Fabian Fröhlich
@frohlichlab.com
Dynamics of Living Systems (https://www.frohlichlab.com) group leader @thecrick.bsky.social Understanding signalling & cell state dynamics through mathematical modelling and machine learning.
Reposted by Fabian Fröhlich
Switzerland is joining Horizon Europe!
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
November 10, 2025 at 2:58 PM
Switzerland is joining Horizon Europe!
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
Reposted by Fabian Fröhlich
Haha, this from the New Yorker is getting passed around the math dork community. I did a comic about this kind of thought a few years ago: www.smbc-comics.com/comic/commut...
November 7, 2025 at 5:26 PM
Haha, this from the New Yorker is getting passed around the math dork community. I did a comic about this kind of thought a few years ago: www.smbc-comics.com/comic/commut...
Reposted by Fabian Fröhlich
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Enabling options for review: from training and transparency to author-centered AI tools - openRxiv
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...
openrxiv.org
November 6, 2025 at 2:32 PM
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Reposted by Fabian Fröhlich
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
October 27, 2025 at 2:07 PM
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Reposted by Fabian Fröhlich
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
October 27, 2025 at 8:50 AM
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Fabian Fröhlich
Skeetorial on our BRAF preprint!
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
Mechanism of MEK1 phosphorylation by the N-terminal acidic motif-mediated asymmetric BRAF dimer
The RAF/MEK/ERK signaling cascade regulates cell proliferation and differentiation and is frequently dysregulated in cancer. Approximately 90% of RAF-mutant cancers harbour mutations in B-type of Rapi...
tinyurl.com
October 14, 2025 at 8:17 AM
Skeetorial on our BRAF preprint!
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
Reposted by Fabian Fröhlich
We just posted an impact story on policies at HHMI, Gates & Astera promoting #OpenAccess #OpenScience #OpenData. Powerful signals to other funders to accelerate discovery in science. Well done @madubs.bsky.social @openaccessmaven.bsky.social @pracheeac.bsky.social! sparcopen.org/impact-story...
Funders Roll Out Next Gen Open Policies - SPARC
sparcopen.org
October 10, 2025 at 3:43 PM
We just posted an impact story on policies at HHMI, Gates & Astera promoting #OpenAccess #OpenScience #OpenData. Powerful signals to other funders to accelerate discovery in science. Well done @madubs.bsky.social @openaccessmaven.bsky.social @pracheeac.bsky.social! sparcopen.org/impact-story...
Reposted by Fabian Fröhlich
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:06 PM
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Opening my lab @crick.ac.uk two years ago has been a privilege, a delight and ultimately the most transformative experience of my sciencific career. Discovery science without boundaries, inspiring colleagues and infinite possibilities. Come join us!
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:56 PM
Opening my lab @crick.ac.uk two years ago has been a privilege, a delight and ultimately the most transformative experience of my sciencific career. Discovery science without boundaries, inspiring colleagues and infinite possibilities. Come join us!
Reposted by Fabian Fröhlich
Motivated graduates with backgrounds in biological or biomedical sciences, physics, chemistry, mathematics, engineering and/or computer science are invited to apply to our 4-year fully funded PhD programme.
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
PhD students
Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.
www.crick.ac.uk
October 2, 2025 at 12:53 PM
Motivated graduates with backgrounds in biological or biomedical sciences, physics, chemistry, mathematics, engineering and/or computer science are invited to apply to our 4-year fully funded PhD programme.
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
Reposted by Fabian Fröhlich
Omg nature is so weird and amazing
Many sea stars begin life as young fairy-like creature (called a brachiolaria) that float through the open ocean. Eventually, a small star forms within them (here in yellow). The fairy-like brachiolaria sinks under the star’s weight, and the star pops out!
🎥@the_story_of_a_biologist (on Insta)
🎥@the_story_of_a_biologist (on Insta)
October 9, 2025 at 8:30 AM
Omg nature is so weird and amazing
Reposted by Fabian Fröhlich
🚀 New talk!
"Automated ML-guided lead optimization: surpassing human-level performance at protein engineering"
▶️ www.youtube.com/watch?v=mEhB...
