George Sflomos
@georgesflomos.bsky.social
Cancer Researcher passionate about Lobular Carcinoma, Preclinical Oncology, Discovery Science & Advocacy @LobularBCA, EACR ECR Council Member @helloeacr.bsky.social
Pinned
George Sflomos
@georgesflomos.bsky.social
· Feb 28
This month we express gratitude to the six presenters who contributed to our highlights presentation of the 2024 ILC Symposium. LBCA SAB members Dr. Muhktar and Dr. Sflomos plus Dr. Covington, Lounes Djerroudi, Dr. Di Meglio and Dr. Sandoval #volunteerappreciation #lobularbreastcancer #ilc
I’m honored to have contributed to the highlights presentation of the 2024 ILC Symposium alongside an incredible group of researchers. Thank you to the organizers and@lobularbca.bsky.social I am grateful to be part of this effort to raise awareness and drive progress in lobular breast cancer!
Reposted by George Sflomos
There's no better day than #WorldCancerResearchDay to register for our next virtual conference, Patient Involvement in Cancer Research! Learn how to make your research better and more impactful. Registration closes on Monday.
Learn more: eacr.org/conference/p...
Learn more: eacr.org/conference/p...
September 24, 2025 at 12:20 PM
There's no better day than #WorldCancerResearchDay to register for our next virtual conference, Patient Involvement in Cancer Research! Learn how to make your research better and more impactful. Registration closes on Monday.
Learn more: eacr.org/conference/p...
Learn more: eacr.org/conference/p...
Reposted by George Sflomos
EACR members! Join us for an interactive workshop on scientific publishing, where expert scientific editors will guide you through the essential steps of getting your research into the academic spotlight.
📅 29 September, 14:00-15:30 CEST
🌍 Zoom
us02web.zoom.us/meeting/regi...
📅 29 September, 14:00-15:30 CEST
🌍 Zoom
us02web.zoom.us/meeting/regi...
September 4, 2025 at 8:00 AM
EACR members! Join us for an interactive workshop on scientific publishing, where expert scientific editors will guide you through the essential steps of getting your research into the academic spotlight.
📅 29 September, 14:00-15:30 CEST
🌍 Zoom
us02web.zoom.us/meeting/regi...
📅 29 September, 14:00-15:30 CEST
🌍 Zoom
us02web.zoom.us/meeting/regi...
Reposted by George Sflomos
Stand out in your career & boost your research impact 💥
Funders & journals now expect real patient involvement. Join this event to get practical insights to collaborate better & future-proof your research.
Registration closes 29 Sept - don’t miss it! 👉 eacr.org/conference/p...
Funders & journals now expect real patient involvement. Join this event to get practical insights to collaborate better & future-proof your research.
Registration closes 29 Sept - don’t miss it! 👉 eacr.org/conference/p...
September 17, 2025 at 6:01 PM
Stand out in your career & boost your research impact 💥
Funders & journals now expect real patient involvement. Join this event to get practical insights to collaborate better & future-proof your research.
Registration closes 29 Sept - don’t miss it! 👉 eacr.org/conference/p...
Funders & journals now expect real patient involvement. Join this event to get practical insights to collaborate better & future-proof your research.
Registration closes 29 Sept - don’t miss it! 👉 eacr.org/conference/p...
Reposted by George Sflomos
New @dev-journal.bsky.social editorial
We know we have high standards - but we're committed to making publishing with us constructive
From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science
journals.biologists.com/dev/article/...
We know we have high standards - but we're committed to making publishing with us constructive
From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science
journals.biologists.com/dev/article/...
Constructive Critics: Development's approach to peer review
We're all familiar with complaints about peer review. Some think it's biased – editors (especially from ‘those’ journals) seem to have too much power to decide what gets published. It can be opaque – ...
journals.biologists.com
December 2, 2024 at 9:19 AM
New @dev-journal.bsky.social editorial
We know we have high standards - but we're committed to making publishing with us constructive
From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science
journals.biologists.com/dev/article/...
We know we have high standards - but we're committed to making publishing with us constructive
From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science
journals.biologists.com/dev/article/...
