Vikram Paralkar
@paralkarlab.bsky.social
Physician-Scientist | University of Pennsylvania | Pol I, rRNA, Ribosomes, Chromatin, Transcription | Hematopoiesis and Leukemia | 🩸🔬🧪🧬
https://paralkarlab.med.upenn.edu
https://paralkarlab.med.upenn.edu
Pinned
Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis
Transcription of ribosomal RNAs (rRNAs) from rDNA repeats is the first step of ribosome biogenesis, accounting for a major portion of all cellular transcription. Often regarded as a housekeeping proce...
www.biorxiv.org
📣 New preprint 📣
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
Reposted by Vikram Paralkar
My cartoon for the latest @newscientist.com
December 29, 2025 at 5:40 PM
My cartoon for the latest @newscientist.com
Reposted by Vikram Paralkar
If you’ve heard me talk in the past ~5 years, you will know I have developed an obsession with acrocentric chromosomes. This is all of that, condensed into one paper. I will do a full thread in the new year, but for those that want something to read over the holidays, have at it. Such a cool story!
Origin and evolution of acrocentric chromosomes in human and great apes https://www.biorxiv.org/content/10.64898/2025.12.22.696095v1
December 24, 2025 at 3:59 AM
If you’ve heard me talk in the past ~5 years, you will know I have developed an obsession with acrocentric chromosomes. This is all of that, condensed into one paper. I will do a full thread in the new year, but for those that want something to read over the holidays, have at it. Such a cool story!
Reposted by Vikram Paralkar
Congrats to Nancy Speck, PhD, recipient of the E. Donnall Thomas Lecture and Prize, honoring seminal discoveries in hematopoiesis and leukemogenesis!
6/12
6/12
December 19, 2025 at 3:01 PM
Congrats to Nancy Speck, PhD, recipient of the E. Donnall Thomas Lecture and Prize, honoring seminal discoveries in hematopoiesis and leukemogenesis!
6/12
6/12
Reposted by Vikram Paralkar
Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...
December 16, 2025 at 4:06 PM
Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...
Between words of endearment, grandma will gently urge you to buy more crypto...
IN DEPTH | If you could speak to your dead grandmother forever, would you?
If you could speak to your dead grandmother forever, would you?
www.independent.co.uk
December 11, 2025 at 12:26 AM
Between words of endearment, grandma will gently urge you to buy more crypto...
Q: Why is the brain anxious?
A: Because it's made of nervous tissue.
A: Because it's made of nervous tissue.
December 10, 2025 at 5:00 PM
Q: Why is the brain anxious?
A: Because it's made of nervous tissue.
A: Because it's made of nervous tissue.
Congratulations to @mafdawson.bsky.social for being awarded the Dameshek Prize by @ash.hematology.org at #ASH25!
December 10, 2025 at 2:13 AM
Congratulations to @mafdawson.bsky.social for being awarded the Dameshek Prize by @ash.hematology.org at #ASH25!
😵💫🤯
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
December 9, 2025 at 9:59 PM
😵💫🤯
Incredible E. Donnall Thomas award talk by Nancy Speck at #ASH25 @ash.hematology.org. Such a beautiful retrospective of her career and landmark contributions! I'm so honored to have her as a friend and mentor.
December 8, 2025 at 2:59 PM
Incredible E. Donnall Thomas award talk by Nancy Speck at #ASH25 @ash.hematology.org. Such a beautiful retrospective of her career and landmark contributions! I'm so honored to have her as a friend and mentor.
Reposted by Vikram Paralkar
Congratulations to Dr. Jorge Di Paola for winning the 2025 ASH Mentor Award and Dr. Diane Krause for winning the ASH Advancing Inclusive Excellence Award!
@ash.hematology.org President Dr. Avalos was honored to present these at #ASH25
@ash.hematology.org President Dr. Avalos was honored to present these at #ASH25
December 7, 2025 at 8:14 PM
Congratulations to Dr. Jorge Di Paola for winning the 2025 ASH Mentor Award and Dr. Diane Krause for winning the ASH Advancing Inclusive Excellence Award!
@ash.hematology.org President Dr. Avalos was honored to present these at #ASH25
@ash.hematology.org President Dr. Avalos was honored to present these at #ASH25
So great to connect at ASH with Jing Luan, who was a technician in the lab of Mitch Weiss (working with me when I was post-doc there), then an MD/PhD student in the lab of Gerd Blobel, and who will begin her Heme-Onc fellowship at Dana Farber next year!
December 6, 2025 at 7:35 PM
So great to connect at ASH with Jing Luan, who was a technician in the lab of Mitch Weiss (working with me when I was post-doc there), then an MD/PhD student in the lab of Gerd Blobel, and who will begin her Heme-Onc fellowship at Dana Farber next year!
My dream at the @ash.hematology.org meeting is to get a string of ribbons all the way down to my ankles! 😂
December 6, 2025 at 7:20 PM
My dream at the @ash.hematology.org meeting is to get a string of ribbons all the way down to my ankles! 😂
Absolutely fantastic Epigenetics and Genomics session on the latest frontiers of enhancer biology by @andersshansen.bsky.social, Martin Rivas and Mira Kassouf at the @ash.hematology.org annual meeting. Chaired by Megan McNerney.
