Vikram Paralkar
@paralkarlab.bsky.social
Physician-Scientist | University of Pennsylvania | Pol I, rRNA, Ribosomes, Chromatin, Transcription | Hematopoiesis and Leukemia | 🩸🔬🧪🧬
https://paralkarlab.med.upenn.edu
https://paralkarlab.med.upenn.edu
Pinned
Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis
Transcription of ribosomal RNAs (rRNAs) from rDNA repeats is the first step of ribosome biogenesis, accounting for a major portion of all cellular transcription. Often regarded as a housekeeping proce...
www.biorxiv.org
📣 New preprint 📣
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
Reposted by Vikram Paralkar
It took some doing, but I finally finished it: the coolest mirror on the planet!
(Sorry @esawebb.org.web.brid.gy, hanging out at a Lagrange point is a disqualifier, I don't make the rules)
(Sorry @esawebb.org.web.brid.gy, hanging out at a Lagrange point is a disqualifier, I don't make the rules)
February 11, 2026 at 12:20 AM
It took some doing, but I finally finished it: the coolest mirror on the planet!
(Sorry @esawebb.org.web.brid.gy, hanging out at a Lagrange point is a disqualifier, I don't make the rules)
(Sorry @esawebb.org.web.brid.gy, hanging out at a Lagrange point is a disqualifier, I don't make the rules)
Totally in line with my expertise and not spam at all!
February 4, 2026 at 12:11 AM
Totally in line with my expertise and not spam at all!
Reposted by Vikram Paralkar
Dr. Pavan spent decades studying rare diseases at NIH. Today, he’s battling one: first diagnosed with MDS-RARSt and, later, myelofibrosis. A stem cell transplant from his son saved his life, made possible in part by NIH-funded research. Learn more: https://ow.ly/XaWp50XXqtu
#Fight4Hematology
#Fight4Hematology
January 29, 2026 at 3:00 PM
Dr. Pavan spent decades studying rare diseases at NIH. Today, he’s battling one: first diagnosed with MDS-RARSt and, later, myelofibrosis. A stem cell transplant from his son saved his life, made possible in part by NIH-funded research. Learn more: https://ow.ly/XaWp50XXqtu
#Fight4Hematology
#Fight4Hematology
Reposted by Vikram Paralkar
This just in. So honored and grateful...
We're proud to join the Vilcek Foundation in recognizing HHMI Investigator Karolin Luger, whose dedication & groundbreaking nucleosome research has led to the development of innovative new drug treatments, including cancer medicines. hhmi.news/49VciEd @vilcekfoundation.bsky.social
February 2, 2026 at 6:24 PM
This just in. So honored and grateful...
Are any of you happy with how your ScienCV-generated biosketch looks? I'm not quite satisfied with mine (formatting, flow, etc), and would love to look at other examples for customization ideas! Please message me if you'd be willing to swap biosketches (confidentially, of course)!
February 1, 2026 at 4:36 PM
Are any of you happy with how your ScienCV-generated biosketch looks? I'm not quite satisfied with mine (formatting, flow, etc), and would love to look at other examples for customization ideas! Please message me if you'd be willing to swap biosketches (confidentially, of course)!
Love to see insights arising from unique and fascinating analyses of existing massive datasets! 😀
Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Population-scale sequencing resolves determinants of persistent EBV DNA - Nature
Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...
www.nature.com
January 28, 2026 at 5:28 PM
Love to see insights arising from unique and fascinating analyses of existing massive datasets! 😀
Credit where credit is due! NCBI helpdesk replied a week after my initial request, and merged my two accounts. I can now make my ScienCV Biosketch!
Just realized that the glitches I'm having with ScienCV are because I have two NCBI accounts... My ORCiD is linked to the obsolete acct, which means that I can't link it to my current acct... I've send a message to NCBI support desk to merge accts, and I hope they are staffed enough to respond...
January 27, 2026 at 4:13 PM
Credit where credit is due! NCBI helpdesk replied a week after my initial request, and merged my two accounts. I can now make my ScienCV Biosketch!