Reposted by George Sflomos
Nature Careers reports on how a new generation of researchers are using Substack as a way to build audiences and monetize their knowledge. #Academicsky 🧪
Why scientists are flocking to Substack
A new generation of researchers is using the platform to build audiences and monetize their knowledge.
go.nature.com
September 8, 2025 at 4:03 PM
Nature Careers reports on how a new generation of researchers are using Substack as a way to build audiences and monetize their knowledge. #Academicsky 🧪
Reposted by George Sflomos
Join us this November in Bergamo to help shape the future of early-onset cancer research!
We're excited to bring you this brand new conference topic, exploring the biology, causes and detection of cancer in younger patients.
In partnership with @themarkfdn.bsky.social 💙
eacr.org/conference/m...
We're excited to bring you this brand new conference topic, exploring the biology, causes and detection of cancer in younger patients.
In partnership with @themarkfdn.bsky.social 💙
eacr.org/conference/m...
March 12, 2025 at 2:49 PM
Join us this November in Bergamo to help shape the future of early-onset cancer research!
We're excited to bring you this brand new conference topic, exploring the biology, causes and detection of cancer in younger patients.
In partnership with @themarkfdn.bsky.social 💙
eacr.org/conference/m...
We're excited to bring you this brand new conference topic, exploring the biology, causes and detection of cancer in younger patients.
In partnership with @themarkfdn.bsky.social 💙
eacr.org/conference/m...
Reposted by George Sflomos
Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers
Chien-Chu Lin et al. reveal the structure of the histone demethylase KDM6B bound to
the nucleosome. The study shows how KDM6B is positioned for H3K27 demethylation and
how heterochromatin features suc...
www.cell.com
July 21, 2025 at 10:20 PM
Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by George Sflomos
We used ~normal human mammary epithelial cells (HMECs) to test CDH1 loss (modeling ILC) vs inhibiting E-cadherin, i.e. genetic suppression vs signaling block, to define how CDH1 loss is fundamentally different that 'simply' losing E-cadh mediated cell contacts. I.e. is this ~EMT, or not? 2/n
June 25, 2025 at 5:26 PM
We used ~normal human mammary epithelial cells (HMECs) to test CDH1 loss (modeling ILC) vs inhibiting E-cadherin, i.e. genetic suppression vs signaling block, to define how CDH1 loss is fundamentally different that 'simply' losing E-cadh mediated cell contacts. I.e. is this ~EMT, or not? 2/n
Reposted by George Sflomos
As we learn more re CDH1 loss-induced lineage reprogramming, we can develop new risk assessment strategies for benign ILC precursors, build prevention strategies, and target "truncal" effects of CDH1 loss in overt ILC to target the changes that likely are important in every single cancer cell. 5/5
June 25, 2025 at 5:26 PM
As we learn more re CDH1 loss-induced lineage reprogramming, we can develop new risk assessment strategies for benign ILC precursors, build prevention strategies, and target "truncal" effects of CDH1 loss in overt ILC to target the changes that likely are important in every single cancer cell. 5/5
Reposted by George Sflomos
So CDH1 loss causes a lineage remodeling in normal HMEC, locking cells in a new luminal progenitor-like state. This may explain why nearly all ILC are luminal-type (i.e. ER+) and point to CDH1 loss as a critical "bottleneck" in breast oncogenesis specific to ILC. 4/n
June 25, 2025 at 5:26 PM
So CDH1 loss causes a lineage remodeling in normal HMEC, locking cells in a new luminal progenitor-like state. This may explain why nearly all ILC are luminal-type (i.e. ER+) and point to CDH1 loss as a critical "bottleneck" in breast oncogenesis specific to ILC. 4/n
Reposted by George Sflomos
We did a thing w @jostrander.bsky.social!
Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n
Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n
CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells https://www.biorxiv.org/content/10.1101/2025.06.20.660633v1
June 25, 2025 at 5:26 PM
We did a thing w @jostrander.bsky.social!
Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n
Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n
Reposted by George Sflomos
🚨 New podcast episode!
In this insightful and honest conversation, award winners Karin de Visser, Ido Amit and @martakova.bsky.social talk about their research, career journeys, and excitement for the future of cancer research:
magazine.eacr.org/curiosity-op...
In this insightful and honest conversation, award winners Karin de Visser, Ido Amit and @martakova.bsky.social talk about their research, career journeys, and excitement for the future of cancer research:
magazine.eacr.org/curiosity-op...
