Fran Rodriguez-Algarra
@franrodalg.bsky.social
🖥️🧬 CompBio Postdoc @rakyanlab.bsky.social
📍🏫 Blizard Institute, QMUL
🃏🚧 Jack of all trades, master of none
🐉✍️ fantasist in training
https://orcid.org/0000-0002-4134-2141
📍🏫 Blizard Institute, QMUL
🃏🚧 Jack of all trades, master of none
🐉✍️ fantasist in training
https://orcid.org/0000-0002-4134-2141
Pinned
Ribosomal DNA copy number variation associates with hematological profiles and renal function in the UK Biobank
Rodriguez-Algarra et al. present an analysis of rDNA copy number (CN) variation in
the UK Biobank (UKB), revealing associations with altered counts of specific blood
cell subtypes, such as neutrophils...
www.cell.com
New paper alert! The RNA ribosomal components are so essential that they appear as tons of back to back copies in the genome, which makes them really hard to analyse, so have been mostly ignored. But does it matter how many copies one has? A thread (1/9)
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Reposted by Fran Rodriguez-Algarra
Recruiting a comp PDRA for the lab 🚨
Working on multiple projects using integrated multi omics in bulk & single cell level
Passion for data, coding, bioinformatics & keen to lead our labs comp workflow
12 months in first instance but extendable for further 19 months
my.corehr.com/pls/coreport...
Working on multiple projects using integrated multi omics in bulk & single cell level
Passion for data, coding, bioinformatics & keen to lead our labs comp workflow
12 months in first instance but extendable for further 19 months
my.corehr.com/pls/coreport...
my.corehr.com
November 10, 2025 at 5:23 PM
Recruiting a comp PDRA for the lab 🚨
Working on multiple projects using integrated multi omics in bulk & single cell level
Passion for data, coding, bioinformatics & keen to lead our labs comp workflow
12 months in first instance but extendable for further 19 months
my.corehr.com/pls/coreport...
Working on multiple projects using integrated multi omics in bulk & single cell level
Passion for data, coding, bioinformatics & keen to lead our labs comp workflow
12 months in first instance but extendable for further 19 months
my.corehr.com/pls/coreport...
Reposted by Fran Rodriguez-Algarra
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Specificity, length and luck drive gene rankings in association studies - Nature
Genetic association tests prioritize candidate genes based on different criteria.
www.nature.com
November 7, 2025 at 12:05 AM
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Reposted by Fran Rodriguez-Algarra
@andreaserio.bsky.social and I are recruiting a postdoc to lead an exciting MNDA-funded project using multi-omics to study long axons in motor neurons and how they shape susceptibility to #ALS.
Get in touch for any questions and apply by 2 December:
my.corehr.com/pls/kclrecru...
Get in touch for any questions and apply by 2 December:
my.corehr.com/pls/kclrecru...
November 4, 2025 at 5:33 PM
@andreaserio.bsky.social and I are recruiting a postdoc to lead an exciting MNDA-funded project using multi-omics to study long axons in motor neurons and how they shape susceptibility to #ALS.
Get in touch for any questions and apply by 2 December:
my.corehr.com/pls/kclrecru...
Get in touch for any questions and apply by 2 December:
my.corehr.com/pls/kclrecru...
Reposted by Fran Rodriguez-Algarra
New study of 800K+ genomes from gnomAD reveals most “pathogenic” variants in healthy people aren’t truly disease-tolerant. They are explained by annotation errors, mosaicism, or compensatory variants. 🧬
A big step for precision medicine!
www.nature.com/articles/s41...
A big step for precision medicine!
www.nature.com/articles/s41...
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database - Nature Communications
Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD),…
www.nature.com
November 4, 2025 at 3:06 PM
New study of 800K+ genomes from gnomAD reveals most “pathogenic” variants in healthy people aren’t truly disease-tolerant. They are explained by annotation errors, mosaicism, or compensatory variants. 🧬
A big step for precision medicine!
www.nature.com/articles/s41...
A big step for precision medicine!
www.nature.com/articles/s41...