If this nation has a conscience, what will it take to shake it from its slumber?
A video of Alex Pretti reading out the final salute of an unnamed veteran he cared for until the end of his life in the ICU, posted to Facebook by his son.
January 25, 2026 at 9:32 PM
If this nation has a conscience, what will it take to shake it from its slumber?
Congratulations to Aishwarya Pawar (@aishwarya2510.bsky.social), @cambupenn.bsky.social PhD graduate from our lab, for the 2025 Kadesch Prize in Genetics. This award, in honor of Tom Kadesch (former chair of @penngenetics.bsky.social) honors graduate student excellence in research & citizenship.
January 23, 2026 at 7:57 PM
Congratulations to Aishwarya Pawar (@aishwarya2510.bsky.social), @cambupenn.bsky.social PhD graduate from our lab, for the 2025 Kadesch Prize in Genetics. This award, in honor of Tom Kadesch (former chair of @penngenetics.bsky.social) honors graduate student excellence in research & citizenship.
Congratulations to Charles Antony (@cantony07.bsky.social), Research Associate in our lab, for being awarded a 2026 American Society of Hematology (ASH) Fellow to Faculty Scholar Award for his investigations into ribosomal RNA transcription in hematopoiesis! Many thanks to ASH for this honor! #ASH
January 23, 2026 at 7:51 PM
Congratulations to Charles Antony (@cantony07.bsky.social), Research Associate in our lab, for being awarded a 2026 American Society of Hematology (ASH) Fellow to Faculty Scholar Award for his investigations into ribosomal RNA transcription in hematopoiesis! Many thanks to ASH for this honor! #ASH
😭
January 18, 2026 at 5:26 PM
😭
Just realized that the glitches I'm having with ScienCV are because I have two NCBI accounts... My ORCiD is linked to the obsolete acct, which means that I can't link it to my current acct... I've send a message to NCBI support desk to merge accts, and I hope they are staffed enough to respond...
January 17, 2026 at 1:04 PM
Just realized that the glitches I'm having with ScienCV are because I have two NCBI accounts... My ORCiD is linked to the obsolete acct, which means that I can't link it to my current acct... I've send a message to NCBI support desk to merge accts, and I hope they are staffed enough to respond...
Reposted by Vikram Paralkar
Portrait of @nobelprize.org laureate Carol Greider for the @nationalacademies.org.
Alongside her mentor Elizabeth Blackburn, Dr Greider identified telomerase, an enzyme that maintains the protective caps at the ends of chromosomes known as telomeres.
More: explorers.com/carol-grieder/ #SciArt
Alongside her mentor Elizabeth Blackburn, Dr Greider identified telomerase, an enzyme that maintains the protective caps at the ends of chromosomes known as telomeres.
More: explorers.com/carol-grieder/ #SciArt
January 16, 2026 at 2:00 PM
Portrait of @nobelprize.org laureate Carol Greider for the @nationalacademies.org.
Alongside her mentor Elizabeth Blackburn, Dr Greider identified telomerase, an enzyme that maintains the protective caps at the ends of chromosomes known as telomeres.
More: explorers.com/carol-grieder/ #SciArt
Alongside her mentor Elizabeth Blackburn, Dr Greider identified telomerase, an enzyme that maintains the protective caps at the ends of chromosomes known as telomeres.
More: explorers.com/carol-grieder/ #SciArt
Reposted by Vikram Paralkar
Delighted to have our work on 🧬 resilience to 🩸cancer led by @g-agarwal.bsky.social & amazing collaborators, including @kharaslab.bsky.social, published in @science.org: www.science.org/doi/10.1126/... 🧵
January 2, 2026 at 2:01 PM
Delighted to have our work on 🧬 resilience to 🩸cancer led by @g-agarwal.bsky.social & amazing collaborators, including @kharaslab.bsky.social, published in @science.org: www.science.org/doi/10.1126/... 🧵
Reposted by Vikram Paralkar
My cartoon for the latest @newscientist.com
December 29, 2025 at 5:40 PM
My cartoon for the latest @newscientist.com
Reposted by Vikram Paralkar
If you’ve heard me talk in the past ~5 years, you will know I have developed an obsession with acrocentric chromosomes. This is all of that, condensed into one paper. I will do a full thread in the new year, but for those that want something to read over the holidays, have at it. Such a cool story!
