latest work, in which we identify Flunarizine as an inhibitor of astrocyte reactivity with therapeutic potential in glioblastoma (GBM). Details in 🧵:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Phenotypic Screening Identifies Flunarizine as an Inhibitor of Radiotherapy-Induced Astrocyte Reactivity with Therapeutic Potential in Glioblastoma
Radiotherapy is part of the standard-of-care for glioblastoma, yet tumors invariably recur as incurable lesions post-treatment. Recent studies suggest that radiation-induced astrocyte reactivity foste...
www.biorxiv.org
July 18, 2025 at 7:01 AM
📣 Preprint alert! Happy to share our latest work, in which we identify Flunarizine as an inhibitor of astrocyte reactivity with therapeutic potential in glioblastoma (GBM). Details in 🧵:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alexander Pietras Lab
Phenotypic Screening Identifies Flunarizine as an Inhibitor of Radiotherapy-Induced Astrocyte Reactivity with Therapeutic Potential in Glioblastoma https://www.biorxiv.org/content/10.1101/2025.07.12.664538v1
July 18, 2025 at 4:50 AM
Phenotypic Screening Identifies Flunarizine as an Inhibitor of Radiotherapy-Induced Astrocyte Reactivity with Therapeutic Potential in Glioblastoma https://www.biorxiv.org/content/10.1101/2025.07.12.664538v1
📣 Preprint alert! Happy to share our latest work, in which we identify Flunarizine as an inhibitor of astrocyte reactivity with therapeutic potential in glioblastoma (GBM). Details in 🧵:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Phenotypic Screening Identifies Flunarizine as an Inhibitor of Radiotherapy-Induced Astrocyte Reactivity with Therapeutic Potential in Glioblastoma
Radiotherapy is part of the standard-of-care for glioblastoma, yet tumors invariably recur as incurable lesions post-treatment. Recent studies suggest that radiation-induced astrocyte reactivity foste...
www.biorxiv.org
July 18, 2025 at 7:01 AM
📣 Preprint alert! Happy to share our latest work, in which we identify Flunarizine as an inhibitor of astrocyte reactivity with therapeutic potential in glioblastoma (GBM). Details in 🧵:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alexander Pietras Lab
🌍 Join us in a supportive, international lab within a vibrant cancer research hub! Strong local bioinformatics community + a high quality of life in the Malmö/Lund region. Great science, great people, great place to live. 💻🧬🏡
May 15, 2025 at 8:27 AM
🌍 Join us in a supportive, international lab within a vibrant cancer research hub! Strong local bioinformatics community + a high quality of life in the Malmö/Lund region. Great science, great people, great place to live. 💻🧬🏡
Reposted by Alexander Pietras Lab
📣 New pre-print from the lab:
👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM
📝 Read the #BioRxiv here:
doi.org/10.1101/2025...
👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM
📝 Read the #BioRxiv here:
doi.org/10.1101/2025...
May 21, 2025 at 8:55 AM
📣 New pre-print from the lab:
👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM
📝 Read the #BioRxiv here:
doi.org/10.1101/2025...
👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM
📝 Read the #BioRxiv here:
doi.org/10.1101/2025...
Reposted by Alexander Pietras Lab
🚨 We’re hiring a bioinformatics-focused PhD student for our ERC-funded project on recurrent GBM! Focus: tumor-supportive microenvironment 🔬 Experience with scRNA-seq, spatial transcriptomics & Python/R a plus. Must be self-motivated & driven. DM for details! Repost=❤️ lu.varbi.com/en/what:job/...
Doctoral Student in Tumor Biology
Description of the workplace The research group conducts experimental research on brain tumors and is led by Associate Professor Alexander Pietras. The group consists of a bioinformatician, two postdo
lu.varbi.com
May 15, 2025 at 8:27 AM
🚨 We’re hiring a bioinformatics-focused PhD student for our ERC-funded project on recurrent GBM! Focus: tumor-supportive microenvironment 🔬 Experience with scRNA-seq, spatial transcriptomics & Python/R a plus. Must be self-motivated & driven. DM for details! Repost=❤️ lu.varbi.com/en/what:job/...
🚨 We’re hiring a bioinformatics-focused PhD student for our ERC-funded project on recurrent GBM! Focus: tumor-supportive microenvironment 🔬 Experience with scRNA-seq, spatial transcriptomics & Python/R a plus. Must be self-motivated & driven. DM for details! Repost=❤️ lu.varbi.com/en/what:job/...