Reposted by Fran Rodriguez-Algarra
We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle
Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
October 29, 2025 at 7:59 AM
We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle
Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
Reposted by Fran Rodriguez-Algarra
Together with Chris Bell and Alexander Dawson, we are recruiting an PhD student (LIDo iCASE) at @qmulepigenetics.bsky.social to work on using long read nanopore technology to investigate DNA methylation on native DNA. This is a joint project with ONT. www.findaphd.com/phds/project...
October 29, 2025 at 10:09 AM
Together with Chris Bell and Alexander Dawson, we are recruiting an PhD student (LIDo iCASE) at @qmulepigenetics.bsky.social to work on using long read nanopore technology to investigate DNA methylation on native DNA. This is a joint project with ONT. www.findaphd.com/phds/project...
Reposted by Fran Rodriguez-Algarra
🚨Second position available in the lab.
Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell.
Please spread the word!
kcl-mrcdtp.com/project/the-...
Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell.
Please spread the word!
kcl-mrcdtp.com/project/the-...
The brain-muscle epigenetic interplay in neuromuscular disease - MRC DTP
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease marked by progressive motor neuron loss. Emerging evidence suggests a critical, previously underappreciated role for skeletal muscle in ALS onset and progression, highlighting pathological and molecular interplay between brain and muscle. However, systematic, high-resolution molecular analyses across these tissues remain scarce. This project will use advanced […]
kcl-mrcdtp.com
September 25, 2025 at 7:27 PM
🚨Second position available in the lab.
Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell.
Please spread the word!
kcl-mrcdtp.com/project/the-...
Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell.
Please spread the word!
kcl-mrcdtp.com/project/the-...
Reposted by Fran Rodriguez-Algarra
🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London
www.kcl.ac.uk
September 25, 2025 at 5:01 PM
🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Reposted by Fran Rodriguez-Algarra
📣 New preprint 📣
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis
Transcription of ribosomal RNAs (rRNAs) from rDNA repeats is the first step of ribosome biogenesis, accounting for a major portion of all cellular transcription. Often regarded as a housekeeping proce...
www.biorxiv.org
August 2, 2025 at 5:50 PM
📣 New preprint 📣
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
Reposted by Fran Rodriguez-Algarra
NIH is allowing us to recruit postbacs and postdocs again. Please reach out if you are interested in working with us! Ad: genomeinformatics.github.io/jobs2025/
We are looking for postbacs and postdocs!
Join our team and contribute to the development of complete, personalized “telomere-to-telomere” (T2T) genome assemblies and the analysis of previously inaccessible regions of the genome! We are curre...
genomeinformatics.github.io
May 12, 2025 at 8:50 PM
NIH is allowing us to recruit postbacs and postdocs again. Please reach out if you are interested in working with us! Ad: genomeinformatics.github.io/jobs2025/
Reposted by Fran Rodriguez-Algarra
Our next guest speaker webinar is happening next Friday, May 9th at 14:00 GMT. Omer Bayraktar will give a talk on: "Mapping the rules of glioblastoma using single cell and spatial multiomics". To join please follow the link below: www.qmul.ac.uk/epigenetics/...
May 2, 2025 at 9:38 AM
Our next guest speaker webinar is happening next Friday, May 9th at 14:00 GMT. Omer Bayraktar will give a talk on: "Mapping the rules of glioblastoma using single cell and spatial multiomics". To join please follow the link below: www.qmul.ac.uk/epigenetics/...
Reposted by Fran Rodriguez-Algarra
🧵1/
🚨Check out our significantly updated preprint, now out on @biorxivpreprint.bsky.social. Together with Sasi Conte lab, we characterize a novel role for intrinsically disordered regions (IDRs) in promoting RNA-binding selectivity in RNA binding proteins (RBPs): www.biorxiv.org/content/10.1...
🚨Check out our significantly updated preprint, now out on @biorxivpreprint.bsky.social. Together with Sasi Conte lab, we characterize a novel role for intrinsically disordered regions (IDRs) in promoting RNA-binding selectivity in RNA binding proteins (RBPs): www.biorxiv.org/content/10.1...