December 6, 2025 at 3:44 PM
Absolutely fantastic Epigenetics and Genomics session on the latest frontiers of enhancer biology by @andersshansen.bsky.social, Martin Rivas and Mira Kassouf at the @ash.hematology.org annual meeting. Chaired by Megan McNerney.
Reposted by Vikram Paralkar
What an awesome stem cell session speaker group for #ASH25 Workshop on Myeloid Development @vangalenlab.bsky.social @thekinglab.bsky.social @paralkarlab.bsky.social Sandra Pinho and Allison Yeh (love the photobomb!)
December 5, 2025 at 10:33 PM
What an awesome stem cell session speaker group for #ASH25 Workshop on Myeloid Development @vangalenlab.bsky.social @thekinglab.bsky.social @paralkarlab.bsky.social Sandra Pinho and Allison Yeh (love the photobomb!)
Reposted by Vikram Paralkar
ASH is coming! Excited to present alongside Vikram Paralkar, Sandra Pinho, Peter Van Galen, and Alison Yeh at the stem cell session of the myeloid workshop on Friday. @ericpietras.bsky.social will be moderating— don’t miss it!
December 2, 2025 at 4:32 PM
ASH is coming! Excited to present alongside Vikram Paralkar, Sandra Pinho, Peter Van Galen, and Alison Yeh at the stem cell session of the myeloid workshop on Friday. @ericpietras.bsky.social will be moderating— don’t miss it!
Reposted by Vikram Paralkar
who decided to call it Secret Santa when Nondisclosure Claus was right there
December 1, 2025 at 10:55 PM
who decided to call it Secret Santa when Nondisclosure Claus was right there
I've been making small donations to Wikipedia for many years. Given the enormous service that it provides to all of us, it's in our collective interest to keep it smoothly running.
I take Wikipedia for granted. Reading this Jimmy Wales interview reminded me in our Fantasyland age what a remarkable and important creation it is. True pillar of civilization. Runs on only $200 million a year. Requires our support. So I’m finally donating. Gift link: www.nytimes.com/2025/10/18/m...
The Culture Wars Came for Wikipedia. Jimmy Wales Is Staying the Course.
www.nytimes.com
December 1, 2025 at 1:02 AM
I've been making small donations to Wikipedia for many years. Given the enormous service that it provides to all of us, it's in our collective interest to keep it smoothly running.
Listening to Bach and marveling, just marveling, at the fact that such music exists on this earth.
November 28, 2025 at 11:38 PM
Listening to Bach and marveling, just marveling, at the fact that such music exists on this earth.
I now know how antigens feel... 😅
November 22, 2025 at 1:24 PM
I now know how antigens feel... 😅
Most of us wouldn't be able to tell that this blot is fake! We're headed towards a topsy-turvy future. 😵💫
Finally the scary example. The image of a western blot with a time course experiment, staining a protein of interest, showing the increase of protein over time and a second staining with a control antibody that does not change over time
November 21, 2025 at 3:16 PM
Most of us wouldn't be able to tell that this blot is fake! We're headed towards a topsy-turvy future. 😵💫
Reposted by Vikram Paralkar
For 40+ years, the ASH Scholar Award has helped jumpstart careers in hematology—funding 678 awards, $82M in research, and $3B in follow-on funding. Learn more: https://bit.ly/4idJLvV
#ASHAwards
#ASHAwards
November 20, 2025 at 8:00 PM
For 40+ years, the ASH Scholar Award has helped jumpstart careers in hematology—funding 678 awards, $82M in research, and $3B in follow-on funding. Learn more: https://bit.ly/4idJLvV
#ASHAwards
#ASHAwards
Why did I never before realize that the Michelin that gives ⭐stars⭐ to restaurants for exquisite dining is the same puffy Michelin dude who sells tyres?!?
a man is hugging a michelin mascot in front of a sign for spark plugs
ALT: a man is hugging a michelin mascot in front of a sign for spark plugs
media.tenor.com
November 19, 2025 at 10:21 PM
Why did I never before realize that the Michelin that gives ⭐stars⭐ to restaurants for exquisite dining is the same puffy Michelin dude who sells tyres?!?
Step 1: Don't own any bitcoin.
November 17, 2025 at 10:32 PM
Step 1: Don't own any bitcoin.
It's so difficult to "score" applicants for our PhD and MD/PhD program this year - they are all so accomplished, eloquent, intelligent, and driven! My recommendation: Recruit them all! 😁
November 14, 2025 at 3:31 PM
It's so difficult to "score" applicants for our PhD and MD/PhD program this year - they are all so accomplished, eloquent, intelligent, and driven! My recommendation: Recruit them all! 😁
Hope this terrible law isn't passed by Congress...
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
U.S. Congress considers sweeping ban on Chinese collaborations
Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students
www.science.org
November 14, 2025 at 12:43 PM
Hope this terrible law isn't passed by Congress...