Doctoral Student in Tumor Biology
Description of the workplace The research group conducts experimental research on brain tumors and is led by Associate Professor Alexander Pietras. The group consists of a bioinformatician, two postdo
lu.varbi.com
May 15, 2025 at 8:27 AM
🚨 We’re hiring a bioinformatics-focused PhD student for our ERC-funded project on recurrent GBM! Focus: tumor-supportive microenvironment 🔬 Experience with scRNA-seq, spatial transcriptomics & Python/R a plus. Must be self-motivated & driven. DM for details! Repost=❤️ lu.varbi.com/en/what:job/...
Just a few spots left for this exciting symposium on brain tumor plasticity—grab yours (free of charge!) before they're gone! 🚨
🎫 Exclusive event: One-day symposium on #Brain #Tumor #Plasticity
🕣September 16, 2025. The Royal Swedish Academy of Sciences, Stockholm @scienceacademyswe.bsky.social
Few spots available. Register here: ui.ungpd.com/Events/ed387...
🕣September 16, 2025. The Royal Swedish Academy of Sciences, Stockholm @scienceacademyswe.bsky.social
Few spots available. Register here: ui.ungpd.com/Events/ed387...
Brain Tumor Plasticity
A growing body of evidence emphasizes the presence of significant intra-tumoral phenotypic diversity and plasticity within brain tumors. Inherent plasticity introduces an additional layer of intricacy...
ui.ungpd.com
May 12, 2025 at 2:37 PM
Just a few spots left for this exciting symposium on brain tumor plasticity—grab yours (free of charge!) before they're gone! 🚨
+1
Great to see this paper finally out. We've been using it for a while, a really great resource for omics in glioblastoma!
doi.org/10.1093/neuo...
doi.org/10.1093/neuo...
Charting the Single-Cell and Spatial Landscape of IDH-Wildtype Glioblastoma with GBmap
AbstractBackground. Glioblastoma (GB), particularly IDH-wildtype, is the most aggressive brain malignancy with a dismal prognosis. Despite advances in mole
doi.org
May 5, 2025 at 1:04 PM
+1
Reposted by Alexander Pietras Lab
👋We have 2 amazing projects: A) basic molecular regulation of the LN lymphatic vasculature & B) lymphatic metastasis with new models & human samples describing completely new phenomena - both projects with solid preliminary data to build on. Open for interested postdoctoral scientists 📩
May 2, 2025 at 8:45 AM
👋We have 2 amazing projects: A) basic molecular regulation of the LN lymphatic vasculature & B) lymphatic metastasis with new models & human samples describing completely new phenomena - both projects with solid preliminary data to build on. Open for interested postdoctoral scientists 📩
Reposted by Alexander Pietras Lab
Join us for innovative explorations of the tumor microenvironment🔬 Learn cutting-edge technologies and grow in a dynamic environment💡 The postdoc will work alongside a doctoral student from @adaptmet.bsky.social, gaining access to collaborative partners across 🇪🇺.
Apply now👇
tinyurl.com/4mby45hf
Apply now👇
tinyurl.com/4mby45hf
Postdoc in Experimental Oncology - Lund (Stad), Skåne (SE) job with Lund University | 12838990
Lunds universitet, 009999 LUNDS UNIVERSITET, 310000 MED Lund University was founded in 1666 and is repeatedly ranked among the world’s top universi...
tinyurl.com
April 23, 2025 at 5:56 AM
Join us for innovative explorations of the tumor microenvironment🔬 Learn cutting-edge technologies and grow in a dynamic environment💡 The postdoc will work alongside a doctoral student from @adaptmet.bsky.social, gaining access to collaborative partners across 🇪🇺.
Apply now👇
tinyurl.com/4mby45hf
Apply now👇
tinyurl.com/4mby45hf
I'm delighted to host @ggargiul.bsky.social for a talk in the LUCC seminar series today. Medicon Village Auditorium @ 1.30 - you don't want to miss out if you're in Lund! Welcome!
April 8, 2025 at 6:49 AM
I'm delighted to host @ggargiul.bsky.social for a talk in the LUCC seminar series today. Medicon Village Auditorium @ 1.30 - you don't want to miss out if you're in Lund! Welcome!
Reposted by Alexander Pietras Lab
Hot off the press! 🧬🔬
We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ:
doi.org/10.1126/scie...
We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ:
doi.org/10.1126/scie...
Ectoderm barcoding reveals neural and cochlear compartmentalization
Placodes and the neural crest are defining features of vertebrates. In this study, we investigate their lineages in mice using in utero approaches. We demonstrated that nanoinjection at embryonic day ...
doi.org
April 4, 2025 at 6:24 AM
Hot off the press! 🧬🔬
We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ:
doi.org/10.1126/scie...
We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ:
doi.org/10.1126/scie...