May 14, 2025 at 7:01 AM
🚨 New podcast episode!
In this insightful and honest conversation, award winners Karin de Visser, Ido Amit and @martakova.bsky.social talk about their research, career journeys, and excitement for the future of cancer research:
magazine.eacr.org/curiosity-op...
In this insightful and honest conversation, award winners Karin de Visser, Ido Amit and @martakova.bsky.social talk about their research, career journeys, and excitement for the future of cancer research:
magazine.eacr.org/curiosity-op...
Reposted by George Sflomos
If you're traveling this weekend (like I will for the EACR Congress in Lisbon) this is a great way to learn something new while waiting on trains and airports. The Cancer Researcher Podcast is available on all major podcast platforms!
Tune into episode 23 of The Cancer Researcher Podcast 🎙️
We chat with Chiara Pozzato & Georgia Konstantinidou (University of Bern) on FAK signalling in KRAS-driven NSCLC and a novel treatment angle.
🎧 Dive in: magazine.eacr.org/novel-approa...
We chat with Chiara Pozzato & Georgia Konstantinidou (University of Bern) on FAK signalling in KRAS-driven NSCLC and a novel treatment angle.
🎧 Dive in: magazine.eacr.org/novel-approa...
June 12, 2025 at 11:44 AM
If you're traveling this weekend (like I will for the EACR Congress in Lisbon) this is a great way to learn something new while waiting on trains and airports. The Cancer Researcher Podcast is available on all major podcast platforms!
Reposted by George Sflomos
As part of the Cancer Researchers to Watch – An Early Career Showcase, the EACR Early Career Researchers Council took a moment to brainstorm with the early-career EACR members in the audience strategies that would better support the next-generation cancer scientists.
#EACR2025
#EACR2025
June 15, 2025 at 5:13 PM
As part of the Cancer Researchers to Watch – An Early Career Showcase, the EACR Early Career Researchers Council took a moment to brainstorm with the early-career EACR members in the audience strategies that would better support the next-generation cancer scientists.
#EACR2025
#EACR2025
Reposted by George Sflomos
New online! The evolutionary foundations of transcriptional regulation in animals
The evolutionary foundations of transcriptional regulation in animals
Nature Reviews Genetics, Published online: 09 July 2025; doi:10.1038/s41576-025-00864-9In this Review, Coyle and King explore how genomic and functional data from diverse species are providing new insights into the types of mechanistic changes that accompanied the evolutionary origin of animals.
www.nature.com
July 9, 2025 at 11:28 AM
New online! The evolutionary foundations of transcriptional regulation in animals
Reposted by George Sflomos
What a wonderful week we’ve had here together in Lisbon for #EACR2025! Thank you to everyone who attended, presented at and helped organise this fantastic event. Sign up here for updates about EACR 2026 in Budapest… 👀 eacr.us5.list-manage.com/subscribe?u=...
June 19, 2025 at 1:08 PM
What a wonderful week we’ve had here together in Lisbon for #EACR2025! Thank you to everyone who attended, presented at and helped organise this fantastic event. Sign up here for updates about EACR 2026 in Budapest… 👀 eacr.us5.list-manage.com/subscribe?u=...
Reposted by George Sflomos
Participants, speakers and exhibitors have been taking the chance to relax and mingle with a drink at the #EACR2025 Welcome Reception here in Lisbon.
June 16, 2025 at 6:20 PM
Participants, speakers and exhibitors have been taking the chance to relax and mingle with a drink at the #EACR2025 Welcome Reception here in Lisbon.
Reposted by George Sflomos
Today is the start of #EACR2025! We’re excited to welcome a record number of participants from 66 countries to our Annual Congress here in Lisbon. Find the programme at 2025.eacr.org and don’t forget to use the hashtag!
June 16, 2025 at 11:39 AM
Today is the start of #EACR2025! We’re excited to welcome a record number of participants from 66 countries to our Annual Congress here in Lisbon. Find the programme at 2025.eacr.org and don’t forget to use the hashtag!
How do tumors escape immune system?
Outstanding presentation Prof. Karin de Visser honored with the Pezcoller–Marina Larcher Fogazzaro–EACR Women in Cancer Research Award 2025.