✨🧪 This was a talk I gave at the recent AIxBIO conference in Cambridge UK. A 10-minute pitch for what we do at Cradle!
"Automated ML-guided lead optimization: surpassing human-level performance at protein engineering"
▶️ www.youtube.com/watch?v=mEhB...
✨🧪 This was a talk I gave at the recent AIxBIO conference in Cambridge UK. A 10-minute pitch for what we do at Cradle!
Automated ML-guided lead optimization: surpassing human-level performance at protein engineering
YouTube video by Patrick Kidger
www.youtube.com
October 7, 2025 at 1:26 PM
🚀 New talk!
"Automated ML-guided lead optimization: surpassing human-level performance at protein engineering"
▶️ www.youtube.com/watch?v=mEhB...
✨🧪 This was a talk I gave at the recent AIxBIO conference in Cambridge UK. A 10-minute pitch for what we do at Cradle!
"Automated ML-guided lead optimization: surpassing human-level performance at protein engineering"
▶️ www.youtube.com/watch?v=mEhB...
✨🧪 This was a talk I gave at the recent AIxBIO conference in Cambridge UK. A 10-minute pitch for what we do at Cradle!
🌊 Signals intertwine,
🔬 cells tell hidden stories,
🤖✨ SciML maps their future.
Come do a PhD with us www.crick.ac.uk/careers-stud...
🔬 cells tell hidden stories,
🤖✨ SciML maps their future.
Come do a PhD with us www.crick.ac.uk/careers-stud...
Fröhlich Lab | Scientific Machine Learning for Signal Transduction
www.crick.ac.uk
October 7, 2025 at 1:44 PM
🌊 Signals intertwine,
🔬 cells tell hidden stories,
🤖✨ SciML maps their future.
Come do a PhD with us www.crick.ac.uk/careers-stud...
🔬 cells tell hidden stories,
🤖✨ SciML maps their future.
Come do a PhD with us www.crick.ac.uk/careers-stud...
Reposted by Fabian Fröhlich
Applications are now open for the @cruk-cityoflondon.bsky.social Black Leaders in Cancer PhD Programme.
If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch!
www.colcc.ac.uk/2026-blic-ph...
If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch!
www.colcc.ac.uk/2026-blic-ph...
October 2, 2025 at 3:01 PM
Applications are now open for the @cruk-cityoflondon.bsky.social Black Leaders in Cancer PhD Programme.
If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch!
www.colcc.ac.uk/2026-blic-ph...
If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch!
www.colcc.ac.uk/2026-blic-ph...
Reposted by Fabian Fröhlich
First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)
Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer https://www.biorxiv.org/content/10.1101/2025.09.26.678760v1
September 28, 2025 at 10:33 AM
First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)
Reposted by Fabian Fröhlich
🚨New Preprint🚨
How do morphogens integrate dynamically with other modes of signalling+what can this do for pattern precision and robustness?
We used the Drosophila visual system as our muse to dive into this question with the amazing Vil Fernandes @ucl.ac.uk 🧠🪰 👇
www.biorxiv.org/content/10.1...
How do morphogens integrate dynamically with other modes of signalling+what can this do for pattern precision and robustness?
We used the Drosophila visual system as our muse to dive into this question with the amazing Vil Fernandes @ucl.ac.uk 🧠🪰 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org
September 22, 2025 at 10:35 AM
🚨New Preprint🚨
How do morphogens integrate dynamically with other modes of signalling+what can this do for pattern precision and robustness?
We used the Drosophila visual system as our muse to dive into this question with the amazing Vil Fernandes @ucl.ac.uk 🧠🪰 👇
www.biorxiv.org/content/10.1...
How do morphogens integrate dynamically with other modes of signalling+what can this do for pattern precision and robustness?
We used the Drosophila visual system as our muse to dive into this question with the amazing Vil Fernandes @ucl.ac.uk 🧠🪰 👇
www.biorxiv.org/content/10.1...
Reposted by Fabian Fröhlich
Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking - Nature Structural & Molecular Biology
By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding in...
www.nature.com
September 19, 2025 at 1:52 PM
Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Fabian Fröhlich
The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
September 20, 2025 at 7:43 AM
The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Reposted by Fabian Fröhlich
Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...