Origin and evolution of acrocentric chromosomes in human and great apes https://www.biorxiv.org/content/10.64898/2025.12.22.696095v1
December 24, 2025 at 3:59 AM
If you’ve heard me talk in the past ~5 years, you will know I have developed an obsession with acrocentric chromosomes. This is all of that, condensed into one paper. I will do a full thread in the new year, but for those that want something to read over the holidays, have at it. Such a cool story!
Reposted by Vikram Paralkar
Congrats to Nancy Speck, PhD, recipient of the E. Donnall Thomas Lecture and Prize, honoring seminal discoveries in hematopoiesis and leukemogenesis!
6/12
6/12
December 19, 2025 at 3:01 PM
Congrats to Nancy Speck, PhD, recipient of the E. Donnall Thomas Lecture and Prize, honoring seminal discoveries in hematopoiesis and leukemogenesis!
6/12
6/12
Reposted by Vikram Paralkar
Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...
December 16, 2025 at 4:06 PM
Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...
Between words of endearment, grandma will gently urge you to buy more crypto...
IN DEPTH | If you could speak to your dead grandmother forever, would you?
If you could speak to your dead grandmother forever, would you?
www.independent.co.uk
December 11, 2025 at 12:26 AM
Between words of endearment, grandma will gently urge you to buy more crypto...
Q: Why is the brain anxious?
A: Because it's made of nervous tissue.
A: Because it's made of nervous tissue.
December 10, 2025 at 5:00 PM
Q: Why is the brain anxious?
A: Because it's made of nervous tissue.
A: Because it's made of nervous tissue.
Congratulations to @mafdawson.bsky.social for being awarded the Dameshek Prize by @ash.hematology.org at #ASH25!
December 10, 2025 at 2:13 AM
Congratulations to @mafdawson.bsky.social for being awarded the Dameshek Prize by @ash.hematology.org at #ASH25!
😵💫🤯
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
December 9, 2025 at 9:59 PM
😵💫🤯
Incredible E. Donnall Thomas award talk by Nancy Speck at #ASH25 @ash.hematology.org. Such a beautiful retrospective of her career and landmark contributions! I'm so honored to have her as a friend and mentor.
December 8, 2025 at 2:59 PM
Incredible E. Donnall Thomas award talk by Nancy Speck at #ASH25 @ash.hematology.org. Such a beautiful retrospective of her career and landmark contributions! I'm so honored to have her as a friend and mentor.
Reposted by Vikram Paralkar
Congratulations to Dr. Jorge Di Paola for winning the 2025 ASH Mentor Award and Dr. Diane Krause for winning the ASH Advancing Inclusive Excellence Award!
@ash.hematology.org President Dr. Avalos was honored to present these at #ASH25
@ash.hematology.org President Dr. Avalos was honored to present these at #ASH25
December 7, 2025 at 8:14 PM
Congratulations to Dr. Jorge Di Paola for winning the 2025 ASH Mentor Award and Dr. Diane Krause for winning the ASH Advancing Inclusive Excellence Award!
@ash.hematology.org President Dr. Avalos was honored to present these at #ASH25
@ash.hematology.org President Dr. Avalos was honored to present these at #ASH25
So great to connect at ASH with Jing Luan, who was a technician in the lab of Mitch Weiss (working with me when I was post-doc there), then an MD/PhD student in the lab of Gerd Blobel, and who will begin her Heme-Onc fellowship at Dana Farber next year!
December 6, 2025 at 7:35 PM
So great to connect at ASH with Jing Luan, who was a technician in the lab of Mitch Weiss (working with me when I was post-doc there), then an MD/PhD student in the lab of Gerd Blobel, and who will begin her Heme-Onc fellowship at Dana Farber next year!