An intrinsically disordered region mediates RNA-binding selectivity and pro-oncogenic activities of LARP6
Intrinsically disordered regions (IDRs) are prevalent in RNA-binding proteins (RBPs), yet their roles in RNA interactions remain poorly defined. Here, we examined the structured and disordered RNA-bin...
www.biorxiv.org
April 15, 2025 at 11:36 PM
🧵1/
🚨Check out our significantly updated preprint, now out on @biorxivpreprint.bsky.social. Together with Sasi Conte lab, we characterize a novel role for intrinsically disordered regions (IDRs) in promoting RNA-binding selectivity in RNA binding proteins (RBPs): www.biorxiv.org/content/10.1...
🚨Check out our significantly updated preprint, now out on @biorxivpreprint.bsky.social. Together with Sasi Conte lab, we characterize a novel role for intrinsically disordered regions (IDRs) in promoting RNA-binding selectivity in RNA binding proteins (RBPs): www.biorxiv.org/content/10.1...
Reposted by Fran Rodriguez-Algarra
I am recruiting for a postdoc in my lab at @blizardinstitute.bsky.social @qmulepigenetics.bsky.social to work on explainable AI/ML and epigenetics with a focus on enhancers. 3-year BBSRC funded position. A collaboration with @a-radzisheuskaya.bsky.social
qmul-jobs.tal.net/vx/mobile-0/.... Pls share.
qmul-jobs.tal.net/vx/mobile-0/.... Pls share.
Quick Check Needed
qmul-jobs.tal.net
April 4, 2025 at 4:04 PM
I am recruiting for a postdoc in my lab at @blizardinstitute.bsky.social @qmulepigenetics.bsky.social to work on explainable AI/ML and epigenetics with a focus on enhancers. 3-year BBSRC funded position. A collaboration with @a-radzisheuskaya.bsky.social
qmul-jobs.tal.net/vx/mobile-0/.... Pls share.
qmul-jobs.tal.net/vx/mobile-0/.... Pls share.
Reposted by Fran Rodriguez-Algarra
Just wanted to remind folks of the upcoming abstract submission deadline for the 2025 Human Genetics and Genomics GRS on March 30! 🧬
Come join us in beautiful Portland, Maine from July 5-6!
Check out this link for more details: www.grc.org/human-geneti...
Come join us in beautiful Portland, Maine from July 5-6!
Check out this link for more details: www.grc.org/human-geneti...
2025 Human Genetics and Genomics Conference GRC
The 2025 Gordon Research Conference on Human Genetics and Genomics will be held in Portland, Maine. Apply today to reserve your spot.
www.grc.org
March 18, 2025 at 12:31 PM
Just wanted to remind folks of the upcoming abstract submission deadline for the 2025 Human Genetics and Genomics GRS on March 30! 🧬
Come join us in beautiful Portland, Maine from July 5-6!
Check out this link for more details: www.grc.org/human-geneti...
Come join us in beautiful Portland, Maine from July 5-6!
Check out this link for more details: www.grc.org/human-geneti...
Reposted by Fran Rodriguez-Algarra
We're excited to announce the official QMUL Centre for Epigenetics Launch Conference 2025! 🎉 To find out more and book your free ticket, please follow the link below:
www.eventbrite.co.uk/e/qmul-centr...
@qmul.ac.uk
@bartscharity.bsky.social
@qmulepigenetics.bsky.social
www.eventbrite.co.uk/e/qmul-centr...
@qmul.ac.uk
@bartscharity.bsky.social
@qmulepigenetics.bsky.social
QMUL Centre for Epigenetics Launch Conference 2025
Join us in celebrating becoming an official Centre for Epigenetics at QMUL!
www.eventbrite.co.uk
February 13, 2025 at 11:07 AM
We're excited to announce the official QMUL Centre for Epigenetics Launch Conference 2025! 🎉 To find out more and book your free ticket, please follow the link below:
www.eventbrite.co.uk/e/qmul-centr...