Gene Network Organization, Mutation, and Selection Collectively Drive Developmental Pattern Evolvability and Predictability
The historical order in which mutations appear during evolution determine the evolutionary trajectory of gene regulatory networks and influence how developmental patterns change and diversify over tim...
journals.aps.org
September 16, 2025 at 7:46 PM
Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...
Reposted by Fabian Fröhlich
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
September 18, 2025 at 8:02 PM
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Reposted by Fabian Fröhlich
🥁 Check out our new preprint on OmniPath, the prior knowledge resource for #SystemsBiology, and its brand-new OmniPath Explorer web app! 🥳
📖 Preprint: www.biorxiv.org/content/10.1...
🔍 Explorer: explore.omnipathdb.org
OmniPath integrates 160+ resources for multi-omics analysis & modeling.
🧶⬇️
📖 Preprint: www.biorxiv.org/content/10.1...
🔍 Explorer: explore.omnipathdb.org
OmniPath integrates 160+ resources for multi-omics analysis & modeling.
🧶⬇️
September 17, 2025 at 1:10 PM
🥁 Check out our new preprint on OmniPath, the prior knowledge resource for #SystemsBiology, and its brand-new OmniPath Explorer web app! 🥳
📖 Preprint: www.biorxiv.org/content/10.1...
🔍 Explorer: explore.omnipathdb.org
OmniPath integrates 160+ resources for multi-omics analysis & modeling.
🧶⬇️
📖 Preprint: www.biorxiv.org/content/10.1...
🔍 Explorer: explore.omnipathdb.org
OmniPath integrates 160+ resources for multi-omics analysis & modeling.
🧶⬇️
Reposted by Fabian Fröhlich
💥 We are *also* organizing Machine Learning for Structural Biology @ EurIPS, Copenhagen!!
Topics include anything in the ML+bio intersection.
Submit your ML+bio short papers! Authors can even present in both locations if they have people in both locations 🚀
Topics include anything in the ML+bio intersection.
Submit your ML+bio short papers! Authors can even present in both locations if they have people in both locations 🚀
You asked and we listened... @workshopmlsb.bsky.social is excited to be expanding to Copenhagen, DK at @euripsconf.bsky.social 🎉
Two workshops (San Diego & Copenhagen) will run concurrently to support broader attendance. You can indicate your location preference(s) in the submission portal💫
Two workshops (San Diego & Copenhagen) will run concurrently to support broader attendance. You can indicate your location preference(s) in the submission portal💫
September 12, 2025 at 1:44 PM
💥 We are *also* organizing Machine Learning for Structural Biology @ EurIPS, Copenhagen!!
Topics include anything in the ML+bio intersection.
Submit your ML+bio short papers! Authors can even present in both locations if they have people in both locations 🚀
Topics include anything in the ML+bio intersection.
Submit your ML+bio short papers! Authors can even present in both locations if they have people in both locations 🚀
Reposted by Fabian Fröhlich
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
www.nature.com
September 10, 2025 at 3:21 PM
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Reposted by Fabian Fröhlich
The advert for the first of these positions (computational/mathematical synbio) is live!
www.ucl.ac.uk/work-at-ucl/...
www.ucl.ac.uk/work-at-ucl/...
September 11, 2025 at 5:04 PM
The advert for the first of these positions (computational/mathematical synbio) is live!
www.ucl.ac.uk/work-at-ucl/...
www.ucl.ac.uk/work-at-ucl/...
Reposted by Fabian Fröhlich
Edith Heard our new CEO shares ten lessons from her life in science, from curiosity, courage and coffee to the secrets of our genetic code.
www.crick.ac.uk/news/2025-09...
www.crick.ac.uk/news/2025-09...
Edith Heard life lessons
Edith Heard, the Crick’s new Director and CEO, shares ten lessons from a life in science, spanning curiosity, courage, coffee, and the secrets of our genetic code.
www.crick.ac.uk
September 10, 2025 at 1:32 PM
Edith Heard our new CEO shares ten lessons from her life in science, from curiosity, courage and coffee to the secrets of our genetic code.
www.crick.ac.uk/news/2025-09...
www.crick.ac.uk/news/2025-09...