Fabian Fröhlich
@frohlichlab.com
Dynamics of Living Systems (https://www.frohlichlab.com) group leader @thecrick.bsky.social Understanding signalling & cell state dynamics through mathematical modelling and machine learning.
Reposted by Fabian Fröhlich
Rewiring of oncogenic signaling in #DrugResistance is a moving target. In our new study, we used biophysical phosphoproteomics to investigate #BRAF mutant cancer, linking phosphorylation changes to protein function and #MolecularMechanisms through #Multi-Omics integration.
tinyurl.com/funsignaling
tinyurl.com/funsignaling
February 11, 2026 at 1:57 PM
Rewiring of oncogenic signaling in #DrugResistance is a moving target. In our new study, we used biophysical phosphoproteomics to investigate #BRAF mutant cancer, linking phosphorylation changes to protein function and #MolecularMechanisms through #Multi-Omics integration.
tinyurl.com/funsignaling
tinyurl.com/funsignaling
Hey journals, if you want reviewers, reconsider the “no AI under any circumstances” policy. I’m happy not to paste unpublished work into the algorithmic equivalent of a public restroom wall, but broad technoskeptic edicts about how I manage my time are unlikely to inspire more volunteering.
February 11, 2026 at 4:16 PM
Hey journals, if you want reviewers, reconsider the “no AI under any circumstances” policy. I’m happy not to paste unpublished work into the algorithmic equivalent of a public restroom wall, but broad technoskeptic edicts about how I manage my time are unlikely to inspire more volunteering.
Not all those who wander are lost.
February 10, 2026 at 10:00 AM
Not all those who wander are lost.
Reposted by Fabian Fröhlich
AlphaGenome is out in @nature.com today along with model weights! 🧬
📄 Paper: www.nature.com/articles/s41...
💻 Weights: github.com/google-deepm...
Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc
📄 Paper: www.nature.com/articles/s41...
💻 Weights: github.com/google-deepm...
Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc
January 28, 2026 at 9:02 PM
AlphaGenome is out in @nature.com today along with model weights! 🧬
📄 Paper: www.nature.com/articles/s41...
💻 Weights: github.com/google-deepm...
Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc
📄 Paper: www.nature.com/articles/s41...
💻 Weights: github.com/google-deepm...
Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc
Reposted by Fabian Fröhlich
“Everything we know about skin has been learned from so-called scientific studies funded by large corporations who have a financial stake in keeping our musculature covered in an unnecessary layer of man-made flesh,” said Health and Human Services Secretary Robert F. Kennedy Jr.
RFK Jr. Questions Efficacy Of Skin
WASHINGTON—In a firm dismissal of decades of scientific research and real-world data on the organ’s benefits and safety, Health and Human Services Secretary Robert F. Kennedy Jr. publicly questioned t...
theonion.com
February 5, 2026 at 1:15 AM
“Everything we know about skin has been learned from so-called scientific studies funded by large corporations who have a financial stake in keeping our musculature covered in an unnecessary layer of man-made flesh,” said Health and Human Services Secretary Robert F. Kennedy Jr.
Reposted by Fabian Fröhlich
New paper alert!🤩Super proud that our story led by superstar postdocs @liujinghui.bsky.social and @nerlielisa.bsky.social is finally out! We found how electrical signals are key for promoting organ regenerative growth!!! A thread 🧵https://www.science.org/doi/10.1126/sciadv.aec0687
Injury-induced electrochemical coupling triggers organ growth
Organ repair and growth rely on coupling tissue-wide membrane depolarization with intracellular proliferative signaling.
www.science.org
February 5, 2026 at 9:33 AM
New paper alert!🤩Super proud that our story led by superstar postdocs @liujinghui.bsky.social and @nerlielisa.bsky.social is finally out! We found how electrical signals are key for promoting organ regenerative growth!!! A thread 🧵https://www.science.org/doi/10.1126/sciadv.aec0687
Reposted by Fabian Fröhlich
Our new paper: Entropy Sorting Feature Selection (ESFS)
A computational framework for gene selection from single cell data that extracts biological signals in noisy data while avoiding artefacts from conventional dimensionality reduction
A thread
www.biorxiv.org/content/10.6...
A computational framework for gene selection from single cell data that extracts biological signals in noisy data while avoiding artefacts from conventional dimensionality reduction
A thread
www.biorxiv.org/content/10.6...
www.biorxiv.org
February 3, 2026 at 6:44 PM
Our new paper: Entropy Sorting Feature Selection (ESFS)
A computational framework for gene selection from single cell data that extracts biological signals in noisy data while avoiding artefacts from conventional dimensionality reduction
A thread
www.biorxiv.org/content/10.6...
A computational framework for gene selection from single cell data that extracts biological signals in noisy data while avoiding artefacts from conventional dimensionality reduction
A thread
www.biorxiv.org/content/10.6...
Reposted by Fabian Fröhlich
Meet Leonie Johanna Lorenz 🇩🇪, a Predoctoral Fellow at EMBL-EBI who is bringing mathematical modelling to microbes.
Find out more about how Leonie’s passion for modelling patterns extends from bacterial evolution to sewing 🧵
www.ebi.ac.uk/about/news/p...
Find out more about how Leonie’s passion for modelling patterns extends from bacterial evolution to sewing 🧵
www.ebi.ac.uk/about/news/p...
February 2, 2026 at 9:58 AM
Meet Leonie Johanna Lorenz 🇩🇪, a Predoctoral Fellow at EMBL-EBI who is bringing mathematical modelling to microbes.
Find out more about how Leonie’s passion for modelling patterns extends from bacterial evolution to sewing 🧵
www.ebi.ac.uk/about/news/p...
Find out more about how Leonie’s passion for modelling patterns extends from bacterial evolution to sewing 🧵
www.ebi.ac.uk/about/news/p...
Reposted by Fabian Fröhlich
We Are hiring!! 👨💻👩💻 CALM's new Data and Systems Steward Role is live 🎉https://crick.wd3.myworkdayjobs.com/External/job/London/Data-and-Systems-Steward_R2551 closing date 8th Feb!
Data and Systems Steward
Salary for this Role: From £43,630 with benefits, subject to skills and experience. Job Title: Data and Systems Steward Reports to: Kurt Anderson Closing Date: 08/Feb/2026 23.59 GMT Job Description: D...
crick.wd3.myworkdayjobs.com
January 19, 2026 at 1:17 PM
We Are hiring!! 👨💻👩💻 CALM's new Data and Systems Steward Role is live 🎉https://crick.wd3.myworkdayjobs.com/External/job/London/Data-and-Systems-Steward_R2551 closing date 8th Feb!
One of the less advertised advantages of using LLMs for writing is that, when OneDrive decides your past few days of work were a mistake, the text still exists somewhere.
January 29, 2026 at 8:28 PM
One of the less advertised advantages of using LLMs for writing is that, when OneDrive decides your past few days of work were a mistake, the text still exists somewhere.
Reposted by Fabian Fröhlich
We are recruiting a Postdoc in computational biology, together with @mariasecrier.bsky.social
4yr, fully funded by @cancerresearchuk.org, ideal for Postdocs wanting to develop their independence
Applications open now: www.imperial.ac.uk/jobs/search-...
4yr, fully funded by @cancerresearchuk.org, ideal for Postdocs wanting to develop their independence
Applications open now: www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
January 21, 2026 at 12:58 PM
We are recruiting a Postdoc in computational biology, together with @mariasecrier.bsky.social
4yr, fully funded by @cancerresearchuk.org, ideal for Postdocs wanting to develop their independence
Applications open now: www.imperial.ac.uk/jobs/search-...
4yr, fully funded by @cancerresearchuk.org, ideal for Postdocs wanting to develop their independence
Applications open now: www.imperial.ac.uk/jobs/search-...
Reposted by Fabian Fröhlich
Apply for the Ascona workshop "Statistical and AI methods for multi-modal multi-scale modeling of biological systems", 28 Jun-3 Jul 2026 on Monte Verità, Lago Maggiore at the foot of the Swiss Alps.
ascona2026.sciencesconf.org
ascona2026.sciencesconf.org
January 15, 2026 at 4:16 PM
Apply for the Ascona workshop "Statistical and AI methods for multi-modal multi-scale modeling of biological systems", 28 Jun-3 Jul 2026 on Monte Verità, Lago Maggiore at the foot of the Swiss Alps.
ascona2026.sciencesconf.org
ascona2026.sciencesconf.org
Reposted by Fabian Fröhlich
🚀 New preprint! Meet ORIGAMI: Mapping cancer cell state heterogeneity and plasticity, predicting and steering therapy-induced trajectories to rationalize genotype-agnostic combination strategies with only two physical metrics (cell surface area and volume)
www.researchsquare.com/article/rs-8...
www.researchsquare.com/article/rs-8...
Simple cell geometry metrics reveal cancer cell diversity and plasticity and guide combination therapy
Intra-tumour heterogeneity (ITH) and cellular plasticity contribute to therapy resistance. Single-cell transcriptomics is the gold standard for assessing ITH, but this approach remains costly and slow...
www.researchsquare.com
January 9, 2026 at 4:40 PM
🚀 New preprint! Meet ORIGAMI: Mapping cancer cell state heterogeneity and plasticity, predicting and steering therapy-induced trajectories to rationalize genotype-agnostic combination strategies with only two physical metrics (cell surface area and volume)
www.researchsquare.com/article/rs-8...
www.researchsquare.com/article/rs-8...
Reposted by Fabian Fröhlich
Looking to start your lab in generative biology / AI?
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Group Leader - Generative Biology and AI
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
tinyurl.com
January 1, 2026 at 12:08 PM
Looking to start your lab in generative biology / AI?
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Reposted by Fabian Fröhlich
Announcing the Ascona Workshop "Statistical and AI methods for multi-modal multi-scale modeling of biological systems" on 28 June - 3 July 2026 in Ascona, CH
www.huber.embl.de/group/events...
Reserve the dates!
www.huber.embl.de/group/events...
Reserve the dates!
December 22, 2025 at 11:10 AM
Announcing the Ascona Workshop "Statistical and AI methods for multi-modal multi-scale modeling of biological systems" on 28 June - 3 July 2026 in Ascona, CH
www.huber.embl.de/group/events...
Reserve the dates!
www.huber.embl.de/group/events...
Reserve the dates!
Reposted by Fabian Fröhlich
Enjoyed reading
“AI for chemistry in 2025 is like AI for images in 2010”
leashbio.substack.com/p/ai-for-che...
“AI for chemistry in 2025 is like AI for images in 2010”
leashbio.substack.com/p/ai-for-che...
December 18, 2025 at 9:39 PM
Enjoyed reading
“AI for chemistry in 2025 is like AI for images in 2010”
leashbio.substack.com/p/ai-for-che...
“AI for chemistry in 2025 is like AI for images in 2010”
leashbio.substack.com/p/ai-for-che...
Reposted by Fabian Fröhlich
We can know more than we can tell, but now Al can capture it. Our multimodal agent analyzes lab videos to generate protocols & catch common lab errors. Preserving tacit knowledge in proteomics. Now in @molsystbiol.org @patiskowronek.bsky.social #Google
link.springer.com/10.1038/s443...
link.springer.com/10.1038/s443...
December 16, 2025 at 9:29 AM
We can know more than we can tell, but now Al can capture it. Our multimodal agent analyzes lab videos to generate protocols & catch common lab errors. Preserving tacit knowledge in proteomics. Now in @molsystbiol.org @patiskowronek.bsky.social #Google
link.springer.com/10.1038/s443...
link.springer.com/10.1038/s443...
Reposted by Fabian Fröhlich
Funny how LLM companies are spending millions to discover what students learn in the first year of business school. At least the employees are having lolz.
Need to start from the original - this is episode 2 where @anthropic.com enlisted @wsj.com to help test www.anthropic.com/research/pro... (link to episode 1 inside). @matt-levine.bsky.social has covered well
Project Vend: Phase two
How Claude turned around its failing vending machine business
www.anthropic.com
December 19, 2025 at 5:54 AM
Funny how LLM companies are spending millions to discover what students learn in the first year of business school. At least the employees are having lolz.
Reposted by Fabian Fröhlich
🎄 We’re hiring in Health AI at @HelmholtzMunich!
🔹 PIs in Health AI/AI Foundations
🔹 Health AI Fellows
🔹 Clinical AI Consultants
Apply👇
PIs: jobs.helmholtz-muenchen.de/jobposting/8...
Fellows: jobs.helmholtz-muenchen.de/jobposting/7...
Consult: jobs.helmholtz-muenchen.de/jobposting/c...
🔹 PIs in Health AI/AI Foundations
🔹 Health AI Fellows
🔹 Clinical AI Consultants
Apply👇
PIs: jobs.helmholtz-muenchen.de/jobposting/8...
Fellows: jobs.helmholtz-muenchen.de/jobposting/7...
Consult: jobs.helmholtz-muenchen.de/jobposting/c...
Principal Investigators (f/m/x) for (i) AI in Biomedicine and (ii) AI Foundations
At Helmholtz Munich, we develop groundbreaking solutions for a healthier society in a rapidly changing world. We believe that diverse perspectives drive innovation. Through strong partnerships, we…
jobs.helmholtz-muenchen.de
December 19, 2025 at 3:49 PM
🎄 We’re hiring in Health AI at @HelmholtzMunich!
🔹 PIs in Health AI/AI Foundations
🔹 Health AI Fellows
🔹 Clinical AI Consultants
Apply👇
PIs: jobs.helmholtz-muenchen.de/jobposting/8...
Fellows: jobs.helmholtz-muenchen.de/jobposting/7...
Consult: jobs.helmholtz-muenchen.de/jobposting/c...
🔹 PIs in Health AI/AI Foundations
🔹 Health AI Fellows
🔹 Clinical AI Consultants
Apply👇
PIs: jobs.helmholtz-muenchen.de/jobposting/8...
Fellows: jobs.helmholtz-muenchen.de/jobposting/7...
Consult: jobs.helmholtz-muenchen.de/jobposting/c...
Reposted by Fabian Fröhlich
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
December 16, 2025 at 12:05 PM
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Reposted by Fabian Fröhlich
🚨Preprint 2/2: Several studies implicate condensates in RTK fusion onco-signaling. So we were surprised to find that condensates are entirely dispensable😮(!). A study from proteins to mice, by dynamic duo @davidgonzmar.bsky.social and @trmumford.bsky.social.
www.biorxiv.org/content/10.6...
👇
www.biorxiv.org/content/10.6...
👇
December 17, 2025 at 3:10 PM
🚨Preprint 2/2: Several studies implicate condensates in RTK fusion onco-signaling. So we were surprised to find that condensates are entirely dispensable😮(!). A study from proteins to mice, by dynamic duo @davidgonzmar.bsky.social and @trmumford.bsky.social.
www.biorxiv.org/content/10.6...
👇
www.biorxiv.org/content/10.6...
👇
Reposted by Fabian Fröhlich
Here's another exciting doctoral project led by Research Group Leader Beatrice Ramm at the Friedrich Miescher Laboratory.
Check the list of other available projects on our website:
lnkd.in/gEMXNQY6
The application portal is open so apply now!
#PhD #IMPRS #graduateprogram #maxplanck
Check the list of other available projects on our website:
lnkd.in/gEMXNQY6
The application portal is open so apply now!
#PhD #IMPRS #graduateprogram #maxplanck
December 9, 2025 at 9:22 AM
Here's another exciting doctoral project led by Research Group Leader Beatrice Ramm at the Friedrich Miescher Laboratory.
Check the list of other available projects on our website:
lnkd.in/gEMXNQY6
The application portal is open so apply now!
#PhD #IMPRS #graduateprogram #maxplanck
Check the list of other available projects on our website:
lnkd.in/gEMXNQY6
The application portal is open so apply now!
#PhD #IMPRS #graduateprogram #maxplanck
Reposted by Fabian Fröhlich
Very excited to announce that MSc computational cancer is now open for applications! A new joint programme from UCL engineering & cancer institute.
Teaching #cancer through a computational lens, integrating cutting edge research with taught components.
Apply below!
www.ucl.ac.uk/prospective-...
Teaching #cancer through a computational lens, integrating cutting edge research with taught components.
Apply below!
www.ucl.ac.uk/prospective-...
Computational Cancer MSc
Be part of the revolution in cancer research and computational science with this interdisciplinary Master’s at UCL. Delivered jointly by UCL Medical Physics and Biomedical Engineering and the UCL Cancer Institute, this programme equips you with cutting-edge skills at the forefront of healthcare innovation.
www.ucl.ac.uk
December 8, 2025 at 12:03 PM
Very excited to announce that MSc computational cancer is now open for applications! A new joint programme from UCL engineering & cancer institute.
Teaching #cancer through a computational lens, integrating cutting edge research with taught components.
Apply below!
www.ucl.ac.uk/prospective-...
Teaching #cancer through a computational lens, integrating cutting edge research with taught components.
Apply below!
www.ucl.ac.uk/prospective-...
Reposted by Fabian Fröhlich
Great to see this published: Fitting dynamical landscape models to single-cell data, creating interpretable maps of cell decision making & developmental logic
Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions
www.pnas.org/doi/10.1073/...
Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions
www.pnas.org/doi/10.1073/...
Reconstructing Waddington’s landscape from data | PNAS
The development of a zygote into a functional organism requires that this single progenitor
cell gives rise to numerous distinct cell types. Attemp...
www.pnas.org
December 4, 2025 at 6:29 AM
Great to see this published: Fitting dynamical landscape models to single-cell data, creating interpretable maps of cell decision making & developmental logic
Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions
www.pnas.org/doi/10.1073/...
Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions
www.pnas.org/doi/10.1073/...
Reposted by Fabian Fröhlich
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
November 27, 2025 at 1:02 PM
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...