@qmul.ac.uk
@bartscharity.bsky.social
@qmulepigenetics.bsky.social
www.eventbrite.co.uk/e/qmul-centr...
@qmul.ac.uk
@bartscharity.bsky.social
@qmulepigenetics.bsky.social
Reposted by Fran Rodriguez-Algarra
Members of the U.K. and international scientific community are invited to sign to show their support: docs.google.com/forms/d/e/1F...
Open letter to the President of the Royal Society – time to stand up for your values
If you wish to show your support for the letter below regarding apparent inaction by the Royal Society in the face of breaches of its code of conduct by Elon Musk FRS, please sign below. I invite anyo...
docs.google.com
February 11, 2025 at 5:17 PM
Members of the U.K. and international scientific community are invited to sign to show their support: docs.google.com/forms/d/e/1F...
Reposted by Fran Rodriguez-Algarra
Had the pleasure of hearing about this cool story from @rakyanlab.bsky.social and @franrodalg.bsky.social last summer, congrats to all involved.
Thrilled to share the lab's latest preprint on the phenotypic impact of SNVs and INDELs in human rDNA using UK Biobank data!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Germline sequence variation within the ribosomal DNA is associated with human complex traits
The ribosome is one of the core macromolecules in the cell. The ribosomal RNAs (rRNA), which are essential components of the ribosome, are coded by the multi-copy ribosomal DNA (rDNA). Despite its hig...
www.biorxiv.org
February 10, 2025 at 4:18 PM
Had the pleasure of hearing about this cool story from @rakyanlab.bsky.social and @franrodalg.bsky.social last summer, congrats to all involved.
Reposted by Fran Rodriguez-Algarra
Thrilled to share the lab's latest preprint on the phenotypic impact of SNVs and INDELs in human rDNA using UK Biobank data!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Germline sequence variation within the ribosomal DNA is associated with human complex traits
The ribosome is one of the core macromolecules in the cell. The ribosomal RNAs (rRNA), which are essential components of the ribosome, are coded by the multi-copy ribosomal DNA (rDNA). Despite its hig...
www.biorxiv.org
February 8, 2025 at 1:15 PM
Thrilled to share the lab's latest preprint on the phenotypic impact of SNVs and INDELs in human rDNA using UK Biobank data!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Fran Rodriguez-Algarra
🚨Thanks to generous support from @cancerresearchuk.org, we have multiple postdoctoral positions available in our lab (www.mardakhehlab.info) @oxfordbiochemistry.bsky.social to study ribosomes synthesis in cancer. Get in touch if you’re interested + RT and spread the word! 📣 #cancer #RNA 🚨
February 5, 2025 at 12:02 AM
🚨Thanks to generous support from @cancerresearchuk.org, we have multiple postdoctoral positions available in our lab (www.mardakhehlab.info) @oxfordbiochemistry.bsky.social to study ribosomes synthesis in cancer. Get in touch if you’re interested + RT and spread the word! 📣 #cancer #RNA 🚨
Reposted by Fran Rodriguez-Algarra
QMUL Epigenetics Centre (www.qmul.ac.uk/epigenetics/) is looking to recruit a senior lecturer with expertise in Genomics/Epigenomics and/or cell-free DNA. This is an excellent opportunity to join a strong Epigenetics and genomics community. Pl share/apply here
qmul-jobs.tal.net/vx/mobile-0/...
qmul-jobs.tal.net/vx/mobile-0/...
January 24, 2025 at 9:13 AM
QMUL Epigenetics Centre (www.qmul.ac.uk/epigenetics/) is looking to recruit a senior lecturer with expertise in Genomics/Epigenomics and/or cell-free DNA. This is an excellent opportunity to join a strong Epigenetics and genomics community. Pl share/apply here
qmul-jobs.tal.net/vx/mobile-0/...
qmul-jobs.tal.net/vx/mobile-0/...
Reposted by Fran Rodriguez-Algarra
@blizardinstitute.bsky.social, @qmulepigenetics.bsky.social
is looking to recruit a senior lecturer with strong expertise in genomics/epigenomics/cell-free nucleic acids. Supported by @bartscharity.bsky.social to develop genomic and epigenomic liquid biopsy analyses for diagnostics.
is looking to recruit a senior lecturer with strong expertise in genomics/epigenomics/cell-free nucleic acids. Supported by @bartscharity.bsky.social to develop genomic and epigenomic liquid biopsy analyses for diagnostics.
QMUL Epigenetics Centre (www.qmul.ac.uk/epigenetics/) is looking to recruit a senior lecturer with expertise in Genomics/Epigenomics and/or cell-free DNA. This is an excellent opportunity to join a strong Epigenetics and genomics community. Pl share/apply here
qmul-jobs.tal.net/vx/mobile-0/...
qmul-jobs.tal.net/vx/mobile-0/...
January 24, 2025 at 9:25 AM
@blizardinstitute.bsky.social, @qmulepigenetics.bsky.social
is looking to recruit a senior lecturer with strong expertise in genomics/epigenomics/cell-free nucleic acids. Supported by @bartscharity.bsky.social to develop genomic and epigenomic liquid biopsy analyses for diagnostics.
is looking to recruit a senior lecturer with strong expertise in genomics/epigenomics/cell-free nucleic acids. Supported by @bartscharity.bsky.social to develop genomic and epigenomic liquid biopsy analyses for diagnostics.
Reposted by Fran Rodriguez-Algarra
The world has been through anti-science cycles before, to disastrous results
On a detour on my lit review, a mosey through the history of our familiar friend, the standard onion (Allium cepa) brought me right to one of botany's greatest cautionary tales of what happens when ideology overrides data
On a detour on my lit review, a mosey through the history of our familiar friend, the standard onion (Allium cepa) brought me right to one of botany's greatest cautionary tales of what happens when ideology overrides data
January 23, 2025 at 9:50 PM
The world has been through anti-science cycles before, to disastrous results
On a detour on my lit review, a mosey through the history of our familiar friend, the standard onion (Allium cepa) brought me right to one of botany's greatest cautionary tales of what happens when ideology overrides data
On a detour on my lit review, a mosey through the history of our familiar friend, the standard onion (Allium cepa) brought me right to one of botany's greatest cautionary tales of what happens when ideology overrides data
Reposted by Fran Rodriguez-Algarra
🚨New review paper alert!🚨 At the
@rakyanlab.bsky.social
, we have summarised what is currently known about genetic variation within the human ribosomal DNA and its potential consequences. Check it out if you are curious!!! Plenty of intriguing possibilities 😊
onlinelibrary.wiley.com/doi/10.1002/...
@rakyanlab.bsky.social
, we have summarised what is currently known about genetic variation within the human ribosomal DNA and its potential consequences. Check it out if you are curious!!! Plenty of intriguing possibilities 😊
onlinelibrary.wiley.com/doi/10.1002/...
Assessing Human Ribosomal DNA Variation and Its Association With Phenotypic Outcomes
Genetic variation within the multi-copy, multi-locus ribosomal DNA (rDNA) can contribute to human complex trait variability. This variation takes the form of copy number, structural arrangement, and ...
onlinelibrary.wiley.com
January 22, 2025 at 11:10 AM
🚨New review paper alert!🚨 At the
@rakyanlab.bsky.social
, we have summarised what is currently known about genetic variation within the human ribosomal DNA and its potential consequences. Check it out if you are curious!!! Plenty of intriguing possibilities 😊
onlinelibrary.wiley.com/doi/10.1002/...
@rakyanlab.bsky.social
, we have summarised what is currently known about genetic variation within the human ribosomal DNA and its potential consequences. Check it out if you are curious!!! Plenty of intriguing possibilities 😊
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Fran Rodriguez-Algarra
We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below.
Please spread the word.
Please spread the word.
Postdoctoral Research Associate - QMUL Jobs
ID: 4897. Title: Postdoctoral Research Associate . Application Deadline:
qmul-jobs.tal.net
January 21, 2025 at 9:33 AM
We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below.
Please spread the word.
Please spread the word.