A truly inspiring opening to #EACR25
Outstanding presentation Prof. Karin de Visser honored with the Pezcoller–Marina Larcher Fogazzaro–EACR Women in Cancer Research Award 2025.
A truly inspiring opening to #EACR25
June 16, 2025 at 5:07 PM
How do tumors escape immune system?
Outstanding presentation Prof. Karin de Visser honored with the Pezcoller–Marina Larcher Fogazzaro–EACR Women in Cancer Research Award 2025.
A truly inspiring opening to #EACR25
Outstanding presentation Prof. Karin de Visser honored with the Pezcoller–Marina Larcher Fogazzaro–EACR Women in Cancer Research Award 2025.
A truly inspiring opening to #EACR25
Reposted by George Sflomos
Acquired resistance in cancer: towards targeted therapeutic strategies
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Acquired resistance in cancer: towards targeted therapeutic strategies - Nature Reviews Cancer
Acquired therapeutic resistance is a key contributor to cancer treatment failure, requiring new approaches to address its complex mechanisms. In this Roadmap, Soragni, Knudsen and colleagues discuss t...
www.nature.com
June 4, 2025 at 3:27 AM
Acquired resistance in cancer: towards targeted therapeutic strategies
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Great overview on the evolving landscape of HER2 testing — from HercepTest to next-gen quantitative tools — and why precise detection of HER2-low matters more than ever in the era of ADCs.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
HER2 testing: evolution and update for a companion diagnostic assay - Nature Reviews Clinical Oncology
The development of companion diagnostic assays enabling the detection and quantification of HER2 expression and ERBB2 amplifications has provided an important early example that has informed the devel...
www.nature.com
June 3, 2025 at 8:04 PM
Great overview on the evolving landscape of HER2 testing — from HercepTest to next-gen quantitative tools — and why precise detection of HER2-low matters more than ever in the era of ADCs.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by George Sflomos
LBCA has developed a new patient resource: Myths and Facts about Invasive Lobular Carcinoma to help clear up common and pervasive myths about invasive lobular carcinoma (ILC). Read it here: lobularbreastcancer.org/myths-vs-fac...
Common Myths vs Facts about Invasive Lobular Carcinoma (ILC) - The Lobular Breast Cancer Alliance
LBCA has developed a new patient resource to help clear up common and pervasive myths about invasive lobular carcinoma (ILC) and its treatment. Many misconceptions […]
lobularbreastcancer.org
May 23, 2025 at 8:54 PM
LBCA has developed a new patient resource: Myths and Facts about Invasive Lobular Carcinoma to help clear up common and pervasive myths about invasive lobular carcinoma (ILC). Read it here: lobularbreastcancer.org/myths-vs-fac...
Reposted by George Sflomos
ERα dysfunction caused by ESR1 mutations and therapeutic pressure promotes lineage plasticity in ER+ breast cancer doi.org/10.1038/s430...
ERα dysfunction caused by ESR1 mutations and therapeutic pressure promotes lineage plasticity in ER+ breast cancer - Nature Cancer
Liang et al. study the impact of ERα antagonist/degraders against different Esr1 mutations in murine models and find that inhibition of mutant ERα induces lineage plasticity, which is also observed in...
doi.org
April 28, 2025 at 8:31 PM
ERα dysfunction caused by ESR1 mutations and therapeutic pressure promotes lineage plasticity in ER+ breast cancer doi.org/10.1038/s430...
Reposted by George Sflomos
Seung Hyun Lee's EACR Travel Fellowship experience shows the value of embracing new environments and challenges in your life as a researcher, allowing you to accelerate your development and contribute meaningfully to the global fight against cancer:
"Step out of your comfort zone and learn new things" - Seung Hyun Lee's EACR Travel Fellowship experience in America - The Cancer Researcher
Seung Hyun Lee is a PhD student at the Cancer Research UK Manchester Institute and University of Manchester, UK who received an EACR Travel Fellowship to visit and work at Stanford University, US…
magazine.eacr.org
May 19, 2025 at 8:02 AM
Seung Hyun Lee's EACR Travel Fellowship experience shows the value of embracing new environments and challenges in your life as a researcher, allowing you to accelerate your development and contribute meaningfully to the global fight against cancer: