Fabian Fröhlich
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frohlichlab.com
Fabian Fröhlich
@frohlichlab.com
1.1K followers 380 following 82 posts
Dynamics of Living Systems (https://www.frohlichlab.com) group leader @thecrick.bsky.social Understanding signalling & cell state dynamics through mathematical modelling and machine learning.

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Reposted by Fabian Fröhlich
wkhuber.bsky.social
Announcing the Ascona Workshop "Statistical and AI methods for multi-modal multi-scale modeling of biological systems" on 28 June - 3 July 2026 in Ascona, CH

www.huber.embl.de/group/events...

Reserve the dates!
View from Monte Verità onto Ascona and Lago Maggiore
December 22, 2025 at 11:10 AM
Reposted by Fabian Fröhlich
lindorfflarsen.bsky.social
Enjoyed reading

“AI for chemistry in 2025 is like AI for images in 2010”

leashbio.substack.com/p/ai-for-che...
December 18, 2025 at 9:39 PM
Reposted by Fabian Fröhlich
mannlab.bsky.social
We can know more than we can tell, but now Al can capture it. Our multimodal agent analyzes lab videos to generate protocols & catch common lab errors. Preserving tacit knowledge in proteomics. Now in @molsystbiol.org @patiskowronek.bsky.social #Google
link.springer.com/10.1038/s443...
December 16, 2025 at 9:29 AM
Reposted by Fabian Fröhlich
cellmorphosero.bsky.social
Funny how LLM companies are spending millions to discover what students learn in the first year of business school. At least the employees are having lolz.
December 19, 2025 at 5:54 AM
Reposted by Fabian Fröhlich
fabiantheis.bsky.social
🎄 We’re hiring in Health AI at @HelmholtzMunich!

🔹 PIs in Health AI/AI Foundations
🔹 Health AI Fellows
🔹 Clinical AI Consultants

Apply👇
PIs: jobs.helmholtz-muenchen.de/jobposting/8...
Fellows: jobs.helmholtz-muenchen.de/jobposting/7...
Consult: jobs.helmholtz-muenchen.de/jobposting/c...
Principal Investigators (f/m/x) for (i) AI in Biomedicine and (ii) AI Foundations
At Helmholtz Munich, we develop groundbreaking solutions for a healthier society in a rapidly changing world. We believe that diverse perspectives drive innovation. Through strong partnerships, we…
jobs.helmholtz-muenchen.de
December 19, 2025 at 3:49 PM
Reposted by Fabian Fröhlich
bugajlab.bsky.social
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.

Led by superb PhD student Carol Gao.

www.biorxiv.org/content/10.1...

Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
December 16, 2025 at 12:05 PM
Reposted by Fabian Fröhlich
bugajlab.bsky.social
🚨Preprint 2/2: Several studies implicate condensates in RTK fusion onco-signaling. So we were surprised to find that condensates are entirely dispensable😮(!). A study from proteins to mice, by dynamic duo @davidgonzmar.bsky.social and @trmumford.bsky.social.

www.biorxiv.org/content/10.6...

👇
December 17, 2025 at 3:10 PM
Reposted by Fabian Fröhlich
mpi-bio-fml.bsky.social
Here's another exciting doctoral project led by Research Group Leader Beatrice Ramm at the Friedrich Miescher Laboratory.

Check the list of other available projects on our website:
lnkd.in/gEMXNQY6
The application portal is open so apply now!

#PhD #IMPRS #graduateprogram #maxplanck
December 9, 2025 at 9:22 AM
Reposted by Fabian Fröhlich
hallben.bsky.social
Very excited to announce that MSc computational cancer is now open for applications! A new joint programme from UCL engineering & cancer institute.

Teaching #cancer through a computational lens, integrating cutting edge research with taught components.

Apply below!

www.ucl.ac.uk/prospective-...
Computational Cancer MSc
Be part of the revolution in cancer research and computational science with this interdisciplinary Master’s at UCL. Delivered jointly by UCL Medical Physics and Biomedical Engineering and the UCL Cancer Institute, this programme equips you with cutting-edge skills at the forefront of healthcare innovation.
www.ucl.ac.uk
December 8, 2025 at 12:03 PM
Reposted by Fabian Fröhlich
jamesbriscoe.bsky.social
Great to see this published: Fitting dynamical landscape models to single-cell data, creating interpretable maps of cell decision making & developmental logic

Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions

www.pnas.org/doi/10.1073/...
Reconstructing Waddington’s landscape from data | PNAS
The development of a zygote into a functional organism requires that this single progenitor cell gives rise to numerous distinct cell types. Attemp...
www.pnas.org
December 4, 2025 at 6:29 AM
Reposted by Fabian Fröhlich
embl.org
Anthony A. Hyman will become EMBL’s next Director General.

He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.

www.embl.org/news/people-...
November 27, 2025 at 1:02 PM
Reposted by Fabian Fröhlich
irbbarcelona.org
🧬 Kinase Inhibitors can do more than block their targets!
A study by @cemm.oeaw.ac.at-@aithyra.bsky.social and #IRBBarcelona reveals that many inhibitors also trigger the degradation of the kinases, uncovering an overlooked mechanism with therapeutic potential.

Out in @nature.com
➡️ bit.ly/43SD9xj
November 26, 2025 at 4:05 PM
Reposted by Fabian Fröhlich
alexisbarr.bsky.social
Great post. “mentoring should be criteria for hiring tenure-track faculty! But alas, it rarely is.”

Also how to measure? Everyone can write about how to be a good mentor on an application form but how can you assess if they actually are?
hormiga.bsky.social Terry McGlynn @hormiga.bsky.social · Nov 25
You know those labs that keep harming students, again and again? Some reflections on why it's so hard to stop this from happening and where our responsibilities lie.

scienceforeveryone.science/bad-mentors-... 🧪
Bad mentors hurt people
What to do about bad mentors?
scienceforeveryone.science
November 26, 2025 at 6:37 AM
Reposted by Fabian Fröhlich
richardsever.bsky.social
[so AI may be bad but probably no worse than your average pundit and definitely not as bad as WSJ 😆] 3/n
November 22, 2025 at 5:59 PM
Reposted by Fabian Fröhlich
pedrobeltrao.bsky.social
I tried the updated Gemini image generator on scientific related image prompts that have failed in the past and I am really impressed by the quality of the outputs. The first is drawing a diagram for a pocket prediction algorithm using Voronoi diagram, Delaunay triangulation and alpha shapes
November 21, 2025 at 1:14 PM
Reposted by Fabian Fröhlich
kordinglab.bsky.social
I think almost all scientific projects should be planned carefully. And I think an app can dramatically improve that. So I wrote an app for that (free for now, if you can fund this let me know). I tested it quite a bit (>8000 users in beta so far). try it: planyourscience.com
November 20, 2025 at 3:33 PM
Reposted by Fabian Fröhlich
wkhuber.bsky.social
This is wild - an open challenge on 'virtual cell' perturbation prediction falls on its face due to flawed metrics:
gmdbioinformatics.substack.com/p/arc-virtua...

Benchmarking is important. It's also difficult. It's not just an engineering challenge. Figuring out what "good performance"...
⬇️
November 19, 2025 at 2:42 PM
Reposted by Fabian Fröhlich
biorxivpreprint.bsky.social
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
November 18, 2025 at 11:03 PM
Reposted by Fabian Fröhlich
jamesbriscoe.bsky.social
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader

Closing date 27th November

www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Reposted by Fabian Fröhlich
johnspringford.bsky.social
New essay out today by me and @acjsissons.bsky.social - ‘Getting Britain out of the hole: a plan for the economy’. You can read the whole thing here getting-out-of-the-hole.uk

A chart mega-thread follows 🧵
Getting Britain out of the hole
A plan for the UK economy
getting-out-of-the-hole.uk
November 17, 2025 at 8:00 AM
frohlichlab.com
To the consumers of LLM tools and of their outputs: Is it really that hard to see that ideation/conception and implementation are distinct skills in writing (of text and code), and that while LLMs are strong at implementation, they continue to fall short on ideation?
November 15, 2025 at 5:17 PM
Reposted by Fabian Fröhlich
andreas-t-schaefer.bsky.social
Enthusiastic about connectomics and X-rays?
Several positions in our group at Crick for postdocs and senior scientists (permanent!).
DM me if interested – and let’s talk if you are at Sfn next days or at the NIH BRAIN CONNECTS meeting today!

Please share!
November 14, 2025 at 3:22 PM
Reposted by Fabian Fröhlich
vonderleyen.ec.europa.eu
Switzerland is joining Horizon Europe!

We are uniting two research powerhouses.

For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.

Today is a good day for science, and for our EU-Switzerland partnership.
November 10, 2025 at 2:58 PM
Reposted by Fabian Fröhlich
zachweinersmith.bsky.social
Haha, this from the New Yorker is getting passed around the math dork community. I did a comic about this kind of thought a few years ago: www.smbc-comics.com/comic/commut...
November 7, 2025 at 5:26 PM
Reposted by Fabian Fröhlich
richardsever.bsky.social
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n

openrxiv.org/enabling-rev...
Enabling options for review: from training and transparency to author-centered AI tools - openRxiv
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...
openrxiv.org
November 6, 2025 at 2:32 PM